AR058287A1 - Derivados de isoquinolina y composicion farmaceutica - Google Patents
Derivados de isoquinolina y composicion farmaceuticaInfo
- Publication number
- AR058287A1 AR058287A1 ARP060105404A ARP060105404A AR058287A1 AR 058287 A1 AR058287 A1 AR 058287A1 AR P060105404 A ARP060105404 A AR P060105404A AR P060105404 A ARP060105404 A AR P060105404A AR 058287 A1 AR058287 A1 AR 058287A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- isoquinoline derivatives
- halogen
- pharmaceutical composition
- alkyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente está relacionada con los derivados de isoquinolina que tienen la formula (1) general donde X es O, S o NH; Y es OH o NH2; m es 0, 1 o 2; n es 1 o 2; R1 es H, cuando Y es NH2; o R1 es H, alquilo C1-4 o halogeno, cuando Y es OH; R2 y R3 son independientemente H, alquilo C1-4 o halogeno; R es H o alquilo C1-6, opcionalmente sustituido por OH, alquiloxi C1-4, alquilcarbonilo C1-4, cicloalquilo C3-7, que puede comprender opcionalmente un heteroátomo seleccionado entre O y S, arilo C6- 10, ariloxi C6-10 o un grupo heteroarilo, de 5 o 6 miembros, comprendiendo 1 a 3 heteroátomos independientemente seleccionados entre O, N y S, estando cada grupo arilo o heteroarilo opcionalmente sustituido por 1 a 3 sustituyentes independientemente seccionados entre alquilo C1-4, alquiloxi C1-4, alquilsulfonilo C1-4 y halogeno; o una sal farmacéuticamente aceptable de él, con las composiciones farmacéuticas, así como también con la utilizacion de los derivados de isoquinolina para preparar medicamentos. Estos compuestos pueden emplearse para tratar trastornos relacionados con ROCK-I, tal como la hipertension, la arteriosclerosis y el glaucoma.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05111813 | 2005-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058287A1 true AR058287A1 (es) | 2008-01-30 |
Family
ID=36569955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105404A AR058287A1 (es) | 2005-12-08 | 2006-12-07 | Derivados de isoquinolina y composicion farmaceutica |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1963304B2 (es) |
| JP (1) | JP5313682B2 (es) |
| CN (1) | CN101321748B (es) |
| AR (1) | AR058287A1 (es) |
| AT (1) | ATE434613T1 (es) |
| CA (1) | CA2629915C (es) |
| CY (1) | CY1110489T1 (es) |
| DE (1) | DE602006007488D1 (es) |
| DK (1) | DK1963304T3 (es) |
| ES (1) | ES2327677T3 (es) |
| HR (1) | HRP20090400T1 (es) |
| PE (1) | PE20070808A1 (es) |
| PL (1) | PL1963304T3 (es) |
| PT (1) | PT1963304E (es) |
| SI (1) | SI1963304T1 (es) |
| TW (1) | TW200738682A (es) |
| WO (1) | WO2007065916A1 (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1899322T1 (sl) | 2005-06-28 | 2010-01-29 | Sanofi Aventis | Izokinolinski derivati kot inhibitorji Rho-kinaze |
| US7470787B2 (en) | 2005-07-11 | 2008-12-30 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
| BRPI0614063A2 (pt) | 2005-07-26 | 2011-03-09 | Sanofi Aventis | derivados de cicloexilamina isoquinolona |
| WO2007012421A1 (en) | 2005-07-26 | 2007-02-01 | Sanofi-Aventis | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
| ES2729424T3 (es) | 2006-09-20 | 2019-11-04 | Aerie Pharmaceuticals Inc | Inhibidores de Rho cinasa |
| MX2009005862A (es) | 2006-12-27 | 2009-06-17 | Sanofi Aventis | Nuevos derivados de isoquinolina e isoquinolinona sustituidos. |
| WO2008077556A1 (en) | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives |
| CN101573353B (zh) * | 2006-12-27 | 2014-08-06 | 塞诺菲-安万特股份有限公司 | 取代的异喹啉和异喹啉酮衍生物 |
| CA2673917C (en) | 2006-12-27 | 2015-01-27 | Sanofi-Aventis | Cycloalkylamine substituted isoquinolone derivatives |
| MX2009005964A (es) | 2006-12-27 | 2009-06-15 | Sanofi Aventis | Derivados de isoquinolina sustituidos con cicloalquilamina. |
| CN101616909B (zh) | 2006-12-27 | 2013-09-11 | 塞诺菲-安万特股份有限公司 | 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物 |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| JP2011507921A (ja) * | 2007-12-26 | 2011-03-10 | サノフィ−アベンティス | ６−置換−１−（２ｈ）−イソキノリノンの製造法 |
| US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| PT2313374E (pt) | 2008-06-24 | 2013-11-29 | Sanofi Sa | Isoquinolinas e isoquinolinonas 6-substituídas |
| CA2728137C (en) | 2008-06-24 | 2016-10-18 | Sanofi-Aventis | Substituted isoquinolines and isoquinolinones as rho kinase inhibitors |
| CN102076667B (zh) | 2008-06-24 | 2014-03-26 | 赛诺菲-安万特 | 二环和多环取代的异喹啉和异喹啉酮衍生物 |
| TW201006821A (en) * | 2008-07-16 | 2010-02-16 | Bristol Myers Squibb Co | Pyridone and pyridazone analogues as GPR119 modulators |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| US8394826B2 (en) | 2009-05-01 | 2013-03-12 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| AU2012283276B2 (en) | 2011-07-08 | 2014-07-24 | Sanofi | Crystalline solvates of 6-(piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride |
| BR112014000279B1 (pt) | 2011-07-08 | 2020-11-24 | Sanofi | composto de fenila substituído de fórmula (vi), seu processo de preparação, seu uso na preparação de um composto de fórmula (i) e processo de preparação de um composto de fórmula (i) |
| US8598201B2 (en) | 2011-07-08 | 2013-12-03 | Sanofi | Polymorphs of 6-(piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride |
| EP2740458B1 (en) | 2012-12-06 | 2016-08-03 | IP Gesellschaft für Management mbH | Packaging comprising forms of sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide |
| CN105263494A (zh) | 2013-03-15 | 2016-01-20 | 爱瑞制药公司 | 联合治疗 |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| JP6832946B2 (ja) | 2015-11-17 | 2021-02-24 | アエリエ ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤およびその中間体の調製方法 |
| WO2018045091A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| AU2018243687C1 (en) | 2017-03-31 | 2020-12-24 | Alcon Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| JP6906105B2 (ja) * | 2017-06-16 | 2021-07-21 | 成都先導薬物開発股▲ふん▼有限公司Ｈｉｔｇｅｎ Ｌｔｄ． | Ｒｏｃｋを阻害する化合物及びその使用 |
| CA3112391A1 (en) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CN113877483B (zh) * | 2021-07-20 | 2023-11-24 | 烟台宁远药业有限公司 | 医药中间体卤代异喹啉类硼酸的低温连续合成装置与方法 |
| IL318082A (en) * | 2022-08-01 | 2025-02-01 | Valo Health Inc | Process for preparing 1-(2H)-ISOQUINOLINONE-type materials modified at position 6, and intermediates obtained in the process |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002100833A1 (fr) * | 2001-06-12 | 2002-12-19 | Sumitomo Pharmaceuticals Company, Limited | Inhibiteurs de rho kinase |
| CN100354264C (zh) * | 2002-07-22 | 2007-12-12 | 旭化成制药株式会社 | 5－取代异喹啉衍生物及含有它们的药物 |
| JPWO2004024717A1 (ja) * | 2002-09-12 | 2006-01-05 | 麒麟麦酒株式会社 | キナーゼ阻害活性を有するイソキノリン誘導体およびそれを含む医薬 |
| WO2007012421A1 (en) * | 2005-07-26 | 2007-02-01 | Sanofi-Aventis | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
-
2006
- 2006-11-29 TW TW095144093A patent/TW200738682A/zh unknown
- 2006-12-06 PT PT06830425T patent/PT1963304E/pt unknown
- 2006-12-06 AT AT06830425T patent/ATE434613T1/de active
- 2006-12-06 JP JP2008543829A patent/JP5313682B2/ja not_active Expired - Fee Related
- 2006-12-06 SI SI200630399T patent/SI1963304T1/sl unknown
- 2006-12-06 DK DK06830425T patent/DK1963304T3/da active
- 2006-12-06 ES ES06830425T patent/ES2327677T3/es active Active
- 2006-12-06 PE PE2006001566A patent/PE20070808A1/es not_active Application Discontinuation
- 2006-12-06 CN CN2006800457133A patent/CN101321748B/zh not_active Expired - Fee Related
- 2006-12-06 EP EP20060830425 patent/EP1963304B2/en active Active
- 2006-12-06 PL PL06830425T patent/PL1963304T3/pl unknown
- 2006-12-06 DE DE602006007488T patent/DE602006007488D1/de active Active
- 2006-12-06 CA CA2629915A patent/CA2629915C/en not_active Expired - Fee Related
- 2006-12-06 WO PCT/EP2006/069392 patent/WO2007065916A1/en active Application Filing
- 2006-12-07 AR ARP060105404A patent/AR058287A1/es unknown
-
2009
- 2009-07-15 HR HR20090400T patent/HRP20090400T1/hr unknown
- 2009-09-08 CY CY20091100933T patent/CY1110489T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20070808A1 (es) | 2007-08-27 |
| DK1963304T3 (da) | 2009-10-12 |
| PT1963304E (pt) | 2009-09-14 |
| JP2009518360A (ja) | 2009-05-07 |
| EP1963304A1 (en) | 2008-09-03 |
| PL1963304T3 (pl) | 2009-12-31 |
| SI1963304T1 (sl) | 2009-12-31 |
| DE602006007488D1 (de) | 2009-08-06 |
| ES2327677T3 (es) | 2009-11-02 |
| CA2629915A1 (en) | 2007-06-14 |
| CY1110489T1 (el) | 2015-04-29 |
| CA2629915C (en) | 2014-03-18 |
| ATE434613T1 (de) | 2009-07-15 |
| CN101321748A (zh) | 2008-12-10 |
| EP1963304B1 (en) | 2009-06-24 |
| WO2007065916A1 (en) | 2007-06-14 |
| CN101321748B (zh) | 2013-03-27 |
| EP1963304B2 (en) | 2015-05-13 |
| JP5313682B2 (ja) | 2013-10-09 |
| TW200738682A (en) | 2007-10-16 |
| HRP20090400T1 (hr) | 2009-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |