NO964059D0 - 5H-indeno[1,2-bÅpyrazin-2,3-dionderivater, deres fremstilling samt medikamenter inneholdende forbindelsene - Google Patents

5H-indeno[1,2-bÅpyrazin-2,3-dionderivater, deres fremstilling samt medikamenter inneholdende forbindelsene

Info

Publication number: NO964059D0
Authority: NO; Norway
Prior art keywords: compounds; pct; receptor; preparation; formula
Prior art date: 1994-03-28

Application number

NO964059A

Other languages

English (en)

Other versions

NO964059L (no

NO308075B1 (no

Inventor

Jean-Claude Aloup

Michel Barreau

Dominique Damour

Patrick Jimonet

Serge Mignani

Yves Ribeill

Arielle Genevois Borella

Francois Audiau

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-28

Filing date

1996-09-26

Publication date

1996-09-26

1996-09-26 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1996-09-26 Publication of NO964059D0 publication Critical patent/NO964059D0/no

1996-09-26 Publication of NO964059L publication Critical patent/NO964059L/no

2000-07-17 Publication of NO308075B1 publication Critical patent/NO308075B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Diabetes (AREA)
Toxicology (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Nutrition Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Liquid Crystal Substances (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

NO964059A 1994-03-28 1996-09-26 5H-indeno[1,2-b]pyrazin-2,3-dionderivater, samt medikamenter inneholdende forbindelsene NO308075B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9403583A FR2717805B1 (fr)	1994-03-28	1994-03-28	Dérivés de 5H-indeno[1,2-b]pyrazine-2,3-dione, leur préparation et les médicaments les contenant .
PCT/FR1995/000359 WO1995026342A1 (fr)	1994-03-28	1995-03-23	DERIVES DE 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT

Publications (3)

Publication Number	Publication Date
NO964059D0 true NO964059D0 (no)	1996-09-26
NO964059L NO964059L (no)	1996-09-26
NO308075B1 NO308075B1 (no)	2000-07-17

Family

ID=9461468

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO964059A NO308075B1 (no)	1994-03-28	1996-09-26	5H-indeno[1,2-b]pyrazin-2,3-dionderivater, samt medikamenter inneholdende forbindelsene

Country Status (20)

Country	Link
US (1)	US5922716A (no)
EP (1)	EP0752988B1 (no)
JP (1)	JP3942631B2 (no)
KR (1)	KR970702262A (no)
AT (1)	ATE180476T1 (no)
AU (1)	AU692853B2 (no)
BR (1)	BR9507446A (no)
CA (1)	CA2184754A1 (no)
DE (1)	DE69509886T2 (no)
DK (1)	DK0752988T3 (no)
ES (1)	ES2134460T3 (no)
FI (1)	FI112219B (no)
FR (1)	FR2717805B1 (no)
GR (1)	GR3030274T3 (no)
HU (1)	HUT75307A (no)
IL (1)	IL113149A0 (no)
NO (1)	NO308075B1 (no)
PL (1)	PL316442A1 (no)
WO (1)	WO1995026342A1 (no)
ZA (1)	ZA952525B (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK12293D0 (da) *	1993-02-02	1993-02-02	Novo Nordisk As	Heterocykliske forbindelser og deres fremstilling og anvendelse
FR2743363A1 (fr) *	1996-01-10	1997-07-11	Rhone Poulenc Rorer Sa	5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-a-ones substituees en position 2, leur preparation et les medicaments les contenant
US6083986A (en) *	1996-07-26	2000-07-04	Icagen, Inc.	Potassium channel inhibitors
US6333337B1 (en)	1998-01-27	2001-12-25	Icagen, Inc.	Potassium channel inhibitors
AU781365B2 (en)	1999-12-21	2005-05-19	Icagen, Inc.	Potassium channel inhibitors
US6566380B2 (en)	2000-07-25	2003-05-20	Icagen, Inc.	Potassium channel inhibitors
US6620849B2 (en)	2000-07-26	2003-09-16	Icafen, Inc.	Potassium channel inhibitors
US6849634B2 (en)	2000-12-21	2005-02-01	Icagen	Potassium channel inhibitors
EP1436258A4 (en) *	2001-03-08	2005-03-23	Univ Emory	PH VALVE DEPENDENT NMDA RECEPTOR ANTAGONISTS
US20040082543A1 (en) *	2002-10-29	2004-04-29	Pharmacia Corporation	Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
DK2091948T3 (da)	2006-11-30	2012-07-23	Probiodrug Ag	Nye inhibitorer af glutaminylcyclase
AU2008220785B2 (en)	2007-03-01	2013-02-21	Vivoryon Therapeutics N.V.	New use of glutaminyl cyclase inhibitors
ES2533484T3 (es)	2007-04-18	2015-04-10	Probiodrug Ag	Derivados de tiourea como inhibidores de la glutaminil ciclasa
US8420680B2 (en) *	2007-06-29	2013-04-16	Emory University	NMDA receptor antagonists for neuroprotection
US8486940B2 (en)	2009-09-11	2013-07-16	Probiodrug Ag	Inhibitors
US9181233B2 (en)	2010-03-03	2015-11-10	Probiodrug Ag	Inhibitors of glutaminyl cyclase
DK2545047T3 (da)	2010-03-10	2014-07-28	Probiodrug Ag	Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
CN101906051B (zh) *	2010-07-13	2013-01-23	成都理工大学	手性氨基茚酮的合成方法
WO2012123563A1 (en)	2011-03-16	2012-09-20	Probiodrug Ag	Benz imidazole derivatives as inhibitors of glutaminyl cyclase
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4400382A (en) *	1980-05-09	1983-08-23	Usv Pharmaceutical Corporation	Thiazoloquinoxalin-1,4-diones for treating allergy
US4507300A (en) *	1980-05-09	1985-03-26	Usv Pharmaceutical Corporation	Pyridotriazolopyrazine-diones for treating allergy
US4668678A (en) *	1980-05-09	1987-05-26	Usv Pharmaceutical Corporation	Triazoloquinoxalin-1,4-diones
US4354027A (en) *	1980-05-19	1982-10-12	Usv Pharmaceutical Corporation	Triazoloquinoxalin-4-ones
US5153196A (en) *	1991-06-05	1992-10-06	Eli Lilly And Company	Excitatory amino acid receptor antagonists and methods for the use thereof
US5196421A (en) *	1991-06-05	1993-03-23	Eli Lilly And Company	Excitatory amino acid receptor antagonists in methods for the use thereof
DK162491D0 (da) *	1991-09-20	1991-09-20	Novo Nordisk As	Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne
DK0647137T3 (da) *	1992-06-22	2008-12-08	State Of Oregon Through Oregon	Glycinreceptorantagonister og anvendelse deraf
FR2696466B1 (fr) *	1992-10-02	1994-11-25	Rhone Poulenc Rorer Sa	Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.
DK12293D0 (da) *	1993-02-02	1993-02-02	Novo Nordisk As	Heterocykliske forbindelser og deres fremstilling og anvendelse
FR2707645B1 (fr) *	1993-07-16	1995-08-11	Rhone Poulenc Rorer Sa	Dérivés d'imidazo[1,2-a]pirazine-4-one, leur préparation et les médicaments les contenant.
FR2707643B1 (fr) *	1993-07-16	1995-08-11	Rhone Poulenc Rorer Sa	Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant.

1994
- 1994-03-28 FR FR9403583A patent/FR2717805B1/fr not_active Expired - Fee Related
1995
- 1995-03-02 CA CA002184754A patent/CA2184754A1/fr not_active Abandoned
- 1995-03-23 HU HU9602658A patent/HUT75307A/hu unknown
- 1995-03-23 DE DE69509886T patent/DE69509886T2/de not_active Expired - Fee Related
- 1995-03-23 EP EP95914405A patent/EP0752988B1/fr not_active Expired - Lifetime
- 1995-03-23 BR BR9507446A patent/BR9507446A/pt not_active Application Discontinuation
- 1995-03-23 PL PL95316442A patent/PL316442A1/xx unknown
- 1995-03-23 JP JP52499695A patent/JP3942631B2/ja not_active Expired - Fee Related
- 1995-03-23 ES ES95914405T patent/ES2134460T3/es not_active Expired - Lifetime
- 1995-03-23 DK DK95914405T patent/DK0752988T3/da active
- 1995-03-23 AU AU21414/95A patent/AU692853B2/en not_active Ceased
- 1995-03-23 AT AT95914405T patent/ATE180476T1/de not_active IP Right Cessation
- 1995-03-23 US US08/714,164 patent/US5922716A/en not_active Expired - Fee Related
- 1995-03-23 WO PCT/FR1995/000359 patent/WO1995026342A1/fr active IP Right Grant
- 1995-03-27 IL IL11314995A patent/IL113149A0/xx unknown
- 1995-03-28 ZA ZA952525A patent/ZA952525B/xx unknown
1996
- 1996-09-25 KR KR1019960705453A patent/KR970702262A/ko not_active Withdrawn
- 1996-09-26 NO NO964059A patent/NO308075B1/no not_active IP Right Cessation
- 1996-09-27 FI FI963881A patent/FI112219B/fi active
1999
- 1999-05-27 GR GR990400320T patent/GR3030274T3/el unknown

Also Published As

Publication number	Publication date
AU692853B2 (en)	1998-06-18
DE69509886T2 (de)	1999-09-30
JPH09510728A (ja)	1997-10-28
GR3030274T3 (en)	1999-08-31
FI963881L (fi)	1996-09-27
ZA952525B (en)	1996-01-15
JP3942631B2 (ja)	2007-07-11
IL113149A0 (en)	1995-06-29
FI963881A0 (fi)	1996-09-27
DE69509886D1 (de)	1999-07-01
FR2717805A1 (fr)	1995-09-29
US5922716A (en)	1999-07-13
ATE180476T1 (de)	1999-06-15
EP0752988B1 (fr)	1999-05-26
PL316442A1 (en)	1997-01-20
AU2141495A (en)	1995-10-17
NO964059L (no)	1996-09-26
FI112219B (fi)	2003-11-14
BR9507446A (pt)	1997-08-12
FR2717805B1 (fr)	1996-05-10
HUT75307A (en)	1997-05-28
ES2134460T3 (es)	1999-10-01
EP0752988A1 (fr)	1997-01-15
NO308075B1 (no)	2000-07-17
HU9602658D0 (en)	1996-11-28
WO1995026342A1 (fr)	1995-10-05
KR970702262A (ko)	1997-05-13
CA2184754A1 (fr)	1995-10-05
DK0752988T3 (da)	1999-11-08

Publication	Publication Date	Title
NO964059D0 (no)	1996-09-26	5H-indeno[1,2-bÅpyrazin-2,3-dionderivater, deres fremstilling samt medikamenter inneholdende forbindelsene
BR9813390A (pt)	2000-10-03	Composto, processo para a preparação do mesmo, e uso do mesmo, composição farmacêutica, processo para a preparação da mesma, e, processo para efetuar a imunossupressão
CA2201812A1 (en)	1997-10-05	1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
NZ514487A (en)	2004-01-30	Carbamic acid derivatives and their use as metabotropic glutamate receptor ligands
BR9811521A (pt)	2000-08-22	Composição para tratar ou impedir a glomerulopatia
NZ515304A (en)	2004-01-30	Bradykinin receptor antagonists
FI960160A0 (fi)	1996-01-12	Imidatso/1,2-a/pyratsin-4-onijohdannaiset, niiden valmistus ja niitä sisältävät lääkkeet
FR2717812B1 (fr)	1996-05-10	Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.
ES2158099T3 (es)	2001-09-01	Derivados de imidazo(1,2-a)indeno(1,2-e)pirazina-4-ona y composiciones farmaceuticas que los contienen.
FR2751650B1 (fr)	1998-10-09	Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique
NO301760B1 (no)	1997-12-08	Farmakologisk aktive <alfa>-[tertiær-aminometyl]-benzenmetanolderivater, farmasöytiske preparater inneholdende disse samt anvendelse av forbindelsene for fremstilling av farmasöytiske preparater
NO20000423L (no)	2000-03-22	Tiazolobenzoheterocykler, deres fremstilling samt medikamenter inneholdende forbindelsene
WO1987007609A1 (en)	1987-12-17	1,1,2-triaryl-1-butene derivatives
TR200101813T2 (tr)	2001-12-21	Alfa2-Antagonistleri olarak benzisoksazoller ve fenonlar
ATA57894A (de)	2000-09-15	Mittel zur behandlung von osteoporose
DE69503635D1 (de)	1998-08-27	Pyrrolidinderivate zur behandlung von cck und gastrin-abhängigen erkrankungen
BR0202279A (pt)	2003-04-29	Compostos de indenoindolona, processo para sua preparação e composições farmacêuticas contendo eles
IL106963A0 (en)	1993-12-28	Ureidoacetamide derivatives,their preparation and medicaments containing them
MX9601659A (es)	1997-07-31	Antagonistas del receptor de adhesion, procedimiento para prepararlos, composiciones farmaceuticas que los contienen y su empleo para preparar medicamentos y combatir enfermedades.

Legal Events

Date	Code	Title	Description
2003-10-27	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN SEPTEMBER 2003