NO317103B1 - Nye substituerte pyridino arylpiperaziner er anvendelige ved behandling av benign prostata hyperplasi - Google Patents

Nye substituerte pyridino arylpiperaziner er anvendelige ved behandling av benign prostata hyperplasi Download PDF

Info

Publication number: NO317103B1
Authority: NO; Norway
Prior art keywords: hydrogen; mmol; compound; alkyl; mixture
Prior art date: 1998-02-20

Application number

NO20004141A

Other languages

English (en)

Norwegian (no)

Other versions

NO20004141D0 (no

NO20004141L (no

Inventor

William V Murray

Catherine P Prouty

Gee-Hong Kuo

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-20

Filing date

2000-08-18

Publication date

2004-08-09

2000-08-18 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2000-08-18 Publication of NO20004141D0 publication Critical patent/NO20004141D0/no

2000-10-19 Publication of NO20004141L publication Critical patent/NO20004141L/no

2004-08-09 Publication of NO317103B1 publication Critical patent/NO317103B1/no

Links

206010004446 Benign prostatic hyperplasia Diseases 0.000 title abstract description 20
238000011282 treatment Methods 0.000 title abstract description 17
150000001875 compounds Chemical class 0.000 claims abstract description 76
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
239000000203 mixture Substances 0.000 claims description 50
229910052739 hydrogen Inorganic materials 0.000 claims description 31
239000001257 hydrogen Substances 0.000 claims description 30
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 22
125000000217 alkyl group Chemical group 0.000 claims description 19
150000002431 hydrogen Chemical class 0.000 claims description 16
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 11
229910052760 oxygen Inorganic materials 0.000 claims description 11
239000001301 oxygen Substances 0.000 claims description 11
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 6
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 6
229910052736 halogen Inorganic materials 0.000 claims description 6
150000002367 halogens Chemical class 0.000 claims description 6
229910052717 sulfur Inorganic materials 0.000 claims description 5
239000011593 sulfur Chemical group 0.000 claims description 5
229910052799 carbon Inorganic materials 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
125000003545 alkoxy group Chemical group 0.000 claims description 3
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
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238000000034 method Methods 0.000 abstract description 13
102000005962 receptors Human genes 0.000 abstract description 11
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HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 5
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CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 4
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QJULELIONYLITF-UHFFFAOYSA-N 1-(2-propan-2-yloxyphenyl)piperazine Chemical compound CC(C)OC1=CC=CC=C1N1CCNCC1 QJULELIONYLITF-UHFFFAOYSA-N 0.000 description 3
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230000001105 regulatory effect Effects 0.000 description 1
238000002271 resection Methods 0.000 description 1
238000012216 screening Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
230000035939 shock Effects 0.000 description 1
238000002741 site-directed mutagenesis Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000001890 transfection Methods 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
208000019206 urinary tract infection Diseases 0.000 description 1
238000012795 verification Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20004141A 1998-02-20 2000-08-18 Nye substituerte pyridino arylpiperaziner er anvendelige ved behandling av benign prostata hyperplasi NO317103B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7532198P	1998-02-20	1998-02-20
PCT/US1999/003608 WO1999042448A1 (en)	1998-02-20	1999-02-19	Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia

Publications (3)

Publication Number	Publication Date
NO20004141D0 NO20004141D0 (no)	2000-08-18
NO20004141L NO20004141L (no)	2000-10-19
NO317103B1 true NO317103B1 (no)	2004-08-09

Family

ID=22124955

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20004141A NO317103B1 (no)	1998-02-20	2000-08-18	Nye substituerte pyridino arylpiperaziner er anvendelige ved behandling av benign prostata hyperplasi

Country Status (24)

Country	Link
US (1)	US6218396B1 (pt)
EP (1)	EP1054868B1 (pt)
JP (1)	JP2002503724A (pt)
KR (1)	KR100591028B1 (pt)
CN (1)	CN1121390C (pt)
AR (1)	AR014626A1 (pt)
AT (1)	ATE250580T1 (pt)
AU (1)	AU766398B2 (pt)
BR (1)	BR9909647A (pt)
CZ (1)	CZ294136B6 (pt)
DE (1)	DE69911582T2 (pt)
DK (1)	DK1054868T3 (pt)
ES (1)	ES2209468T3 (pt)
HK (1)	HK1030776A1 (pt)
HU (1)	HUP0100781A3 (pt)
IL (2)	IL137954A0 (pt)
NO (1)	NO317103B1 (pt)
NZ (1)	NZ506462A (pt)
PL (1)	PL342339A1 (pt)
PT (1)	PT1054868E (pt)
TR (1)	TR200003220T2 (pt)
TW (1)	TW565555B (pt)
WO (1)	WO1999042448A1 (pt)
ZA (1)	ZA991315B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2206928T3 (es) *	1997-05-12	2004-05-16	Ortho-Mcneil Pharmaceutical, Inc.	Piperacinas sustituidas con arilo utiles en el tratamiento de la hiperplasia benigna de prostata.
HUP0302893A3 (en)	2000-08-08	2006-04-28	Ortho Mcneil Pharm Inc	Non-imidazole aryloxypiperidines and pharmaceutical compositions containing them and their use
AU2002367425B2 (en)	2001-12-28	2006-03-09	Takeda Pharmaceutical Company Limited	Preventives/remedies for urinary disturbance
US8470859B2 (en)	2006-10-23	2013-06-25	Takeda Pharmaceutical Company Limited	Iminopyridine derivative and use thereof
UY31781A (es) *	2008-04-23	2009-12-14	Takeda Pharmaceutical	Derivados de iminopiridina y su uso
US8481569B2 (en)	2008-04-23	2013-07-09	Takeda Pharmaceutical Company Limited	Iminopyridine derivatives and use thereof
US20110039892A1 (en) *	2008-04-23	2011-02-17	Takeda Pharmaceutical Company Limited	Iminopyridine derivative and use thereof
CN103980195A (zh) *	2014-04-28	2014-08-13	广州医科大学	酰胺类苯基哌嗪衍生物及其盐与在制备治疗良性前列腺增生症药物中的应用
CN108530391B (zh) *	2018-05-17	2022-05-17	袁牧	一种酰胺类芳基哌嗪衍生物及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2027898A6 (es) *	1991-01-24	1992-06-16	Espanola Prod Quimicos	Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina.
US5403847A (en)	1992-11-13	1995-04-04	Synaptic Pharmaceutical Corporation	Use of α1C specific compounds to treat benign prostatic hyperlasia
IT1266582B1 (it) *	1993-07-30	1997-01-09	Recordati Chem Pharm	Derivati (di)azacicloesanici e diazacicloeptanici
DE4425146A1 (de) *	1994-07-15	1996-01-18	Basf Ag	Verwendung heterocyclischer Verbindungen
US5688795A (en) *	1994-11-08	1997-11-18	Syntex (U.S.A.) Inc.	3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
WO1999003833A1 (en) *	1997-07-15	1999-01-28	Sankyo Company, Limited	Piperazine derivatives

1999
- 1999-02-18 US US09/252,313 patent/US6218396B1/en not_active Expired - Lifetime
- 1999-02-18 ZA ZA9901315A patent/ZA991315B/xx unknown
- 1999-02-19 PL PL99342339A patent/PL342339A1/xx unknown
- 1999-02-19 CZ CZ20003044A patent/CZ294136B6/cs not_active IP Right Cessation
- 1999-02-19 DK DK99934281T patent/DK1054868T3/da active
- 1999-02-19 KR KR1020007009156A patent/KR100591028B1/ko not_active IP Right Cessation
- 1999-02-19 WO PCT/US1999/003608 patent/WO1999042448A1/en active IP Right Grant
- 1999-02-19 PT PT99934281T patent/PT1054868E/pt unknown
- 1999-02-19 AU AU33025/99A patent/AU766398B2/en not_active Ceased
- 1999-02-19 HU HU0100781A patent/HUP0100781A3/hu unknown
- 1999-02-19 EP EP99934281A patent/EP1054868B1/en not_active Expired - Lifetime
- 1999-02-19 BR BR9909647-1A patent/BR9909647A/pt not_active Application Discontinuation
- 1999-02-19 TR TR2000/03220T patent/TR200003220T2/xx unknown
- 1999-02-19 ES ES99934281T patent/ES2209468T3/es not_active Expired - Lifetime
- 1999-02-19 JP JP2000532400A patent/JP2002503724A/ja active Pending
- 1999-02-19 IL IL13795499A patent/IL137954A0/xx active IP Right Grant
- 1999-02-19 DE DE69911582T patent/DE69911582T2/de not_active Expired - Fee Related
- 1999-02-19 NZ NZ506462A patent/NZ506462A/en unknown
- 1999-02-19 CN CN99803027A patent/CN1121390C/zh not_active Expired - Fee Related
- 1999-02-19 AT AT99934281T patent/ATE250580T1/de not_active IP Right Cessation
- 1999-02-23 AR ARP990100675A patent/AR014626A1/es active IP Right Grant
- 1999-04-02 TW TW088102511A patent/TW565555B/zh not_active IP Right Cessation
2000
- 2000-08-18 IL IL137954A patent/IL137954A/en not_active IP Right Cessation
- 2000-08-18 NO NO20004141A patent/NO317103B1/no not_active IP Right Cessation
2001
- 2001-03-08 HK HK01101679A patent/HK1030776A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE250580T1 (de)	2003-10-15
ES2209468T3 (es)	2004-06-16
HK1030776A1 (en)	2001-05-18
AU3302599A (en)	1999-09-06
NZ506462A (en)	2003-07-25
US6218396B1 (en)	2001-04-17
EP1054868A1 (en)	2000-11-29
IL137954A (en)	2007-06-03
AR014626A1 (es)	2001-03-28
PT1054868E (pt)	2004-01-30
CN1291188A (zh)	2001-04-11
PL342339A1 (en)	2001-06-04
WO1999042448A1 (en)	1999-08-26
TW565555B (en)	2003-12-11
CN1121390C (zh)	2003-09-17
HUP0100781A2 (hu)	2001-08-28
KR100591028B1 (ko)	2006-06-22
TR200003220T2 (tr)	2001-04-20
EP1054868B1 (en)	2003-09-24
DE69911582T2 (de)	2005-09-15
DK1054868T3 (da)	2003-12-22
DE69911582D1 (de)	2003-10-30
AU766398B2 (en)	2003-10-16
BR9909647A (pt)	2000-11-21
NO20004141D0 (no)	2000-08-18
NO20004141L (no)	2000-10-19
KR20010041115A (ko)	2001-05-15
CZ20003044A3 (cs)	2001-04-11
ZA991315B (en)	2000-11-20
CZ294136B6 (cs)	2004-10-13
HUP0100781A3 (en)	2002-12-28
IL137954A0 (en)	2001-10-31
JP2002503724A (ja)	2002-02-05

Publication	Publication Date	Title
NO317103B1 (no)	2004-08-09	Nye substituerte pyridino arylpiperaziner er anvendelige ved behandling av benign prostata hyperplasi
EP1025085B1 (en)	2003-03-26	Heterocycles useful in the treatment of benign prostatic hyperplasia and intermediates thereof
AP1349A (en)	2004-12-17	Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia.
NO317104B1 (no)	2004-08-09	Ftalimidoarylpiperaziner som <alfa> 1A reseptorantagonister anvendelige ved behandling av benign prostata hyperplasi, og farmasoytisk sammensetning innbefattende samme
US6063785A (en)	2000-05-16	Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia
US6362338B1 (en)	2002-03-26	Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia
MXPA00008220A (en)	2001-12-04	Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia
EP1346983A2 (en)	2003-09-24	Phthalimido arylpiperazines as alpha 1A receptor antagonists useful in the treatment of benign prostatic hyperplasia
MXPA00008219A (en)	2001-12-04	Phtalimido arylpiperazines as alpha 1a receptor antagonists useful in the treatment of benign prostatic hyperplasia
CZ20003045A3 (cs)	2001-03-14	Ftalimidoarylpiperaziny jako antagonisty alfa IA receptorů použitelné při léčení benigního zbytnění prostaty
EP1273572B9 (en)	2005-03-02	Thiophene substituted piperazines useful in the treatment of benign prostatic hyperplasia

Legal Events

Date	Code	Title	Description
2010-09-27	MM1K	Lapsed by not paying the annual fees