PL1960387T3 - Pochodne izochinoliny i benzo[h]izochinoliny, ich wytwarzanie i ich zastosowanie w leczeniu jako antagonistów receptora histaminowego h3 - Google Patents
Pochodne izochinoliny i benzo[h]izochinoliny, ich wytwarzanie i ich zastosowanie w leczeniu jako antagonistów receptora histaminowego h3Info
- Publication number
- PL1960387T3 PL1960387T3 PL06829734T PL06829734T PL1960387T3 PL 1960387 T3 PL1960387 T3 PL 1960387T3 PL 06829734 T PL06829734 T PL 06829734T PL 06829734 T PL06829734 T PL 06829734T PL 1960387 T3 PL1960387 T3 PL 1960387T3
- Authority
- PL
- Poland
- Prior art keywords
- isoquinoline
- histamine
- benzo
- antagonists
- receptor
- Prior art date
Links
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 2
- 102000004384 Histamine H3 receptors Human genes 0.000 title 1
- 108090000981 Histamine H3 receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- FZICDBOJOMQACG-UHFFFAOYSA-N benzo[h]isoquinoline Chemical class C1=NC=C2C3=CC=CC=C3C=CC2=C1 FZICDBOJOMQACG-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05111248A EP1790646A1 (fr) | 2005-11-24 | 2005-11-24 | Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3. |
PCT/EP2006/012246 WO2007060027A1 (fr) | 2005-11-24 | 2006-11-22 | Derives de isoquinoline et benzo[h]isoquinoline, leur preparation et leur utilisation en therapeutique en tant qu’antagonistes du recepteur de l’histamine h3 |
EP06829734A EP1960387B1 (fr) | 2005-11-24 | 2006-11-22 | Derives de isoquinoline et benzo[h]isoquinoline, leur preparation et leur utilisation en therapeutique en tant qu antagonistes du recepteur de l histamine h3 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1960387T3 true PL1960387T3 (pl) | 2012-03-30 |
Family
ID=36295552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL06829734T PL1960387T3 (pl) | 2005-11-24 | 2006-11-22 | Pochodne izochinoliny i benzo[h]izochinoliny, ich wytwarzanie i ich zastosowanie w leczeniu jako antagonistów receptora histaminowego h3 |
Country Status (25)
Country | Link |
---|---|
US (1) | US7678807B2 (pl) |
EP (2) | EP1790646A1 (pl) |
JP (1) | JP5165578B2 (pl) |
KR (1) | KR101386318B1 (pl) |
CN (1) | CN101312961B (pl) |
AR (1) | AR057615A1 (pl) |
AT (1) | ATE531707T1 (pl) |
AU (1) | AU2006316706B2 (pl) |
BR (1) | BRPI0618971A2 (pl) |
CA (1) | CA2630655C (pl) |
CY (1) | CY1112386T1 (pl) |
DK (1) | DK1960387T3 (pl) |
DO (1) | DOP2006000253A (pl) |
ES (1) | ES2376894T3 (pl) |
GT (1) | GT200600490A (pl) |
HK (1) | HK1126200A1 (pl) |
IL (1) | IL191214A (pl) |
PE (1) | PE20070827A1 (pl) |
PL (1) | PL1960387T3 (pl) |
PT (1) | PT1960387E (pl) |
RU (1) | RU2418794C2 (pl) |
SI (1) | SI1960387T1 (pl) |
TW (1) | TW200738681A (pl) |
UY (1) | UY29971A1 (pl) |
WO (1) | WO2007060027A1 (pl) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2870846B1 (fr) * | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
WO2011143161A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
TW201206898A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1070714B1 (en) * | 1998-04-10 | 2004-08-04 | Japan Tobacco Inc. | Amidine compounds |
AU6123699A (en) * | 1998-10-16 | 2000-05-08 | Takeda Chemical Industries Ltd. | Nitrogenous fused heterocycle compounds, process for the preparation thereof andagents containing the same |
EP1379493A2 (en) * | 2001-03-23 | 2004-01-14 | Eli Lilly and Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
NL1020155C2 (nl) * | 2002-03-11 | 2003-09-17 | Bernardus Johannes Jos Bekkers | Inrichting voor het dragen van een golftas alsmede werkwijze voor het vervaardigen ervan. |
GB0206033D0 (en) * | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
US20060089347A1 (en) * | 2002-08-20 | 2006-04-27 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
GB0408083D0 (en) * | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
FR2870846B1 (fr) | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
-
2005
- 2005-11-24 EP EP05111248A patent/EP1790646A1/fr not_active Withdrawn
-
2006
- 2006-11-15 DO DO2006000253A patent/DOP2006000253A/es unknown
- 2006-11-20 GT GT200600490A patent/GT200600490A/es unknown
- 2006-11-20 TW TW095142885A patent/TW200738681A/zh unknown
- 2006-11-20 PE PE2006001478A patent/PE20070827A1/es not_active Application Discontinuation
- 2006-11-22 WO PCT/EP2006/012246 patent/WO2007060027A1/fr active Application Filing
- 2006-11-22 AR ARP060105107A patent/AR057615A1/es not_active Application Discontinuation
- 2006-11-22 PL PL06829734T patent/PL1960387T3/pl unknown
- 2006-11-22 AT AT06829734T patent/ATE531707T1/de active
- 2006-11-22 CA CA2630655A patent/CA2630655C/fr not_active Expired - Fee Related
- 2006-11-22 PT PT06829734T patent/PT1960387E/pt unknown
- 2006-11-22 KR KR1020087012407A patent/KR101386318B1/ko not_active Expired - Fee Related
- 2006-11-22 DK DK06829734.0T patent/DK1960387T3/da active
- 2006-11-22 JP JP2008541661A patent/JP5165578B2/ja not_active Expired - Fee Related
- 2006-11-22 BR BRPI0618971-7A patent/BRPI0618971A2/pt not_active IP Right Cessation
- 2006-11-22 EP EP06829734A patent/EP1960387B1/fr active Active
- 2006-11-22 CN CN2006800440166A patent/CN101312961B/zh not_active Expired - Fee Related
- 2006-11-22 AU AU2006316706A patent/AU2006316706B2/en not_active Ceased
- 2006-11-22 RU RU2008125136/04A patent/RU2418794C2/ru not_active IP Right Cessation
- 2006-11-22 SI SI200631253T patent/SI1960387T1/sl unknown
- 2006-11-22 ES ES06829734T patent/ES2376894T3/es active Active
- 2006-11-24 UY UY29971A patent/UY29971A1/es unknown
-
2008
- 2008-05-01 IL IL191214A patent/IL191214A/en not_active IP Right Cessation
- 2008-05-19 US US12/122,795 patent/US7678807B2/en not_active Expired - Fee Related
-
2009
- 2009-05-20 HK HK09104609.6A patent/HK1126200A1/xx not_active IP Right Cessation
-
2012
- 2012-02-02 CY CY20121100117T patent/CY1112386T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AR057615A1 (es) | 2007-12-05 |
EP1960387B1 (fr) | 2011-11-02 |
UY29971A1 (es) | 2007-06-29 |
US20080269199A1 (en) | 2008-10-30 |
CY1112386T1 (el) | 2015-12-09 |
JP2009517357A (ja) | 2009-04-30 |
CA2630655A1 (fr) | 2007-05-31 |
RU2008125136A (ru) | 2009-12-27 |
PE20070827A1 (es) | 2007-08-17 |
AU2006316706B2 (en) | 2012-05-03 |
TW200738681A (en) | 2007-10-16 |
CA2630655C (fr) | 2014-08-26 |
CN101312961B (zh) | 2012-04-11 |
HK1126200A1 (en) | 2009-08-28 |
BRPI0618971A2 (pt) | 2011-09-20 |
AU2006316706A1 (en) | 2007-05-31 |
KR101386318B1 (ko) | 2014-04-17 |
KR20080076910A (ko) | 2008-08-20 |
IL191214A (en) | 2012-07-31 |
CN101312961A (zh) | 2008-11-26 |
EP1790646A1 (fr) | 2007-05-30 |
RU2418794C2 (ru) | 2011-05-20 |
DK1960387T3 (da) | 2012-02-27 |
US7678807B2 (en) | 2010-03-16 |
DOP2006000253A (es) | 2007-07-15 |
JP5165578B2 (ja) | 2013-03-21 |
SI1960387T1 (sl) | 2012-03-30 |
ATE531707T1 (de) | 2011-11-15 |
ES2376894T3 (es) | 2012-03-20 |
GT200600490A (es) | 2007-07-06 |
PT1960387E (pt) | 2012-02-09 |
WO2007060027A1 (fr) | 2007-05-31 |
EP1960387A1 (fr) | 2008-08-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT2176252E (pt) | Derivados 2,3-di-hidrobenzo[1,4]dioxin-2-ilmetilo como antagonistas alfa2c para utilização no tratamento de doenças do sistema nervoso periférico e central | |
ZA200610416B (en) | Indole derivatives as histamine receptor antagonists | |
IL195510A0 (en) | Urea derivatives of tropane, their preparation and their therapeutic application | |
ZA200702772B (en) | Quinuclidine derivatives and their use as muscarinic M3 receptor antagonists | |
PL1951661T3 (pl) | Antagoniści receptora glukagonu, wytwarzanie i terapeutyczne zastosowania | |
IL180284A0 (en) | 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof | |
SI1951658T1 (sl) | Antagonisti glukagonskega receptorja priprava interapevtska uporaba | |
SI1863476T1 (sl) | Kombinacija antiholinergikov in antagonistov receptorja levkotriena za zdravljenje respiratornih bolezni | |
AP1983A (en) | Carboxamide derivatives as muscarinic receptor antagonists | |
IL180770A0 (en) | Oxopiperidine derivatives, preparation and therapeutic use thereof | |
HK1131779A1 (en) | Dimers of artemisinin derivatives, preparation thereof and therapeutic use thereof | |
IL207356A0 (en) | 5, 6 - bisaryl-2- pyridine - carboxamide derivatives, preparation thereof and therapeutic application thereof as antagonists for urotensine ii receptors | |
HK1126200A1 (en) | Isoquinoline et benzo[h]isoquinoline derivatives, preparation and therapeutic use thereof as antagonists of histamine h3 receptor | |
IL180797A0 (en) | Amino-tropane derivatives, preparation thereof and therapeutic use thereof | |
ZA201004644B (en) | "derivatives of 6-heterocyclic-imidazo[1,2-a]pyrroine-2-carboxamides,preparation thereof and therapeutic application thereof" | |
ZA201000582B (en) | 1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives,preparation and therapeutic use thereof | |
HK1107340A1 (en) | 4-arylmorpholin-3-one derivatives, preparation and therapeutic use thereof | |
PL1951659T3 (pl) | Antagoniści receptora glukagonu, wytwarzanie i zastosowania terapeutyczne |