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PE20142164A1 - Inhibidores de diacilglicerol aciltransferasa 2 - Google Patents

Inhibidores de diacilglicerol aciltransferasa 2

Info

Publication number
PE20142164A1
PE20142164A1 PE2014001527A PE2014001527A PE20142164A1 PE 20142164 A1 PE20142164 A1 PE 20142164A1 PE 2014001527 A PE2014001527 A PE 2014001527A PE 2014001527 A PE2014001527 A PE 2014001527A PE 20142164 A1 PE20142164 A1 PE 20142164A1
Authority
PE
Peru
Prior art keywords
methanone
pyrrolidin
piperidin
cyclopropyl
cycloalkyl
Prior art date
Application number
PE2014001527A
Other languages
English (en)
Inventor
Kay Ahn
Markus Boehm
Shawn Cabral
Philip A Carpino
Kentaro Futatsugi
David Hepworth
Daniel W Kung
Suvi Orr
Jian Wang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48428540&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20142164(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of PE20142164A1 publication Critical patent/PE20142164A1/es

Links

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE A ES O, S, ENTRE OTROS; B ES UN ENLACE, OXETANILO, ENTRE OTROS; C Y D SON CADA UNO N, CH, CF O C(CH3); R1 ES -C(O)-HETEROCICLILO, -C(O)-NR4R5 O HETEROARILO, EN DONDE R4 Y R5 SON CADA UNO H, ALQUILO(C1-C4), CICLOALQUILO(C3-C6), ARILOXI, ENTRE OTROS; R2 ES ALQUILO(C1-C4), ALCOXI(C1-C4), CICLOALQUILO(C3-C6), ENTRE OTROS; R3 ES ALQUILO(C1-C4), CICLOALQUILO(C3-C6), HIDROXILO O FLUOR; n ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: (1-(2-(1-(4-FLUORO-1H-PIRAZOL-1-IL)CICLOPROPIL)-3H-IMIDAZO[4,5-b]PIRIDIN-5-IL)PIPERIDIN-3-IL)(PIRROLIDIN-1-IL)METANONA; (1-(8-(1-(4-CLORO-1H-PIRAZOL-1-IL)CICLOPROPIL)-9H-PURIN-2-IL)PIPERIDIN-3-IL)(PIRROLIDIN-1-IL)METANONA; (1-(2-(1-(4-CLORO-1H-PIRAZOL-1-IL)CICLOPROPIL)-3H-IMIDAZO[4,5-b]PIRIDIN-5-IL)PIPERIDIN-3-IL)(PIRROLIDIN-1-IL)METANONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE LA DIACILGLICEROL ACILTRANSFERASA 2 (DGAT2) SIENDO UTILES EN EL TRATAMIENTO DE DIABETES, HIPERLIPIDEMIA, OBESIDAD
PE2014001527A 2012-04-06 2013-03-26 Inhibidores de diacilglicerol aciltransferasa 2 PE20142164A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261621144P 2012-04-06 2012-04-06

Publications (1)

Publication Number Publication Date
PE20142164A1 true PE20142164A1 (es) 2014-12-27

Family

ID=48428540

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001527A PE20142164A1 (es) 2012-04-06 2013-03-26 Inhibidores de diacilglicerol aciltransferasa 2

Country Status (27)

Country Link
US (1) US9296745B2 (es)
EP (1) EP2834238B1 (es)
JP (1) JP2015515472A (es)
KR (1) KR20140137404A (es)
CN (1) CN104334557A (es)
AP (1) AP2014007953A0 (es)
AU (1) AU2013245353A1 (es)
CA (1) CA2869587A1 (es)
CL (1) CL2014002541A1 (es)
CO (1) CO7160030A2 (es)
CR (1) CR20140468A (es)
CU (1) CU20140115A7 (es)
DO (1) DOP2014000225A (es)
EA (1) EA201400990A1 (es)
EC (1) ECSP14021251A (es)
GT (1) GT201400213A (es)
HK (1) HK1206735A1 (es)
IL (1) IL234928A0 (es)
MA (1) MA37385B1 (es)
MD (1) MD20140103A2 (es)
MX (1) MX2014011373A (es)
NI (1) NI201400120A (es)
PE (1) PE20142164A1 (es)
PH (1) PH12014502057A1 (es)
SG (1) SG11201405477XA (es)
TN (1) TN2014000419A1 (es)
WO (1) WO2013150416A1 (es)

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TWI841671B (zh) 2019-01-24 2024-05-11 日商第一三共股份有限公司 具有取代基之脲化合物
TWI771766B (zh) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
CN111214449B (zh) * 2020-03-02 2021-09-07 广东彼迪药业有限公司 一种盐酸西替利嗪片剂及其制备方法
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AR123286A1 (es) * 2020-08-19 2022-11-16 Bristol Myers Squibb Co Compuestos de benzimidazol sustituidos útiles como inhibidores de tlr9
TWI817191B (zh) * 2020-09-04 2023-10-01 南韓商Ｌｇ化學股份有限公司 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶２之抑制劑之用途
CR20230159A (es) 2020-10-08 2023-06-02 Merck Sharp & Dohme Llc Preparación de derivados de benzoimidazolona como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2
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