NO914236L - Fremstilling og anvendelse av tienoimidazolderivater - Google Patents

Fremstilling og anvendelse av tienoimidazolderivater

Info

Publication number: NO914236L
Authority: NO; Norway
Prior art keywords: group; diseases; ring; derivatives; tienoimidazold
Prior art date: 1990-10-30

Application number

NO91914236A

Other languages

English (en)

Norwegian (no)

Other versions

NO914236D0 (no

Inventor

Takehiko Naka

Yoshiyuki Inada

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-30

Filing date

1991-10-29

Publication date

1992-05-04

1991-10-29 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1991-10-29 Publication of NO914236D0 publication Critical patent/NO914236D0/no

1992-05-04 Publication of NO914236L publication Critical patent/NO914236L/no

Links

208000006011 Stroke Diseases 0.000 abstract 2
102000005862 Angiotensin II Human genes 0.000 abstract 1
101800000733 Angiotensin-2 Proteins 0.000 abstract 1
206010008190 Cerebrovascular accident Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
206010061216 Infarction Diseases 0.000 abstract 1
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
229950006323 angiotensin ii Drugs 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
229940058303 antinematodal benzimidazole derivative Drugs 0.000 abstract 1
125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
208000019622 heart disease Diseases 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000007574 infarction Effects 0.000 abstract 1
201000008383 nephritis Diseases 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Lubricants (AREA)
Steroid Compounds (AREA)

NO91914236A 1990-10-30 1991-10-29 Fremstilling og anvendelse av tienoimidazolderivater NO914236L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP29465590		1990-10-30
JP9208191		1991-04-23
JP15064391		1991-06-21

Publications (2)

Publication Number	Publication Date
NO914236D0 NO914236D0 (no)	1991-10-29
NO914236L true NO914236L (no)	1992-05-04

Family

ID=27306934

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO91914236A NO914236L (no)	1990-10-30	1991-10-29	Fremstilling og anvendelse av tienoimidazolderivater

Country Status (13)

Country	Link
US (1)	US5463073A (pt)
EP (1)	EP0483683B1 (pt)
KR (1)	KR920008046A (pt)
CN (1)	CN1061973A (pt)
AT (1)	ATE134633T1 (pt)
AU (1)	AU636066B2 (pt)
DE (1)	DE69117431T2 (pt)
FI (1)	FI915099A0 (pt)
HU (1)	HUT62005A (pt)
IE (1)	IE913773A1 (pt)
MX (1)	MX9101768A (pt)
NO (1)	NO914236L (pt)
PT (1)	PT99357A (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0461040A1 (fr) *	1990-06-08	1991-12-11	Roussel Uclaf	Dérivés de l'imidazole, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant
TW274551B (pt) *	1991-04-16	1996-04-21	Takeda Pharm Industry Co Ltd
IL102183A (en) *	1991-06-27	1999-11-30	Takeda Chemical Industries Ltd	Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
DE69330593T2 (de) *	1992-12-22	2002-06-27	Takeda Chemical Industries, Ltd.	Heterocyclische Verbindungen mit Angiotensin-II-antagonistischer Wirkung und ihre Anwendung
CA2115985A1 (en) *	1993-02-25	1994-08-26	Kohei Nishikawa	Vascular hypertrophy suppressor
JP3810020B2 (ja) *	1993-04-22	2006-08-16	武田薬品工業株式会社	腎疾患の予防または治療剤
US5721263A (en) *	1993-06-07	1998-02-24	Takeda Chemical Industries, Ltd.	Pharmaceutical composition for angiotensin II-mediated diseases
CZ154994A3 (en) *	1993-07-02	1995-09-13	Senju Pharma Co	Visual hypotensive agent
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
US7812044B2 (en)	2001-11-13	2010-10-12	Takeda Pharmaceutical Company Limited	Anticancer agents
US7232828B2 (en) *	2002-08-10	2007-06-19	Bethesda Pharmaceuticals, Inc.	PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
DE10341240A1 (de)	2003-09-08	2005-04-07	Aventis Pharma Deutschland Gmbh	Substituierte Thienoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US20070282099A1 (en) *	2006-06-02	2007-12-06	Steffen Zahn	Heterocyclic fused imidazolone, dioxolone, imidazolethione and dioxolethione monomers
EP2253630A1 (en)	2007-05-21	2010-11-24	Takeda Pharmaceutical Company Limited	Heterocyclic compound and use thereof
EP2998314B1 (en)	2007-06-04	2020-01-22	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009149279A2 (en)	2008-06-04	2009-12-10	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
WO2014151206A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
CN113388007A (zh)	2013-06-05	2021-09-14	博士医疗爱尔兰有限公司	鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5671074A (en) *	1979-11-12	1981-06-13	Takeda Chem Ind Ltd	1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4812462A (en) *	1986-04-01	1989-03-14	Warner-Lambert Company	4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
CA1334092C (en) *	1986-07-11	1995-01-24	David John Carini	Angiotensin ii receptor blocking imidazoles
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles
US5015651A (en) *	1988-01-07	1991-05-14	E. I. Du Pont De Nemours And Company	Treatment of hypertension with 1,2,4-angiotensin II antagonists
DE3928177A1 (de) *	1989-04-08	1991-02-28	Thomae Gmbh Dr K	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0400835A1 (en) *	1989-05-15	1990-12-05	Merck & Co. Inc.	Substituted benzimidazoles as angiotensin II antagonists
GB8911854D0 (en) *	1989-05-23	1989-07-12	Ici Plc	Heterocyclic compounds
US5164407A (en) *	1989-07-03	1992-11-17	Merck & Co., Inc.	Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
DE69013607T2 (de) *	1989-08-02	1995-03-02	Takeda Chemical Industries Ltd	Pyrazol-Derivate, Verfahren zu deren Herstellung und Anwendung.
IE70593B1 (en) *	1989-09-29	1996-12-11	Eisai Co Ltd	Biphenylmethane derivative the use of it and pharmacological compositions containing same
EP0461040A1 (fr) *	1990-06-08	1991-12-11	Roussel Uclaf	Dérivés de l'imidazole, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant

1991
- 1991-10-22 AU AU86707/91A patent/AU636066B2/en not_active Ceased
- 1991-10-25 MX MX9101768A patent/MX9101768A/es not_active IP Right Cessation
- 1991-10-25 EP EP91118234A patent/EP0483683B1/en not_active Expired - Lifetime
- 1991-10-25 DE DE69117431T patent/DE69117431T2/de not_active Expired - Fee Related
- 1991-10-25 AT AT91118234T patent/ATE134633T1/de not_active IP Right Cessation
- 1991-10-29 PT PT99357A patent/PT99357A/pt not_active Application Discontinuation
- 1991-10-29 FI FI915099A patent/FI915099A0/fi not_active Application Discontinuation
- 1991-10-29 IE IE377391A patent/IE913773A1/en not_active Application Discontinuation
- 1991-10-29 NO NO91914236A patent/NO914236L/no unknown
- 1991-10-30 HU HU913417A patent/HUT62005A/hu unknown
- 1991-10-30 CN CN91108382A patent/CN1061973A/zh active Pending
- 1991-10-30 KR KR1019910019177A patent/KR920008046A/ko not_active IP Right Cessation
1993
- 1993-08-27 US US08/112,793 patent/US5463073A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0483683B1 (en)	1996-02-28
HU913417D0 (en)	1992-01-28
ATE134633T1 (de)	1996-03-15
DE69117431T2 (de)	1996-06-13
EP0483683A3 (en)	1992-06-03
AU636066B2 (en)	1993-04-08
PT99357A (pt)	1992-09-30
MX9101768A (es)	1992-06-05
IE913773A1 (en)	1992-05-22
EP0483683A2 (en)	1992-05-06
DE69117431D1 (de)	1996-04-04
NO914236D0 (no)	1991-10-29
KR920008046A (ko)	1992-05-27
CN1061973A (zh)	1992-06-17
US5463073A (en)	1995-10-31
FI915099L (fi)	1992-08-11
AU8670791A (en)	1992-05-07
FI915099A0 (fi)	1992-08-11
HUT62005A (en)	1993-03-29

Publication	Publication Date	Title
NO914236D0 (no)	1991-10-29	Fremstilling og anvendelse av tienoimidazolderivater
DE69233113D1 (de)	2003-08-07	Kondensierte heterocyclische Verbindungen, ihre Herstellung und Verwendung
CA2040955A1 (en)	1991-10-28	Benzimidazole derivatives, their production and use
ATE123771T1 (de)	1995-06-15	Stickstoff enthaltende heterozyklische verbindungen, ihre herstellung und verwendung.
ATE169915T1 (de)	1998-09-15	Pyrimidindionderivate, deren herstellung und verwendung
ATE139233T1 (de)	1996-06-15	Annelierte thiophen-derivate, ihre herstellung und verwendung
CA2047496A1 (en)	1992-01-24	Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them
ATE135701T1 (de)	1996-04-15	Imidazolderivate, starke und selektive angiotensin-ii-rezeptor-antagonisten
DE69233057D1 (de)	2003-06-18	Heterozyklische Verbindungen, Verfahren zu deren Herstellung und deren Anwendung als Angiotensin-II-Antagonist
NO882241D0 (no)	1988-05-20	Tetrazol-mellomprodukter for fremstilling av antihypertensive forbindelser.
ES2058342T3 (es)	1994-11-01	Pirroles, pirazoles y triazoles sustituidos antagonistas de la angiotensina ii.
NZ235959A (en)	1991-09-25	Substituted n-(imidazolyl) alkyl alanine derivatives and pharmaceutical compositions
ATE295841T1 (de)	2005-06-15	Substituierte benzylthiazolidin-2,4-dion derivate
DE602006010353D1 (de)	2009-12-24	Neue 3-phenylpropionsäurederivate und ihre verwendung als ppar-gamma-rezeptorliganden
JO1326B1 (en)	1986-11-30	Vehicles
GEP19970838B (en)	1997-02-10	Process for obtaining 3-(methyltio, methylsulphinyl or methylsulphonyl)-4-quinolone
KR950025037A (ko)	1995-09-15	신규의 치환된 이미다졸 유도체 및 그의 제조방법