NO995723L - Nye triptolidderivater som er anvendbare ved behandling av autoimmune sykdommer - Google Patents
Nye triptolidderivater som er anvendbare ved behandling av autoimmune sykdommerInfo
- Publication number
- NO995723L NO995723L NO995723A NO995723A NO995723L NO 995723 L NO995723 L NO 995723L NO 995723 A NO995723 A NO 995723A NO 995723 A NO995723 A NO 995723A NO 995723 L NO995723 L NO 995723L
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- autoimmune diseases
- derivatives useful
- triptolide derivatives
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86248897A | 1997-05-23 | 1997-05-23 | |
| PCT/US1998/008470 WO1998052951A1 (en) | 1997-05-23 | 1998-04-27 | Novel triptolide derivatives useful in the treatment of autoimmune diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO995723D0 NO995723D0 (no) | 1999-11-22 |
| NO995723L true NO995723L (no) | 2000-01-21 |
Family
ID=25338616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO995723A NO995723L (no) | 1997-05-23 | 1999-11-22 | Nye triptolidderivater som er anvendbare ved behandling av autoimmune sykdommer |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0983275B1 (da) |
| JP (1) | JP2001525851A (da) |
| KR (1) | KR20010012822A (da) |
| CN (1) | CN1257507A (da) |
| AR (1) | AR012723A1 (da) |
| AT (1) | ATE222910T1 (da) |
| AU (1) | AU741917B2 (da) |
| BR (1) | BR9809678A (da) |
| CA (1) | CA2287977A1 (da) |
| DE (1) | DE69807466T2 (da) |
| DK (1) | DK0983275T3 (da) |
| ES (1) | ES2178207T3 (da) |
| HK (1) | HK1026096A1 (da) |
| HU (1) | HUP0003398A3 (da) |
| IL (1) | IL133088A0 (da) |
| NO (1) | NO995723L (da) |
| NZ (1) | NZ500762A (da) |
| PT (1) | PT983275E (da) |
| TW (1) | TW434235B (da) |
| WO (1) | WO1998052951A1 (da) |
| ZA (1) | ZA984174B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329148B1 (en) | 1999-02-16 | 2001-12-11 | The Board Of Trustees Of The Leland Stanford University | Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells |
| EP1390358A4 (en) * | 2001-03-15 | 2004-06-16 | Pharmagenesis Inc | AMINO ACID DERIVATIVES OF TRIPTOLIDE COMPOUNDS AS IMMUNOMODULATORS AND ANTICROPHES |
| US7847109B2 (en) | 2002-05-31 | 2010-12-07 | Pharmagenesis, Inc. | Triptolide derivatives for modulation of apoptosis and immunosuppression |
| CN100398544C (zh) * | 2002-09-18 | 2008-07-02 | 成都达远药物有限公司 | 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用 |
| JP2006513209A (ja) * | 2002-12-17 | 2006-04-20 | ファーマジェネシス， インコーポレイテッド | 免疫調節因子および抗癌剤としてのトリプトライド誘導体 |
| CN1223595C (zh) | 2002-12-27 | 2005-10-19 | 中国科学院上海药物研究所 | 雷公藤内酯醇衍生物及其应用 |
| US6943259B2 (en) * | 2003-02-25 | 2005-09-13 | Pharmagenesis, Inc. | Halogenated triptolide derivatives as immunomodulators and anticancer agents |
| US7820834B2 (en) | 2003-12-24 | 2010-10-26 | Pharmagenesis, Inc. | Triptolide 5,6-derivatives as immunomodulators and anticancer agents |
| WO2005077008A2 (en) | 2004-02-09 | 2005-08-25 | Pharmagenesis, Inc. | Methods for isolation of triptolide compounds from tripterygium wilfordii |
| JP5057966B2 (ja) | 2004-03-02 | 2012-10-24 | ファーマジェネシス， インコーポレイテッド | 免疫調節剤および抗癌剤としてのトリプトライドラクトン環誘導体 |
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| WO2006044496A2 (en) | 2004-10-13 | 2006-04-27 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| JP5653939B2 (ja) * | 2009-02-05 | 2015-01-14 | ファーマジェネシス， インコーポレイテッド | 抗癌剤および免疫調節因子としてのトリプトリドｃ環誘導体 |
| KR102452412B1 (ko) * | 2015-10-29 | 2022-10-06 | 항조우 웨벤 파마슈티컬스 인크 | 트리프톨리드의 c14-히드록실 에스테르화 아미노산 유도체, 및 그의 제조 방법 및 용도 |
| CN114716503B (zh) * | 2022-03-23 | 2024-03-12 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 一种雷公藤氯内酯醇的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005108A (en) * | 1973-04-03 | 1977-01-25 | Research Corporation | Novel anti-leukemic diterpenoid triepoxides |
| US5430054A (en) * | 1989-12-22 | 1995-07-04 | Jiangsu Family Planning Institute | Preparation methods of diterpene lactone compounds and application of the same to antifertility |
| US5663335A (en) * | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
-
1998
- 1998-04-27 PT PT98919928T patent/PT983275E/pt unknown
- 1998-04-27 IL IL13308898A patent/IL133088A0/xx unknown
- 1998-04-27 AU AU72607/98A patent/AU741917B2/en not_active Ceased
- 1998-04-27 DE DE69807466T patent/DE69807466T2/de not_active Expired - Lifetime
- 1998-04-27 DK DK98919928T patent/DK0983275T3/da active
- 1998-04-27 EP EP98919928A patent/EP0983275B1/en not_active Expired - Lifetime
- 1998-04-27 WO PCT/US1998/008470 patent/WO1998052951A1/en not_active Application Discontinuation
- 1998-04-27 CA CA002287977A patent/CA2287977A1/en not_active Abandoned
- 1998-04-27 NZ NZ500762A patent/NZ500762A/en not_active IP Right Cessation
- 1998-04-27 ES ES98919928T patent/ES2178207T3/es not_active Expired - Lifetime
- 1998-04-27 AT AT98919928T patent/ATE222910T1/de active
- 1998-04-27 HU HU0003398A patent/HUP0003398A3/hu unknown
- 1998-04-27 BR BR9809678-8A patent/BR9809678A/pt not_active Application Discontinuation
- 1998-04-27 CN CN98805397A patent/CN1257507A/zh active Pending
- 1998-04-27 KR KR19997010786A patent/KR20010012822A/ko not_active Application Discontinuation
- 1998-04-27 JP JP55037798A patent/JP2001525851A/ja active Pending
- 1998-05-18 ZA ZA984174A patent/ZA984174B/xx unknown
- 1998-05-19 TW TW087107719A patent/TW434235B/zh not_active IP Right Cessation
- 1998-05-20 AR ARP980102327A patent/AR012723A1/es unknown
-
1999
- 1999-11-22 NO NO995723A patent/NO995723L/no not_active Application Discontinuation
-
2000
- 2000-08-16 HK HK00105108A patent/HK1026096A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO995723D0 (no) | 1999-11-22 |
| AU741917B2 (en) | 2001-12-13 |
| NZ500762A (en) | 2001-08-31 |
| TW434235B (en) | 2001-05-16 |
| EP0983275A1 (en) | 2000-03-08 |
| CA2287977A1 (en) | 1998-11-26 |
| ZA984174B (en) | 1998-11-23 |
| CN1257507A (zh) | 2000-06-21 |
| DE69807466T2 (de) | 2003-04-24 |
| WO1998052951A1 (en) | 1998-11-26 |
| IL133088A0 (en) | 2001-03-19 |
| HUP0003398A2 (en) | 2001-03-28 |
| ATE222910T1 (de) | 2002-09-15 |
| KR20010012822A (ko) | 2001-02-26 |
| AR012723A1 (es) | 2000-11-08 |
| HK1026096A1 (en) | 2000-12-01 |
| AU7260798A (en) | 1998-12-11 |
| DK0983275T3 (da) | 2002-12-23 |
| BR9809678A (pt) | 2000-07-11 |
| PT983275E (pt) | 2003-01-31 |
| DE69807466D1 (de) | 2002-10-02 |
| HUP0003398A3 (en) | 2001-09-28 |
| JP2001525851A (ja) | 2001-12-11 |
| ES2178207T3 (es) | 2002-12-16 |
| EP0983275B1 (en) | 2002-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |