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PE20141146A1 - Inhibidores de la enzima activadora de nedd8 - Google Patents

Inhibidores de la enzima activadora de nedd8

Info

Publication number
PE20141146A1
PE20141146A1 PE2014000250A PE2014000250A PE20141146A1 PE 20141146 A1 PE20141146 A1 PE 20141146A1 PE 2014000250 A PE2014000250 A PE 2014000250A PE 2014000250 A PE2014000250 A PE 2014000250A PE 20141146 A1 PE20141146 A1 PE 20141146A1
Authority
PE
Peru
Prior art keywords
enzyme inhibitors
activating enzyme
nedd8 activating
refers
nedd8
Prior art date
Application number
PE2014000250A
Other languages
English (en)
Inventor
Ashley Sue Mccarron
Todd B Sells
Matthew Stirling
Stephen G Stroud
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of PE20141146A1 publication Critical patent/PE20141146A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE AL COMPUESTO SULFAMATO DE {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-CLORO-2-METOXI-2,3-DIHIDRO-1H-INDEN-1-IL]AMINO}PIRIMIDIN-4-IL)OXI]-2-HIDROXICICLOPENTIL}METILO, QUE SE CARACTERIZA POR UN PATRON DE DIFRACCION DE RAYOS X EN POLVO (XRPD) QUE TIENE PICOS EN EL ANGULO 2 THETA DE 4.5�, 15.2�, 21.3�, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA EL TRATAMIENTO DE CANCER.
PE2014000250A 2011-08-24 2012-08-23 Inhibidores de la enzima activadora de nedd8 PE20141146A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161526830P 2011-08-24 2011-08-24

Publications (1)

Publication Number Publication Date
PE20141146A1 true PE20141146A1 (es) 2014-09-21

Family

ID=47747080

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014000250A PE20141146A1 (es) 2011-08-24 2012-08-23 Inhibidores de la enzima activadora de nedd8

Country Status (29)

Country Link
US (3) US8809356B2 (es)
EP (2) EP3323414A1 (es)
JP (1) JP6038150B2 (es)
KR (1) KR20140054288A (es)
CN (1) CN103889988B (es)
AR (1) AR087672A1 (es)
AU (1) AU2012298813B2 (es)
BR (1) BR112014004239A2 (es)
CA (1) CA2846231C (es)
CL (1) CL2014000441A1 (es)
CO (1) CO6900148A2 (es)
CR (1) CR20140128A (es)
DO (1) DOP2014000037A (es)
EA (1) EA031067B1 (es)
EC (1) ECSP14013263A (es)
GE (1) GEP201606522B (es)
HK (1) HK1199252A1 (es)
IL (1) IL231069B (es)
MA (1) MA35439B1 (es)
MX (1) MX2014002015A (es)
MY (1) MY166889A (es)
PE (1) PE20141146A1 (es)
PH (1) PH12014500419A1 (es)
SG (2) SG11201400102WA (es)
TN (1) TN2014000080A1 (es)
TW (1) TWI577667B (es)
UA (1) UA114894C2 (es)
UY (1) UY34292A (es)
WO (1) WO2013028832A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
PH12014500419A1 (en) * 2011-08-24 2020-06-22 Millennium Pharm Inc Inhibitors of nedd8-activating enzyme
KR20140123104A (ko) 2012-02-17 2014-10-21 밀레니엄 파머슈티컬스 인코퍼레이티드 유비퀴틴 활성화 효소의 피라졸로피리미디닐 억제제
CN104684559A (zh) 2012-08-03 2015-06-03 米伦纽姆医药公司 针对Uba6的吲哚取代的吡咯并嘧啶基抑制剂
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
EA032577B1 (ru) * 2013-07-02 2019-06-28 Милленниум Фармасьютикалз, Инк. Гетероарильные соединения, пригодные в качестве ингибиторов sumo-активирующего фермента
CN103948590A (zh) * 2014-05-22 2014-07-30 中国药科大学 Nedd8激活酶抑制剂及其医药用途
CR20170021A (es) * 2014-07-01 2017-04-04 Millennium Pharm Inc Compuestos de heteroarilo útiles como inhibidores de enzima activadora de sumo
WO2017183927A1 (ko) * 2016-04-20 2017-10-26 한국화학연구원 신규한 헤테로고리 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
WO2018213258A1 (en) * 2017-05-15 2018-11-22 Millennium Pharmaceuticals, Inc. Treatment of merlin-deficient tumors using nae inhibitors
JP7235047B2 (ja) 2018-05-08 2023-03-08 日本新薬株式会社 アザベンゾイミダゾール化合物及び医薬
WO2023025668A1 (en) 2021-08-25 2023-03-02 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Methods for the generation of stem cell memory t cells for adoptive t cell therapy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194446A (en) 1989-06-12 1993-03-16 A. H. Robins Company, Incorporated Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
WO1997005132A1 (en) 1995-07-28 1997-02-13 Cubist Pharmaceuticals, Inc. Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents
AU2003291024A1 (en) 2002-11-13 2004-06-03 Rigel Pharmaceuticals, Inc. Rhodanine derivatives and pharmaceutical compositions containing them
WO2005037845A1 (en) 2003-10-17 2005-04-28 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors
WO2006002284A1 (en) 2004-06-22 2006-01-05 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
ME02012B (me) 2005-02-04 2013-02-28 Millennium Pharm Inc INHIBITORI El AKTIVIRAJUĆIH ENZIMA
RS52437B (en) * 2006-02-02 2013-02-28 Millennium Pharmaceuticals Inc. ACTIVE INHIBITORS Enzyme E1
US8008307B2 (en) * 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
ZA200900670B (en) 2006-08-08 2010-04-28 Millennium Pharm Inc Heteroaryl compounds useful as inhititors of E1 activating enzymes
EP2430026A1 (en) * 2009-05-14 2012-03-21 Millennium Pharmaceuticals, Inc. Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate
PH12014500419A1 (en) * 2011-08-24 2020-06-22 Millennium Pharm Inc Inhibitors of nedd8-activating enzyme
KR101987861B1 (ko) * 2011-11-03 2019-06-11 밀레니엄 파머슈티컬스 인코퍼레이티드 Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여

Also Published As

Publication number Publication date
CO6900148A2 (es) 2014-03-20
HK1199252A1 (en) 2015-06-26
TN2014000080A1 (en) 2015-07-01
US20130150388A1 (en) 2013-06-13
WO2013028832A3 (en) 2013-05-02
IL231069B (en) 2018-02-28
EP3323414A1 (en) 2018-05-23
UY34292A (es) 2013-04-05
CR20140128A (es) 2014-05-15
US20180290983A1 (en) 2018-10-11
TW201313689A (zh) 2013-04-01
CN103889988A (zh) 2014-06-25
UA114894C2 (uk) 2017-08-28
BR112014004239A2 (pt) 2017-03-21
MA35439B1 (fr) 2014-09-01
CL2014000441A1 (es) 2014-09-26
CA2846231A1 (en) 2013-02-28
NZ622220A (en) 2016-04-29
KR20140054288A (ko) 2014-05-08
EP2748168A4 (en) 2015-04-22
PH12014500419A1 (en) 2020-06-22
MY166889A (en) 2018-07-24
JP6038150B2 (ja) 2016-12-07
EA031067B1 (ru) 2018-11-30
SG11201400102WA (en) 2014-03-28
IL231069A0 (en) 2014-03-31
MX2014002015A (es) 2014-03-27
EA201400249A1 (ru) 2014-05-30
JP2014524476A (ja) 2014-09-22
US20150011572A1 (en) 2015-01-08
WO2013028832A2 (en) 2013-02-28
TWI577667B (zh) 2017-04-11
AU2012298813A1 (en) 2013-05-02
DOP2014000037A (es) 2014-04-15
SG10201601023UA (en) 2016-03-30
US9850214B2 (en) 2017-12-26
EP2748168A2 (en) 2014-07-02
US8809356B2 (en) 2014-08-19
AU2012298813B2 (en) 2016-07-28
ECSP14013263A (es) 2014-04-30
CA2846231C (en) 2017-06-20
GEP201606522B (en) 2016-08-10
AR087672A1 (es) 2014-04-09
CN103889988B (zh) 2018-05-04

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