PE20142450A1 - Difluoro-hexahidro-ciclopentaoxacinilos y difluoro-hexahidro-benzooxacinilos como inhibidores de bace1 - Google Patents
Difluoro-hexahidro-ciclopentaoxacinilos y difluoro-hexahidro-benzooxacinilos como inhibidores de bace1Info
- Publication number
- PE20142450A1 PE20142450A1 PE2014002406A PE2014002406A PE20142450A1 PE 20142450 A1 PE20142450 A1 PE 20142450A1 PE 2014002406 A PE2014002406 A PE 2014002406A PE 2014002406 A PE2014002406 A PE 2014002406A PE 20142450 A1 PE20142450 A1 PE 20142450A1
- Authority
- PE
- Peru
- Prior art keywords
- difluoro
- hexahydro
- cyclopentaoxacinyls
- benzooxacinyls
- bace1 inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE DIFLUORO-CICLOPENTAOXACINILOS Y DIFLUOROENZOOXACINILOS DE FORMULA (I) DONDE R1, R2, R3, R4, R5 Y n SON COMO SE DESCRIBEN EN EL PRESENTE. SON COMPUESTOS PREFERIDOS: [3-((4S,4aR,7aR)-2-AMINO-5,5-DIFLUORO-4-METIL-4,4a,5,6,7,7a-HEXAHIDRO-CICLOPENTA[e][1,3]OXAZIN-4-IL)-4-FLUORO-FENIL]-AMIDA DEL ACIDO 5-BUT-2-INILOXI-PIRAZINA-2-CARBOXILICO; [3-((4S,4aR,7aR)-2-AMINO-5,5-DIFLUORO-4-METIL-4,4a,5,6,7,7a-HEXAHIDRO-CICLOPENTA[e][1,3]OXAZIN-4-IL)-4-FLUORO-FENIL]-AMIDA DEL ACIDO 5-FLUOROMETIL-PIRAZINA-2-CARBOXILICO; ENTRE OTROS. TAMBIEN SE REFIERE A COMPOSICIONES FARMACEUTICAS. DICHOS COMPUESTOS TIENEN ACTIVIDAD INHIBIDORA BACE1 SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12173690 | 2012-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20142450A1 true PE20142450A1 (es) | 2015-01-28 |
Family
ID=48672630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014002406A PE20142450A1 (es) | 2012-06-26 | 2013-06-24 | Difluoro-hexahidro-ciclopentaoxacinilos y difluoro-hexahidro-benzooxacinilos como inhibidores de bace1 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9181232B2 (es) |
| EP (1) | EP2864324B1 (es) |
| JP (1) | JP6251257B2 (es) |
| KR (1) | KR20150023450A (es) |
| CN (1) | CN104470915B (es) |
| AU (1) | AU2013283524B2 (es) |
| BR (1) | BR112014029742A2 (es) |
| CA (1) | CA2872181A1 (es) |
| CL (1) | CL2014003325A1 (es) |
| CO (1) | CO7151509A2 (es) |
| CR (1) | CR20140528A (es) |
| EA (1) | EA025273B1 (es) |
| HK (1) | HK1206344A1 (es) |
| IL (1) | IL236138A (es) |
| MA (1) | MA37763B1 (es) |
| MX (1) | MX2014014937A (es) |
| NZ (1) | NZ702253A (es) |
| PE (1) | PE20142450A1 (es) |
| PH (1) | PH12014502623B1 (es) |
| SG (1) | SG11201407576YA (es) |
| UA (1) | UA113309C2 (es) |
| WO (1) | WO2014001228A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009151098A1 (ja) | 2008-06-13 | 2009-12-17 | 塩野義製薬株式会社 | βセクレターゼ阻害作用を有する含硫黄複素環誘導体 |
| PH12012501081A1 (en) | 2009-12-11 | 2012-10-29 | Shionogi & Co | Oxazine derivatives |
| US9540359B2 (en) | 2012-10-24 | 2017-01-10 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity |
| US9296734B2 (en) | 2013-03-01 | 2016-03-29 | Amgen Inc. | Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use |
| EA201591614A1 (ru) | 2013-03-08 | 2015-12-30 | Эмджен Инк. | Соединения 1,3-оксазин-2-амина, конденсированные с перфторированным циклопропилом, в качестве ингибиторов бета-секретазы и способы их применения |
| TW201623295A (zh) | 2014-04-11 | 2016-07-01 | 塩野義製藥股份有限公司 | 具有ｂａｃｅ１抑制活性之二氫噻及二氫衍生物 |
| CA2957544C (en) | 2014-08-08 | 2023-01-24 | Amgen Inc. | Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use |
| RU2712272C2 (ru) | 2015-03-20 | 2020-01-28 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы бета-секретазы |
| JP7353708B2 (ja) * | 2018-04-27 | 2023-10-02 | 塩野義製薬株式会社 | 選択的ｂａｃｅ１阻害活性を有するテトラヒドロピラノオキサジン誘導体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2360155A4 (en) | 2008-10-22 | 2012-06-20 | Shionogi & Co | 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT |
| GB0912778D0 (en) * | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
| PH12012501081A1 (en) * | 2009-12-11 | 2012-10-29 | Shionogi & Co | Oxazine derivatives |
| UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
-
2013
- 2013-06-24 US US14/406,289 patent/US9181232B2/en not_active Expired - Fee Related
- 2013-06-24 EP EP13730887.0A patent/EP2864324B1/en not_active Not-in-force
- 2013-06-24 CA CA2872181A patent/CA2872181A1/en not_active Abandoned
- 2013-06-24 SG SG11201407576YA patent/SG11201407576YA/en unknown
- 2013-06-24 AU AU2013283524A patent/AU2013283524B2/en not_active Expired - Fee Related
- 2013-06-24 PE PE2014002406A patent/PE20142450A1/es not_active Application Discontinuation
- 2013-06-24 JP JP2015519008A patent/JP6251257B2/ja not_active Expired - Fee Related
- 2013-06-24 NZ NZ702253A patent/NZ702253A/en not_active IP Right Cessation
- 2013-06-24 EA EA201590066A patent/EA025273B1/ru not_active IP Right Cessation
- 2013-06-24 UA UAA201500578A patent/UA113309C2/uk unknown
- 2013-06-24 MX MX2014014937A patent/MX2014014937A/es unknown
- 2013-06-24 WO PCT/EP2013/063086 patent/WO2014001228A1/en active Application Filing
- 2013-06-24 BR BR112014029742A patent/BR112014029742A2/pt not_active IP Right Cessation
- 2013-06-24 CN CN201380033783.7A patent/CN104470915B/zh not_active Expired - Fee Related
- 2013-06-24 KR KR20147036016A patent/KR20150023450A/ko not_active Application Discontinuation
- 2013-06-24 MA MA37763A patent/MA37763B1/fr unknown
-
2014
- 2014-11-18 CR CR20140528A patent/CR20140528A/es unknown
- 2014-11-24 PH PH12014502623A patent/PH12014502623B1/en unknown
- 2014-12-05 CL CL2014003325A patent/CL2014003325A1/es unknown
- 2014-12-08 IL IL236138A patent/IL236138A/en not_active IP Right Cessation
- 2014-12-10 CO CO14271199A patent/CO7151509A2/es unknown
-
2015
- 2015-07-21 HK HK15106931.2A patent/HK1206344A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US9181232B2 (en) | 2015-11-10 |
| PH12014502623A1 (en) | 2015-01-21 |
| NZ702253A (en) | 2016-06-24 |
| MA37763B1 (fr) | 2017-05-31 |
| EP2864324B1 (en) | 2018-03-28 |
| CO7151509A2 (es) | 2014-12-29 |
| CR20140528A (es) | 2015-01-12 |
| PH12014502623B1 (en) | 2015-01-21 |
| HK1206344A1 (en) | 2016-01-08 |
| MX2014014937A (es) | 2015-03-09 |
| US20150133440A1 (en) | 2015-05-14 |
| UA113309C2 (xx) | 2017-01-10 |
| JP2015521640A (ja) | 2015-07-30 |
| AU2013283524A1 (en) | 2014-11-13 |
| WO2014001228A1 (en) | 2014-01-03 |
| SG11201407576YA (en) | 2015-03-30 |
| AU2013283524B2 (en) | 2017-03-30 |
| EA201590066A1 (ru) | 2015-04-30 |
| JP6251257B2 (ja) | 2017-12-20 |
| EA025273B1 (ru) | 2016-12-30 |
| CA2872181A1 (en) | 2014-01-03 |
| IL236138A (en) | 2016-10-31 |
| KR20150023450A (ko) | 2015-03-05 |
| CL2014003325A1 (es) | 2015-04-24 |
| IL236138A0 (en) | 2015-02-01 |
| MA37763A1 (fr) | 2016-08-31 |
| EP2864324A1 (en) | 2015-04-29 |
| BR112014029742A2 (pt) | 2017-06-27 |
| CN104470915B (zh) | 2019-07-26 |
| CN104470915A (zh) | 2015-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |