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PE20010516A1 - Peptidos ciclicos con afinidad mejorada por los receptores de somatostatina - Google Patents

Peptidos ciclicos con afinidad mejorada por los receptores de somatostatina

Info

Publication number
PE20010516A1
PE20010516A1 PE2000000852A PE0008522000A PE20010516A1 PE 20010516 A1 PE20010516 A1 PE 20010516A1 PE 2000000852 A PE2000000852 A PE 2000000852A PE 0008522000 A PE0008522000 A PE 0008522000A PE 20010516 A1 PE20010516 A1 PE 20010516A1
Authority
PE
Peru
Prior art keywords
somatostatin
compounds
somatostatin receptors
cyclic peptides
enhanced affinity
Prior art date
Application number
PE2000000852A
Other languages
English (en)
Inventor
Richard T Dean
David M Wilson
Daniel A Pearson
John Lister-James
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatide Inc filed Critical Diatide Inc
Publication of PE20010516A1 publication Critical patent/PE20010516A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE REFIERE A PEPTIDOS DE FORMULA CICLO-B1-B2-B3-B4-C-A; B1 ES PHE, TYR, NAL, AIN; B2 ES TRP; B3 ES LYS, HLY, ACHXA, AMF, AEC, APC, AES, APS; B4 ES THR, SER, VAL, PHE, ILE, ABU, NLE, LEU, NVA, AIB; C ES UN L-AMINOACIDO; A ES N-ALQUIL-AMINOACIDO COMO (N-CH3)Cys, (N-CH3)Hcy, ENTRE OTROS; A ES S, ESTA UNIDO A UN QUELANTE DE FORMULA b-Dap.Xaa.Cys.Zaa; Xaa ES UN L-AMINOACIDO, ETER AMINOETILICO, DE PREFERENCIA 1,4,7,10-TETRAAZACICLODECANO-1,4,7-TRIACETICO, ENTRE OTROS, LIGANTE DE METAL RADIOACTIVO, EL LIGANTE ES UNA FRACCION DE HIDRAZINONICOTINAMIDA, EL RADIOFARMACO ES 68Ga, 67Ga, 67Cu, 47Sc, 111In, 99mTc, 186Re, 188Re, 212Bi, 213Bi, 90Y, 64Cu, 153Sm, 94mTc, 166Ho, 223Ra, 225Ac, 18F, 125I, 131I, 123I, 211At. UN COMPUESTO PREFERIDO ES CICLO TYR-D-TRP-LYS-THR-PHE-(N-CH3)HCY(CH2CO-b-DAP-PHE(4-NH2)-CYS-THR-SER, ENTRE OTROS. LOS PEPTIDOS SON ANALOGOS DE SOMATOSTATINA CON AFINIDAD MEJORADA POR LOS RECEPTORES DE SOMATOSTATINA (SSTRs), POR LO QUE TIENEN UNA ALTA ABSORCION POR EL TUMOR
PE2000000852A 1999-08-27 2000-08-22 Peptidos ciclicos con afinidad mejorada por los receptores de somatostatina PE20010516A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15100199P 1999-08-27 1999-08-27
US09/397,792 US6358491B1 (en) 1999-08-27 1999-09-16 Somatostatin analogs

Publications (1)

Publication Number Publication Date
PE20010516A1 true PE20010516A1 (es) 2001-04-29

Family

ID=26848228

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000852A PE20010516A1 (es) 1999-08-27 2000-08-22 Peptidos ciclicos con afinidad mejorada por los receptores de somatostatina

Country Status (12)

Country Link
US (1) US6358491B1 (es)
EP (1) EP1208116B1 (es)
JP (1) JP2003517037A (es)
AT (1) ATE393781T1 (es)
AU (1) AU782873B2 (es)
CA (1) CA2383936A1 (es)
CO (1) CO5460266A1 (es)
DE (1) DE60038739T2 (es)
ES (1) ES2305000T3 (es)
PE (1) PE20010516A1 (es)
TW (1) TWI243178B (es)
WO (1) WO2001044177A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2307325T3 (es) * 1997-11-24 2008-11-16 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Metodo para aumentar la acumulacion en tejidos de compuestos raiomarcados.
EP1283216A1 (en) * 2001-08-10 2003-02-12 Mallinckrodt Inc. Somatostatin analogues binding to all somatostatin receptor subtypes and their use
DE10215336A1 (de) 2002-03-28 2003-10-23 Schering Ag N-Methyl-Homocysteine und ihre Verwendung sowie Verfahren zu ihrer Herstellung
AU2002359359A1 (en) * 2001-12-28 2003-07-24 Somatocor Pharmaceuticals, Inc. Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands
WO2005027981A1 (en) 2003-09-17 2005-03-31 Board Of Regents, The University Of Texas System Mechanism-based targeted pancreatic beta cell imaging and therapy
EP1700608A1 (en) 2005-03-10 2006-09-13 Schering AG Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
JP2008538204A (ja) * 2005-03-10 2008-10-16 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 安定化側鎖を含む放射性標識複合体キレート剤
WO2006114324A1 (en) * 2005-04-28 2006-11-02 Schering Ag Compounds comprising cyclized somatostatin receptor binding peptides
EP1717219A1 (en) * 2005-04-28 2006-11-02 Schering AG Orthogonally protected bifunctional amino acid
EP1717247A1 (en) * 2005-04-28 2006-11-02 Schering AG Cyclic peptides binding to the somatostatin receptor
US20070025910A1 (en) 2005-07-29 2007-02-01 Norenberg Jeffrey P Anticancer therapy
ES2351569B8 (es) * 2009-05-07 2012-06-20 Bcn Peptides S.A. Ligandos peptídicos de receptores de somatostatina.
RU2528414C1 (ru) * 2013-01-25 2014-09-20 Закрытое Акционерное Общество "Фарм-Синтез" Циклический октапептид, радиофармацевтическое средство на его основе и способ применения радиофармацевтического средства для получения лекарственных (фармацевтических) средств для лечения новообразований, экспрессирующих соматостатиновые рецепторы
US20160031935A1 (en) * 2013-03-15 2016-02-04 Adaerata, Limited Partnership Small molecule modulators of pcsk9 and methods of use thereof
EP3160518A4 (en) 2014-06-30 2018-05-23 Tarveda Therapeutics, Inc. Targeted conjugates and particles and formulations thereof
CN108473538B (zh) 2015-10-28 2022-01-28 塔弗达治疗有限公司 Sstr靶向缀合物及其颗粒和制剂
PL3568205T3 (pl) 2017-01-12 2024-03-18 Radiomedix Inc. Leczenie komórek nowotworowych z nadekspresją receptorów somatostatyny z użyciem pochodnych okreotydu chelatowanych z radioizotopami

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310518A (en) 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4486415A (en) 1983-08-15 1984-12-04 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4522813A (en) 1983-10-27 1985-06-11 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
EP0222578A3 (en) 1985-11-06 1990-04-04 Merck & Co. Inc. Use of cyclic somatostatin analogues in the treatment of immediate hypersensitivity diseases
US5776894A (en) 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US5985240A (en) 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
ES2158897T3 (es) * 1993-06-23 2001-09-16 Diatide Inc Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos.
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5597894A (en) 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5830431A (en) 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
US5770687A (en) 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
MY147327A (en) 1995-06-29 2012-11-30 Novartis Ag Somatostatin peptides
US5708135A (en) 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
AT405906B (de) 1997-03-14 1999-12-27 Irene Dr Virgolini Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie

Also Published As

Publication number Publication date
CO5460266A1 (es) 2004-11-30
US6358491B1 (en) 2002-03-19
DE60038739D1 (de) 2008-06-12
ATE393781T1 (de) 2008-05-15
CA2383936A1 (en) 2001-06-21
EP1208116B1 (en) 2008-04-30
EP1208116A2 (en) 2002-05-29
TWI243178B (en) 2005-11-11
ES2305000T3 (es) 2008-11-01
AU782873B2 (en) 2005-09-08
AU4865901A (en) 2001-06-25
WO2001044177A2 (en) 2001-06-21
JP2003517037A (ja) 2003-05-20
WO2001044177A3 (en) 2002-03-28
DE60038739T2 (de) 2009-05-20

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed