NO324405B1 - Agonistanalog av amylin og preparat omfattende denne. - Google Patents

Agonistanalog av amylin og preparat omfattende denne. Download PDF

Info

Publication number: NO324405B1
Authority: NO; Norway
Prior art keywords: amylin; asn; ser; thr; leu
Prior art date: 1991-11-19

Application number

NO19932603A

Other languages

English (en)

Norwegian (no)

Other versions

NO932603D0 (no

NO932603L (no

Inventor

Elisabeth Albrecht

Howard Jones

Laura S L Gatea

Original Assignee

Amylin Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-19

Filing date

1993-07-19

Publication date

2007-10-08

1993-07-19 Application filed by Amylin Pharmaceuticals Inc filed Critical Amylin Pharmaceuticals Inc

1993-07-19 Publication of NO932603D0 publication Critical patent/NO932603D0/no

1993-09-17 Publication of NO932603L publication Critical patent/NO932603L/no

2007-10-08 Publication of NO324405B1 publication Critical patent/NO324405B1/no

Links

108010041872 Islet Amyloid Polypeptide Proteins 0.000 title claims abstract description 81
102000036770 Islet Amyloid Polypeptide Human genes 0.000 title claims abstract description 81
239000000556 agonist Substances 0.000 title claims abstract description 55
238000002360 preparation method Methods 0.000 title claims description 35
125000003275 alpha amino acid group Chemical group 0.000 claims abstract description 14
125000003545 alkoxy group Chemical group 0.000 claims abstract description 13
125000003282 alkyl amino group Chemical group 0.000 claims abstract description 13
125000001691 aryl alkyl amino group Chemical group 0.000 claims abstract description 13
125000002102 aryl alkyloxo group Chemical group 0.000 claims abstract description 13
125000001769 aryl amino group Chemical group 0.000 claims abstract description 13
125000004104 aryloxy group Chemical group 0.000 claims abstract description 13
125000006310 cycloalkyl amino group Chemical group 0.000 claims abstract description 13
125000004663 dialkyl amino group Chemical group 0.000 claims abstract description 13
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 8
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 53
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230000000694 effects Effects 0.000 claims description 20
150000003839 salts Chemical class 0.000 claims description 14
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MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 6
150000008574 D-amino acids Chemical group 0.000 claims description 6
125000000998 L-alanino group Chemical group [H]N([*])[C@](C([H])([H])[H])([H])C(=O)O[H] 0.000 claims description 6
125000000539 amino acid group Chemical group 0.000 claims description 6
150000003951 lactams Chemical class 0.000 claims description 6
125000000534 N(2)-L-lysino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C([H])([H])C(C([H])([H])N([H])[H])([H])[H] 0.000 claims description 5
125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 2
159000000021 acetate salts Chemical class 0.000 claims 2
VFRSADQPWYCXDG-LEUCUCNGSA-N ethyl (2s,5s)-5-methylpyrrolidine-2-carboxylate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CCOC(=O)[C@@H]1CC[C@H](C)N1 VFRSADQPWYCXDG-LEUCUCNGSA-N 0.000 claims 2
RFCVXVPWSPOMFJ-STQMWFEESA-N Phe-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 RFCVXVPWSPOMFJ-STQMWFEESA-N 0.000 claims 1
108010073101 phenylalanylleucine Proteins 0.000 claims 1
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DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 25
150000001413 amino acids Chemical class 0.000 description 24
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 22
RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 description 20
238000000034 method Methods 0.000 description 17
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 16
239000008103 glucose Substances 0.000 description 16
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BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 10
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PSHNNUKOUQCMSG-UHFFFAOYSA-K bis[(2,2,2-trifluoroacetyl)oxy]thallanyl 2,2,2-trifluoroacetate Chemical compound [Tl+3].[O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F PSHNNUKOUQCMSG-UHFFFAOYSA-K 0.000 description 10
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UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 10
SHDMMLFAFLZUEV-UHFFFAOYSA-N n-methyl-1,1-diphenylmethanamine Chemical compound C=1C=CC=CC=1C(NC)C1=CC=CC=C1 SHDMMLFAFLZUEV-UHFFFAOYSA-N 0.000 description 10
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229960004666 glucagon Drugs 0.000 description 8
238000004007 reversed phase HPLC Methods 0.000 description 8
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125000004432 carbon atom Chemical group C* 0.000 description 6
YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 6
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238000003556 assay Methods 0.000 description 5
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 5
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238000012360 testing method Methods 0.000 description 5
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JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 4
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LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
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YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
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XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO19932603A 1991-11-19 1993-07-19 Agonistanalog av amylin og preparat omfattende denne. NO324405B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US79426691A	1991-11-19	1991-11-19
PCT/US1992/009842 WO1993010146A1 (en)	1991-11-19	1992-11-19	Amylin agonist peptides and uses therefor

Publications (3)

Publication Number	Publication Date
NO932603D0 NO932603D0 (no)	1993-07-19
NO932603L NO932603L (no)	1993-09-17
NO324405B1 true NO324405B1 (no)	2007-10-08

Family

ID=25162163

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO19932603A NO324405B1 (no)	1991-11-19	1993-07-19	Agonistanalog av amylin og preparat omfattende denne.
NO20073265A NO20073265L (no)	1991-11-19	2007-06-25	Agonistananalog av amylin

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20073265A NO20073265L (no)	1991-11-19	2007-06-25	Agonistananalog av amylin

Country Status (17)

Country	Link
EP (2)	EP0567626B1 (de)
JP (4)	JP2902115B2 (de)
AT (1)	ATE205854T1 (de)
AU (1)	AU714439B2 (de)
CA (1)	CA2100745C (de)
CZ (1)	CZ288029B6 (de)
DE (1)	DE69232064T2 (de)
DK (1)	DK0567626T3 (de)
ES (1)	ES2161697T3 (de)
FI (1)	FI118601B (de)
GR (1)	GR3036794T3 (de)
HK (1)	HK1041891A1 (de)
MD (1)	MD960317A (de)
NO (2)	NO324405B1 (de)
RU (1)	RU2130463C1 (de)
SK (1)	SK88793A3 (de)
WO (1)	WO1993010146A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU222249B1 (hu)	1991-03-08	2003-05-28	Amylin Pharmaceuticals Inc.	Eljárás amilin agonista peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
US5625032A (en) *	1993-07-21	1997-04-29	Amylin Pharmaceuticals, Inc.	Selective amylin antagonist peptides and uses therefor
ZA946881B (en)	1993-09-07	1995-10-30	Amylin Pharmaceuticals Inc	Methods for treating gastrointestinal motility
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1992
- 1992-11-19 DK DK92924442T patent/DK0567626T3/da active
- 1992-11-19 CZ CZ19931689A patent/CZ288029B6/cs not_active IP Right Cessation
- 1992-11-19 MD MD96-0317A patent/MD960317A/ro unknown
- 1992-11-19 JP JP5509441A patent/JP2902115B2/ja not_active Expired - Lifetime
- 1992-11-19 AT AT92924442T patent/ATE205854T1/de active
- 1992-11-19 RU RU93053497A patent/RU2130463C1/ru active
- 1992-11-19 CA CA002100745A patent/CA2100745C/en not_active Expired - Lifetime
- 1992-11-19 ES ES92924442T patent/ES2161697T3/es not_active Expired - Lifetime
- 1992-11-19 EP EP92924442A patent/EP0567626B1/de not_active Expired - Lifetime
- 1992-11-19 SK SK887-93A patent/SK88793A3/sk unknown
- 1992-11-19 DE DE69232064T patent/DE69232064T2/de not_active Expired - Lifetime
- 1992-11-19 WO PCT/US1992/009842 patent/WO1993010146A1/en active IP Right Grant
- 1992-11-19 EP EP01114132A patent/EP1162207A1/de not_active Ceased
1993
- 1993-07-16 FI FI933252A patent/FI118601B/fi not_active IP Right Cessation
- 1993-07-19 NO NO19932603A patent/NO324405B1/no not_active IP Right Cessation
1997
- 1997-01-31 AU AU12456/97A patent/AU714439B2/en not_active Expired
1998
- 1998-09-30 JP JP10277573A patent/JPH11152299A/ja not_active Withdrawn
2001
- 2001-10-04 GR GR20010401656T patent/GR3036794T3/el unknown
2002
- 2002-05-02 HK HK02103291.8A patent/HK1041891A1/zh unknown
2003
- 2003-01-15 JP JP2003007228A patent/JP2003238594A/ja not_active Withdrawn
2006
- 2006-02-03 JP JP2006027334A patent/JP4018116B2/ja not_active Expired - Lifetime
2007
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Also Published As

Publication number	Publication date
EP0567626B1 (de)	2001-09-19
AU673147B2 (en)	1996-10-31
CA2100745A1 (en)	1993-05-20
JP2003238594A (ja)	2003-08-27
DE69232064D1 (de)	2001-10-25
DK0567626T3 (da)	2001-12-17
EP0567626A1 (de)	1993-11-03
JPH11152299A (ja)	1999-06-08
MD960317A (ro)	1998-05-31
ATE205854T1 (de)	2001-10-15
RU2130463C1 (ru)	1999-05-20
FI118601B (fi)	2008-01-15
WO1993010146A1 (en)	1993-05-27
JP4018116B2 (ja)	2007-12-05
FI933252A0 (fi)	1993-07-16
NO932603D0 (no)	1993-07-19
AU1245697A (en)	1997-03-27
EP1162207A1 (de)	2001-12-12
GR3036794T3 (en)	2002-01-31
SK88793A3 (en)	1994-12-07
ES2161697T3 (es)	2001-12-16
AU3075392A (en)	1993-06-15
CZ288029B6 (cs)	2001-04-11
CA2100745C (en)	2007-07-31
JP2006213716A (ja)	2006-08-17
HK1041891A1 (zh)	2002-07-26
NO932603L (no)	1993-09-17
NO20073265L (no)	1993-09-17
DE69232064T2 (de)	2002-03-28
FI933252L (fi)	1993-08-23
JP2902115B2 (ja)	1999-06-07
JPH06504794A (ja)	1994-06-02
AU714439B2 (en)	2000-01-06
CZ168993A3 (en)	1994-04-13

Publication	Publication Date	Title
NO324405B1 (no)	2007-10-08	Agonistanalog av amylin og preparat omfattende denne.
US7271238B2 (en)	2007-09-18	Amylin agonist peptides and uses therefor
CA2337971C (en)	2011-04-26	Novel anti-diabetic peptides
HUT64367A (en)	1993-12-28	Method for producing glucagon-like peptides and insulino-tropine derivatives as well as medical preparatives containing said compounds
NZ230549A (en)	1993-03-26	Linear and cyclic growth hormone releasing factor analogues
AU669636B2 (en)	1996-06-13	Amylin antagonists and agonists
JP3802863B2 (ja)	2006-07-26	ペプチドを有効成分とする糖尿病の治療用医薬
AU673147C (en)	1998-04-23	Amylin agonist peptides and uses therefor
MXPA98010361A (en)	1999-09-20	Exandin analogues, processes for preparation and medications that contains

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2012-12-10	MK1K	Patent expired