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PE20191403A1 - Anticuerpos anti-ox40 y sus usos - Google Patents

Anticuerpos anti-ox40 y sus usos

Info

Publication number
PE20191403A1
PE20191403A1 PE2019001249A PE2019001249A PE20191403A1 PE 20191403 A1 PE20191403 A1 PE 20191403A1 PE 2019001249 A PE2019001249 A PE 2019001249A PE 2019001249 A PE2019001249 A PE 2019001249A PE 20191403 A1 PE20191403 A1 PE 20191403A1
Authority
PE
Peru
Prior art keywords
antibodies
cdrs
seq
nos
chain
Prior art date
Application number
PE2019001249A
Other languages
English (en)
Inventor
Fiona A Harding
Original Assignee
Abbvie Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Biotherapeutics Inc filed Critical Abbvie Biotherapeutics Inc
Publication of PE20191403A1 publication Critical patent/PE20191403A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Referido a un anticuerpo anti-OX40 que comprende una cadena VH que comprende tres CDR de SEQ ID NOs: 101, 102 y 103; y una cadena VL que comprende tres CDR de SEQ ID NOs: 104, 105 y 106. Tambien se refiere a un acido nucleico, un vector, una celula huesped, una composicion farmaceutica incluyen dichos anticuerpos y metodos para su elaboracion; ademas de uso para tratar el cancer de vejiga, mama, gastrico, entre otros.
PE2019001249A 2016-12-15 2017-12-15 Anticuerpos anti-ox40 y sus usos PE20191403A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662434761P 2016-12-15 2016-12-15
PCT/US2017/066680 WO2018112346A1 (en) 2016-12-15 2017-12-15 Anti-ox40 antibodies and their uses

Publications (1)

Publication Number Publication Date
PE20191403A1 true PE20191403A1 (es) 2019-10-04

Family

ID=60937946

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019001249A PE20191403A1 (es) 2016-12-15 2017-12-15 Anticuerpos anti-ox40 y sus usos

Country Status (37)

Country Link
US (7) US10556962B2 (es)
EP (2) EP3504242B1 (es)
JP (2) JP6772385B2 (es)
KR (2) KR102341926B1 (es)
CN (1) CN110573527A (es)
AR (1) AR110526A1 (es)
AU (1) AU2017377036B2 (es)
BR (2) BR122020025629B1 (es)
CA (1) CA3045940A1 (es)
CL (1) CL2019001646A1 (es)
CO (1) CO2019007288A2 (es)
CR (1) CR20190330A (es)
CY (1) CY1123274T1 (es)
DK (1) DK3504242T3 (es)
DO (1) DOP2019000165A (es)
EC (1) ECSP19050049A (es)
ES (1) ES2813057T3 (es)
HR (1) HRP20201259T1 (es)
HU (1) HUE050399T2 (es)
IL (1) IL267070A (es)
LT (1) LT3504242T (es)
MA (1) MA53184A (es)
MX (1) MX2019007121A (es)
MY (1) MY198059A (es)
PE (1) PE20191403A1 (es)
PH (1) PH12019501357A1 (es)
PL (1) PL3504242T3 (es)
PT (1) PT3504242T (es)
RS (1) RS60664B1 (es)
RU (1) RU2753493C2 (es)
SG (1) SG10201914126RA (es)
SI (1) SI3504242T1 (es)
SM (1) SMT202000462T1 (es)
TW (1) TWI734879B (es)
UA (1) UA125041C2 (es)
UY (1) UY37523A (es)
WO (1) WO2018112346A1 (es)

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EP3504242B1 (en) * 2016-12-15 2020-06-24 AbbVie Biotherapeutics Inc. Anti-ox40 antibodies and their uses
JP2020522541A (ja) * 2017-06-09 2020-07-30 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 癌を治療するためのｉｃｏｓアゴニストおよびｏｘ４０アゴニストでの組み合わせ療法
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CN111303285B (zh) * 2019-12-27 2023-06-02 百力司康生物医药(杭州)有限公司 靶向ox40的抗体及其制备方法和应用
JP2023519584A (ja) * 2020-03-23 2023-05-11 バイオ － テラ ソリューションズ、リミテッド 免疫細胞活性化剤の開発及び応用
TWI802923B (zh) * 2020-06-30 2023-05-21 大陸商和鉑醫藥（上海）有限責任公司 標靶ｏｘ４０的抗體及其製備方法和應用
CN111704671B (zh) * 2020-08-19 2020-11-24 广东赛尔生物科技有限公司 Ox40抗体及其在治疗癌症中的应用
CN112442121A (zh) * 2020-08-20 2021-03-05 山东兴瑞生物科技有限公司 Ox40抗体、其编码基因、及抗体的制备方法和在增强人体免疫功能中的应用
CN114106173A (zh) * 2020-08-26 2022-03-01 上海泰槿生物技术有限公司 抗ox40抗体、其药物组合物及应用
CN111763258B (zh) * 2020-09-01 2020-12-29 北京百奥赛图基因生物技术有限公司 抗ox40抗体及其用途
CN114515335A (zh) * 2020-11-19 2022-05-20 百奥泰生物制药股份有限公司 抗ox40抗体在治疗肿瘤或癌症中的应用
JP2024508207A (ja) 2020-12-02 2024-02-26 ブイアイビー ブイゼットダブリュ がんに対する組み合わせ治療におけるｌｔｂｒアゴニスト
CN115260312B (zh) * 2021-04-30 2025-02-14 保诺科技（北京）有限公司 结合ox40的抗体或抗原结合片段

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LT3504242T (lt) 2020-09-10
WO2018112346A1 (en) 2018-06-21
KR20210157471A (ko) 2021-12-28
JP2020504101A (ja) 2020-02-06
US10556962B2 (en) 2020-02-11
ECSP19050049A (es) 2019-07-31
EP3504242A1 (en) 2019-07-03
ES2813057T3 (es) 2021-03-22
US20210017289A1 (en) 2021-01-21
HUE050399T2 (hu) 2020-12-28
TWI734879B (zh) 2021-08-01
PL3504242T3 (pl) 2020-11-16
CL2019001646A1 (es) 2019-08-23
UA125041C2 (uk) 2021-12-29
RU2019121895A3 (es) 2021-02-15
SI3504242T1 (sl) 2020-10-30
AU2017377036B2 (en) 2022-06-23
MY198059A (en) 2023-07-31
SMT202000462T1 (it) 2020-09-10
UY37523A (es) 2018-07-31
JP6772385B2 (ja) 2020-10-21
AU2017377036A1 (en) 2019-07-11
US20180346593A1 (en) 2018-12-06
RU2753493C2 (ru) 2021-08-17
AR110526A1 (es) 2019-04-10
BR122020025629B1 (pt) 2022-05-31
MA53184A (fr) 2021-05-26
SG10201914126RA (en) 2020-02-27
EP3725809A1 (en) 2020-10-21
CN110573527A (zh) 2019-12-13
US20180171023A1 (en) 2018-06-21
PT3504242T (pt) 2020-08-26
KR20190092552A (ko) 2019-08-07
US20180194855A1 (en) 2018-07-12
US20200181282A1 (en) 2020-06-11
JP2021019603A (ja) 2021-02-18
KR102341926B1 (ko) 2021-12-23
RS60664B1 (sr) 2020-09-30
PH12019501357A1 (en) 2020-01-20
EP3504242B1 (en) 2020-06-24
RU2019121895A (ru) 2021-01-15
IL267070A (en) 2019-08-29
DOP2019000165A (es) 2019-07-15
US20220112304A1 (en) 2022-04-14
CY1123274T1 (el) 2021-12-31
HRP20201259T1 (hr) 2020-11-13
TW201825520A (zh) 2018-07-16
CR20190330A (es) 2019-12-19
BR112019012328A2 (pt) 2019-11-19
CO2019007288A2 (es) 2019-08-20
US10604584B2 (en) 2020-03-31
MX2019007121A (es) 2020-02-05
US20200048363A1 (en) 2020-02-13
DK3504242T3 (da) 2020-08-17
US10040864B2 (en) 2018-08-07
CA3045940A1 (en) 2018-06-21

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