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NO341631B1 - Hydroksybenzamidderivater og deres anvendelse, fremgangsmåte for fremstilling og farmasøytiske sammensetninger - Google Patents

Hydroksybenzamidderivater og deres anvendelse, fremgangsmåte for fremstilling og farmasøytiske sammensetninger

Info

Publication number
NO341631B1
NO341631B1 NO20075768A NO20075768A NO341631B1 NO 341631 B1 NO341631 B1 NO 341631B1 NO 20075768 A NO20075768 A NO 20075768A NO 20075768 A NO20075768 A NO 20075768A NO 341631 B1 NO341631 B1 NO 341631B1
Authority
NO
Norway
Prior art keywords
optionally substituted
hydroxy
hydrogen
ring members
hydrocarbyl
Prior art date
Application number
NO20075768A
Other languages
English (en)
Other versions
NO20075768L (no
Inventor
Robert Downham
Michael Alistair O'brien
Maria Grazia Carr
Andrew James Woodhead
Alison Jo-Anne Woolford
Eva Figueroa Navarro
Theresa Rachel Phillips
Gianni Chessari
Miles Stuart Congreve
Martyn Frederickson
Christopher Murray
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36808863&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO341631(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0507474A external-priority patent/GB0507474D0/en
Priority claimed from GB0604111A external-priority patent/GB0604111D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of NO20075768L publication Critical patent/NO20075768L/no
Publication of NO341631B1 publication Critical patent/NO341631B1/no

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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
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Abstract

Foreliggende oppfinnelse tilveiebringer forbindelser med formel (I): eller salter, tautomerer, solvater og N-oksider derav; hvori R1 er hydroksy eller hydrogen; R2 er hydroksy; metoksy eller hydrogen; forutsatt at minst en av R1 og R er hydroksy; R3 er valgt fra hydrogen; halogen; cyano; eventuelt substituert C1-5 hydro-karbyl og eventuelt substituert C1-5 hydrokarbyloksy; R4 er valgt fra hydrogen; en gruppe -(O)n-R7 hvor n er 0 eller 1 og R7 er en eventuelt substituert acyklisk C1-5 hydro-karbylgruppe eller en monocyklisk, karbocyklisk eller heterocyklisk gruppe som har 3 til 7 ringledd; halogen; cyano; hydroksy; amino; og eventuelt substituert mono- eller di-C1-5 hydrokarbylamino; eller R3 og R4 sammen med en monocyklisk, karbocyklisk eller heterocyklisk ring med 5 til 7 ringledd; og NR5R6 danner en eventuelt substituert bicyklisk heterocyklisk gruppe med 8 til 12 ringledd av hvilke opp til 5 ringledd er heteroatomer valgt fra oksygen, nitrogen og svovel. Forbindelsene har aktivitet som Hsp90 inhibitorer.
NO20075768A 2005-04-13 2007-11-09 Hydroksybenzamidderivater og deres anvendelse, fremgangsmåte for fremstilling og farmasøytiske sammensetninger NO341631B1 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US67089705P 2005-04-13 2005-04-13
GB0507474A GB0507474D0 (en) 2005-04-13 2005-04-13 Pharmaceutical compounds
US77798906P 2006-03-01 2006-03-01
GB0604111A GB0604111D0 (en) 2006-03-01 2006-03-01 Pharmaceutical compounds
PCT/GB2006/001382 WO2006109085A1 (en) 2005-04-13 2006-04-13 Hydroxybenzamide derivatives and their use as inhibitors of hsp90

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NO20075768L NO20075768L (no) 2007-11-27
NO341631B1 true NO341631B1 (no) 2017-12-11

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NO20075768A NO341631B1 (no) 2005-04-13 2007-11-09 Hydroksybenzamidderivater og deres anvendelse, fremgangsmåte for fremstilling og farmasøytiske sammensetninger

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US (7) US20080306054A1 (no)
EP (3) EP2332909B1 (no)
JP (2) JP5154406B2 (no)
KR (1) KR101411167B1 (no)
CN (1) CN101193862B (no)
AU (1) AU2006235735C1 (no)
CA (1) CA2604042C (no)
DK (2) DK1877379T3 (no)
ES (2) ES2402469T3 (no)
ME (2) ME01541B (no)
MX (1) MX2007012659A (no)
NO (1) NO341631B1 (no)
NZ (1) NZ562199A (no)
PL (2) PL1877379T3 (no)
PT (2) PT2332909E (no)
RS (2) RS53668B1 (no)
RU (1) RU2458919C2 (no)
SI (2) SI2332909T1 (no)
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WO (2) WO2006109075A2 (no)

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BRPI0607235A2 (pt) 2005-02-24 2009-08-25 Amgen Inc mutações do receptor do fator de crescimento epidérmico
US20080306054A1 (en) 2005-04-13 2008-12-11 Astex Therapeutics Limited Pharmaceutical Compounds
US20090215742A1 (en) * 2005-05-03 2009-08-27 Pfizer, Inc. Amide resorcinol compounds
US7754725B2 (en) * 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
US7893264B2 (en) * 2006-07-07 2011-02-22 Gilead Sciences, Inc. Antiviral phosphinate compounds
JP5528807B2 (ja) * 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008044027A2 (en) * 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical compounds having hsp90 inhibitory or modulating activity
US8277807B2 (en) * 2006-10-12 2012-10-02 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) * 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
GB0620259D0 (en) * 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
EP2073804B1 (en) 2006-10-12 2017-09-13 Astex Therapeutics Limited Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain
DE102007028521A1 (de) * 2007-06-21 2008-12-24 Merck Patent Gmbh Indazolamidderivate
DE102007041116A1 (de) * 2007-08-30 2009-03-05 Merck Patent Gmbh 1,3-Dihydro-isoindolderivate
GB0806527D0 (en) * 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
LT5623B (lt) 2008-04-30 2010-01-25 Biotechnologijos Institutas, , 5-aril-4-(5-pakeistieji 2,4-dihidroksifenil)-1,2,3-tiadiazolai kaip hsp90 šaperono slopikliai ir tarpiniai junginiai jiems gauti
GB0815781D0 (en) * 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
JP2012102018A (ja) * 2009-03-03 2012-05-31 Astellas Pharma Inc アミド化合物
MX2012000435A (es) 2009-07-08 2012-06-01 Dermira Canada Inc Analogos de acido 5-(tetradeciloxi)-2-furancarboxilico (tofa) utiles en el tratamiento de trastornos o afecciones dermatologicas.
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
CN101838191A (zh) * 2010-05-28 2010-09-22 李继贞 一种甘草查尔酮e的合成方法
GB201009853D0 (en) 2010-06-11 2010-07-21 Chroma Therapeutics Ltd HSP90 inhibitors
CN102796100B (zh) * 2011-05-27 2015-05-06 中国医学科学院医药生物技术研究所 一种取代苯基-(二氮杂螺环-n)-甲酮类衍生物
US20120309796A1 (en) 2011-06-06 2012-12-06 Fariborz Firooznia Benzocycloheptene acetic acids
CA2905417A1 (en) * 2013-03-15 2014-09-18 Rexahn Pharmaceuticals, Inc. Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl) methanone compounds as cancer cell growth inhibitors
JP6497767B2 (ja) * 2013-12-16 2019-04-10 日本化薬株式会社 癌治療におけるｈｓｐ９０阻害剤の抗腫瘍効果を予測する方法
EP3527569B1 (en) 2014-02-03 2021-08-25 Vitae Pharmaceuticals, LLC Dihydropyrrolopyridine inhibitors of ror-gamma for use in treating drye eye
JP2017512831A (ja) 2014-03-20 2017-05-25 大塚製薬株式会社 置換フェニル−（１，３−ジヒドロ−イソインドール−２−イル）−メタノンを含んでなる医薬処方物
CN104173283B (zh) * 2014-08-27 2016-09-07 广州暨南生物医药研究开发基地有限公司 一种以苯甲酰胺为基本骨架的Hsp90抑制剂的纳米混悬剂及其制备方法
JP6564029B2 (ja) 2014-10-14 2019-08-21 ヴァイティー ファーマシューティカルズ，エルエルシー Ｒｏｒ−ガンマのジヒドロピロロピリジン阻害剤
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
EP3331876B1 (en) 2015-08-05 2020-10-07 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
AU2016341884B2 (en) 2015-10-19 2021-06-10 Board Of Regents, The University Of Texas System Piperazinyl norbenzomorphan compounds and methods for using the same
JP6914257B2 (ja) 2015-11-20 2021-08-04 ヴァイティー ファーマシューティカルズ，エルエルシー Ｒｏｒ−ガンマのモジュレーター
KR101925395B1 (ko) * 2016-01-29 2019-02-27 계명대학교 산학협력단 Ｈｓｐ９０ 억제 활성을 갖는 신규 디히드록시페닐계 화합물 또는 이의 약제학적으로 허용가능한 염 및 이의 의학적 용도
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US10464907B2 (en) * 2016-01-29 2019-11-05 Industry Academic Cooperation Foundation Keimyung University Compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof
AU2017257153A1 (en) * 2016-04-29 2018-11-22 Board Of Regents, The University Of Texas System Sigma receptor binders
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
KR101789269B1 (ko) 2016-08-31 2017-10-23 계명대학교 산학협력단 신규한 화합물 및 이를 유효성분으로 함유하는 항바이러스성 조성물
ES2978159T3 (es) 2016-09-16 2024-09-06 Hsf Pharmaceuticals Inhibidores de factores de choque térmico (HSF) y usos de los mismos
EP3601226A4 (en) * 2017-03-20 2021-03-03 Taipei Medical University Heat shock protein 90 inhibitors
AR112461A1 (es) 2017-07-24 2019-10-30 Vitae Pharmaceuticals Inc PROCESOS PARA LA PRODUCCIÓN DE SALES Y FORMAS CRISTALINAS DE INHIBIDORES DE RORg
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
WO2019027203A1 (ko) * 2017-08-02 2019-02-07 계명대학교 산학협력단 Ｈｓｐ９０ 억제 활성을 갖는 디히드록시페닐계 입체이성질체 및 이의 의학적 용도
KR101977970B1 (ko) 2017-08-04 2019-05-14 중원대학교 산학협력단 신규한 벤즈아미드계 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학 조성물
CN115160314B (zh) * 2022-07-28 2023-12-05 南方医科大学 杂环芳酰胺类化合物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072051A1 (en) * 2003-02-11 2004-08-26 Vernalis (Cambridge) Limited Isoxazole compounds as inhibitors of heat shock proteins

Family Cites Families (165)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US353753A (en) * 1886-12-07 Boot-pattern
US474403A (en) * 1892-05-10 Truck for electrically-propelled vehicles
US87834A (en) * 1869-03-16 Improvement in locks for pianos
US194450A (en) * 1877-08-21 Improvement in car brake and starter
US500336A (en) * 1893-06-27 Ventilator
US347168A (en) * 1886-08-10 Check-rower
US18319A (en) * 1857-10-06 belleville
US486386A (en) * 1892-11-15 Bookkeeping apparatus
US911447A (en) * 1909-02-02 William Roessler Electric-light bracket.
US90053A (en) * 1869-05-11 Improved wine and cider-press
US36351A (en) * 1862-09-02 Joseph hollen
US722723A (en) * 1902-04-16 1903-03-17 Frederick Lamplough Steering-gear for motor-vehicles.
US1283199A (en) * 1918-04-29 1918-10-29 Frederick Wm Irwin Water-power apparatus.
US1352650A (en) * 1919-12-10 1920-09-14 Casper E Blanchard Bottle-closure
US1514544A (en) * 1921-05-12 1924-11-04 Arthur J Lang Automatic cord adjuster
US1512396A (en) * 1922-11-10 1924-10-21 Adelbert E Bronson Hub for steering wheels
US1510210A (en) * 1923-04-09 1924-09-30 Day William Harper Machine for molding night lights
US1642880A (en) * 1925-08-17 1927-09-20 Permutit Co Manufacture of precipitated zeolites
US1995528A (en) * 1932-03-16 1935-03-26 Ironsides Company Method for applying metal forming lubricants
FR1479207A (fr) * 1962-04-20 1967-05-05 Procédé de préparation des morpholides d'acides cycliques mono- et polyhydroxylés et des sels alcalins hydrosolubles de ces morpholides, et produits en résultant
JPS4910506Y1 (no) 1970-10-20 1974-03-13
JPS4910506B1 (no) 1970-10-29 1974-03-11
JPS4910506A (no) 1972-05-31 1974-01-30
US4582909A (en) * 1984-02-02 1986-04-15 Warner-Lambert Company Benzobicyclic lactam acids and derivatives as cognition activators
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4760064A (en) * 1984-12-18 1988-07-26 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
JPH07100696B2 (ja) * 1984-12-18 1995-11-01 大塚製薬株式会社 カルボスチリル誘導体
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
JPH066578B2 (ja) * 1985-12-27 1994-01-26 三共株式会社 チアゾリジン誘導体
CA1340191C (en) 1988-06-13 1998-12-15 Katsuhiro Imaki Derivatives of p-substituted phenyl ester of pivalic acid
DE3822449A1 (de) * 1988-07-02 1990-01-04 Henkel Kgaa Oxidationshaarfaerbemittel mit neuen kupplern
US4990511A (en) * 1988-08-03 1991-02-05 Takeda Chemical Industries, Ltd. Amide compounds, their production and use
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
JPH0384078A (ja) * 1989-08-29 1991-04-09 Toray Ind Inc 導電性接着剤
GB8926560D0 (en) 1989-11-24 1990-01-17 Zambeletti Spa L Pharmaceuticals
US5124350A (en) 1990-06-28 1992-06-23 G. D. Searle & Co. Leukotriene b4 antagonists
ZA916555B (en) 1990-08-27 1993-04-28 Lilly Co Eli Method of treating inflammatory bowel disease
FR2669029B1 (fr) 1990-11-14 1994-09-02 Adir Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5280046A (en) 1991-02-22 1994-01-18 The University Of Colorado Foundation, Inc. Method of treating type I diabetes
WO1992017467A1 (en) 1991-04-06 1992-10-15 Dr Lo. Zambeletti S.P.A. Substituted azacyclic compounds, process for their preparation and their use as analgesics
EP0518819B1 (en) * 1991-06-11 1995-08-02 Ciba-Geigy Ag Amidino compounds, their manufacture and use as medicament
US5356904A (en) * 1992-10-07 1994-10-18 Merck & Co., Inc. Carbostyril oxytocin receptor antagonists
US5633283A (en) 1995-01-23 1997-05-27 Eli Lilly And Company Method for treating multiple sclerosis
JP3081773B2 (ja) * 1995-03-31 2000-08-28 株式会社資生堂 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤
JPH0910506A (ja) 1995-06-30 1997-01-14 Toshiba Corp 脱気器
US6218529B1 (en) 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
US5882864A (en) 1995-07-31 1999-03-16 Urocor Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
JPH09221476A (ja) * 1995-12-15 1997-08-26 Otsuka Pharmaceut Co Ltd 医薬組成物
JP3855026B2 (ja) 1996-01-16 2006-12-06 富士レビオ株式会社 アミド誘導体の製造方法
NZ331549A (en) 1996-01-29 2000-09-29 Univ California Compounds useful in treating sexual dysfunction
GB9606187D0 (en) 1996-03-23 1996-05-29 Inst Of Food Research Production of vanillin
AU715658B2 (en) 1996-04-03 2000-02-10 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2250856A1 (en) 1996-04-19 1997-10-30 The Regents Of The University Of California Treatment of mood/affective disorders by glutamatergic upmodulators
IL118657A0 (en) 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
US6466687B1 (en) * 1997-02-12 2002-10-15 The University Of Iowa Research Foundation Method and apparatus for analyzing CT images to determine the presence of pulmonary tissue pathology
EP0973778A1 (en) 1997-03-07 2000-01-26 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO 3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
UY24949A1 (es) 1997-04-08 2001-04-30 Smithkline Beecham Corp Compuestos calcilíticos
EP0975614A1 (en) 1997-04-18 2000-02-02 Smithkline Beecham Plc A bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5ht1a, 5ht1b and 5ht1d receptor antagonistic activity
US6329368B1 (en) 1997-05-09 2001-12-11 The Regents Of The University Of California Endocrine modulation with positive modulators of AMPA type glutamate receptors
WO1999021422A1 (en) 1997-10-27 1999-05-06 Cortex Pharmaceuticals, Inc. Treatment of schizophrenia with ampakines and neuroleptics
WO1999029705A2 (en) 1997-12-08 1999-06-17 Glycomed Incorporated Sialyl lewis x and sialyl lewis a glycomimetics
US20020049818A1 (en) * 1998-05-29 2002-04-25 Gilhuly Barry J. System and method for pushing encrypted information between a host system and a mobile data communication device
US7047272B2 (en) * 1998-10-06 2006-05-16 Texas Instruments Incorporated Rounding mechanisms in processors
AU3546100A (en) 1999-03-30 2000-10-23 Pharmacor Inc. Hydroxyphenyl derivatives with hiv integrase inhibitory properties
JP4831907B2 (ja) * 1999-10-08 2011-12-07 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
DE19955283A1 (de) 1999-11-17 2001-05-23 Aventis Res & Tech Gmbh & Co Verfahren zur enantioselektiven Gewinnung von Aminosäuren und Aminosäurederivaten unter Verwendung von Racemisierungskatalysatoren
US6677473B1 (en) 1999-11-19 2004-01-13 Corvas International Inc Plasminogen activator inhibitor antagonists
WO2001060369A1 (en) 2000-02-18 2001-08-23 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
DE10014296A1 (de) * 2000-03-23 2001-09-27 Merck Patent Gmbh Verfahren zur Dehydratisierung organischer Verbindungen zu ungesättigten Verbindungen
GB0008305D0 (en) * 2000-04-06 2000-05-24 Neutec Pharma Plc Treatment of fungal infections
ES2252230T3 (es) 2000-05-11 2006-05-16 Bristol-Myers Squibb Company Analogos de tetrahidroisoquinolina utiles como secretores de la hormona del crecimiento.
CA2408913A1 (en) * 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Melanin-concentrating hormone antagonist
DE10024939A1 (de) 2000-05-19 2001-11-29 Bayer Ag Neue Diphenylmethanderivate für Arzneimittel
CA2308994A1 (en) 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
US20050044054A1 (en) * 2000-07-06 2005-02-24 Helmick Joseph Dale Combinational circuit for detector and communication system
FR2812876B1 (fr) 2000-08-08 2002-09-27 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
MXPA03001654A (es) 2000-08-25 2004-09-10 Warner Lambert Co Proceso para la elaboracion del acido n-aril-antranilico y sus derivados.
US6609722B1 (en) * 2000-09-14 2003-08-26 Shimano Inc. Bicycle crown or crown cover with electrical connector support
US8263657B2 (en) * 2000-12-18 2012-09-11 Institute Of Medicinal Molecular Design, Inc. Inhibitors against the production and release of inflammatory cytokines
US20040096757A1 (en) * 2001-03-27 2004-05-20 Hiroyuki Tokuda Photosensitive resin compositon, photosesitive resist for color filter, and process for producing color filter
KR100424178B1 (ko) * 2001-09-20 2004-03-24 주식회사 하이닉스반도체 반도체 메모리 장치의 내부어드레스 발생회로
TWI263395B (en) * 2001-11-02 2006-10-01 Delta Electronics Inc Power supply device
US6649606B1 (en) * 2001-11-09 2003-11-18 Bristol-Myers Squibb Co. Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
WO2003051877A1 (en) 2001-12-18 2003-06-26 Bayer Corporation 2-substituted pyrrolo[2.1-a]isoquinolines against cancer
ATE458483T1 (de) 2001-12-20 2010-03-15 Osi Pharm Inc Selektive pyrimidin-a2b-antagonistenverbindungen, ihre synthese und verwendung
US7247734B2 (en) 2001-12-21 2007-07-24 Vernalis (Cambridge) Limited 3,4-diarylpyrazoles and their use in the therapy of cancer
US20030164555A1 (en) * 2002-03-01 2003-09-04 Tong Quinn K. B-stageable underfill encapsulant and method for its application
EP1497268A4 (en) 2002-04-05 2006-01-18 Nitromed Inc NITROGEN OXIDE DISPENSER, COMPOSITIONS AND METHOD OF USE
JP2005538945A (ja) * 2002-05-08 2005-12-22 ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア 心不整脈を線維芽細胞で治療するためのシステム及び方法
AU2003242127A1 (en) 2002-06-05 2003-12-22 Institute Of Medicinal Molecular Design, Inc. Inhibitors against the activation of ap-1 and nfat
US20060019958A1 (en) * 2002-06-05 2006-01-26 Susumu Muto Immunity-related protein kinase inhibitors
CN100379410C (zh) * 2002-06-05 2008-04-09 株式会社医药分子设计研究所 糖尿病治疗药
US20060122243A1 (en) 2002-06-06 2006-06-08 Susumu Muto Antiallergic
CA2432323A1 (en) * 2002-06-14 2003-12-14 Riddell, Inc. Method and apparatus for testing football helmets
SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
BR0312662A (pt) 2002-07-16 2005-05-03 Amura Therapeutics Ltd Compostos biologicamente ativos
AU2003261756A1 (en) * 2002-08-28 2004-03-29 Toray Industries, Inc. Acrylamide derivatives
US20050215614A1 (en) 2002-10-15 2005-09-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
CA2504814A1 (en) 2002-12-02 2004-06-17 Kyukyu Pharmaceutical Co., Ltd. Process for producing edible orally administered agent of laminate film form and compression bonding apparatus
GB0228417D0 (en) 2002-12-05 2003-01-08 Cancer Rec Tech Ltd Pyrazole compounds
GB0229618D0 (en) * 2002-12-19 2003-01-22 Cancer Rec Tech Ltd Pyrazole compounds
TWI228885B (en) * 2003-01-23 2005-03-01 Mediatek Inc Method for controlling a mobile communication device to enter a power-saving mode and to recover timing after the mobile communication device leaves the power-saving mode
KR20050109498A (ko) * 2003-02-20 2005-11-21 유니버시티 오브 코네티컷 헬스 센터 암 또는 전염병 치료에서 열 충격 단백질 또는알파-2-마크로글로불린을 포함하는 조성물을 사용하는 방법
EP1597256A1 (en) 2003-02-21 2005-11-23 Pfizer Inc. N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors
MXPA05011597A (es) 2003-04-30 2005-12-15 Novartis Ag Derivados de aminopropanol como moduladores del receptor 1-fosfato de esfingosina.
US6983661B2 (en) * 2003-05-15 2006-01-10 Endress + Hauser Flowtec Ag Electromagnetic flow sensor
GB0315111D0 (en) 2003-06-27 2003-07-30 Cancer Rec Tech Ltd Substituted 5-membered ring compounds and their use
AU2004251949B2 (en) * 2003-06-27 2009-05-07 Kyowa Hakko Kirin Co., Ltd. Hsp90 family protein inhibitors
TWI312345B (en) 2003-06-30 2009-07-21 Mitsubishi Tanabe Pharma Corp Process of preparating 3-acylaminobenzofuran-2-carboxylic acid derivatives
US20050009940A1 (en) * 2003-07-09 2005-01-13 The Procter & Gamble Company Method of promoting the sale of a melamine foam piece and an article of manufacture
KR20060054308A (ko) 2003-07-16 2006-05-22 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 피부 색소침착의 치료제
WO2005012256A1 (en) 2003-07-22 2005-02-10 Astex Therapeutics Limited 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
CA2530302C (en) 2003-07-24 2013-12-03 Leo Pharma A/S Novel aminobenzophenone compounds
JP2005041509A (ja) * 2003-07-25 2005-02-17 Konica Minolta Medical & Graphic Inc トレー容器の製造方法及びトレー容器
US20050023818A1 (en) * 2003-07-28 2005-02-03 Hughes Dennis R. Books having removable panels for forming structures
ATE405562T1 (de) 2003-07-28 2008-09-15 Janssen Pharmaceutica Nv Benzimidazol-, benzothiazol- und benzoxazolderivate und deren verwendung als lta4h-modulatoren
DE10335584B4 (de) 2003-07-31 2006-06-29 Philipps-Universität Marburg Verfahren zur Herstellung zyklischer Moleküle
DE10335726A1 (de) 2003-08-05 2005-03-03 Bayer Cropscience Gmbh Verwendung von Hydroxyaromaten als Safener
WO2005016889A1 (en) 2003-08-08 2005-02-24 Virginia Commonwealth University Compounds having antiestrogenic and tissue selective estrogenic properties
JP2005078161A (ja) * 2003-08-28 2005-03-24 Canon Inc 記録装置
WO2005023818A2 (en) 2003-09-10 2005-03-17 Gpc Biotech Ag Heterobicyclic compounds as pharmaceutically active agents
JP2007505933A (ja) * 2003-09-18 2007-03-15 コンフォーマ・セラピューティクス・コーポレイション Ｈｓｐ９０インヒビターとしての新規なヘテロ環化合物
EA011857B8 (ru) * 2003-10-14 2012-08-30 Интермьюн, Инк. Макроциклические карбоновые кислоты и ацилсульфонамиды в качестве ингибиторов репликации вируса гепатита с
US7451509B2 (en) 2003-10-17 2008-11-18 Jordan Dawes Enhancer device for enhancing the utility of a user's bed
WO2005043805A1 (en) * 2003-10-29 2005-05-12 Koninklijke Philips Electronics N.V. System and method of reliable forward secret key sharing with physical random functions
CN1902171A (zh) 2003-11-10 2007-01-24 舍林股份公司 用作ccr－5拮抗剂的苄醚胺化合物
JPWO2005063222A1 (ja) 2003-12-26 2007-07-19 協和醗酵工業株式会社 Ｈｓｐ９０ファミリー蛋白質阻害剤
US7351709B2 (en) 2004-06-09 2008-04-01 Wyeth Estrogen receptor ligands
AU2005269386A1 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7668233B2 (en) * 2004-07-28 2010-02-23 Circadiant Systems, Inc. Method of determining jitter and apparatus for determining jitter
BRPI0514504A (pt) * 2004-08-20 2008-06-10 Univ Michigan pequenas moléculas inibidoras de membros da famìlia bcl-2 anti-apoptóticos e os usos das mesmas
DE102004049078A1 (de) 2004-10-08 2006-04-13 Merck Patent Gmbh Phenylpyrazole
JP4625674B2 (ja) * 2004-10-15 2011-02-02 株式会社東芝 プリント配線基板及びこの基板を搭載する情報処理装置
US7208630B2 (en) * 2004-10-27 2007-04-24 University Of Kansas Heat shock protein 90 inhibitors
US7781485B2 (en) * 2004-11-09 2010-08-24 Kyowa Hakko Kirin Co., Ltd. Hsp90 family protein inhibitors
DK1817295T3 (da) 2004-11-18 2013-02-18 Synta Pharmaceuticals Corp Triazolforbindelser, der modulerer HSP90-aktivitet
KR101351209B1 (ko) * 2004-12-03 2014-02-06 머크 샤프 앤드 돔 코포레이션 Ｃｂ1 길항제로서 치환된 피페라진
RU2416610C2 (ru) 2004-12-30 2011-04-20 Астекс Терапьютикс Лимитед Фармацевтические соединения
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
ES2334578T3 (es) * 2005-02-07 2010-03-12 F. Hoffmann-La Roche Ag Fenil-metanonas sustituidas por heterociclo como inhibidores del transportador 1 de la glicina.
WO2006088954A1 (en) * 2005-02-15 2006-08-24 Janssen Pharmaceutica, N.V. Dihydroindolyl methanones as alpha 1a/1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms
EA011617B1 (ru) 2005-02-21 2009-04-28 Киова Хакко Кирин Ко., Лтд. Противоопухолевое средство
US20080306054A1 (en) * 2005-04-13 2008-12-11 Astex Therapeutics Limited Pharmaceutical Compounds
US20090215742A1 (en) * 2005-05-03 2009-08-27 Pfizer, Inc. Amide resorcinol compounds
CA2609053C (en) 2005-05-17 2017-04-25 Sarcode Corporation Compositions and methods for treatment of eye disorders
WO2007050124A1 (en) 2005-05-19 2007-05-03 Xenon Pharmaceuticals Inc. Fused piperidine derivatives and their uses as therapeutic agents
DE102005039757A1 (de) * 2005-08-23 2007-03-01 Robert Bosch Gmbh Verfahren zum Betreiben einer Brennkraftmaschine
US7425633B2 (en) * 2005-08-26 2008-09-16 National Health Research Institutes Pyrrolidine compounds
US7754725B2 (en) * 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
US20080044045A1 (en) * 2006-08-15 2008-02-21 Dobbs-Stanford Corporation Externally fused speaker terminal cup
US8767972B2 (en) * 2006-08-16 2014-07-01 Apherma, Llc Auto-fit hearing aid and fitting process therefor
US8311243B2 (en) * 2006-08-21 2012-11-13 Cirrus Logic, Inc. Energy-efficient consumer device audio power output stage
US20080053319A1 (en) * 2006-09-06 2008-03-06 Illinois Tool Works Inc. Pad printing of video targets for strain measurement
WO2008044027A2 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical compounds having hsp90 inhibitory or modulating activity
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8277807B2 (en) 2006-10-12 2012-10-02 Astex Therapeutics Limited Pharmaceutical combinations
EP2073804B1 (en) 2006-10-12 2017-09-13 Astex Therapeutics Limited Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008053319A1 (en) 2006-10-30 2008-05-08 Pfizer Products Inc. Amide resorcinol compounds
GB0806527D0 (en) * 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
US8277857B2 (en) 2008-06-11 2012-10-02 Morinaga Milk Industry Co., Ltd. Method for producing fermented milk
DE102010038720A1 (de) * 2010-07-30 2012-02-02 Günther Veit Schwingungsabsorber zur Dämpfung mechanischer Schwingungen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072051A1 (en) * 2003-02-11 2004-08-26 Vernalis (Cambridge) Limited Isoxazole compounds as inhibitors of heat shock proteins

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