NO328697B1 - Ny fremgangsmate for den industrielle syntese av metyldiesteren av 5-amino-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater - Google Patents

Ny fremgangsmate for den industrielle syntese av metyldiesteren av 5-amino-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater Download PDF

Info

Publication number: NO328697B1
Authority: NO; Norway
Prior art keywords: formula; compound; synthesis; acid; hydrates
Prior art date: 2002-09-24

Application number

NO20034237A

Other languages

English (en)

Norwegian (no)

Other versions

NO20034237L (no

NO20034237D0 (no

Inventor

Jean-Pierre Lecouve

Lucile Vaysse-Ludot

Pascal Langlois

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2003-09-23

Publication date

2010-04-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29415190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO328697(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-09-23 Application filed by Servier Lab filed Critical Servier Lab

2003-09-23 Publication of NO20034237D0 publication Critical patent/NO20034237D0/no

2004-03-25 Publication of NO20034237L publication Critical patent/NO20034237L/no

2010-04-26 Publication of NO328697B1 publication Critical patent/NO328697B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NO20034237A 2002-09-24 2003-09-23 Ny fremgangsmate for den industrielle syntese av metyldiesteren av 5-amino-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater NO328697B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0211764A FR2844796A1 (fr)	2002-09-24	2002-09-24	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Publications (3)

Publication Number	Publication Date
NO20034237D0 NO20034237D0 (no)	2003-09-23
NO20034237L NO20034237L (no)	2004-03-25
NO328697B1 true NO328697B1 (no)	2010-04-26

Family

ID=29415190

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20034237A NO328697B1 (no)	2002-09-24	2003-09-23	Ny fremgangsmate for den industrielle syntese av metyldiesteren av 5-amino-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater

Country Status (39)

Country	Link
US (3)	US7105683B2 (es)
EP (1)	EP1403264B1 (es)
JP (1)	JP4136865B2 (es)
KR (1)	KR100551503B1 (es)
CN (2)	CN1280285C (es)
AP (1)	AP1942A (es)
AR (1)	AR041356A1 (es)
AT (1)	ATE286041T1 (es)
AU (2)	AU2003282178A1 (es)
BR (1)	BR0304194A (es)
CA (1)	CA2442875C (es)
DE (1)	DE60300252T2 (es)
DK (1)	DK1403264T3 (es)
EA (1)	EA007496B1 (es)
EC (1)	ECSP055742A (es)
ES (1)	ES2235144T3 (es)
FR (1)	FR2844796A1 (es)
GE (1)	GEP20074140B (es)
HK (2)	HK1061845A1 (es)
HR (1)	HRP20050360B1 (es)
IL (1)	IL167314A (es)
IS (1)	IS2136B (es)
MA (1)	MA26101A1 (es)
ME (1)	ME00451B (es)
MX (1)	MXPA03008645A (es)
MY (1)	MY131939A (es)
NI (1)	NI200500065A (es)
NO (1)	NO328697B1 (es)
NZ (1)	NZ528400A (es)
OA (1)	OA12933A (es)
PL (1)	PL214414B1 (es)
PT (1)	PT1403264E (es)
RS (1)	RS50929B (es)
SG (1)	SG110070A1 (es)
SI (1)	SI1403264T1 (es)
TN (1)	TNSN05089A1 (es)
UA (1)	UA79991C2 (es)
WO (1)	WO2004029035A1 (es)
ZA (1)	ZA200307410B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
EP1745791B1 (en) *	2003-05-07	2013-06-26	Osteologix A/S	Treating cartilage/bone conditions with water-soluble strontium salts
EP2266584B1 (en) *	2003-05-07	2012-09-05	Osteologix A/S	Composition with strontium and vitamin D for the prophylaxis and/or treatment of cartilage and/or bone conditions
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
CA2557324C (en)	2004-02-26	2012-10-16	Osteologix A/S	Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
KR20070034075A (ko)	2004-06-25	2007-03-27	스트론틴 에이피에스	스트론튬과 비타민 ｄ를 함유하는 조성물 및 그의 용도
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
CN101665483B (zh) *	2008-09-01	2013-01-23	河北医科大学	一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011110597A1 (de)	2010-03-11	2011-09-15	Azad Pharmaceutical Ingredients Ag	Verfahren zur herstellung von strontiumranelat
CN103319454B (zh) *	2013-06-14	2014-06-18	广东众生药业股份有限公司	一种高纯度雷尼酸四乙酯及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR415850A (fr)	1909-07-22	1910-10-05	Gustave Auguste Ferrie	Dispositif de mesure permettant de lire directement la valeur d'une grandeur fonction de deux variables
FR2651497B1 (fr) *	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2844797B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

2002
- 2002-09-24 FR FR0211764A patent/FR2844796A1/fr active Pending
2003
- 2003-09-17 MY MYPI20033534A patent/MY131939A/en unknown
- 2003-09-22 DE DE60300252T patent/DE60300252T2/de not_active Expired - Lifetime
- 2003-09-22 AT AT03292317T patent/ATE286041T1/de active
- 2003-09-22 AU AU2003282178A patent/AU2003282178A1/en not_active Abandoned
- 2003-09-22 OA OA1200500082A patent/OA12933A/en unknown
- 2003-09-22 WO PCT/FR2003/002776 patent/WO2004029035A1/fr not_active Application Discontinuation
- 2003-09-22 DK DK03292317T patent/DK1403264T3/da active
- 2003-09-22 ES ES03292317T patent/ES2235144T3/es not_active Expired - Lifetime
- 2003-09-22 SI SI200330013T patent/SI1403264T1/xx unknown
- 2003-09-22 AP AP2005003259A patent/AP1942A/xx active
- 2003-09-22 ME MEP-2008-685A patent/ME00451B/me unknown
- 2003-09-22 AU AU2003248279A patent/AU2003248279B2/en not_active Ceased
- 2003-09-22 BR BR0304194-8A patent/BR0304194A/pt not_active Application Discontinuation
- 2003-09-22 PT PT03292317T patent/PT1403264E/pt unknown
- 2003-09-22 GE GEAP20038760A patent/GEP20074140B/en unknown
- 2003-09-22 UA UAA200503859A patent/UA79991C2/uk unknown
- 2003-09-22 RS YUP-2005/0242A patent/RS50929B/sr unknown
- 2003-09-22 EP EP03292317A patent/EP1403264B1/fr not_active Expired - Lifetime
- 2003-09-22 JP JP2003330438A patent/JP4136865B2/ja not_active Expired - Fee Related
- 2003-09-23 NO NO20034237A patent/NO328697B1/no not_active IP Right Cessation
- 2003-09-23 EA EA200300926A patent/EA007496B1/ru not_active IP Right Cessation
- 2003-09-23 ZA ZA200307410A patent/ZA200307410B/xx unknown
- 2003-09-23 NZ NZ528400A patent/NZ528400A/en not_active IP Right Cessation
- 2003-09-23 AR ARP030103454A patent/AR041356A1/es not_active Application Discontinuation
- 2003-09-23 PL PL362367A patent/PL214414B1/pl unknown
- 2003-09-23 CA CA002442875A patent/CA2442875C/fr not_active Expired - Fee Related
- 2003-09-23 KR KR1020030065785A patent/KR100551503B1/ko not_active IP Right Cessation
- 2003-09-23 MX MXPA03008645A patent/MXPA03008645A/es active IP Right Grant
- 2003-09-24 US US10/669,738 patent/US7105683B2/en not_active Expired - Fee Related
- 2003-09-24 SG SG200305554A patent/SG110070A1/en unknown
- 2003-09-24 CN CNB031348076A patent/CN1280285C/zh not_active Expired - Fee Related
- 2003-09-24 MA MA27320A patent/MA26101A1/fr unknown
- 2003-09-24 CN CNB2006100073351A patent/CN100393707C/zh not_active Expired - Fee Related
2004
- 2004-07-05 HK HK04104808A patent/HK1061845A1/xx not_active IP Right Cessation
2005
- 2005-03-08 IL IL167314A patent/IL167314A/en not_active IP Right Cessation
- 2005-03-18 NI NI200500065A patent/NI200500065A/es unknown
- 2005-03-23 TN TNP2005000089A patent/TNSN05089A1/fr unknown
- 2005-04-19 IS IS7808A patent/IS2136B/xx unknown
- 2005-04-21 HR HRP20050360AA patent/HRP20050360B1/hr not_active IP Right Cessation
- 2005-04-22 EC EC2005005742A patent/ECSP055742A/es unknown
2006
- 2006-02-21 US US11/358,034 patent/US7462714B2/en not_active Expired - Fee Related
- 2006-02-21 US US11/358,496 patent/US7238815B2/en not_active Expired - Fee Related
2007
- 2007-02-01 HK HK07101197A patent/HK1096661A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN100393707C (zh)	2008-06-11
IL167314A (en)	2010-04-29
US7462714B2 (en)	2008-12-09
IS2136B (is)	2006-08-15
JP4136865B2 (ja)	2008-08-20
EA007496B1 (ru)	2006-10-27
AU2003282178A1 (en)	2004-04-19
CA2442875A1 (fr)	2004-03-24
NO20034237L (no)	2004-03-25
US20060142567A1 (en)	2006-06-29
ES2235144T3 (es)	2005-07-01
GEP20074140B (en)	2007-06-25
US7105683B2 (en)	2006-09-12
ECSP055742A (es)	2005-07-06
MY131939A (en)	2007-09-28
US7238815B2 (en)	2007-07-03
NI200500065A (es)	2006-01-03
PT1403264E (pt)	2005-04-29
KR100551503B1 (ko)	2006-02-13
AP2005003259A0 (en)	2005-03-31
HRP20050360B1 (hr)	2013-08-31
TNSN05089A1 (fr)	2007-05-14
KR20040026627A (ko)	2004-03-31
HK1061845A1 (en)	2004-10-08
SI1403264T1 (en)	2005-04-30
NZ528400A (en)	2004-06-25
MXPA03008645A (es)	2005-04-19
AR041356A1 (es)	2005-05-11
JP2004269495A (ja)	2004-09-30
DE60300252D1 (de)	2005-02-03
EP1403264B1 (fr)	2004-12-29
US20040059135A1 (en)	2004-03-25
US20060142596A1 (en)	2006-06-29
AU2003248279B2 (en)	2009-08-06
CA2442875C (fr)	2009-06-02
PL214414B1 (pl)	2013-07-31
AP1942A (en)	2009-01-28
SG110070A1 (en)	2005-04-28
HRP20050360A2 (en)	2005-06-30
BR0304194A (pt)	2004-09-08
FR2844796A1 (fr)	2004-03-26
EA200300926A1 (ru)	2004-04-29
RS20050242A (en)	2007-06-04
DE60300252T2 (de)	2005-12-22
MA26101A1 (fr)	2004-04-01
CN1817869A (zh)	2006-08-16
HK1096661A1 (en)	2007-06-08
UA79991C2 (en)	2007-08-10
NO20034237D0 (no)	2003-09-23
WO2004029035A1 (fr)	2004-04-08
EP1403264A1 (fr)	2004-03-31
ZA200307410B (en)	2004-07-07
CN1500783A (zh)	2004-06-02
ATE286041T1 (de)	2005-01-15
PL362367A1 (en)	2004-04-05
DK1403264T3 (da)	2005-04-04
IS7808A (is)	2005-04-19
RS50929B (sr)	2010-08-31
CN1280285C (zh)	2006-10-18
ME00451B (me)	2011-10-10
OA12933A (en)	2006-10-13
AU2003248279A1 (en)	2004-04-08

Publication	Publication Date	Title
US7462714B2 (en)	2008-12-09	Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates
JP4136867B2 (ja)	2008-08-20	ラネリック酸ストロンチウム及びその水和物の新規な工業的合成方法
US8063100B2 (en)	2011-11-22	Process for the synthesis of strontium ranelate and its hydrates
JP4136866B2 (ja)	2008-08-20	５−〔ビス（カルボキシメチル）アミノ〕−３−カルボキシメチル−４−シアノ−２−チオフェンカルボン酸のテトラエステル類の新規な工業的合成方法、並びにラネリック酸の二価塩類及びそれらの水和物の合成への応用
JPH029874A (ja)	1990-01-12	α‐アミノアセトニトリル塩酸塩類の製造方法
CZ20041073A3 (cs)	2006-06-14	Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
NO774285L (no)	1978-06-15	Analogifremgangsmaate ved fremstilling av terapeutisk aktive indanderivater
JPS63107974A (ja)	1988-05-12	２−　（α−アルコキシイミノ）　エチルチオフエン及びその製造方法
KR20050011020A (ko)	2005-01-29	3,4,5,7,8,9-헥사히드로-2수소-디벤조퓨란-1-온, 및 이를중간체로 하는 1-히드록시디벤조퓨란, 4-히드록시카바졸의제조 방법

Legal Events

Date	Code	Title	Description
2019-04-29	MM1K	Lapsed by not paying the annual fees