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PE20210042A1 - Metodos para detectar transtiretina - Google Patents

Metodos para detectar transtiretina

Info

Publication number
PE20210042A1
PE20210042A1 PE2020000647A PE2020000647A PE20210042A1 PE 20210042 A1 PE20210042 A1 PE 20210042A1 PE 2020000647 A PE2020000647 A PE 2020000647A PE 2020000647 A PE2020000647 A PE 2020000647A PE 20210042 A1 PE20210042 A1 PE 20210042A1
Authority
PE
Peru
Prior art keywords
ttr
antibody
misfolded
biological sample
transthyretin
Prior art date
Application number
PE2020000647A
Other languages
English (en)
Inventor
Joshua Reginald Salmans
Svetlana Alexander
Robin Barbour
Jianmin Li
Jeffrey N Higaki
Tarlochan S Nijjar
Original Assignee
Prothena Biosciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prothena Biosciences Ltd filed Critical Prothena Biosciences Ltd
Publication of PE20210042A1 publication Critical patent/PE20210042A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/603—Salicylic acid; Derivatives thereof having further aromatic rings, e.g. diflunisal
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
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    • G01N2333/4728—Details alpha-Glycoproteins
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    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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Abstract

Se refiere a un metodo para detectar transtiretina (TTR) mal plegada en una muestra biologica, comprendiendo el metodo: (a) poner en contacto una muestra biologica con un anticuerpo de captura que se une especificamente a un epitope dentro de los residuos 89-97 de TTR y un anticuerpo reportero que se une especificamente a un epitope diferente de TTR; en donde si esta presente TTR mal plegada en la muestra, el anticuerpo de captura y el anticuerpo reportero se unen a la TTR mal plegada formando un complejo sandwich; y (b) detectar el anticuerpo reportero que forma un complejo sandwich en la etapa (a), para indicar la presencia o ausencia de la TTR mal plegada. La muestra biologica es de un paciente con amiloidosis mediada por transtiretina hereditaria (ATTR). El anticuerpo de captura es 9D5 y el anticuerpo reportero es un anticuerpo anti-TTR policlonal. Tambien se refiere a un metodo para determinar una proporcion del nivel de transtiretina (TTR) mal plegada multimerica total en relacion con el nivel de TTR mal plegada total en una muestra biologica y un metodo para determinar acoplamiento a diana in vivo de un anticuerpo de ensayo administrado a un sujeto. Dichos metodos pueden ser utilizados para diagnosticar enfermedades o trastornos asociados con acumulacion de TTR
PE2020000647A 2017-10-06 2018-10-05 Metodos para detectar transtiretina PE20210042A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762569438P 2017-10-06 2017-10-06
US201762579817P 2017-10-31 2017-10-31
US201862647582P 2018-03-23 2018-03-23
PCT/US2018/054723 WO2019071206A1 (en) 2017-10-06 2018-10-05 METHODS OF DETECTING TRANSTHYRETIN

Publications (1)

Publication Number Publication Date
PE20210042A1 true PE20210042A1 (es) 2021-01-08

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PE2020000647A PE20210042A1 (es) 2017-10-06 2018-10-05 Metodos para detectar transtiretina

Country Status (14)

Country Link
US (1) US12247985B2 (es)
EP (1) EP3691626A4 (es)
JP (1) JP7292569B2 (es)
KR (1) KR102581734B1 (es)
CN (1) CN111757730A (es)
AU (1) AU2018345807B2 (es)
BR (1) BR112020006791A2 (es)
CA (1) CA3077353A1 (es)
CU (1) CU20200022A7 (es)
MX (1) MX2020003043A (es)
PE (1) PE20210042A1 (es)
SG (1) SG11202002490UA (es)
WO (1) WO2019071206A1 (es)
ZA (1) ZA202002137B (es)

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US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
TWI718122B (zh) 2015-01-28 2021-02-11 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
CU24731B1 (es) 2017-10-06 2025-01-15 Prothena Biosciences Ltd Anticuerpos anti-transtiretina
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