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NZ743714A - Methods of reducing the risk of a cardiovascular event in a subject on statin therapy - Google Patents

Methods of reducing the risk of a cardiovascular event in a subject on statin therapy

Info

Publication number
NZ743714A
NZ743714A NZ743714A NZ74371413A NZ743714A NZ 743714 A NZ743714 A NZ 743714A NZ 743714 A NZ743714 A NZ 743714A NZ 74371413 A NZ74371413 A NZ 74371413A NZ 743714 A NZ743714 A NZ 743714A
Authority
NZ
New Zealand
Prior art keywords
subject
risk
statin therapy
reducing
cardiovascular event
Prior art date
Application number
NZ743714A
Inventor
Paresh Soni
Original Assignee
Amarin Pharmaceuticals Ie Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49784037&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ743714(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amarin Pharmaceuticals Ie Ltd filed Critical Amarin Pharmaceuticals Ie Ltd
Publication of NZ743714A publication Critical patent/NZ743714A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)

Abstract

In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, use of eicosapentaenoic acid ethyl ester in the manufacture of a medicament for reducing a risk of cardiovascular death, coronary revascularization, and/or unstable angina in a subject having metabolic syndrome and on stable statin therapy, wherein: (a) the subject has been identified as having dyslipidemia, as being on stable statin therapy, and as having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, optionally wherein said subject has established cardiovascular disease or has a high risk of developing cardiovascular disease; and (b) the medicament is formulated for daily administration in an amount to provide about 4 g of the eicosapentaenoic acid ethyl ester per day.
NZ743714A 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy NZ743714A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261666447P 2012-06-29 2012-06-29
NZ737380A NZ737380A (en) 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy

Publications (1)

Publication Number Publication Date
NZ743714A true NZ743714A (en) 2019-08-30

Family

ID=49784037

Family Applications (5)

Application Number Title Priority Date Filing Date
NZ727849A NZ727849A (en) 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
NZ703267A NZ703267A (en) 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
NZ737380A NZ737380A (en) 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
NZ743706A NZ743706A (en) 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
NZ743714A NZ743714A (en) 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy

Family Applications Before (4)

Application Number Title Priority Date Filing Date
NZ727849A NZ727849A (en) 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
NZ703267A NZ703267A (en) 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
NZ737380A NZ737380A (en) 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
NZ743706A NZ743706A (en) 2012-06-29 2013-06-28 Methods of reducing the risk of a cardiovascular event in a subject on statin therapy

Country Status (42)

Country Link
US (26) US9603826B2 (en)
EP (6) EP3363433B1 (en)
JP (3) JP2015522029A (en)
KR (1) KR20150036252A (en)
CN (4) CN104582698A (en)
AU (3) AU2013282394B2 (en)
BR (1) BR112014032905B1 (en)
CA (3) CA3067012C (en)
CL (1) CL2014003534A1 (en)
CO (1) CO7190236A2 (en)
CR (1) CR20140591A (en)
CU (1) CU20140151A7 (en)
CY (1) CY1123749T1 (en)
DK (4) DK3815684T3 (en)
DO (1) DOP2014000301A (en)
EA (2) EA039108B1 (en)
EC (1) ECSP15002815A (en)
ES (4) ES3040240T3 (en)
FI (3) FI4342546T3 (en)
GE (1) GEP201706768B (en)
HK (1) HK1204271A1 (en)
HR (4) HRP20241269T1 (en)
HU (4) HUE069516T2 (en)
IL (3) IL313596A (en)
LT (4) LT4342546T (en)
MA (2) MA50258B2 (en)
MX (6) MX394764B (en)
MY (1) MY187464A (en)
NI (1) NI201400155A (en)
NZ (5) NZ727849A (en)
PE (1) PE20150770A1 (en)
PH (1) PH12014502849A1 (en)
PL (4) PL4342546T3 (en)
PT (4) PT4342546T (en)
RS (4) RS67162B1 (en)
SG (5) SG10201913647QA (en)
SI (4) SI3363433T1 (en)
SM (4) SMT202500326T1 (en)
TN (1) TN2014000540A1 (en)
UA (2) UA128280C2 (en)
WO (1) WO2014005013A2 (en)
ZA (1) ZA201500040B (en)

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