NO328152B1 - Glyburid og glyburid-preparater samt anvendelse av disse for fremstilling av medikament for behandling av sykdom - Google Patents

Glyburid og glyburid-preparater samt anvendelse av disse for fremstilling av medikament for behandling av sykdom Download PDF

Info

Publication number: NO328152B1
Authority: NO; Norway
Prior art keywords: glyburide; drug; tablet; undersize value; particle size
Prior art date: 2000-01-14

Application number

NO20023367A

Other languages

English (en)

Norwegian (no)

Other versions

NO20023367L (no

NO20023367D0 (no

Inventor

Gillian Cave

Sarah J Nicholson

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-14

Filing date

2002-07-12

Publication date

2009-12-21

2002-07-12 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2002-07-12 Publication of NO20023367D0 publication Critical patent/NO20023367D0/no

2002-09-04 Publication of NO20023367L publication Critical patent/NO20023367L/no

2009-12-21 Publication of NO328152B1 publication Critical patent/NO328152B1/no

Links

ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 title claims description 80
229960004580 glibenclamide Drugs 0.000 title claims description 79
239000003814 drug Substances 0.000 title claims description 27
238000004519 manufacturing process Methods 0.000 title claims description 3
238000002360 preparation method Methods 0.000 title description 3
201000010099 disease Diseases 0.000 title description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 2
239000002245 particle Substances 0.000 claims description 27
229940079593 drug Drugs 0.000 claims description 26
239000000203 mixture Substances 0.000 claims description 25
238000009472 formulation Methods 0.000 claims description 20
239000000546 pharmaceutical excipient Substances 0.000 claims description 16
239000002775 capsule Substances 0.000 claims description 11
238000009826 distribution Methods 0.000 claims description 10
239000000126 substance Substances 0.000 claims description 7
-1 cyclohexylamino Chemical group 0.000 claims description 6
XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 6
HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims description 6
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VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 5
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GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
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GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
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NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
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MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
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HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Cephalosporin Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

NO20023367A 2000-01-14 2002-07-12 Glyburid og glyburid-preparater samt anvendelse av disse for fremstilling av medikament for behandling av sykdom NO328152B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US48370300A	2000-01-14	2000-01-14
PCT/US2001/000234 WO2001051463A1 (en)	2000-01-14	2001-01-04	Glyburide composition

Publications (3)

Publication Number	Publication Date
NO20023367D0 NO20023367D0 (no)	2002-07-12
NO20023367L NO20023367L (no)	2002-09-04
NO328152B1 true NO328152B1 (no)	2009-12-21

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NO20023367A NO328152B1 (no)	2000-01-14	2002-07-12	Glyburid og glyburid-preparater samt anvendelse av disse for fremstilling av medikament for behandling av sykdom

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US (2)	US20010036479A1 (et)
EP (1)	EP1250321B1 (et)
JP (1)	JP4787446B2 (et)
KR (1)	KR100739906B1 (et)
CN (1)	CN1210258C (et)
AR (1)	AR031547A1 (et)
AT (1)	ATE330937T1 (et)
AU (1)	AU771705B2 (et)
BG (1)	BG65782B1 (et)
BR (1)	BR0107564A (et)
CA (1)	CA2397294C (et)
CY (1)	CY1106328T1 (et)
CZ (1)	CZ20022429A3 (et)
DE (1)	DE60120916T2 (et)
DK (1)	DK1250321T3 (et)
EE (1)	EE05020B1 (et)
ES (1)	ES2264967T3 (et)
GE (1)	GEP20043299B (et)
HU (1)	HU228825B1 (et)
IL (2)	IL150383A0 (et)
LT (1)	LT5024B (et)
LV (1)	LV12914B (et)
MX (1)	MXPA02006835A (et)
MY (1)	MY128577A (et)
NO (1)	NO328152B1 (et)
NZ (1)	NZ519920A (et)
PT (1)	PT1250321E (et)
RO (1)	RO121381B1 (et)
RU (1)	RU2244707C2 (et)
SK (1)	SK286925B6 (et)
TN (1)	TNSN01005A1 (et)
TR (1)	TR200201798T2 (et)
TW (1)	TWI287989B (et)
UA (1)	UA73968C2 (et)
UY (1)	UY26529A1 (et)
WO (1)	WO2001051463A1 (et)
ZA (1)	ZA200205528B (et)

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2000
- 2000-12-11 US US09/735,334 patent/US20010036479A1/en not_active Abandoned
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2001
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- 2001-01-04 CA CA2397294A patent/CA2397294C/en not_active Expired - Lifetime
- 2001-01-04 IL IL15038301A patent/IL150383A0/xx active IP Right Grant
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- 2001-01-04 PT PT01900328T patent/PT1250321E/pt unknown
- 2001-01-04 GE GE4874A patent/GEP20043299B/en unknown
- 2001-01-04 DE DE60120916T patent/DE60120916T2/de not_active Expired - Lifetime
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- 2001-01-04 ES ES01900328T patent/ES2264967T3/es not_active Expired - Lifetime
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- 2001-01-04 RU RU2002121626/04A patent/RU2244707C2/ru active
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2002
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Publication number	Publication date
BR0107564A (pt)	2002-10-01
HU228825B1 (en)	2013-05-28
IL150383A (en)	2007-03-08
DK1250321T3 (da)	2006-07-31
DE60120916D1 (de)	2006-08-03
CA2397294C (en)	2011-03-22
PL356210A1 (en)	2004-06-14
RU2244707C2 (ru)	2005-01-20
ATE330937T1 (de)	2006-07-15
LT2002085A (en)	2003-01-27
EE05020B1 (et)	2008-06-16
EP1250321A1 (en)	2002-10-23
IL150383A0 (en)	2002-12-01
LV12914B (en)	2003-01-20
AR031547A1 (es)	2003-09-24
US20010036479A1 (en)	2001-11-01
GEP20043299B (en)	2004-03-10
RU2002121626A (ru)	2004-01-10
CN1395560A (zh)	2003-02-05
NO20023367L (no)	2002-09-04
PT1250321E (pt)	2006-09-29
LT5024B (lt)	2003-06-25
ES2264967T3 (es)	2007-02-01
HUP0203852A2 (hu)	2003-04-28
DE60120916T2 (de)	2007-02-15
RO121381B1 (ro)	2007-04-30
HUP0203852A3 (en)	2005-05-30
NZ519920A (en)	2004-06-25
US6830760B2 (en)	2004-12-14
JP4787446B2 (ja)	2011-10-05
AU771705B2 (en)	2004-04-01
CN1210258C (zh)	2005-07-13
UA73968C2 (en)	2005-10-17
AU2474001A (en)	2001-07-24
MY128577A (en)	2007-02-28
ZA200205528B (en)	2003-10-10
TWI287989B (en)	2007-10-11
JP2003519681A (ja)	2003-06-24
WO2001051463A1 (en)	2001-07-19
MXPA02006835A (es)	2003-01-28
TR200201798T2 (tr)	2002-11-21
CA2397294A1 (en)	2001-07-19
EP1250321B1 (en)	2006-06-21
UY26529A1 (es)	2001-08-27
KR20020073169A (ko)	2002-09-19
SK9832002A3 (en)	2003-07-01
BG65782B1 (bg)	2009-11-30
TNSN01005A1 (en)	2005-11-10
US20030185880A1 (en)	2003-10-02
EE200200393A (et)	2003-10-15
KR100739906B1 (ko)	2007-07-16
CY1106328T1 (el)	2011-10-12
BG106870A (en)	2003-03-31
NO20023367D0 (no)	2002-07-12
SK286925B6 (sk)	2009-07-06
CZ20022429A3 (cs)	2003-06-18

Publication	Publication Date	Title
NO328152B1 (no)	2009-12-21	Glyburid og glyburid-preparater samt anvendelse av disse for fremstilling av medikament for behandling av sykdom
RU2286788C2 (ru)	2006-11-10	Твердая дозированная лекарственная форма для орального введения, содержащая комбинацию метформина и глибенкламида
KR910004571B1 (ko)	1991-07-06	경구용 당뇨병치료 제제를 제조하는 방법
US20100029721A1 (en)	2010-02-04	Pharmaceutical Formulation Comprising Metformin and Repaglinide
WO2006109175A2 (en)	2006-10-19	Solid dosage form of an antidiabetic drug
EA008585B1 (ru)	2007-06-29	Капсулы флуконазола с улучшенным высвобождением
PL203547B1 (pl)	2009-10-30	Kompozycje gliburidu
WO2004082591A2 (en)	2004-09-30	Pharmaceutical composition for treatment of diabetes mellitus
WO2005092319A1 (en)	2005-10-06	Rapidly disintegrating pharmaceutical compositions comprising nateglinide and a disintegrant
WO2009105049A1 (en)	2009-08-27	Oral tablet compositions containing nateglinide and surfactan ph adjusting agent
US20080182880A1 (en)	2008-07-31	Pioglitazone composition

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