NO995723L - Nye triptolidderivater som er anvendbare ved behandling av autoimmune sykdommer - Google Patents

Nye triptolidderivater som er anvendbare ved behandling av autoimmune sykdommer

Info

Publication number: NO995723L
Authority: NO; Norway
Prior art keywords: treatment; autoimmune diseases; derivatives useful; triptolide derivatives; new
Prior art date: 1997-05-23

Application number

NO995723A

Other languages

English (en)

Other versions

NO995723D0 (no

Inventor

Michel Jean Jung

Mahinda Wickramaratne

Michael Hepperle

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-23

Filing date

1999-11-22

Publication date

2000-01-21

1999-11-22 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1999-11-22 Publication of NO995723D0 publication Critical patent/NO995723D0/no

2000-01-21 Publication of NO995723L publication Critical patent/NO995723L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO995723A 1997-05-23 1999-11-22 Nye triptolidderivater som er anvendbare ved behandling av autoimmune sykdommer NO995723L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86248897A	1997-05-23	1997-05-23
PCT/US1998/008470 WO1998052951A1 (en)	1997-05-23	1998-04-27	Novel triptolide derivatives useful in the treatment of autoimmune diseases

Publications (2)

Publication Number	Publication Date
NO995723D0 NO995723D0 (no)	1999-11-22
NO995723L true NO995723L (no)	2000-01-21

Family

ID=25338616

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO995723A NO995723L (no)	1997-05-23	1999-11-22	Nye triptolidderivater som er anvendbare ved behandling av autoimmune sykdommer

Country Status (21)

Country	Link
EP (1)	EP0983275B1 (no)
JP (1)	JP2001525851A (no)
KR (1)	KR20010012822A (no)
CN (1)	CN1257507A (no)
AR (1)	AR012723A1 (no)
AT (1)	ATE222910T1 (no)
AU (1)	AU741917B2 (no)
BR (1)	BR9809678A (no)
CA (1)	CA2287977A1 (no)
DE (1)	DE69807466T2 (no)
DK (1)	DK0983275T3 (no)
ES (1)	ES2178207T3 (no)
HK (1)	HK1026096A1 (no)
HU (1)	HUP0003398A3 (no)
IL (1)	IL133088A0 (no)
NO (1)	NO995723L (no)
NZ (1)	NZ500762A (no)
PT (1)	PT983275E (no)
TW (1)	TW434235B (no)
WO (1)	WO1998052951A1 (no)
ZA (1)	ZA984174B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6329148B1 (en)	1999-02-16	2001-12-11	The Board Of Trustees Of The Leland Stanford University	Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
EP1390358A4 (en) *	2001-03-15	2004-06-16	Pharmagenesis Inc	AMINO ACID DERIVATIVES OF TRIPTOLIDE COMPOUNDS AS IMMUNOMODULATORS AND ANTICROPHES
EP1511478A4 (en) *	2002-05-31	2009-12-02	Pharmagenesis Inc	TRIPTOLIDE DERIVATIVES FOR MODULATING APOPTOSIS AND IMMUNOSUPPRESSION
CN100398544C (zh) *	2002-09-18	2008-07-02	成都达远药物有限公司	高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
CN1726025A (zh) *	2002-12-17	2006-01-25	泛华医药公司	作为免疫调节剂和抗癌剂的雷公藤内酯醇衍生物
CN1223595C (zh)	2002-12-27	2005-10-19	中国科学院上海药物研究所	雷公藤内酯醇衍生物及其应用
US6943259B2 (en) *	2003-02-25	2005-09-13	Pharmagenesis, Inc.	Halogenated triptolide derivatives as immunomodulators and anticancer agents
WO2005062913A2 (en)	2003-12-24	2005-07-14	Pharmagenesis, Inc.	Triplide 5,6-derivatives as immunomodulators and anticancer agents
EP1722806A4 (en)	2004-02-09	2009-09-16	Pharmagenesis Inc	METHOD OF ISOLATING TRIPTOLIDE COMPOUNDS FROM TRIPTERYGIUM WILFORDII
DK1732536T3 (da)	2004-03-02	2012-06-25	Pharmagenesis Inc	Tripolidlactonringderivater som immunomodulatorer og anticancermidler
EP1768662A2 (en)	2004-06-24	2007-04-04	Novartis Vaccines and Diagnostics, Inc.	Small molecule immunopotentiators and assays for their detection
WO2006044496A2 (en)	2004-10-13	2006-04-27	Pharmagenesis, Inc.	Identification and screening of triptolide target molecules
CA2750844A1 (en) *	2009-02-05	2010-08-12	Pharmagenesis, Inc.	Triptolide c-ring derivatives as anticancer agents and immune modulators
US10238623B2 (en)	2015-10-29	2019-03-26	Hangzhou Weben Pharmaceuticals Inc	C14-hydroxyl esterified amino acid derivative of triptolide, and preparation method and use thereof
CN114716503B (zh) *	2022-03-23	2024-03-12	广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院）	一种雷公藤氯内酯醇的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4005108A (en) *	1973-04-03	1977-01-25	Research Corporation	Novel anti-leukemic diterpenoid triepoxides
US5430054A (en) *	1989-12-22	1995-07-04	Jiangsu Family Planning Institute	Preparation methods of diterpene lactone compounds and application of the same to antifertility
US5663335A (en) *	1996-03-01	1997-09-02	Pharmagenesis, Inc.	Immunosuppressive compounds and methods

1998
- 1998-04-27 HU HU0003398A patent/HUP0003398A3/hu unknown
- 1998-04-27 ES ES98919928T patent/ES2178207T3/es not_active Expired - Lifetime
- 1998-04-27 BR BR9809678-8A patent/BR9809678A/pt not_active Application Discontinuation
- 1998-04-27 DK DK98919928T patent/DK0983275T3/da active
- 1998-04-27 AT AT98919928T patent/ATE222910T1/de active
- 1998-04-27 AU AU72607/98A patent/AU741917B2/en not_active Ceased
- 1998-04-27 DE DE69807466T patent/DE69807466T2/de not_active Expired - Lifetime
- 1998-04-27 PT PT98919928T patent/PT983275E/pt unknown
- 1998-04-27 CN CN98805397A patent/CN1257507A/zh active Pending
- 1998-04-27 EP EP98919928A patent/EP0983275B1/en not_active Expired - Lifetime
- 1998-04-27 WO PCT/US1998/008470 patent/WO1998052951A1/en not_active Application Discontinuation
- 1998-04-27 JP JP55037798A patent/JP2001525851A/ja active Pending
- 1998-04-27 IL IL13308898A patent/IL133088A0/xx unknown
- 1998-04-27 NZ NZ500762A patent/NZ500762A/en not_active IP Right Cessation
- 1998-04-27 KR KR19997010786A patent/KR20010012822A/ko not_active Application Discontinuation
- 1998-04-27 CA CA002287977A patent/CA2287977A1/en not_active Abandoned
- 1998-05-18 ZA ZA984174A patent/ZA984174B/xx unknown
- 1998-05-19 TW TW087107719A patent/TW434235B/zh not_active IP Right Cessation
- 1998-05-20 AR ARP980102327A patent/AR012723A1/es unknown
1999
- 1999-11-22 NO NO995723A patent/NO995723L/no not_active Application Discontinuation
2000
- 2000-08-16 HK HK00105108A patent/HK1026096A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR9809678A (pt)	2000-07-11
ES2178207T3 (es)	2002-12-16
EP0983275A1 (en)	2000-03-08
AU7260798A (en)	1998-12-11
KR20010012822A (ko)	2001-02-26
HUP0003398A3 (en)	2001-09-28
CN1257507A (zh)	2000-06-21
NO995723D0 (no)	1999-11-22
ZA984174B (en)	1998-11-23
DK0983275T3 (da)	2002-12-23
JP2001525851A (ja)	2001-12-11
HK1026096A1 (en)	2000-12-01
AR012723A1 (es)	2000-11-08
DE69807466D1 (de)	2002-10-02
TW434235B (en)	2001-05-16
HUP0003398A2 (en)	2001-03-28
WO1998052951A1 (en)	1998-11-26
ATE222910T1 (de)	2002-09-15
IL133088A0 (en)	2001-03-19
DE69807466T2 (de)	2003-04-24
CA2287977A1 (en)	1998-11-26
NZ500762A (en)	2001-08-31
EP0983275B1 (en)	2002-08-28
AU741917B2 (en)	2001-12-13
PT983275E (pt)	2003-01-31

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Legal Events

Date	Code	Title	Description
2008-03-31	FC2A	Withdrawal, rejection or dismissal of laid open patent application