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GEP19970838B - Process for obtaining 3-(methyltio, methylsulphinyl or methylsulphonyl)-4-quinolone - Google Patents

Process for obtaining 3-(methyltio, methylsulphinyl or methylsulphonyl)-4-quinolone

Info

Publication number
GEP19970838B
GEP19970838B GEAP19942160A GEAP1994002160A GEP19970838B GE P19970838 B GEP19970838 B GE P19970838B GE AP19942160 A GEAP19942160 A GE AP19942160A GE AP1994002160 A GEAP1994002160 A GE AP1994002160A GE P19970838 B GEP19970838 B GE P19970838B
Authority
GE
Georgia
Prior art keywords
lower alkyl
sulphonamide
dihydroquinoline
oxo
quinolones
Prior art date
Application number
GEAP19942160A
Inventor
David Brian Yastes
Malcolm Freemen Sim
Raymond Parkinson
Kenneth John Nikol
James Fraser
Roy Vistor Davies
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co Plc filed Critical Boots Co Plc
Priority to GEAP19942160A priority Critical patent/GEP19970838B/en
Publication of GEP19970838B publication Critical patent/GEP19970838B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Quinolones with antihypertensive activity have the general formula I, I wherein X is the residue of an optionally substituted benzene ring; R is lower alkyl; R3 is hydrogen or lower alkyl; R1 and R2, which may be the same or different, are hydrogen, lower alkyl, or, together with the nitrogen atom to which they are attached, form a 5 to 7 membered saturated heterocyclic ring optionally containing an additional hetero atom selected from nitrogen, oxygen and sulphur and optionally substituted by 1 or more lower alkyl groups; and the dotted line between positions 2 and 3 of the quinolone nucleus represents an optional bond. The compounds are useful as antihypertensive agents. They are also indicated for use in treating heart failure and ischaemic heart disease. With the exception of the three compounds 1-methyl-4-oxo-1,4-dihydroquinoline-3-sulphonamide, 1,N-dimethyl-4-oxo-1,4-dihydroquinoline-3-sulphonamide and 6,7-dimethoxyl-methyl-4-oxo-1,4-dihydroquinoline-3-sulphonamide, the quinolones of formula I are novel. Pharmaceutical compositions containing the compounds of formula I are described. Processes for preparing the novel quinolones are also described.
GEAP19942160A 1994-09-07 1994-09-07 Process for obtaining 3-(methyltio, methylsulphinyl or methylsulphonyl)-4-quinolone GEP19970838B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GEAP19942160A GEP19970838B (en) 1994-09-07 1994-09-07 Process for obtaining 3-(methyltio, methylsulphinyl or methylsulphonyl)-4-quinolone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GEAP19942160A GEP19970838B (en) 1994-09-07 1994-09-07 Process for obtaining 3-(methyltio, methylsulphinyl or methylsulphonyl)-4-quinolone

Publications (1)

Publication Number Publication Date
GEP19970838B true GEP19970838B (en) 1997-02-10

Family

ID=82484180

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP19942160A GEP19970838B (en) 1994-09-07 1994-09-07 Process for obtaining 3-(methyltio, methylsulphinyl or methylsulphonyl)-4-quinolone

Country Status (1)

Country Link
GE (1) GEP19970838B (en)

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