NO322460B1 - Heteropolysykliske forbindelser og deres anvendelse som metabotropiske glutamatreseptorantagonister - Google Patents

Heteropolysykliske forbindelser og deres anvendelse som metabotropiske glutamatreseptorantagonister Download PDF

Info

Publication number: NO322460B1
Authority: NO; Norway
Prior art keywords: pyridyl; oxazole; oxadiazole; cyanophenyl; chloro
Prior art date: 1999-08-19

Application number

NO20020823A

Other languages

English (en)

Norwegian (no)

Other versions

NO20020823D0 (no

NO20020823L (no

Inventor

Bradford C Van Wagenen

Daryl L Smith

Susan M Sheehan

Donald A Mcleod

Thomas M Stormann

Scott T Moe

Abdelmalik Slassi

Methvin Benjamin Isaac

Original Assignee

Nps Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-19

Filing date

2002-02-19

Publication date

2006-10-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22530400&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO322460(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-02-19 Application filed by Nps Pharma Inc filed Critical Nps Pharma Inc

2002-02-19 Publication of NO20020823D0 publication Critical patent/NO20020823D0/no

2002-04-17 Publication of NO20020823L publication Critical patent/NO20020823L/no

2006-10-09 Publication of NO322460B1 publication Critical patent/NO322460B1/no

Links

102000016193 Metabotropic glutamate receptors Human genes 0.000 title claims abstract description 56
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Classifications

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Urology & Nephrology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)

NO20020823A 1999-08-19 2002-02-19 Heteropolysykliske forbindelser og deres anvendelse som metabotropiske glutamatreseptorantagonister NO322460B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14946499P	1999-08-19	1999-08-19
PCT/US2000/022618 WO2001012627A1 (en)	1999-08-19	2000-08-18	Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists

Publications (3)

Publication Number	Publication Date
NO20020823D0 NO20020823D0 (no)	2002-02-19
NO20020823L NO20020823L (no)	2002-04-17
NO322460B1 true NO322460B1 (no)	2006-10-09

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NO20020823A NO322460B1 (no)	1999-08-19	2002-02-19	Heteropolysykliske forbindelser og deres anvendelse som metabotropiske glutamatreseptorantagonister

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EP (1)	EP1210344B1 (bg)
JP (2)	JP3790472B2 (bg)
KR (1)	KR100875222B1 (bg)
CN (1)	CN1313465C (bg)
AT (1)	ATE307129T1 (bg)
AU (1)	AU780191B2 (bg)
BG (1)	BG65586B1 (bg)
BR (1)	BR0013427A (bg)
CA (1)	CA2381975A1 (bg)
CY (1)	CY1105253T1 (bg)
CZ (1)	CZ2002599A3 (bg)
DE (1)	DE60023318T2 (bg)
DK (1)	DK1210344T3 (bg)
EE (1)	EE200200079A (bg)
ES (1)	ES2250177T3 (bg)
HK (1)	HK1047929A1 (bg)
HU (1)	HUP0202757A3 (bg)
IL (2)	IL148157A0 (bg)
IS (1)	IS6275A (bg)
MX (1)	MXPA02001764A (bg)
NO (1)	NO322460B1 (bg)
NZ (1)	NZ517221A (bg)
PL (1)	PL353825A1 (bg)
RU (1)	RU2296127C9 (bg)
SK (1)	SK2512002A3 (bg)
UA (1)	UA75871C2 (bg)
WO (1)	WO2001012627A1 (bg)
ZA (1)	ZA200201358B (bg)

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CN1853630A (zh) *	2001-02-21	2006-11-01	Nps制药公司	杂多环化合物及其在亲代谢的谷氨酸受体拮抗剂中的应用
ATE339968T1 (de)	2001-04-02	2006-10-15	Univ Brown Res Found	Verwendung von mglur5 antagonists zur herstellung von medikamenten zur behandlung von empfindlichen x syndrome, autismus und geistiger zurückgebliebenheit
US6916821B2 (en)	2001-04-02	2005-07-12	Brown University	Methods of treating disorders with Group I mGluR antagonists
WO2003051315A2 (en) *	2001-12-18	2003-06-26	Merck & Co., Inc.	Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
WO2003051833A2 (en) *	2001-12-18	2003-06-26	Merck & Co., Inc.	Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
AU2002360621B2 (en) *	2001-12-19	2007-01-25	Merck & Co., Inc.	heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5
ATE486600T1 (de) *	2002-03-12	2010-11-15	Merck Sharp & Dohme	Di-aryl-substituierte tetrazol-modulatoren des metabotropen glutamat-rezeptors-5
US7964609B2 (en)	2002-06-20	2011-06-21	Astrazeneca Ab	Use of mGluR5 antagonists for the treatment of gerd
SE0201943D0 (sv) *	2002-06-20	2002-06-20	Astrazeneca Ab	New use
CA2495179A1 (en) *	2002-08-09	2004-02-19	Astrazeneca Ab	Compounds having an activity at metabotropic glutamate receptors
PL375256A1 (en)	2002-08-09	2005-11-28	Astra Zeneca Ab	1,2,4-oxadiazoles as modulators of metabotropic glutamate receptor-5
US20040132726A1 (en) *	2002-08-09	2004-07-08	Astrazeneca Ab And Nps Pharmaceuticals, Inc.	New compounds
GB0303503D0 (en) *	2003-02-14	2003-03-19	Novartis Ag	Organic compounds
EP1613617A4 (en) *	2003-04-04	2009-02-18	Merck & Co Inc	METABOTROPIC GLUTAMATE RECEPTOR-5 DIARYLSUBSTITUTED TRIAZOLE MODULATORS
WO2004103279A2 (en) *	2003-05-15	2004-12-02	Merck & Co., Inc.	3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists
WO2005060961A2 (en) *	2003-12-18	2005-07-07	Astrazeneca Ab	Treatment of transient lower esophageal sphincter relaxations (tlesrs) and gastro-esophageal reflux disease (gerd)
US8207147B2 (en)	2003-12-24	2012-06-26	Prosidion Limited	Heterocyclic derivatives as GPCR receptor agonists
US20070185095A1 (en) *	2004-02-18	2007-08-09	Astrazeneca Ab	Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
US7585881B2 (en) *	2004-02-18	2009-09-08	Astrazeneca Ab	Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
TW200538108A (en)	2004-02-19	2005-12-01	Astrazeneca Ab	Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1764362A4 (en) *	2004-06-30	2009-12-30	Banyu Pharma Co Ltd	Biaryl derivatives
KR100621192B1 (ko) *	2004-10-13	2006-09-19	한국화학연구원	무스카린 수용체 작용물질로서 작용하는1,2,3,4-테트라하이드로피리미디닐-1,2,4-옥사다이아졸유도체와 이의 제조방법
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2000
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Publication number	Publication date
IL148157A (en)	2007-07-04
ES2250177T3 (es)	2006-04-16
ATE307129T1 (de)	2005-11-15
JP2006143746A (ja)	2006-06-08
UA75871C2 (en)	2006-06-15
CY1105253T1 (el)	2010-03-03
DE60023318D1 (de)	2006-03-02
AU6782400A (en)	2001-03-13
DK1210344T3 (da)	2006-03-06
EE200200079A (et)	2003-06-16
WO2001012627A1 (en)	2001-02-22
NO20020823D0 (no)	2002-02-19
HUP0202757A2 (hu)	2002-12-28
RU2296127C2 (ru)	2007-03-27
CN1313465C (zh)	2007-05-02
EP1210344A1 (en)	2002-06-05
AU780191B2 (en)	2005-03-03
JP2003507378A (ja)	2003-02-25
HK1047929A1 (en)	2003-03-14
CN1379775A (zh)	2002-11-13
ZA200201358B (en)	2003-07-30
MXPA02001764A (es)	2004-03-19
BG106493A (bg)	2003-01-31
BR0013427A (pt)	2002-07-30
CZ2002599A3 (cs)	2002-06-12
JP3790472B2 (ja)	2006-06-28
RU2296127C9 (ru)	2007-08-27
KR20020038731A (ko)	2002-05-23
SK2512002A3 (en)	2002-07-02
DE60023318T2 (de)	2006-07-20
BG65586B1 (bg)	2009-01-30
HUP0202757A3 (en)	2006-03-28
KR100875222B1 (ko)	2008-12-19
PL353825A1 (en)	2003-12-01
NZ517221A (en)	2004-01-30
IL148157A0 (en)	2002-09-12
IS6275A (is)	2002-02-18
CA2381975A1 (en)	2001-02-22
EP1210344B1 (en)	2005-10-19
NO20020823L (no)	2002-04-17

Publication	Publication Date	Title
NO322460B1 (no)	2006-10-09	Heteropolysykliske forbindelser og deres anvendelse som metabotropiske glutamatreseptorantagonister
JP4519404B2 (ja)	2010-08-04	ヘテロ多環式化合物およびその代謝型グルタミン酸受容体アンタゴニストとしての使用
US6660753B2 (en)	2003-12-09	Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
TWI477499B (zh)	2015-03-21	代謝型麩胺酸受體異唑配位體及其作為增效劑之用途－２８６
US20070078121A1 (en)	2007-04-05	Enzyme modulators and treatments
AU2002306517A1 (en)	2003-03-06	Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
CA3175429A1 (en)	2021-09-16	Gpr52 modulator compounds
IE61045B1 (en)	1994-09-07	4-aryl-5-carbamoyl-1, 4-dihydropyridines
US20060189661A1 (en)	2006-08-24	Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1582519A2 (en)	2005-10-05	Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
JP3082243B2 (ja)	2000-08-28	血管拡張活性を有するニトロ化合物

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