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NO924076L - Antihypertensive midler - Google Patents

Antihypertensive midler

Info

Publication number
NO924076L
NO924076L NO92924076A NO924076A NO924076L NO 924076 L NO924076 L NO 924076L NO 92924076 A NO92924076 A NO 92924076A NO 924076 A NO924076 A NO 924076A NO 924076 L NO924076 L NO 924076L
Authority
NO
Norway
Prior art keywords
lower alkyl
aryl
groups
optionally substituted
halogen
Prior art date
Application number
NO92924076A
Other languages
English (en)
Other versions
NO924076D0 (no
Inventor
Jose Repolles Moliner
Francisco Pubill Coy
Lydia Cabeza Llorente
Carlos Malet Falco
Original Assignee
Lacer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer Sa filed Critical Lacer Sa
Publication of NO924076D0 publication Critical patent/NO924076D0/no
Publication of NO924076L publication Critical patent/NO924076L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Antihypertensive N-(a-substituert pyridinyl)karbonyl- dipeptidderivater med den generelle formel (I) <R3>n CONH¿CH-CON OOR, inkluderende farmasøytisk tålbare salter derav og tautomere former, hvori: n er O eller et helt tall fra l til 3; R er OH, SH, COOH, NH2. halogen, OR4 , SR4, COOR4, NHR4 eller N(R4>2. idet R4 er valgt fra eventuelt substituert lavere alkyl, aryl og acyl; R! står for OH, eventuelt substituert lavere alkoksy, aryl lavere alkoksy, aryloksy eller disubstituerte aminogrupper; R2 er valgt fra lavere alkyl og amino lavere alkyl; R3 står for halogen, NC>2, lavere alkyl, halogen lavere alkyl, aryl lavere alkyl eller aryl; De nevnte derivater er blant annet nyttige ved behandling av hypertensjon.
NO92924076A 1991-02-27 1992-10-21 Antihypertensive midler NO924076L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91102950A EP0500989B1 (en) 1991-02-27 1991-02-27 N-(alpha-substituted-pyridinyl) carbonyl dipeptide antihypertensive agents
PCT/EP1992/000400 WO1992015608A1 (en) 1991-02-27 1992-02-26 N-(α-SUBSTITUTED-PYRIDINYL)CARBONYL DIPEPTIDE ANTIHYPERTENSIVE AGENTS

Publications (2)

Publication Number Publication Date
NO924076D0 NO924076D0 (no) 1992-10-21
NO924076L true NO924076L (no) 1992-12-21

Family

ID=8206465

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92924076A NO924076L (no) 1991-02-27 1992-10-21 Antihypertensive midler

Country Status (18)

Country Link
US (1) US5432159A (no)
EP (1) EP0500989B1 (no)
JP (1) JPH05507295A (no)
AT (1) ATE174343T1 (no)
AU (1) AU650954B2 (no)
BR (1) BR9204779A (no)
CA (1) CA2081471A1 (no)
CZ (1) CZ280952B6 (no)
DE (1) DE69130605T2 (no)
ES (1) ES2037613B1 (no)
FI (1) FI924850A (no)
HU (1) HUT62313A (no)
NO (1) NO924076L (no)
PL (1) PL167915B1 (no)
PT (1) PT100148B (no)
RO (1) RO111369B1 (no)
RU (1) RU2098424C1 (no)
WO (1) WO1992015608A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5825094A (en) * 1993-11-19 1995-06-06 Astra Aktiebolag Novel dipeptide derivatives
CN1254335A (zh) * 1997-04-04 2000-05-24 辉瑞产品公司 烟酰胺衍生物
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
PL365443A1 (en) 2001-01-31 2005-01-10 Pfizer Products Inc. Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
NZ526531A (en) 2001-01-31 2005-02-25 Pfizer Prod Inc Ether derivatives useful as inhibitors of phosphodiesterase type IV (PDE4) isozymes
EA200300621A1 (ru) 2001-01-31 2003-12-25 Пфайзер Продактс Инк. Биарильные производные никотинамида, полезные в качестве ингибиторов изоферментов pde4
WO2003033471A1 (fr) * 2001-10-17 2003-04-24 Tobishi Pharmaceutical Co.,Ltd Nouveau derive de pyridone et agent therapeutique pour les maladies du systeme circulatoire les contenant
BR0307279A (pt) * 2002-01-29 2004-12-28 Wyeth Corp Métodos para fechar e abrir um semi-canal e uma célula, tecido orgãnico ou órgão, para prevenir ou tratar o estresse de tecido orgãnico ou órgão em um mamìfero, para aumentar a comunicação intracelular da junção com intervalo em uma célula, tecido orgãnico ou órgão, para tratamento de queimaduras, de tromboses, da acidose respitatória e metabólica, e da arritmia focal, para tratar e prevenir o dano de célula e tecido orgãnico resultante de nìveis elevados de glicose no sangue, para tratamento da fibrilação atrial crÈnica e da epilepsia, para criar composto candidatos que modulem a função de semi-canal, para citoproteger tecido orgãnico ou um órgão de um mamìfero em necessidade de tal tratamento, e para prevenir ou tratar o dano da reperfusão em um mamìfero
US20090048308A1 (en) * 2005-04-14 2009-02-19 Stock Nicholas S VLA-4 Antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
NZ202232A (en) * 1981-11-06 1985-08-16 Smithkline Beckman Corp N-carboxyalkylproline-containing tripeptides and pharmaceutical compositions
DE3332633A1 (de) * 1983-09-09 1985-04-04 Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel

Also Published As

Publication number Publication date
NO924076D0 (no) 1992-10-21
EP0500989A1 (en) 1992-09-02
PT100148A (pt) 1993-05-31
BR9204779A (pt) 1993-08-17
US5432159A (en) 1995-07-11
CZ322092A3 (en) 1993-02-17
HUT62313A (en) 1993-04-28
CZ280952B6 (cs) 1996-05-15
FI924850A0 (fi) 1992-10-26
FI924850A (fi) 1992-10-26
DE69130605T2 (de) 1999-05-20
DE69130605D1 (de) 1999-01-21
PL167915B1 (pl) 1995-12-30
PL296625A1 (en) 1993-08-09
JPH05507295A (ja) 1993-10-21
PT100148B (pt) 1999-06-30
ES2037613A1 (es) 1993-06-16
AU650954B2 (en) 1994-07-07
ES2037613B1 (es) 1994-03-16
ATE174343T1 (de) 1998-12-15
CA2081471A1 (en) 1992-08-28
HU9203324D0 (en) 1993-01-28
RU2098424C1 (ru) 1997-12-10
WO1992015608A1 (en) 1992-09-17
AU1278392A (en) 1992-10-06
EP0500989B1 (en) 1998-12-09
RO111369B1 (ro) 1996-09-30

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