[go: up one dir, main page]

NO913007D0 - Vannopploeselige derivater av taksol. - Google Patents

Vannopploeselige derivater av taksol.

Info

Publication number
NO913007D0
NO913007D0 NO913007A NO913007A NO913007D0 NO 913007 D0 NO913007 D0 NO 913007D0 NO 913007 A NO913007 A NO 913007A NO 913007 A NO913007 A NO 913007A NO 913007 D0 NO913007 D0 NO 913007D0
Authority
NO
Norway
Prior art keywords
taksol
water soluble
soluble derivatives
derivatives
water
Prior art date
Application number
NO913007A
Other languages
English (en)
Other versions
NO913007L (no
Inventor
David G I Kingston
Zhi-Yang Zhao
Original Assignee
Virginia Tech Intell Prop
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intell Prop filed Critical Virginia Tech Intell Prop
Publication of NO913007D0 publication Critical patent/NO913007D0/no
Publication of NO913007L publication Critical patent/NO913007L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO91913007A 1990-08-28 1991-08-01 Vannopploeselige derivater av taksol. NO913007L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/573,731 US5059699A (en) 1990-08-28 1990-08-28 Water soluble derivatives of taxol

Publications (2)

Publication Number Publication Date
NO913007D0 true NO913007D0 (no) 1991-08-01
NO913007L NO913007L (no) 1992-03-02

Family

ID=24293168

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91913007A NO913007L (no) 1990-08-28 1991-08-01 Vannopploeselige derivater av taksol.

Country Status (24)

Country Link
US (2) US5059699A (no)
EP (1) EP0473326A1 (no)
JP (1) JPH0699410B2 (no)
KR (1) KR0132157B1 (no)
CN (1) CN1059337A (no)
AU (2) AU645340B2 (no)
CA (1) CA2049160C (no)
CS (1) CS263291A3 (no)
EG (1) EG19914A (no)
FI (1) FI913651A (no)
HU (1) HU210326B (no)
IE (1) IE913015A1 (no)
IL (1) IL99183A0 (no)
MX (2) MX9100832A (no)
MY (1) MY107794A (no)
NO (1) NO913007L (no)
NZ (1) NZ239377A (no)
OA (1) OA10035A (no)
PL (4) PL166224B1 (no)
PT (1) PT98787A (no)
RU (2) RU2059630C1 (no)
TW (1) TW209214B (no)
YU (1) YU144891A (no)
ZA (1) ZA916450B (no)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469868A (en) * 1982-05-24 1984-09-04 Warner-Lambert Company Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5475120A (en) * 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US6080777A (en) * 1992-01-31 2000-06-27 The Trustees Of Columbia University In The City Of New York Taxol as a radiation sensitizer
JPH07506341A (ja) * 1992-01-31 1995-07-13 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 放射線増感剤としてのタキソール
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
JPH069600A (ja) * 1992-05-06 1994-01-18 Bristol Myers Squibb Co タクソールのベンゾエート誘導体
WO1993024476A1 (en) * 1992-06-04 1993-12-09 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5364947A (en) * 1992-07-02 1994-11-15 Hauser Chemical Research, Inc. Process for separating cephalomannine from taxol using ozone and water-soluble hydrazines or hydrazides
US5470866A (en) * 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
US5789189A (en) * 1993-09-24 1998-08-04 The Regents Of The University Of California Inhibition of cyst formation by cytoskeletal specific drugs
FR2697019B1 (fr) * 1992-10-15 1994-11-25 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5411984A (en) * 1992-10-16 1995-05-02 Virginia Tech Intellectual Properties, Inc. Water soluble analogs and prodrugs of taxol
US5356927A (en) * 1992-12-02 1994-10-18 Thomas Jefferson University Methods of treating plasmodium and babesia parasitic infections
US5631278A (en) * 1992-12-02 1997-05-20 Thomas Jefferson University Methods of killing protozoal parasites
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
CA2111527C (en) * 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
PT693924E (pt) * 1993-02-22 2004-09-30 American Biosciences Processos para administracao (in vivo) de substancias biologicas e composicoes utilizadas nestes processos
US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US20030133955A1 (en) * 1993-02-22 2003-07-17 American Bioscience, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US20030068362A1 (en) * 1993-02-22 2003-04-10 American Bioscience, Inc. Methods and formulations for the delivery of pharmacologically active agents
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
ATE232854T1 (de) * 1993-03-05 2003-03-15 Univ Florida State Verfahren zur herstellung von 9-desoxotaxanen
US6710191B2 (en) * 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
AU6361294A (en) * 1993-03-09 1994-09-26 Enzon, Inc. Taxol-based compositions with enhanced bioactivity
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
US5336684A (en) * 1993-04-26 1994-08-09 Hauser Chemical Research, Inc. Oxidation products of cephalomannine
HU213200B (en) * 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
ES2145829T3 (es) * 1993-06-11 2000-07-16 Upjohn Co Uso antineoplasico de delta 6,7-taxoles y composiciones farmaceuticas que los contienen.
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
AU8052194A (en) * 1993-10-20 1995-05-08 Enzon, Inc. 2'- and/or 7- substituted taxoids
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
JP3778929B2 (ja) 1994-01-11 2006-05-24 ザ スクリップス リサーチ インスティチュート 自己会合タキソ−ジテルペノイドナノ構造
AU698382B2 (en) * 1994-01-11 1998-10-29 Scripps Research Institute, The Chemical switching of taxo-diterpenoids between low solubility active forms and high solubility inactive forms
PT739343E (pt) * 1994-01-11 2000-08-31 Scripps Research Inst Sal onio de taxo-diterpenoide, soluvel em agua
US5731334A (en) * 1994-01-11 1998-03-24 The Scripps Research Institute Method for treating cancer using taxoid onium salt prodrugs
IL112412A (en) * 1994-01-28 2000-02-29 Upjohn Co Delta 12,13-iso-taxol analogs and antineoplastic pharmaceutical compositions containing them
GB9405400D0 (en) * 1994-03-18 1994-05-04 Erba Carlo Spa Taxane derivatives
US5508447A (en) * 1994-05-24 1996-04-16 Board Of Regents, The University Of Texas System Short synthetic route to taxol and taxol derivatives
US5677470A (en) 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
EP0788493A1 (en) * 1994-10-28 1997-08-13 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
US6458976B1 (en) 1994-10-28 2002-10-01 The Research Foundation Of State University Of New York Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5489589A (en) * 1994-12-07 1996-02-06 Bristol-Myers Squibb Company Amino acid derivatives of paclitaxel
CA2178541C (en) 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
US6051600A (en) * 1995-09-12 2000-04-18 Mayhew; Eric Liposomal hydrolysis-promoting hydrophobic taxane derivatives
ES2252347T3 (es) * 1995-09-12 2006-05-16 Zeneus Pharma Limited Hidrolisis que promueve derivados hidrofobos de taxano.
EP1229030B1 (en) * 1995-09-12 2005-11-09 Zeneus Pharma Limited Hydrolysis-promoting taxane hydrophobic derivates
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
US5840748A (en) * 1995-10-02 1998-11-24 Xechem International, Inc. Dihalocephalomannine and methods of use therefor
US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5854278A (en) * 1995-12-13 1998-12-29 Xechem International, Inc. Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
FR2742751B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
ES2448467T3 (es) 1996-03-12 2014-03-14 Pg-Txl Company, L.P. Profármacos solubles en agua
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
JP2000510470A (ja) * 1996-05-06 2000-08-15 フロリダ・ステイト・ユニバーシティ １―デオキシバッカチンｉｉｉ、１―デオキシタキソールおよび１―デオキシタキソール類似体、ならびにこれらの製造方法
US5696152A (en) * 1996-05-07 1997-12-09 Wisconsin Alumni Research Foundation Taxol composition for use as organ preservation and cardioplegic agents
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
GB9705903D0 (en) 1997-03-21 1997-05-07 Elliott Gillian D VP22 Proteins and uses thereof
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
DK1023050T3 (da) * 1997-06-27 2013-10-14 Abraxis Bioscience Llc Nye formuleringer af farmakologiske midler, fremgangsmåder til fremstillingen deraf og fremgangsmåder til anvendelsen deraf
EP3266450A1 (en) 1997-06-27 2018-01-10 Abraxis BioScience, LLC Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
PT1105379E (pt) * 1998-08-21 2002-10-31 Pharmachemie Bv Analogos e pro-drogas de paclitaxel soluveis em agua
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
CN1088703C (zh) * 1999-09-17 2002-08-07 漆又毛 水溶性紫杉醇衍生物
US20030054977A1 (en) * 1999-10-12 2003-03-20 Cell Therapeutics, Inc. Manufacture of polyglutamate-therapeutic agent conjugates
US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
US20020077290A1 (en) * 2000-03-17 2002-06-20 Rama Bhatt Polyglutamic acid-camptothecin conjugates and methods of preparation
CN1098846C (zh) * 2000-04-20 2003-01-15 复旦大学 紫杉醇的多羟基水溶性衍生物及其制备方法
US6395771B1 (en) * 2000-05-31 2002-05-28 Dabur Research Foundation Paclitaxel derivatives for the treatment of cancer
WO2002024179A2 (en) * 2000-09-22 2002-03-28 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
CA2440935A1 (en) 2001-03-13 2002-09-19 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
JP4634694B2 (ja) * 2001-03-23 2011-02-16 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド 脂肪アルコール薬物複合体
US8552054B2 (en) * 2001-03-23 2013-10-08 Luitpold Pharmaceuticals, Inc. Fatty amine drug conjugates
EP1392254B1 (en) * 2001-04-20 2007-06-06 The University of British Columbia Micellar drug delivery systems for hydrophobic drugs
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
HUP0600533A2 (en) * 2001-11-30 2006-11-28 Bristol Myers Squibb Co Paclitaxel solvates
EP1594459B1 (en) 2002-12-30 2010-02-17 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US8003122B2 (en) * 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
US7846940B2 (en) * 2004-03-31 2010-12-07 Cordis Corporation Solution formulations of sirolimus and its analogs for CAD treatment
US20070073385A1 (en) * 2005-09-20 2007-03-29 Cook Incorporated Eluting, implantable medical device
WO2008005284A2 (en) 2006-06-30 2008-01-10 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20080241215A1 (en) * 2007-03-28 2008-10-02 Robert Falotico Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, aaa and stroke
US8409601B2 (en) * 2008-03-31 2013-04-02 Cordis Corporation Rapamycin coated expandable devices
US8420110B2 (en) 2008-03-31 2013-04-16 Cordis Corporation Drug coated expandable devices
AU2009234127B2 (en) * 2008-04-10 2015-04-30 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
US8273404B2 (en) 2008-05-19 2012-09-25 Cordis Corporation Extraction of solvents from drug containing polymer reservoirs
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US9198968B2 (en) 2008-09-15 2015-12-01 The Spectranetics Corporation Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
EP2588490B1 (en) 2010-07-02 2017-02-22 Angiochem Inc. Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
US20120302954A1 (en) 2011-05-25 2012-11-29 Zhao Jonathon Z Expandable devices coated with a paclitaxel composition
US20120303115A1 (en) 2011-05-25 2012-11-29 Dadino Ronald C Expandable devices coated with a rapamycin composition
PL2833905T3 (pl) 2012-04-04 2019-01-31 Halozyme, Inc. Terapia skojarzona hialuronidazą i taksanem ukierunkowanym na guza
CN103044363B (zh) * 2012-04-17 2015-04-22 湘北威尔曼制药股份有限公司 紫杉醇衍生物及其制备与应用
US9956385B2 (en) 2012-06-28 2018-05-01 The Spectranetics Corporation Post-processing of a medical device to control morphology and mechanical properties
CN104434808A (zh) 2014-07-03 2015-03-25 石药集团中奇制药技术（石家庄）有限公司 一种治疗性纳米粒子及其制备方法
US10517961B2 (en) 2015-09-25 2019-12-31 ZY Therapeutics, Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
CN106800542A (zh) * 2016-12-31 2017-06-06 辰欣药业股份有限公司 一种亲水性紫杉醇类化合物及其制备方法
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
CN115385875B (zh) * 2022-07-18 2023-06-13 中国药科大学 一类紫杉醇衍生物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof

Also Published As

Publication number Publication date
RU2059630C1 (ru) 1996-05-10
MY107794A (en) 1996-06-15
PL166224B1 (pl) 1995-04-28
JPH0699410B2 (ja) 1994-12-07
MX9205895A (es) 1994-04-29
US5352805A (en) 1994-10-04
CA2049160C (en) 1997-11-18
PL291546A1 (en) 1993-01-25
PL295892A1 (en) 1993-03-08
PL166242B1 (pl) 1995-04-28
JPH04230676A (ja) 1992-08-19
ZA916450B (en) 1994-09-26
PL166218B1 (pl) 1995-04-28
NZ239377A (en) 1993-09-27
PL295891A1 (en) 1993-03-08
HU912755D0 (en) 1992-01-28
FI913651A0 (fi) 1991-07-31
EG19914A (en) 1996-06-30
AU645340B2 (en) 1994-01-13
CN1059337A (zh) 1992-03-11
KR0132157B1 (ko) 1998-04-17
PL166213B1 (pl) 1995-04-28
EP0473326A1 (en) 1992-03-04
US5059699A (en) 1991-10-22
KR920004370A (ko) 1992-03-27
CS263291A3 (en) 1992-05-13
FI913651A (fi) 1992-02-29
MX9100832A (es) 1992-04-01
NO913007L (no) 1992-03-02
PT98787A (pt) 1992-07-31
IE913015A1 (en) 1992-03-11
TW209214B (no) 1993-07-11
AU654085B1 (en) 1994-10-20
AU8274591A (en) 1992-03-05
IL99183A0 (en) 1992-07-15
HUT59119A (en) 1992-04-28
YU144891A (sh) 1994-01-20
RU2043346C1 (ru) 1995-09-10
CA2049160A1 (en) 1992-03-01
HU210326B (en) 1995-03-28
PL295890A1 (en) 1993-03-08
OA10035A (en) 1996-10-14

Similar Documents

Publication Publication Date Title
NO913007D0 (no) Vannopploeselige derivater av taksol.
NO913234D0 (no) Fremgangsmaate for fremstilling av pyrazolderivater.
ATE136898T1 (de) Wasserlösliche camptothecinderivate
FI915487L (fi) 4-bensoylisoxazolderivat.
DE69119329D1 (de) Actinonin-Derivate
NO912051D0 (no) Fremgangsmaate for fremstilling av azolderivater.
DE69125099D1 (de) Indolderivate
DE69110254D1 (de) Hydroxychinolonderivate.
FI913142L (fi) Migraenfoerhindrande alkoxipyrimidinderivat.
FI911942L (fi) Kolhydratderivat innehaollande en trisackaridenhet.
ATE144765T1 (de) Hiv-hemmende benzenacetamidderivate
DE59106881D1 (de) Hydantoinderivate.
ATE171449T1 (de) Oxadolderivate
NO912242D0 (no) Sorpsjon av trialkylarsiner.
DK0472733T3 (da) Phenantrenderivater
MX9205003A (es) Derivados novedosos de benzopirano.
FI912598L (fi) Dioxo-tetrahydrokinolinderivat.
FI906203L (fi) Framstaellningsfoerfaranden av glycerolderivat.
FI900688A0 (fi) Anordning foer luftning av liggunderlag i sjuksaeng.
MX9204370A (es) Derivados de pirazol.
FI912963A0 (fi) Hjaernverksamheten oekande pyrimidinylderivat.
DE59106761D1 (de) N-Acylpyrrolidin-Derivate.
DE69118016D1 (de) Cyclobutan-Derivate
MX9205973A (es) Derivados de benzo-isoquinolinas.
MX9201931A (es) Nuevos derivados de tiazol.