NO953837D0 - Heterocykliske derivater som inhibitorer for blodplateaggregering - Google Patents

Heterocykliske derivater som inhibitorer for blodplateaggregering

Info

Publication number: NO953837D0
Authority: NO; Norway
Prior art keywords: inhibitors; platelet aggregation; heterocyclic derivatives; ylüphenoxybutyric; piperazin
Prior art date: 1993-03-29

Application number

NO953837A

Other languages

English (en)

Other versions

NO953837L (no

NO305244B1 (no

Inventor

Michael Garth Wayne

Michael James Smithers

John Wall Rayner

Alan Wellington Faull

Robert James Pearce

Andrew George Brewster

Richard Eden Shute

Stuart Dennett Mills

Peter William Rodney Caulkett

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-29

Filing date

1995-09-28

Publication date

1995-09-28

1993-03-29 Priority claimed from GB939306453A external-priority patent/GB9306453D0/en

1993-12-15 Priority claimed from GB939325605A external-priority patent/GB9325605D0/en

1995-09-28 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1995-09-28 Publication of NO953837L publication Critical patent/NO953837L/no

1995-09-28 Publication of NO953837D0 publication Critical patent/NO953837D0/no

1999-04-26 Publication of NO305244B1 publication Critical patent/NO305244B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Electroluminescent Light Sources (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyridine Compounds (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)

NO953837A 1993-03-29 1995-09-28 Heterocykliske derivater som inhibitorer for blodplateaggregering, anvendelse derav og farmas°ytisk blanding NO305244B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB939306453A GB9306453D0 (en)	1993-03-29	1993-03-29	Heterocyclic derivatives
GB939325605A GB9325605D0 (en)	1993-12-15	1993-12-15	Heterocyclic derivatives
PCT/GB1994/000647 WO1994022834A1 (en)	1993-03-29	1994-03-28	Heterocyclic derivatives as platelet aggregation inhibitors

Publications (3)

Publication Number	Publication Date
NO953837L NO953837L (no)	1995-09-28
NO953837D0 true NO953837D0 (no)	1995-09-28
NO305244B1 NO305244B1 (no)	1999-04-26

Family

ID=26302668

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO953837A NO305244B1 (no)	1993-03-29	1995-09-28	Heterocykliske derivater som inhibitorer for blodplateaggregering, anvendelse derav og farmas°ytisk blanding

Country Status (26)

Country	Link
US (1)	US5556977A (no)
EP (2)	EP0825184B1 (no)
JP (1)	JPH08508291A (no)
KR (1)	KR100231089B1 (no)
CN (1)	CN1120334A (no)
AT (2)	ATE168678T1 (no)
AU (1)	AU692438B2 (no)
BR (1)	BR9406613A (no)
CA (1)	CA2156070A1 (no)
CZ (1)	CZ250995A3 (no)
DE (2)	DE69427548T2 (no)
DK (2)	DK0691959T3 (no)
ES (2)	ES2159798T3 (no)
FI (1)	FI954616A0 (no)
GB (1)	GB9406143D0 (no)
GR (2)	GR3027751T3 (no)
HU (2)	HUT72088A (no)
IL (1)	IL109144A (no)
NO (1)	NO305244B1 (no)
NZ (1)	NZ262941A (no)
PL (1)	PL310889A1 (no)
PT (1)	PT825184E (no)
SK (1)	SK120895A3 (no)
TW (1)	TW276254B (no)
WO (1)	WO1994022834A1 (no)
ZW (1)	ZW4294A1 (no)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5750754A (en) *	1993-03-29	1998-05-12	Zeneca Limited	Heterocyclic compounds
IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
US5700801A (en) *	1994-12-23	1997-12-23	Karl Thomae, Gmbh	Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
MX9704745A (es) *	1994-12-23	1997-10-31	Thomae Gmbh Dr K	Derivados de piperazina, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion.
ES2137886B1 (es) *	1995-06-01	2000-08-16	Zeneca Ltd	Acido (-)-(3r)-3-metil-4-(4-(4-(4-piridil)piperazin-1-il)fenoxi) butirico como inhibidor de la adhesion celular.
FR2734818B1 (fr) *	1995-06-01	1998-07-10	Zeneca Ltd	Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazine-1-yl- phenoxy}-butyrique, procede pour sa preparation et composition pharmaceutique le contenant
DE19524765A1 (de) *	1995-07-07	1997-01-09	Boehringer Mannheim Gmbh	Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
WO1997019068A1 (en) *	1995-11-17	1997-05-29	Warner-Lambert Company	Sulfonamide inhibitors of matrix metalloproteinases
GB9525620D0 (en)	1995-12-15	1996-02-14	Glaxo Group Ltd	Chemical compounds
GB9602166D0 (en) *	1996-02-02	1996-04-03	Zeneca Ltd	Aminoheterocyclic derivatives
EP0880501A1 (en) *	1996-02-02	1998-12-02	Zeneca Limited	Heterocyclic compounds useful as pharmaceutical agents
US5780480A (en) *	1996-02-28	1998-07-14	Merck & Co., Inc.	Fibrinogen receptor antagonists
WO1997031910A1 (en) *	1996-02-28	1997-09-04	Merck & Co., Inc.	Fibrinogen receptor antagonists
EP0897920A4 (en) *	1996-03-29	1999-06-30	Meiji Seika Co	NOVEL HETEROCYCLIC COMPOUNDS HAVING AN INHIBITION EFFECT OF PLATELET AGGREGATION
US5854245A (en) *	1996-06-28	1998-12-29	Merck & Co., Inc.	Fibrinogen receptor antagonists
AU709631B2 (en) *	1996-06-28	1999-09-02	Merck & Co., Inc.	Fibrinogen receptor antagonist prodrugs
US5932582A (en) *	1996-06-28	1999-08-03	Merck & Co., Inc.	Fibrinogen receptor antagonist prodrugs
EP0912175A4 (en) *	1996-06-28	1999-09-08	Merck & Co Inc	FIBRINOGENIC RECEPTOR ANTAGONISTS
US5990107A (en) *	1996-06-28	1999-11-23	Merck & Co., Inc.	Fibrinogen receptor antagonist prodrugs
GB9821483D0 (en)	1998-10-03	1998-11-25	Glaxo Group Ltd	Chemical compounds
UA56197C2 (uk)	1996-11-08	2003-05-15	Зенека Лімітед	Гетероциклічні похідні
US5945545A (en) *	1996-12-13	1999-08-31	Merck & Co., Inc.	Fibrinogen receptor antagonists
WO1998035956A1 (en)	1997-02-13	1998-08-20	Zeneca Limited	Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
EP0966462B1 (en)	1997-02-13	2003-06-11	AstraZeneca AB	Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
GB9715895D0 (en)	1997-07-29	1997-10-01	Zeneca Ltd	Heterocyclic compounds
US6232322B1 (en)	1998-05-12	2001-05-15	American Home Products Corporation	Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
JP2002516305A (ja)	1998-05-12	2002-06-04	アメリカン・ホーム・プロダクツ・コーポレイション	インスリン抵抗性および高血糖症の治療に有用な２，３，５−置換ビフェニル
US6110963A (en) *	1998-05-12	2000-08-29	American Home Products Corporation	Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6451827B2 (en)	1998-05-12	2002-09-17	Wyeth	2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6221902B1 (en)	1998-05-12	2001-04-24	American Home Products Corporation	Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6166069A (en) *	1998-05-12	2000-12-26	American Home Products Corporation	Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6699896B1 (en)	1998-05-12	2004-03-02	Wyeth	Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
JP2002521444A (ja)	1998-07-31	2002-07-16	イーライ・リリー・アンド・カンパニー	複素環スルホンアミド誘導体
GB9902989D0 (en)	1999-02-11	1999-03-31	Zeneca Ltd	Heterocyclic derivatives
DE60021368T2 (de) *	1999-04-19	2006-07-27	Lexicon Pharmaceuticals (New Jersey), Inc.	Ppar-(gamma) agonisten zur behandlung von type ii diabetes
US6310081B1 (en)	1999-05-10	2001-10-30	American Home Products Corporation	Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
DE60144284D1 (de)	2000-11-01	2011-05-05	Millennium Pharm Inc	Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
DE202011000090U1 (de)	2011-01-14	2011-04-21	E-LEAD ELECTRONIC CO., LTD., Shengang Shiang	Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
RU2764243C2 (ru)	2017-09-22	2022-01-14	ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи	Гетероциклические соединения в качестве ингибиторов PAD
DK3697785T3 (da)	2017-10-18	2023-04-03	Jubilant Epipad LLC	Imidazo-pyridine forbindelser som pad-inhibitorer
CA3080677A1 (en)	2017-11-06	2019-05-09	Jubilant Prodel LLC	Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation
JP7368369B2 (ja)	2017-11-24	2023-10-24	ジュビラント・エピスクライブ・エルエルシー	Ｐｒｍｔ５阻害剤としてのヘテロ環式化合物
WO2019175897A1 (en)	2018-03-13	2019-09-19	Jubilant Biosys Limited	Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3875165A (en) *	1973-02-22	1975-04-01	Wyeth John & Brother Ltd	(4-Quinolylamino)-(N-piperidyl)benzamides and N-{8 (quinolylamino)-benzoyl{9 piperidines
GB1474296A (en) *	1975-01-23	1977-05-18	Wyeth John & Brother Ltd	4-aminoquinoline derivatives
JPS57183738A (en) *	1981-05-06	1982-11-12	Yamanouchi Pharmaceut Co Ltd	Aromatic carboxylic acid derivative
ZA825719B (en) *	1981-09-03	1983-06-29	Recordati Chem Pharm	Alkanoylanilides
EP0100158A3 (en) *	1982-07-28	1985-03-27	The Upjohn Company	(3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
US4613598A (en) *	1984-03-13	1986-09-23	Mitsubishi Chemical Industries Limited	Piperazine derivatives and their acid addition salts
AU5428686A (en) *	1985-03-12	1986-09-18	Smith Kline & French Laboratories Limited	Imidazolinone and thiazolinone derivatives
GB8603120D0 (en) *	1986-02-07	1986-03-12	Pfizer Ltd	Anti-dysrhythmia agents
GB8609630D0 (en) *	1986-04-19	1986-05-21	Pfizer Ltd	Anti-arrhythmia agents
EP0264883A3 (en) *	1986-10-21	1990-04-04	Banyu Pharmaceutical Co., Ltd.	Substituted pyridine derivatives
MY104343A (en) *	1987-11-23	1994-03-31	Janssen Pharmaceutica Nv	Novel pyridizinamine deravatives
GB8819307D0 (en) *	1988-08-13	1988-09-14	Pfizer Ltd	Antiarrhythmic agents
US5039805A (en) *	1988-12-08	1991-08-13	Hoffmann-La Roche Inc.	Novel benzoic and phenylacetic acid derivatives
US5084466A (en) *	1989-01-31	1992-01-28	Hoffmann-La Roche Inc.	Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2008116C (en) *	1989-02-23	2001-11-20	Thomas Weller	Glycine derivatives
DE4134467A1 (de) *	1991-10-18	1993-04-22	Thomae Gmbh Dr K	Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5318899A (en) *	1989-06-16	1994-06-07	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
AU641676B2 (en) *	1989-07-25	1993-09-30	Pharmacia & Upjohn Company	Antiarrhythmic tertiary amine-alkenyl-phenyl-alkanesulfonamides
US5051405A (en) *	1989-10-10	1991-09-24	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Anti-thrombotic peptides and pseudopeptides
CA2037153A1 (en) *	1990-03-09	1991-09-10	Leo Alig	Acetic acid derivatives
GB9007751D0 (en) *	1990-04-05	1990-06-06	Ciba Geigy Ag	Novel platelet-aggregation inhibitors
US5252735A (en) *	1990-06-29	1993-10-12	The Upjohn Company	Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
IL99537A (en) *	1990-09-27	1995-11-27	Merck & Co Inc	Fibrinogen receptor antagonists and pharmaceutical compositions containing them
US5264420A (en) *	1990-09-27	1993-11-23	Merck & Co., Inc.	Fibrinogen receptor antagonists
NZ239846A (en) *	1990-09-27	1994-11-25	Merck & Co Inc	Sulphonamide derivatives and pharmaceutical compositions thereof
NZ239876A (en) *	1990-09-27	1993-12-23	Merck & Co Inc	Glycyl-b-alanine derivatives and pharmaceutical compositions thereof.
IL99539A0 (en) *	1990-09-27	1992-08-18	Merck & Co Inc	Fibrinogen receptor antagonists and pharmaceutical compositions containing them
DE4102024A1 (de) *	1991-01-24	1992-07-30	Thomae Gmbh Dr K	Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0570507A4 (en) *	1991-02-05	1994-09-21	Smithkline Beecham Corp	Anti-aggregatory peptides containing an aromatic ester or amide
DE4107857A1 (de) *	1991-03-12	1992-09-17	Thomae Gmbh Dr K	Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
RU2097378C1 (ru) *	1991-03-26	1997-11-27	Ф.Хоффманн-Ля Рош Аг	ПРОИЗВОДНЫЕ N-АЦИЛ- α -АМИНОКИСЛОТЫ ИЛИ ИХ ФИЗИОЛОГИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ, ПРОСТЫЕ ИЛИ СЛОЖНЫЕ ЭФИРЫ, АМИДЫ ИЛИ ГИДРАТЫ И КОМПОЗИЦИЯ ИНГИБИРУЮЩАЯ СВЯЗЫВАНИЕ АДГЕЗИВНЫХ ПРОТЕИНОВ С ТРОМБОЦИТАМИ И АГРЕГАЦИЮ ТРОМБОЦИТОВ
MX9201416A (es) *	1991-03-28	1992-10-01	Rhone Poulenc Rorer Int	Peptidos y pseudopeptidos antitromboticos.
AU661659B2 (en) *	1991-04-11	1995-08-03	Rhone-Poulenc Rorer International (Holdings) Inc.	Anti-thrombotic peptide and pseudopeptide derivatives
US5321034A (en) *	1991-05-07	1994-06-14	Merck & Co., Inc.	Fibrinogen receptor antagonists
HUT68769A (en) *	1991-05-07	1995-07-28	Merck & Co Inc	FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE
DK0513675T3 (da) *	1991-05-13	1996-09-30	Fujisawa Pharmaceutical Co	Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf
JPH05213884A (ja) *	1991-06-14	1993-08-24	Upjohn Co:The	新規な４−アミノキノリン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
DE4124942A1 (de) *	1991-07-27	1993-01-28	Thomae Gmbh Dr K	5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4127404A1 (de) *	1991-08-19	1993-02-25	Thomae Gmbh Dr K	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
AU646966B2 (en) *	1991-08-23	1994-03-10	Takeda Chemical Industries Ltd.	2-piperazinone compounds, their production and use
US5254573A (en) *	1991-10-15	1993-10-19	Monsanto Company	Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
CA2115848A1 (en) *	1991-10-15	1993-04-16	Philippe Roger Bovy	Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
US5239113A (en) *	1991-10-15	1993-08-24	Monsanto Company	Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
GB9122016D0 (en) *	1991-10-16	1991-11-27	Glaxo Group Ltd	Chemical compounds
US5250679A (en) *	1991-10-18	1993-10-05	Genentech, Inc.	Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5272158A (en) *	1991-10-29	1993-12-21	Merck & Co., Inc.	Fibrinogen receptor antagonists
EP0542363A3 (en) *	1991-11-14	1993-07-14	Glaxo Group Limited	Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
US5424334A (en) *	1991-12-19	1995-06-13	G. D. Searle & Co.	Peptide mimetic compounds useful as platelet aggregation inhibitors
WO1993014077A1 (en) *	1992-01-21	1993-07-22	Glaxo Group Limited	Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
US5264457A (en) *	1992-02-14	1993-11-23	G. D. Searle & Co.	Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
US5227490A (en) *	1992-02-21	1993-07-13	Merck & Co., Inc.	Fibrinogen receptor antagonists
HUT63609A (en) *	1992-03-10	1993-09-28	Sandoz Ag	Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds
DE4212304A1 (de) *	1992-04-13	1993-10-14	Cassella Ag	Asparaginsäurederivate, ihre Herstellung und Verwendung
GB9208740D0 (en) *	1992-04-23	1992-06-10	Glaxo Group Ltd	Chemical compounds
DE4213634A1 (de) *	1992-04-24	1993-10-28	Cassella Ag	2,4-Dioxo-imidazolidin-Derivate
DE4219158A1 (de) *	1992-06-11	1993-12-16	Thomae Gmbh Dr K	Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5726192A (en) *	1992-12-29	1998-03-10	Smithkline Beecham Corporation	Platelet aggregation inhibiting compounds
TW301607B (no) *	1993-03-09	1997-04-01	Takeda Pharm Industry Co Ltd

1994
- 1994-03-28 PT PT97117909T patent/PT825184E/pt unknown
- 1994-03-28 AU AU62889/94A patent/AU692438B2/en not_active Ceased
- 1994-03-28 DE DE69427548T patent/DE69427548T2/de not_active Expired - Fee Related
- 1994-03-28 EP EP97117909A patent/EP0825184B1/en not_active Expired - Lifetime
- 1994-03-28 ES ES97117909T patent/ES2159798T3/es not_active Expired - Lifetime
- 1994-03-28 PL PL94310889A patent/PL310889A1/xx unknown
- 1994-03-28 SK SK1208-95A patent/SK120895A3/sk unknown
- 1994-03-28 AT AT94910494T patent/ATE168678T1/de not_active IP Right Cessation
- 1994-03-28 IL IL10914494A patent/IL109144A/xx not_active IP Right Cessation
- 1994-03-28 NZ NZ262941A patent/NZ262941A/en unknown
- 1994-03-28 JP JP6521810A patent/JPH08508291A/ja active Pending
- 1994-03-28 HU HU9502290A patent/HUT72088A/hu unknown
- 1994-03-28 AT AT97117909T patent/ATE202345T1/de not_active IP Right Cessation
- 1994-03-28 ZW ZW4294A patent/ZW4294A1/xx unknown
- 1994-03-28 KR KR1019950704314A patent/KR100231089B1/ko not_active Expired - Fee Related
- 1994-03-28 BR BR9406613A patent/BR9406613A/pt not_active Application Discontinuation
- 1994-03-28 EP EP94910494A patent/EP0691959B1/en not_active Expired - Lifetime
- 1994-03-28 CN CN94191664A patent/CN1120334A/zh active Pending
- 1994-03-28 ES ES94910494T patent/ES2119184T3/es not_active Expired - Lifetime
- 1994-03-28 GB GB9406143A patent/GB9406143D0/en active Pending
- 1994-03-28 WO PCT/GB1994/000647 patent/WO1994022834A1/en not_active Application Discontinuation
- 1994-03-28 DK DK94910494T patent/DK0691959T3/da active
- 1994-03-28 DE DE69411900T patent/DE69411900T2/de not_active Expired - Fee Related
- 1994-03-28 US US08/218,171 patent/US5556977A/en not_active Expired - Fee Related
- 1994-03-28 CA CA002156070A patent/CA2156070A1/en not_active Abandoned
- 1994-03-28 TW TW083102802A patent/TW276254B/zh active
- 1994-03-28 DK DK97117909T patent/DK0825184T3/da active
- 1994-03-28 CZ CZ952509A patent/CZ250995A3/cs unknown
1995
- 1995-06-13 HU HU95P/P00193P patent/HU211336A9/hu unknown
- 1995-09-28 NO NO953837A patent/NO305244B1/no not_active IP Right Cessation
- 1995-09-28 FI FI954616A patent/FI954616A0/fi unknown
1998
- 1998-08-27 GR GR980401930T patent/GR3027751T3/el unknown
2001
- 2001-09-18 GR GR20010401498T patent/GR3036640T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0825184B1 (en)	2001-06-20
ZW4294A1 (en)	1994-12-21
EP0825184A1 (en)	1998-02-25
GR3027751T3 (en)	1998-11-30
PL310889A1 (en)	1996-01-08
FI954616L (fi)	1995-09-28
JPH08508291A (ja)	1996-09-03
CN1120334A (zh)	1996-04-10
NZ262941A (en)	1997-07-27
CA2156070A1 (en)	1994-10-13
ES2159798T3 (es)	2001-10-16
NO953837L (no)	1995-09-28
GB9406143D0 (en)	1994-05-18
PT825184E (pt)	2001-11-30
ES2119184T3 (es)	1998-10-01
CZ250995A3 (en)	1996-01-17
IL109144A (en)	2000-02-29
SK120895A3 (en)	1996-06-05
DK0825184T3 (da)	2001-09-10
KR100231089B1 (ko)	1999-11-15
TW276254B (no)	1996-05-21
DE69427548D1 (de)	2001-07-26
AU692438B2 (en)	1998-06-11
HU9502290D0 (en)	1995-10-30
DK0691959T3 (da)	1999-04-26
HUT72088A (en)	1996-03-28
IL109144A0 (en)	1994-06-24
GR3036640T3 (en)	2001-12-31
ATE168678T1 (de)	1998-08-15
DE69411900D1 (de)	1998-08-27
AU6288994A (en)	1994-10-24
BR9406613A (pt)	1996-02-06
DE69411900T2 (de)	1998-12-10
ATE202345T1 (de)	2001-07-15
FI954616A0 (fi)	1995-09-28
HU211336A9 (en)	1995-11-28
WO1994022834A1 (en)	1994-10-13
DE69427548T2 (de)	2002-04-18
EP0691959B1 (en)	1998-07-22
EP0691959A1 (en)	1996-01-17
NO305244B1 (no)	1999-04-26
US5556977A (en)	1996-09-17

Publication	Publication Date	Title
NO953837L (no)	1995-09-28	Heterocykliske derivater som inhibitorer for blodplateaggregering
DK0560268T3 (da)	1995-06-12	Substituerede pipecolinsyrederivater som HIV-proteasehæmmere
NO914092L (no)	1992-04-21	Nye mercaptoacetylamid-derivater som er anvendbare som inhibitorer for enkefalinase og ace
ATE269312T1 (de)	2004-07-15	N-(amidinophenyl)-n'-(subst.)-3h-2,4- benzodiazepin-3-on derivative als faktor xa inhibitoren
FI924310A (fi)	1993-03-28	Nya 2-substituerade indan-2-karboxialkylderivat anvaendbara som inhibitorer av enkefalinas och ace
EA200200510A1 (ru)	2002-10-31	4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр
NO923744L (no)	1993-03-29	Nye 2-substituerte indan-2-mercaptoacetylamidderivater anvendbare som inhibitorer av enkefalinase og ace
DK0630366T3 (da)	2003-04-22	Substituerede heterocycliske derivater, der er nyttige som blodpladeaggregeringsinhibitorer
PT1023267E (pt)	2004-01-30	Compostos de piridilo e composicoes farmaceuticas que os contem
NO944371D0 (no)	1994-11-16	Kjemisk forbindelse med blodplateaggregeringsinhiberende virkning
DK0530639T3 (da)	1994-12-05	Heterocyclisk substituerede quinolylmethoxy-phenylacetamider som lipoxygenasehæmmere
DE69629838D1 (de)	2003-10-09	Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate
NO921706D0 (no)	1992-04-30	Nye 2-merkaptomethylen-tetrahydronafthalen- og indan-2-carboxamidderivater som enkefalinaseinhibitorer
NO932002L (no)	1993-12-06	Nye tiosemikarbazonsyreestere
DE3770433D1 (de)	1991-07-04	4-oxo-1,3-benzodioxan-derivat.
NO951134D0 (no)	1995-03-24	N-(hydroksyletyl) butandiamed-derivater som renin-inhibitorer

Legal Events

Date	Code	Title	Description
2002-11-04	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN SEPTEMBER 2002