PE20070827A1 - DERIVADOS DE ISOQUINOLINA Y BENZO[h]ISOQUINOLINA, SU PREPARACION Y SU UTILIZACION EN TERAPEUTICA - Google Patents
DERIVADOS DE ISOQUINOLINA Y BENZO[h]ISOQUINOLINA, SU PREPARACION Y SU UTILIZACION EN TERAPEUTICAInfo
- Publication number
- PE20070827A1 PE20070827A1 PE2006001478A PE2006001478A PE20070827A1 PE 20070827 A1 PE20070827 A1 PE 20070827A1 PE 2006001478 A PE2006001478 A PE 2006001478A PE 2006001478 A PE2006001478 A PE 2006001478A PE 20070827 A1 PE20070827 A1 PE 20070827A1
- Authority
- PE
- Peru
- Prior art keywords
- isoquinoline
- preparation
- therapeutics
- benzo
- derivatives
- Prior art date
Links
- FZICDBOJOMQACG-UHFFFAOYSA-N benzo[h]isoquinoline Chemical compound C1=NC=C2C3=CC=CC=C3C=CC2=C1 FZICDBOJOMQACG-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000004384 Histamine H3 receptors Human genes 0.000 abstract 1
- 108090000981 Histamine H3 receptors Proteins 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE A ES CARBOCICLO INSATURADO OPCIONALMENTE SUSTITUIDO CON UNO O DOS SUSTITUYENTES ELEGIDOS DE HALOGENO, HIDROXI, NITRO, ENTRE OTROS; l ES 0-4; m ES 0-3, n ES 0-6; R1 ES H, ALQUILO C1-C3, ALQUILCARBONILO C1-C6, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C6 SUSTITUIDO O NO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 7-{2-[1-METILPIPERIDIN-2-IL]ETOXI}-2-PROPIL-1,2,3,4-TETRAHIDROISOQUINOLINA; 2-ISOBUTIL-7-[2-(1-METILPIRROLIDIN-2-IL)ETOXI]-1,2,3,4-TETRAHODROISOQUINOLINA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS SON MODULADORES DEL RECEPTOR H3 DE LA HISTAMINA, UTILES EN EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO, TRANSTORNOS DE LA VIGILANCIA Y DEL SUENO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05111248A EP1790646A1 (fr) | 2005-11-24 | 2005-11-24 | Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070827A1 true PE20070827A1 (es) | 2007-08-17 |
Family
ID=36295552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001478A PE20070827A1 (es) | 2005-11-24 | 2006-11-20 | DERIVADOS DE ISOQUINOLINA Y BENZO[h]ISOQUINOLINA, SU PREPARACION Y SU UTILIZACION EN TERAPEUTICA |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7678807B2 (es) |
| EP (2) | EP1790646A1 (es) |
| JP (1) | JP5165578B2 (es) |
| KR (1) | KR101386318B1 (es) |
| CN (1) | CN101312961B (es) |
| AR (1) | AR057615A1 (es) |
| AT (1) | ATE531707T1 (es) |
| AU (1) | AU2006316706B2 (es) |
| BR (1) | BRPI0618971A2 (es) |
| CA (1) | CA2630655C (es) |
| CY (1) | CY1112386T1 (es) |
| DK (1) | DK1960387T3 (es) |
| DO (1) | DOP2006000253A (es) |
| ES (1) | ES2376894T3 (es) |
| GT (1) | GT200600490A (es) |
| HK (1) | HK1126200A1 (es) |
| IL (1) | IL191214A (es) |
| PE (1) | PE20070827A1 (es) |
| PL (1) | PL1960387T3 (es) |
| PT (1) | PT1960387E (es) |
| RU (1) | RU2418794C2 (es) |
| SI (1) | SI1960387T1 (es) |
| TW (1) | TW200738681A (es) |
| UY (1) | UY29971A1 (es) |
| WO (1) | WO2007060027A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2870846B1 (fr) | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
| AR081382A1 (es) * | 2010-05-11 | 2012-08-29 | Sanofi Aventis | Derivados de n-heterocicloalquil bipirrolidinilfenil amida sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central. |
| JP5968307B2 (ja) * | 2010-05-11 | 2016-08-10 | サノフイ | 置換フェニルシクロアルキルピロリジン（ピペリジン）スピロラクタム類及びアミド類、それらの製造及び治療的使用 |
| WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| TW201206898A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305470A (zh) * | 1998-04-10 | 2001-07-25 | 日本烟草产业株式会社 | 脒化合物 |
| AU6123699A (en) * | 1998-10-16 | 2000-05-08 | Takeda Chemical Industries Ltd. | Nitrogenous fused heterocycle compounds, process for the preparation thereof andagents containing the same |
| AU2002254114A1 (en) * | 2001-03-23 | 2002-10-08 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
| NL1020155C2 (nl) * | 2002-03-11 | 2003-09-17 | Bernardus Johannes Jos Bekkers | Inrichting voor het dragen van een golftas alsmede werkwijze voor het vervaardigen ervan. |
| GB0206033D0 (en) * | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
| EP1539704A1 (en) * | 2002-08-20 | 2005-06-15 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
| GB0408083D0 (en) * | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
| FR2870846B1 (fr) * | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
-
2005
- 2005-11-24 EP EP05111248A patent/EP1790646A1/fr not_active Withdrawn
-
2006
- 2006-11-15 DO DO2006000253A patent/DOP2006000253A/es unknown
- 2006-11-20 TW TW095142885A patent/TW200738681A/zh unknown
- 2006-11-20 GT GT200600490A patent/GT200600490A/es unknown
- 2006-11-20 PE PE2006001478A patent/PE20070827A1/es not_active Application Discontinuation
- 2006-11-22 JP JP2008541661A patent/JP5165578B2/ja not_active Expired - Fee Related
- 2006-11-22 EP EP06829734A patent/EP1960387B1/fr active Active
- 2006-11-22 SI SI200631253T patent/SI1960387T1/sl unknown
- 2006-11-22 PT PT06829734T patent/PT1960387E/pt unknown
- 2006-11-22 AU AU2006316706A patent/AU2006316706B2/en not_active Ceased
- 2006-11-22 CA CA2630655A patent/CA2630655C/fr not_active Expired - Fee Related
- 2006-11-22 RU RU2008125136/04A patent/RU2418794C2/ru not_active IP Right Cessation
- 2006-11-22 AR ARP060105107A patent/AR057615A1/es not_active Application Discontinuation
- 2006-11-22 KR KR1020087012407A patent/KR101386318B1/ko not_active Expired - Fee Related
- 2006-11-22 PL PL06829734T patent/PL1960387T3/pl unknown
- 2006-11-22 AT AT06829734T patent/ATE531707T1/de active
- 2006-11-22 BR BRPI0618971-7A patent/BRPI0618971A2/pt not_active IP Right Cessation
- 2006-11-22 ES ES06829734T patent/ES2376894T3/es active Active
- 2006-11-22 WO PCT/EP2006/012246 patent/WO2007060027A1/fr active Application Filing
- 2006-11-22 DK DK06829734.0T patent/DK1960387T3/da active
- 2006-11-22 CN CN2006800440166A patent/CN101312961B/zh not_active Expired - Fee Related
- 2006-11-24 UY UY29971A patent/UY29971A1/es unknown
-
2008
- 2008-05-01 IL IL191214A patent/IL191214A/en not_active IP Right Cessation
- 2008-05-19 US US12/122,795 patent/US7678807B2/en not_active Expired - Fee Related
-
2009
- 2009-05-20 HK HK09104609.6A patent/HK1126200A1/xx not_active IP Right Cessation
-
2012
- 2012-02-02 CY CY20121100117T patent/CY1112386T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2630655C (fr) | 2014-08-26 |
| ATE531707T1 (de) | 2011-11-15 |
| BRPI0618971A2 (pt) | 2011-09-20 |
| DOP2006000253A (es) | 2007-07-15 |
| AU2006316706A1 (en) | 2007-05-31 |
| AU2006316706B2 (en) | 2012-05-03 |
| ES2376894T3 (es) | 2012-03-20 |
| AR057615A1 (es) | 2007-12-05 |
| JP5165578B2 (ja) | 2013-03-21 |
| TW200738681A (en) | 2007-10-16 |
| KR20080076910A (ko) | 2008-08-20 |
| WO2007060027A1 (fr) | 2007-05-31 |
| GT200600490A (es) | 2007-07-06 |
| CN101312961B (zh) | 2012-04-11 |
| EP1790646A1 (fr) | 2007-05-30 |
| JP2009517357A (ja) | 2009-04-30 |
| CY1112386T1 (el) | 2015-12-09 |
| CN101312961A (zh) | 2008-11-26 |
| PL1960387T3 (pl) | 2012-03-30 |
| PT1960387E (pt) | 2012-02-09 |
| EP1960387B1 (fr) | 2011-11-02 |
| HK1126200A1 (en) | 2009-08-28 |
| US20080269199A1 (en) | 2008-10-30 |
| EP1960387A1 (fr) | 2008-08-27 |
| US7678807B2 (en) | 2010-03-16 |
| KR101386318B1 (ko) | 2014-04-17 |
| RU2418794C2 (ru) | 2011-05-20 |
| CA2630655A1 (fr) | 2007-05-31 |
| IL191214A (en) | 2012-07-31 |
| RU2008125136A (ru) | 2009-12-27 |
| UY29971A1 (es) | 2007-06-29 |
| SI1960387T1 (sl) | 2012-03-30 |
| DK1960387T3 (da) | 2012-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |