[go: up one dir, main page]

NO904333D0 - 9alfa-hydroksy-17-metylensteroider, fremgangsmaate ved fremstilling derav og anvendelse derav ved fremstilling av corticosteroider. - Google Patents

9alfa-hydroksy-17-metylensteroider, fremgangsmaate ved fremstilling derav og anvendelse derav ved fremstilling av corticosteroider.

Info

Publication number
NO904333D0
NO904333D0 NO1990904333A NO904333A NO904333D0 NO 904333 D0 NO904333 D0 NO 904333D0 NO 1990904333 A NO1990904333 A NO 1990904333A NO 904333 A NO904333 A NO 904333A NO 904333 D0 NO904333 D0 NO 904333D0
Authority
NO
Norway
Prior art keywords
9alfa
corticosteroids
hydroxy
preparing
procedure
Prior art date
Application number
NO1990904333A
Other languages
English (en)
Other versions
NO904333L (no
NO300894B1 (no
Inventor
Jacobus Nicolaas Maria Batist
Arthur Friedrich Marx
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of NO904333D0 publication Critical patent/NO904333D0/no
Publication of NO904333L publication Critical patent/NO904333L/no
Publication of NO300894B1 publication Critical patent/NO300894B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
    • C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
    • C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/009—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by only one oxygen atom doubly bound

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO904333A 1988-04-08 1990-10-05 9<alfa>-hydroksy-17-metylensteroider NO300894B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP88200675 1988-04-08
PCT/NL1989/000020 WO1989009781A1 (en) 1988-04-08 1989-04-07 9-alpha-hydroxy-17-methylene steroids, their preparation and utilization

Publications (3)

Publication Number Publication Date
NO904333D0 true NO904333D0 (no) 1990-10-05
NO904333L NO904333L (no) 1990-12-03
NO300894B1 NO300894B1 (no) 1997-08-11

Family

ID=8199778

Family Applications (1)

Application Number Title Priority Date Filing Date
NO904333A NO300894B1 (no) 1988-04-08 1990-10-05 9<alfa>-hydroksy-17-metylensteroider

Country Status (18)

Country Link
US (1) US5194602A (no)
EP (1) EP0336521B1 (no)
JP (1) JP2812397B2 (no)
KR (1) KR0138777B1 (no)
CN (2) CN1187365C (no)
AU (1) AU618350B2 (no)
CA (1) CA1332409C (no)
DE (1) DE68901104D1 (no)
DK (1) DK175401B1 (no)
ES (1) ES2033516T3 (no)
FI (1) FI108436B (no)
GR (1) GR3004539T3 (no)
HU (1) HU208437B (no)
IE (1) IE62277B1 (no)
IL (1) IL89880A (no)
NO (1) NO300894B1 (no)
PT (1) PT90227B (no)
WO (1) WO1989009781A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ236206A (en) * 1989-11-27 1993-03-26 Schering Corp Preparation of 2'-methyl-4'-methylenespiro(androstadiene-17,5'(4'h)-oxazol)-3-one derivatives from pregn-5-en-20-ylideneacetamide derivatives by treatment with vilsmeier reagent or acid
FR2677028B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trien-3-one.
FR2676740B1 (fr) * 1991-05-23 1993-11-05 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.
FR2677029B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides de l'andostra-4,9(11),16-trien-3-one.
FR2681069B1 (fr) * 1991-09-06 1995-04-28 Roussel Uclaf Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.
FR2683530B1 (fr) * 1991-11-08 1994-01-21 Roussel Uclaf Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.
WO1993015103A2 (en) * 1992-01-28 1993-08-05 Schering Corporation Novel steroid intermediates and processes for their preparation
CN1061984C (zh) * 1996-04-18 2001-02-14 上海华联制药有限公司 甾体激素化合物中引入9-11双键的一种方法
WO1999061055A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US6855836B2 (en) * 2000-10-26 2005-02-15 Jenapharm Gmbh & Co. Kg 17-Methylene steroids, process for their production and pharmaceutical compositions that contain these compounds
EP1889198B1 (en) 2005-04-28 2014-11-26 Proteus Digital Health, Inc. Pharma-informatics system
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
US8242294B2 (en) 2007-06-19 2012-08-14 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
JOP20180077A1 (ar) 2007-06-19 2019-01-30 Kythera Biopharmaceuticals Inc تركيبات وطرق لحمض صفراوي تخليقي
US20080318870A1 (en) 2007-06-19 2008-12-25 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
JP2010530876A (ja) * 2007-06-19 2010-09-16 カイセラ バイオファーマシューティカルズ， インコーポレイテッド 合成胆汁酸組成物、その方法およびその調製
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
EP4218718A3 (en) 2009-05-06 2024-04-24 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
GB2480632A (en) 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
AU2010359050B2 (en) 2010-08-12 2016-03-17 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
WO2013044119A1 (en) * 2011-09-22 2013-03-28 Kythera Biopharmaceuticals, Inc. Compositions and methods related to deoxycholic acid and its polymorphs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL103170C (no) * 1958-11-14
DE1568506A1 (de) * 1966-03-23 1970-07-16 Hoechst Ag Verfahren zur Herstellung von delta?-Pregnen-3,21-diol-20-on-21-acylaten
US3445907A (en) * 1967-02-16 1969-05-27 Ind Tectonics Inc Roller retaining method for roller bearing separators
US4255344A (en) * 1978-11-08 1981-03-10 Mitsubishi Chemical Industries, Limited 9-α-Hydroxy steroids
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2486947A1 (fr) * 1980-07-15 1982-01-22 Roussel Uclaf Nouveaux derives steroides 20-isonitriles 17(20) insatures, leur procede de preparation et leur application a la preparation des steroides 17a-hydroxy 20-ceto
DE3136917A1 (de) * 1980-09-27 1982-05-19 Barmag Barmer Maschinenfabrik Ag, 5630 Remscheid "kraftstoffoerderpumpe"
FR2493324B1 (no) * 1980-11-05 1983-01-21 Roussel Uclaf
FR2521567A1 (fr) * 1982-02-18 1983-08-19 Roussel Uclaf Nouveaux derives steroides 17(20)nitro, leur procede de preparation et leur application a la preparation de corticosteroides
EP0123734A1 (en) * 1983-04-29 1984-11-07 Gist-Brocades N.V. 17-(Isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation

Also Published As

Publication number Publication date
US5194602A (en) 1993-03-16
CA1332409C (en) 1994-10-11
NO904333L (no) 1990-12-03
DK175401B1 (da) 2004-09-27
CN1141301A (zh) 1997-01-29
HUT55411A (en) 1991-05-28
DK240890A (da) 1990-10-05
EP0336521B1 (en) 1992-04-01
HU208437B (en) 1993-10-28
KR900700499A (ko) 1990-08-13
DK240890D0 (da) 1990-10-05
CN1036774A (zh) 1989-11-01
AU618350B2 (en) 1991-12-19
AU3431389A (en) 1989-11-03
PT90227A (pt) 1989-11-10
IL89880A0 (en) 1989-12-15
PT90227B (pt) 1994-06-30
NO300894B1 (no) 1997-08-11
GR3004539T3 (no) 1993-04-28
CN1032211C (zh) 1996-07-03
ES2033516T3 (es) 1993-03-16
EP0336521A1 (en) 1989-10-11
KR0138777B1 (ko) 1998-04-30
IE891134L (en) 1989-10-08
DE68901104D1 (de) 1992-05-07
IL89880A (en) 1994-06-24
FI108436B (fi) 2002-01-31
WO1989009781A1 (en) 1989-10-19
CN1187365C (zh) 2005-02-02
FI904877A0 (fi) 1990-10-03
HU892602D0 (en) 1991-03-28
IE62277B1 (en) 1995-01-25
JPH03503645A (ja) 1991-08-15
JP2812397B2 (ja) 1998-10-22

Similar Documents

Publication Publication Date Title
NO904333L (no) 9alfa-hydroksy-17-metylensteroider, fremgangsmaate ved fremstilling derav og anvendelse derav ved fremstilling av corticosteroider.
NO892270D0 (no) Fremgangsmaate for fremstilling av preparater for anvendelse ved behandlingen av alkoholisme.
NO891640L (no) Fremgangsmaate ved fremstilling av deig og broed.
NO900613D0 (no) Fremgangsmaate for fremstilling av aktiverte chitosaner oganvendelse ved fremstilling av chitosanderivater.
DK313188A (da) 9-alfa-hydroxy-steroider, deres og de tilsvarende 9(11)-dehydro-derivaters fremstilling og laegemidler indeholdende steroiderne
PH22975A (en) Substituted hydrazones, process for the preparation and their use
DE3477469D1 (en) Enzyme-protein conjugate, process for its preparation and pharmaceutical use thereof
IL99135A0 (en) Corticoid-17-alkylcarbonates substituted in the 17-position,process for their preparation and pharmaceutcals containing them
NO172439C (no) Fremgangsmaate for fremstilling av tetrazolforbindelser ogforbindelse som anvendes i fremgangsmaaten
NO882940D0 (no) Fremgangsmaate for fremstilling av castanosperminestere og glycosider.
NO905029L (no) Fremgangsmaate for fremstilling av steroider.
AU578916B2 (en) Milbemycin derivative, process for the preparation thereof, and use thereof in pest control
NO873197D0 (no) Bedoevelsespreparat og fremgangsmaate for anvendelse av dette.
NO891630D0 (no) Fremgangsmaate og anordning for fremstilling av diafragmer.
NO890816D0 (no) De-emulgeringsblandinger og fremgangsmaate ved fremstilling og anvendelse derav.
NO905543D0 (no) Fremgangsmaate for fremstilling og anvendelse av aminopyridinylmetanoler og aminometylpyridinaminer.
IL100187A0 (en) Process for the preparation of bromonitro-alcohols,dibromonitro-alcohols and mixtures thereof
EP0344112A3 (en) Substituted bisacyloxynaphthacenes, and process for the preparation of tetrathiotetracenes
PL276723A1 (en) Method for preparation of the new, n-phenylcarbamyle derivatives of difurylethane and difurylvinylchloride
EP0267537A3 (en) Process for the preparation of vinylglyoxal derivatives, vinylglyoxal derivatives and their use
NO157842C (no) Engangshanske og fremgangsmaate for fremstilling av samme.
NO912889L (no) Mellomprodukt til anvendelse ved fremstilling av di-t-butylfenyl-alkyl og fenyletere.
NO912279D0 (no) Fremgangsmaate for fremstilling og anvendelse av eksplosjonssikre 1-dimetylamino-3-dimetylimino-2-arylprop-1-en-salter.
ZA876485B (en) 5-aminoethyloxazolidin-2-one derivatives,process for the preparation thereof and their therapeutic use
AU1980488A (en) Wall-traversing inlet, and procedure for implementing such inlet

Legal Events

Date Code Title Description
MK1K Patent expired