NO323466B1 - Nye kinolinyl-piperidin-4-yliden-metyl-benzamidderivater, fremgangsmate til fremstilling derav, anvendelse derav i medikamenter til behandling av smerte, samt farmasoytisk sammensetning som innbefatter slike derivater - Google Patents

Nye kinolinyl-piperidin-4-yliden-metyl-benzamidderivater, fremgangsmate til fremstilling derav, anvendelse derav i medikamenter til behandling av smerte, samt farmasoytisk sammensetning som innbefatter slike derivater

Info

Publication number: NO323466B1
Authority: NO; Norway
Prior art keywords: derivatives; ylidene; quinolinyl; piperidin; medicaments
Prior art date: 2000-04-04

Application number

NO20024777A

Other languages

English (en)

Norwegian (no)

Other versions

NO20024777D0 (no

NO20024777L (no

Inventor

William L Brown

Christopher Walpole

Zhong-Yong Wei

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-04

Filing date

2002-10-03

Publication date

2007-05-21

2002-10-03 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2002-10-03 Publication of NO20024777D0 publication Critical patent/NO20024777D0/no

2002-12-03 Publication of NO20024777L publication Critical patent/NO20024777L/no

2007-05-21 Publication of NO323466B1 publication Critical patent/NO323466B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Toxicology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20024777A 2000-04-04 2002-10-03 Nye kinolinyl-piperidin-4-yliden-metyl-benzamidderivater, fremgangsmate til fremstilling derav, anvendelse derav i medikamenter til behandling av smerte, samt farmasoytisk sammensetning som innbefatter slike derivater NO323466B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0001208A SE0001208D0 (sv)	2000-04-04	2000-04-04	Novel compounds
PCT/SE2001/000708 WO2001074806A1 (en)	2000-04-04	2001-03-30	Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain

Publications (3)

Publication Number	Publication Date
NO20024777D0 NO20024777D0 (no)	2002-10-03
NO20024777L NO20024777L (no)	2002-12-03
NO323466B1 true NO323466B1 (no)	2007-05-21

Family

ID=20279147

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20024777A NO323466B1 (no)	2000-04-04	2002-10-03	Nye kinolinyl-piperidin-4-yliden-metyl-benzamidderivater, fremgangsmate til fremstilling derav, anvendelse derav i medikamenter til behandling av smerte, samt farmasoytisk sammensetning som innbefatter slike derivater

Country Status (28)

Country	Link
US (1)	US6753335B2 (de)
EP (1)	EP1286986B1 (de)
JP (1)	JP2003529598A (de)
KR (1)	KR100755153B1 (de)
CN (1)	CN1182134C (de)
AR (1)	AR029823A1 (de)
AT (1)	ATE289603T1 (de)
AU (2)	AU2001244982B2 (de)
BR (1)	BR0109817A (de)
CA (1)	CA2403600A1 (de)
CZ (1)	CZ20023288A3 (de)
DE (1)	DE60109032T2 (de)
EE (1)	EE200200577A (de)
ES (1)	ES2236203T3 (de)
HK (1)	HK1051692A1 (de)
HU (1)	HUP0300402A3 (de)
IL (1)	IL151891A0 (de)
IS (1)	IS6574A (de)
MX (1)	MXPA02009759A (de)
NO (1)	NO323466B1 (de)
NZ (1)	NZ522143A (de)
PL (1)	PL357770A1 (de)
PT (1)	PT1286986E (de)
RU (1)	RU2002125506A (de)
SE (1)	SE0001208D0 (de)
SK (1)	SK285076B6 (de)
WO (1)	WO2001074806A1 (de)
ZA (1)	ZA200207973B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW548271B (en)	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE0101765D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101766D0 (sv)	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0101768D0 (sv) *	2001-05-18	2001-05-18	Astrazeneca Ab	Novel compounds
SE0103313D0 (sv)	2001-10-03	2001-10-03	Astrazeneca Ab	Novel compounds
AU2003214800A1 (en)	2002-01-02	2003-07-24	Ardent Pharmaceuticals, Inc.	Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
KR20060010811A (ko) *	2003-05-16	2006-02-02	아스트라제네카 아베	디아릴메틸리덴 피페리딘 유도체, 그의 제조 및 그의 용도
SE0301442D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations therof and uses thereof
SE0301441D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
CN1890208A (zh)	2003-12-12	2007-01-03	伊莱利利公司	类鸦片受体拮抗剂
SE0400026D0 (sv) *	2004-01-09	2004-01-09	Astrazeneca Ab	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0402485D0 (sv)	2004-10-13	2004-10-13	Astrazeneca Ab	Polymorph of N,N-Diethyl-4-(3-Fluorophenyl-Piperidin-4-Ylidene-Methyl)-Benzamide Hydrochloride salt
MY148880A (en) *	2006-10-20	2013-06-14	Astrazeneca Ab	N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2898339A (en)	1957-07-29	1959-08-04	Wm S Merrell Co	N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US4581171A (en)	1983-07-27	1986-04-08	Janssen Pharmaceutica, N.V.	[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4816586A (en)	1987-07-29	1989-03-28	Regents Of The University Of Minnesota	Delta opioid receptor antagonists
US5140029A (en)	1989-01-09	1992-08-18	Janssen Pharmaceutica N.V.	2-aminopyrimidinone derivatives
US4939137A (en)	1989-06-28	1990-07-03	Ortho Pharmaceutical Corporation	Ring-fused thienopyrimidinedione derivatives
US5683998A (en)	1991-04-23	1997-11-04	Toray Industries, Inc.	Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
US5574159A (en)	1992-02-03	1996-11-12	Delta Pharmaceuticals, Inc.	Opioid compounds and methods for making therefor
GB9202238D0 (en)	1992-02-03	1992-03-18	Wellcome Found	Compounds
SE9504661D0 (sv)	1995-12-22	1995-12-22	Astra Pharma Inc	New compounds
TW548271B (en) *	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
AU2009799A (en) *	1997-12-24	1999-07-19	Ortho-Mcneil Pharmaceutical, Inc.	4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor

2000
- 2000-04-04 SE SE0001208A patent/SE0001208D0/xx unknown
2001
- 2001-03-28 AR ARP010101478A patent/AR029823A1/es not_active Application Discontinuation
- 2001-03-30 PL PL01357770A patent/PL357770A1/xx not_active Application Discontinuation
- 2001-03-30 CA CA002403600A patent/CA2403600A1/en not_active Abandoned
- 2001-03-30 HU HU0300402A patent/HUP0300402A3/hu unknown
- 2001-03-30 JP JP2001572496A patent/JP2003529598A/ja not_active Abandoned
- 2001-03-30 AU AU2001244982A patent/AU2001244982B2/en not_active Ceased
- 2001-03-30 EP EP01918114A patent/EP1286986B1/de not_active Expired - Lifetime
- 2001-03-30 MX MXPA02009759A patent/MXPA02009759A/es active IP Right Grant
- 2001-03-30 IL IL15189101A patent/IL151891A0/xx unknown
- 2001-03-30 KR KR1020027013208A patent/KR100755153B1/ko not_active IP Right Cessation
- 2001-03-30 SK SK1424-2002A patent/SK285076B6/sk unknown
- 2001-03-30 US US10/240,114 patent/US6753335B2/en not_active Expired - Fee Related
- 2001-03-30 AU AU4498201A patent/AU4498201A/xx active Pending
- 2001-03-30 RU RU2002125506/04A patent/RU2002125506A/ru not_active Application Discontinuation
- 2001-03-30 CZ CZ20023288A patent/CZ20023288A3/cs unknown
- 2001-03-30 WO PCT/SE2001/000708 patent/WO2001074806A1/en active IP Right Grant
- 2001-03-30 CN CNB018104231A patent/CN1182134C/zh not_active Expired - Fee Related
- 2001-03-30 EE EEP200200577A patent/EE200200577A/xx unknown
- 2001-03-30 PT PT01918114T patent/PT1286986E/pt unknown
- 2001-03-30 ES ES01918114T patent/ES2236203T3/es not_active Expired - Lifetime
- 2001-03-30 BR BR0109817-9A patent/BR0109817A/pt not_active IP Right Cessation
- 2001-03-30 DE DE60109032T patent/DE60109032T2/de not_active Expired - Fee Related
- 2001-03-30 AT AT01918114T patent/ATE289603T1/de not_active IP Right Cessation
- 2001-03-30 NZ NZ522143A patent/NZ522143A/en unknown
2002
- 2002-09-30 IS IS6574A patent/IS6574A/is unknown
- 2002-10-03 ZA ZA200207973A patent/ZA200207973B/en unknown
- 2002-10-03 NO NO20024777A patent/NO323466B1/no unknown
2003
- 2003-06-06 HK HK03104019A patent/HK1051692A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT1286986E (pt)	2005-05-31
EP1286986B1 (de)	2005-02-23
CN1432012A (zh)	2003-07-23
NZ522143A (en)	2004-06-25
SK14242002A3 (sk)	2003-06-03
EP1286986A1 (de)	2003-03-05
HUP0300402A3 (en)	2005-07-28
DE60109032D1 (de)	2005-03-31
MXPA02009759A (es)	2003-05-27
SK285076B6 (sk)	2006-05-04
ES2236203T3 (es)	2005-07-16
KR20020084286A (ko)	2002-11-04
JP2003529598A (ja)	2003-10-07
HK1051692A1 (en)	2003-08-15
IS6574A (is)	2002-09-30
ZA200207973B (en)	2004-01-22
EE200200577A (et)	2004-06-15
US20030199548A1 (en)	2003-10-23
AU2001244982B2 (en)	2005-11-24
DE60109032T2 (de)	2006-04-06
SE0001208D0 (sv)	2000-04-04
HUP0300402A2 (hu)	2003-06-28
RU2002125506A (ru)	2004-04-10
NO20024777D0 (no)	2002-10-03
WO2001074806A1 (en)	2001-10-11
CN1182134C (zh)	2004-12-29
AU4498201A (en)	2001-10-15
PL357770A1 (en)	2004-07-26
CA2403600A1 (en)	2001-10-11
AR029823A1 (es)	2003-07-16
NO20024777L (no)	2002-12-03
CZ20023288A3 (cs)	2003-03-12
IL151891A0 (en)	2003-04-10
KR100755153B1 (ko)	2007-09-04
US6753335B2 (en)	2004-06-22
BR0109817A (pt)	2003-01-21
ATE289603T1 (de)	2005-03-15

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