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JO3146B1 - مشتقات غير متجانسة الحلقية و استخدامها في علاج الاضطرابات العصبية - Google Patents

مشتقات غير متجانسة الحلقية و استخدامها في علاج الاضطرابات العصبية

Info

Publication number
JO3146B1
JO3146B1 JOP/2012/0010A JOP20120010A JO3146B1 JO 3146 B1 JO3146 B1 JO 3146B1 JO P20120010 A JOP20120010 A JO P20120010A JO 3146 B1 JO3146 B1 JO 3146B1
Authority
JO
Jordan
Prior art keywords
treatment
neurological disorders
heterocyclic derivatives
novel heterocyclic
bace
Prior art date
Application number
JOP/2012/0010A
Other languages
English (en)
Inventor
Jacob Veenstra Siem
Martin Lueoend Rainer
Machauer Rainer
Badiger Sangamesh
Jacquier Sebastien
Hurth 5-Konstanze
Voegtle Markus
TINTELNOT-BLOM LEY Marina
Chebrolu Murali
Rueeger Heinrich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46491227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3146(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3146B1 publication Critical patent/JO3146B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

يتعلق الاختراع الحالي بمشتقات حلقة غير متجانسة جديدة لها الصيغة والتي تعرف فيها المتغيرات في التخصيصات و بتركيبات صيدلية منها و و باستخدامها كدواء و خصوصا لعلاج مرض الزهايمر و السكري من خلال تثبيط BACE-1 أو BACE-2 .
JOP/2012/0010A 2011-01-13 2012-01-12 مشتقات غير متجانسة الحلقية و استخدامها في علاج الاضطرابات العصبية JO3146B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN77DE2011 2011-01-13
US201161534591P 2011-09-14 2011-09-14

Publications (1)

Publication Number Publication Date
JO3146B1 true JO3146B1 (ar) 2017-09-20

Family

ID=46491227

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2012/0010A JO3146B1 (ar) 2011-01-13 2012-01-12 مشتقات غير متجانسة الحلقية و استخدامها في علاج الاضطرابات العصبية

Country Status (41)

Country Link
US (6) US8637508B2 (ar)
EP (1) EP2663561B1 (ar)
JP (1) JP5715710B2 (ar)
KR (1) KR101569260B1 (ar)
CN (2) CN106117193B (ar)
AP (1) AP3807A (ar)
AR (1) AR084849A1 (ar)
AU (1) AU2012206561B2 (ar)
CA (1) CA2824220C (ar)
CL (2) CL2013001964A1 (ar)
CO (1) CO6751293A2 (ar)
CR (1) CR20130339A (ar)
CU (1) CU20130101A7 (ar)
CY (1) CY1117580T1 (ar)
DK (1) DK2663561T3 (ar)
EA (1) EA024059B1 (ar)
ES (1) ES2576182T3 (ar)
GT (1) GT201300179A (ar)
HK (1) HK1188453A1 (ar)
HR (1) HRP20160647T1 (ar)
HU (1) HUE029226T2 (ar)
IL (1) IL227294A (ar)
JO (1) JO3146B1 (ar)
MA (1) MA34898B1 (ar)
ME (1) ME02409B (ar)
MX (1) MX336966B (ar)
MY (1) MY162413A (ar)
PE (1) PE20141110A1 (ar)
PH (1) PH12013501480A1 (ar)
PL (1) PL2663561T3 (ar)
PT (1) PT2663561E (ar)
RS (1) RS54782B1 (ar)
SG (1) SG191812A1 (ar)
SI (1) SI2663561T1 (ar)
SM (1) SMT201600144B (ar)
TN (1) TN2013000285A1 (ar)
TW (1) TWI531570B (ar)
UA (1) UA113051C2 (ar)
UY (1) UY33865A (ar)
WO (1) WO2012095469A1 (ar)
ZA (1) ZA201304921B (ar)

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