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PE20151776A1 - Compuestos de heteroarilo y sus usos - Google Patents

Compuestos de heteroarilo y sus usos

Info

Publication number
PE20151776A1
PE20151776A1 PE2015002022A PE2015002022A PE20151776A1 PE 20151776 A1 PE20151776 A1 PE 20151776A1 PE 2015002022 A PE2015002022 A PE 2015002022A PE 2015002022 A PE2015002022 A PE 2015002022A PE 20151776 A1 PE20151776 A1 PE 20151776A1
Authority
PE
Peru
Prior art keywords
diseases
optionally substituted
compounds
bivalent
halogen
Prior art date
Application number
PE2015002022A
Other languages
English (en)
Inventor
Laura Akullian D'agostino
Robert Tjin Tham Sjin
Deqiang Niu
Joseph John Mcdonald
Zhendong Zhu
Haibo Liu
Hormoz Mazdiyasni
Russell C Petter
Juswinder Singh
Matthieu Barrague
Alexandre Gross
Mark Munson
Darren Harvey
Andrew Scholte
Sachin Maniar
Original Assignee
Celgene Avilomics Res Inc
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Avilomics Res Inc, Sanofi Sa filed Critical Celgene Avilomics Res Inc
Publication of PE20151776A1 publication Critical patent/PE20151776A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA I O SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, EN LOS CUALES X1 ES NH, N, CH2 o CH, ENTRE OTROS; X2 ES NH, N, CH2 o CH, ENTRE OTROS; X3 Y X4 SON INDEPENDIENTEMENTE N o CH, ENTRE OTROS; X5 ES N, C o CH; EN DONDE AL MENOS UNO DE X1, X2, X3, X4 o X5 ES N; G ES H, O, OH o NH2, ENTRE OTROS; A ES FENILO OPCIONALMENTE SUSTITUIDO, UN ANILLO CARBOCICLICO C3-8 OPCIONALMENTE SUSTITUIDO, O UN ANILLO HETEROCICLICO DE 4-7 MIEMBROS CONTENIENDO 1-4 HETEROATOMOS (O, N o S) OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; R1 ES -L-Y, DONDE L ES UNA CADENA DE HIDROCARBURO C2-8 BIVALENTE, ENTRE OTROS, E Y ES H, HALOGENO, NO2 O CN, ENTRE OTROS; CADA R2 ES INDEPENDIENTEMENTE H, HALOGENO, OH, SH, CN, NO2, SO2H, C(O)H, C(O)OH, C(O)NH2, NH2, ENTRE OTROS; R3 ESTA AUSENTE, O ES H, ALQUENILO C2-6 O ALQUILO C1-6, ENTRE OTROS; Y ES O o NH, ENTRE OTROS; T ES UN ENLACE COVALENTE O UNA CADENA DE HIDROCARBURO C1-6 BIVALENTE, ENTRE OTROS; Y q ES 0-6. DICHOS COMPUESTOS SON INHIBIDORES DE UNA O VARIAS PROTEINAS CINASAS (EN PARTICULAR DE FGFR4) QUE CONTIENEN UN RESIDUO DE CISTEINA EN EL SITIO DE UNION A ATP, POR LO CUAL SON UTILES EN LA TERAPIA DE UNA VARIEDAD DE ENFERMEDADES, TRASTORNOS O AFECCIONES ASICOADAS CON RESPUESTAS CELULARES ANORMALES DESENCADENADAS POR EVENTOS MEDIADOS POR PROTEINAS CINASAS, PARTICULARMENTE PREVENIR EL CRECIMIENTO O INDUCIR LA APOPTOSIS DE TUMORES, EN ESPECIAL AL INHIBIR LA ANGIOGENESIS
PE2015002022A 2013-03-15 2014-03-14 Compuestos de heteroarilo y sus usos PE20151776A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361793113P 2013-03-15 2013-03-15
EP14305361 2014-03-13

Publications (1)

Publication Number Publication Date
PE20151776A1 true PE20151776A1 (es) 2015-12-11

Family

ID=50390019

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015002022A PE20151776A1 (es) 2013-03-15 2014-03-14 Compuestos de heteroarilo y sus usos

Country Status (13)

Country Link
US (1) US9663524B2 (es)
EP (1) EP2968337B1 (es)
JP (1) JP6576325B2 (es)
KR (1) KR102219695B1 (es)
CN (2) CN105307657B (es)
AU (1) AU2014228746B2 (es)
BR (1) BR112015022191A8 (es)
EA (1) EA036160B1 (es)
MA (1) MA38393B1 (es)
MX (1) MX374558B (es)
PE (1) PE20151776A1 (es)
SG (1) SG11201507478VA (es)
WO (1) WO2014144737A1 (es)

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US20160046634A1 (en) 2016-02-18
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