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NZ236206A - Preparation of 2'-methyl-4'-methylenespiro(androstadiene-17,5'(4'h)-oxazol)-3-one derivatives from pregn-5-en-20-ylideneacetamide derivatives by treatment with vilsmeier reagent or acid - Google Patents

Preparation of 2'-methyl-4'-methylenespiro(androstadiene-17,5'(4'h)-oxazol)-3-one derivatives from pregn-5-en-20-ylideneacetamide derivatives by treatment with vilsmeier reagent or acid

Info

Publication number
NZ236206A
NZ236206A NZ236206A NZ23620690A NZ236206A NZ 236206 A NZ236206 A NZ 236206A NZ 236206 A NZ236206 A NZ 236206A NZ 23620690 A NZ23620690 A NZ 23620690A NZ 236206 A NZ236206 A NZ 236206A
Authority
NZ
New Zealand
Prior art keywords
derivatives
ylideneacetamide
methylenespiro
androstadiene
pregn
Prior art date
Application number
NZ236206A
Inventor
Nicholas Carruthers
Sohaila Garshasb
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NZ236206A publication Critical patent/NZ236206A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NZ236206A 1989-11-27 1990-11-23 Preparation of 2'-methyl-4'-methylenespiro(androstadiene-17,5'(4'h)-oxazol)-3-one derivatives from pregn-5-en-20-ylideneacetamide derivatives by treatment with vilsmeier reagent or acid NZ236206A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44150089A 1989-11-27 1989-11-27

Publications (1)

Publication Number Publication Date
NZ236206A true NZ236206A (en) 1993-03-26

Family

ID=23753123

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ236206A NZ236206A (en) 1989-11-27 1990-11-23 Preparation of 2'-methyl-4'-methylenespiro(androstadiene-17,5'(4'h)-oxazol)-3-one derivatives from pregn-5-en-20-ylideneacetamide derivatives by treatment with vilsmeier reagent or acid

Country Status (14)

Country Link
EP (1) EP0502112A1 (en)
JP (1) JPH05504561A (en)
KR (1) KR927003619A (en)
AU (1) AU636433B2 (en)
CA (1) CA2069645A1 (en)
HU (1) HUT61030A (en)
IE (1) IE904252A1 (en)
IL (1) IL96459A0 (en)
MY (1) MY105302A (en)
NZ (1) NZ236206A (en)
PT (1) PT95988A (en)
TW (1) TW218022B (en)
WO (1) WO1991008218A1 (en)
ZA (1) ZA909444B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108033990A (en) * 2017-12-29 2018-05-15 广西万德药业有限公司 The preparation method of Dexamethasone Intermediate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4102907A (en) * 1977-03-07 1978-07-25 The Upjohn Company Desulfinylation process for preparing androsta-4,9(11)-diene-3,17-dione
US4127596A (en) * 1977-04-11 1978-11-28 The Upjohn Company Non-aromatic oxygenated strong acid dehydration of 9α-hydroxyandrostenediones
FR2493324B1 (en) * 1980-11-05 1983-01-21 Roussel Uclaf
US4585590A (en) * 1984-02-03 1986-04-29 The Upjohn Company Cyanohydrin process
EP0263569B1 (en) * 1986-10-10 1992-12-09 Roussel-Uclaf 9-alpha-hydroxysteroids, process for their preparation and process for the preparation of the corresponding 9(11)-dehydro-derivatives.
PT87687B (en) * 1987-06-12 1992-09-30 Gist Brocades Nv PROCESS FOR THE PREPARATION OF 9 (11) -DEHYROID STEROIDS
WO1989009781A1 (en) * 1988-04-08 1989-10-19 Gist-Brocades N.V. 9-alpha-hydroxy-17-methylene steroids, their preparation and utilization

Also Published As

Publication number Publication date
HUT61030A (en) 1992-11-30
HU9201750D0 (en) 1992-08-28
EP0502112A1 (en) 1992-09-09
AU636433B2 (en) 1993-04-29
TW218022B (en) 1993-12-21
MY105302A (en) 1994-09-30
ZA909444B (en) 1991-08-28
KR927003619A (en) 1992-12-18
JPH05504561A (en) 1993-07-15
WO1991008218A1 (en) 1991-06-13
IL96459A0 (en) 1991-08-16
IE904252A1 (en) 1991-06-05
CA2069645A1 (en) 1991-05-28
AU6962591A (en) 1991-06-26
PT95988A (en) 1991-09-13

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