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PA8842201A1 - Inhibidores macrocíclicos de serina proteasas de hepatitis c - Google Patents

Inhibidores macrocíclicos de serina proteasas de hepatitis c

Info

Publication number
PA8842201A1
PA8842201A1 PA20098842201A PA8842201A PA8842201A1 PA 8842201 A1 PA8842201 A1 PA 8842201A1 PA 20098842201 A PA20098842201 A PA 20098842201A PA 8842201 A PA8842201 A PA 8842201A PA 8842201 A1 PA8842201 A1 PA 8842201A1
Authority
PA
Panama
Prior art keywords
proteasas
serina
hepatitis
macrocyclic inhibitors
present
Prior art date
Application number
PA20098842201A
Other languages
English (en)
Inventor
Ku Yiyin
F Mcdaniel Keith
Ju Chen Hui
P Shanley Jason
J Kempf Dale
J Grampovnil David
Sun Ying
Liu Dong
Gai Yonghua
Sun Or Yat
H Wagaw Seble
Engstrom Ken
Grieme Tim
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42005677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8842201(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of PA8842201A1 publication Critical patent/PA8842201A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCIÓN SE RELACIONA CON NUEVOS COMPUESTOS MACROCÍCLICOS Y CON MÉTODOS DE USO DE LOS MISMOS.LA PRESENTE INVENCIÓN TAMBIÉN SE RELACIONA CON COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN LOS COMPUESTOS DE LA PRESENTE INVENCIÓN,O LAS SALES,ÉSTERES O PRODROGAS FARMACÉUTICAMENTE ACEPTABLES,EN COMBINACIÓN CON UN VEHÍCULO O EXCIPIENTE FARMACÉUTICAMENTE ACEPTBLES,EN COMBINACIÓN CON UN VEHÍCULO O EXCIPIENTE FARMACÉUTICAMENTE ACEPTABLE.
PA20098842201A 2008-09-11 2009-09-10 Inhibidores macrocíclicos de serina proteasas de hepatitis c PA8842201A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19172508P 2008-09-11 2008-09-11
US20968909P 2009-03-10 2009-03-10

Publications (1)

Publication Number Publication Date
PA8842201A1 true PA8842201A1 (es) 2010-04-21

Family

ID=42005677

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20098842201A PA8842201A1 (es) 2008-09-11 2009-09-10 Inhibidores macrocíclicos de serina proteasas de hepatitis c

Country Status (42)

Country Link
US (3) US8420596B2 (es)
EP (5) EP2468287B1 (es)
JP (4) JP5259537B2 (es)
KR (3) KR101379365B1 (es)
CN (3) CN102641271B (es)
AR (3) AR073568A1 (es)
AU (1) AU2009292182B2 (es)
BR (2) BR122012005261A8 (es)
CA (1) CA2736895C (es)
CL (2) CL2011000512A1 (es)
CO (1) CO6341565A2 (es)
CR (1) CR20140180A (es)
CY (6) CY1115137T1 (es)
DK (5) DK2468285T3 (es)
DO (1) DOP2011000077A (es)
EA (2) EA022891B1 (es)
EC (2) ECSP11010879A (es)
ES (5) ES2475163T3 (es)
GT (2) GT201100056AA (es)
HK (4) HK1170936A1 (es)
HR (5) HRP20140492T1 (es)
HU (2) HUE039478T2 (es)
IL (2) IL218441A (es)
LT (2) LT2805726T (es)
LU (1) LU92667I2 (es)
MX (1) MX2011002486A (es)
MY (1) MY159820A (es)
NL (1) NL300730I1 (es)
NO (1) NO2015014I1 (es)
NZ (2) NZ592170A (es)
PA (1) PA8842201A1 (es)
PE (3) PE20121312A1 (es)
PL (5) PL2468285T3 (es)
PT (5) PT2468286E (es)
SG (1) SG179414A1 (es)
SI (5) SI2468285T1 (es)
SM (1) SMT201800407T1 (es)
TR (1) TR201809771T4 (es)
TW (3) TWI429449B (es)
UY (3) UY32099A (es)
WO (1) WO2010030359A2 (es)
ZA (2) ZA201101558B (es)

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