NO991234L - Trisykliske inhibitorer av farnesylproteintransferase - Google Patents
Trisykliske inhibitorer av farnesylproteintransferaseInfo
- Publication number
- NO991234L NO991234L NO991234A NO991234A NO991234L NO 991234 L NO991234 L NO 991234L NO 991234 A NO991234 A NO 991234A NO 991234 A NO991234 A NO 991234A NO 991234 L NO991234 L NO 991234L
- Authority
- NO
- Norway
- Prior art keywords
- protein transferase
- farnesyl protein
- tricyclic inhibitors
- formula
- compounds
- Prior art date
Links
- 102000004357 Transferases Human genes 0.000 title abstract 2
- 108090000992 Transferases Proteins 0.000 title abstract 2
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
- Cereal-Derived Products (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71332396A | 1996-09-13 | 1996-09-13 | |
| PCT/US1997/015907 WO1998011093A1 (en) | 1996-09-13 | 1997-09-11 | Tricyclic inhibitors of farnesyl protein transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO991234D0 NO991234D0 (no) | 1999-03-12 |
| NO991234L true NO991234L (no) | 1999-05-12 |
Family
ID=24865689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO991234A NO991234L (no) | 1996-09-13 | 1999-03-12 | Trisykliske inhibitorer av farnesylproteintransferase |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0929545B1 (zh) |
| JP (1) | JP2001500510A (zh) |
| KR (1) | KR20000036120A (zh) |
| CN (1) | CN1104427C (zh) |
| AT (1) | ATE286046T1 (zh) |
| AU (1) | AU4337997A (zh) |
| BR (1) | BR9712831A (zh) |
| CA (1) | CA2266016C (zh) |
| CZ (1) | CZ84399A3 (zh) |
| DE (1) | DE69732120T2 (zh) |
| ES (1) | ES2235252T3 (zh) |
| HU (1) | HUP0000121A2 (zh) |
| ID (1) | ID21699A (zh) |
| IL (1) | IL128928A0 (zh) |
| NO (1) | NO991234L (zh) |
| NZ (1) | NZ334453A (zh) |
| PL (1) | PL332242A1 (zh) |
| SK (1) | SK33899A3 (zh) |
| TR (1) | TR199901276T2 (zh) |
| WO (1) | WO1998011093A1 (zh) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3962B (en) | 1993-12-21 | 1996-05-27 | Albright & Wilson | Funcional fluids |
| US5939416A (en) * | 1997-06-17 | 1999-08-17 | Schering Corporation | Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| JP2002501052A (ja) | 1998-01-21 | 2002-01-15 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | ケモカイン受容体アンタゴニストおよびその使用方法 |
| EP1049700B9 (en) | 1998-01-21 | 2006-05-10 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| US8679096B2 (en) | 2007-06-21 | 2014-03-25 | Board Of Regents Of The University Of Nebraska | Multifunctional operational component for robotic devices |
| TW200902007A (en) * | 2007-05-25 | 2009-01-16 | Astrazeneca Ab | Spirocyclopropyl piperidine derivatives |
| EP3673855B1 (en) | 2007-07-12 | 2021-09-08 | Board of Regents of the University of Nebraska | Systems of actuation in robotic devices |
| US20090076536A1 (en) | 2007-08-15 | 2009-03-19 | Board Of Regents Of The University Of Nebraska | Medical inflation, attachment, and delivery devices and related methods |
| CA2838637C (en) | 2011-06-10 | 2020-11-17 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to surgical end effectors |
| CA2841459C (en) | 2011-07-11 | 2020-07-28 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| CA2880220C (en) | 2011-10-03 | 2020-10-13 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| WO2013106569A2 (en) | 2012-01-10 | 2013-07-18 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices for surgical access and insertion |
| CA2871149C (en) | 2012-05-01 | 2020-08-25 | Board Of Regents Of The University Of Nebraska | Single site robotic device and related systems and methods |
| EP3943255B1 (en) | 2012-06-22 | 2023-06-14 | Board of Regents of the University of Nebraska | Local control robotic surgical devices |
| US9770305B2 (en) | 2012-08-08 | 2017-09-26 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| WO2014025399A1 (en) | 2012-08-08 | 2014-02-13 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
| WO2014160086A2 (en) | 2013-03-14 | 2014-10-02 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to robotic surgical devices, end effectors, and controllers |
| WO2014152418A1 (en) | 2013-03-14 | 2014-09-25 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to force control surgical systems |
| US10667883B2 (en) | 2013-03-15 | 2020-06-02 | Virtual Incision Corporation | Robotic surgical devices, systems, and related methods |
| WO2015009949A2 (en) | 2013-07-17 | 2015-01-22 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems and related methods |
| CA2961213A1 (en) | 2014-09-12 | 2016-03-17 | Board Of Regents Of The University Of Nebraska | Quick-release end effectors and related systems and methods |
| JP6608928B2 (ja) | 2014-11-11 | 2019-11-20 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ | 小型の関節デザインを備えるロボットデバイスおよび関連するシステムおよび方法 |
| CN114027986B (zh) | 2015-08-03 | 2024-06-14 | 内布拉斯加大学董事会 | 机器人手术装置系统及相关方法 |
| WO2017201310A1 (en) | 2016-05-18 | 2017-11-23 | Virtual Incision Corporation | Robotic surgicla devices, systems and related methods |
| CA3034671A1 (en) | 2016-08-25 | 2018-03-01 | Shane Farritor | Quick-release tool coupler and related systems and methods |
| CA3035064A1 (en) | 2016-08-30 | 2018-03-08 | Board Of Regents Of The University Of Nebraska | Robotic device with compact joint design and an additional degree of freedom and related systems and methods |
| US11357595B2 (en) | 2016-11-22 | 2022-06-14 | Board Of Regents Of The University Of Nebraska | Gross positioning device and related systems and methods |
| CN110462259B (zh) | 2016-11-29 | 2022-10-28 | 虚拟切割有限公司 | 具有用户存在检测的用户控制器及相关系统和方法 |
| US10722319B2 (en) | 2016-12-14 | 2020-07-28 | Virtual Incision Corporation | Releasable attachment device for coupling to medical devices and related systems and methods |
| US11051894B2 (en) | 2017-09-27 | 2021-07-06 | Virtual Incision Corporation | Robotic surgical devices with tracking camera technology and related systems and methods |
| US11013564B2 (en) | 2018-01-05 | 2021-05-25 | Board Of Regents Of The University Of Nebraska | Single-arm robotic device with compact joint design and related systems and methods |
| JP7546926B2 (ja) | 2019-01-07 | 2024-09-09 | バーチャル インシジョン コーポレイション | ロボット支援手術システムと関連する装置と方法 |
| CA3186863A1 (en) | 2020-07-06 | 2022-01-13 | Virtual Incision Corporation | Surgical robot positioning system and related devices and methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| JPH0676403B2 (ja) * | 1991-01-18 | 1994-09-28 | エスエス製薬株式会社 | 新規なベンゾ［５，６ シクロヘプタ［１，２−ｂ ピリジン誘導体及びこれを含有する抗アレルギー剤 |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| DK0723538T3 (da) * | 1993-10-15 | 2002-03-18 | Schering Corp | Tricykliske carbamatforbindelser, der er nyttige til inhibition af funktion af G-protein og til behandling af proliferative sygdomme |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| HUT76057A (en) * | 1993-10-15 | 1997-06-30 | Schering Corp | Tricyclic sulfonamide compounds, pharmaceutical compositions containing them, which are useful for inhibition of g-protein function and for treatment of proliferative diseases and process for producing them |
| US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| EP1380581A1 (en) * | 1995-12-22 | 2004-01-14 | Schering Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative diseases |
-
1997
- 1997-09-11 CN CN97199598A patent/CN1104427C/zh not_active Expired - Fee Related
- 1997-09-11 CZ CZ99843A patent/CZ84399A3/cs unknown
- 1997-09-11 DE DE69732120T patent/DE69732120T2/de not_active Expired - Fee Related
- 1997-09-11 PL PL97332242A patent/PL332242A1/xx unknown
- 1997-09-11 CA CA002266016A patent/CA2266016C/en not_active Expired - Fee Related
- 1997-09-11 NZ NZ334453A patent/NZ334453A/xx unknown
- 1997-09-11 AT AT97941480T patent/ATE286046T1/de not_active IP Right Cessation
- 1997-09-11 BR BR9712831-7A patent/BR9712831A/pt unknown
- 1997-09-11 SK SK338-99A patent/SK33899A3/sk unknown
- 1997-09-11 IL IL12892897A patent/IL128928A0/xx unknown
- 1997-09-11 WO PCT/US1997/015907 patent/WO1998011093A1/en active IP Right Grant
- 1997-09-11 AU AU43379/97A patent/AU4337997A/en not_active Abandoned
- 1997-09-11 ES ES97941480T patent/ES2235252T3/es not_active Expired - Lifetime
- 1997-09-11 TR TR1999/01276T patent/TR199901276T2/xx unknown
- 1997-09-11 JP JP10513765A patent/JP2001500510A/ja not_active Ceased
- 1997-09-11 EP EP97941480A patent/EP0929545B1/en not_active Expired - Lifetime
- 1997-09-11 HU HU0000121A patent/HUP0000121A2/hu unknown
- 1997-09-11 KR KR1019997002149A patent/KR20000036120A/ko not_active Application Discontinuation
- 1997-11-09 ID IDW990086A patent/ID21699A/id unknown
-
1999
- 1999-03-12 NO NO991234A patent/NO991234L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69732120T2 (de) | 2005-12-08 |
| CA2266016A1 (en) | 1998-03-19 |
| CN1104427C (zh) | 2003-04-02 |
| TR199901276T2 (xx) | 1999-09-21 |
| CZ84399A3 (cs) | 1999-11-17 |
| ES2235252T3 (es) | 2005-07-01 |
| HUP0000121A2 (hu) | 2001-04-28 |
| ID21699A (id) | 1999-07-15 |
| CA2266016C (en) | 2004-06-01 |
| JP2001500510A (ja) | 2001-01-16 |
| NZ334453A (en) | 2000-08-25 |
| AU4337997A (en) | 1998-04-02 |
| NO991234D0 (no) | 1999-03-12 |
| EP0929545B1 (en) | 2004-12-29 |
| PL332242A1 (en) | 1999-08-30 |
| BR9712831A (pt) | 1999-11-16 |
| CN1237165A (zh) | 1999-12-01 |
| EP0929545A1 (en) | 1999-07-21 |
| KR20000036120A (ko) | 2000-06-26 |
| ATE286046T1 (de) | 2005-01-15 |
| SK33899A3 (en) | 2000-02-14 |
| IL128928A0 (en) | 2000-02-17 |
| DE69732120D1 (de) | 2005-02-03 |
| WO1998011093A1 (en) | 1998-03-19 |
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| TR200000114T2 (tr) | Farnesil protein transferazı'nın önlenmesine mahsus benzo(5,6)siklohepta(1,2-B)piridin türevleri. | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |