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MXPA05011597A - Derivados de aminopropanol como moduladores del receptor 1-fosfato de esfingosina. - Google Patents

Derivados de aminopropanol como moduladores del receptor 1-fosfato de esfingosina.

Info

Publication number
MXPA05011597A
MXPA05011597A MXPA05011597A MXPA05011597A MXPA05011597A MX PA05011597 A MXPA05011597 A MX PA05011597A MX PA05011597 A MXPA05011597 A MX PA05011597A MX PA05011597 A MXPA05011597 A MX PA05011597A MX PA05011597 A MXPA05011597 A MX PA05011597A
Authority
MX
Mexico
Prior art keywords
sphingosine
receptor modulators
phosphate receptor
aminopropanol derivatives
aminopropanol
Prior art date
Application number
MXPA05011597A
Other languages
English (en)
Inventor
Peter Nussbaumer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0329501A external-priority patent/GB0329501D0/en
Priority claimed from GB0329494A external-priority patent/GB0329494D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MXPA05011597A publication Critical patent/MXPA05011597A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • C07F9/06—Phosphorus compounds without P—C bonds
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
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    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)

Abstract

Compuestos de la formula (I): en la que X, a, b, R1, R2, R3, R4 y R5 son como se define en la memoria descriptiva; procesos para su produccion; sus usos, y composiciones farmaceuticas que los contienen.
MXPA05011597A 2003-04-30 2004-04-29 Derivados de aminopropanol como moduladores del receptor 1-fosfato de esfingosina. MXPA05011597A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0309946 2003-04-30
GB0329501A GB0329501D0 (en) 2003-12-19 2003-12-19 Organic compounds
GB0329494A GB0329494D0 (en) 2003-12-19 2003-12-19 Organic compounds
PCT/EP2004/004572 WO2004096757A1 (en) 2003-04-30 2004-04-29 Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators

Publications (1)

Publication Number Publication Date
MXPA05011597A true MXPA05011597A (es) 2005-12-15

Family

ID=33424536

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011597A MXPA05011597A (es) 2003-04-30 2004-04-29 Derivados de aminopropanol como moduladores del receptor 1-fosfato de esfingosina.

Country Status (10)

Country Link
US (1) US7825260B2 (es)
EP (1) EP1622866B1 (es)
JP (1) JP4638410B2 (es)
CN (1) CN1809531B (es)
AU (1) AU2004234067B2 (es)
BR (1) BRPI0409977A (es)
CA (1) CA2523677A1 (es)
ES (1) ES2392167T3 (es)
MX (1) MXPA05011597A (es)
WO (1) WO2004096757A1 (es)

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US7638637B2 (en) 2003-11-03 2009-12-29 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
GB0411929D0 (en) * 2004-05-27 2004-06-30 Novartis Ag Organic compounds
US8039674B2 (en) 2004-06-23 2011-10-18 Ono Pharmaceutical Co., Ltd. Compound having S1P receptor binding potency and use thereof
WO2006009092A1 (ja) * 2004-07-16 2006-01-26 Kyorin Pharmaceutical Co., Ltd. 効果的な医薬の使用法及び副作用発現の防御に関する方法
AU2005272619A1 (en) 2004-08-13 2006-02-23 Praecis Pharmaceuticals, Inc. Methods and compositions for modulating sphingosine-1-phosphate (SIP) receptor activity
PL1806338T3 (pl) 2004-10-12 2016-07-29 Kyorin Seiyaku Kk Sposób wytwarzania chlorowodorku 2-amino-2-[2-[4-(3-benzyloksyfenylotio)-2-chlorofenyio]etylo]-1,3-propanodioiu i jego hydratów oraz produkty pośrednie w ich wytwarzaniu
US7888527B2 (en) 2004-12-06 2011-02-15 University Of Virginia Patent Foundation Aryl amide sphingosine 1-phosphate analogs
GB0504544D0 (en) * 2005-03-04 2005-04-13 Novartis Ag Organic compounds
DK2332909T3 (da) 2005-04-13 2014-11-10 Astex Therapeutics Ltd Hydroxybenzamidderivater og deres anvendelse som inhibitorer af hsp90
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