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BR9909647A - Compostos de piridino arilpiperazinas substituìdos, de utilidade no tratamento de hiperplasia prostática benigna - Google Patents

Compostos de piridino arilpiperazinas substituìdos, de utilidade no tratamento de hiperplasia prostática benigna

Info

Publication number
BR9909647A
BR9909647A BR9909647-1A BR9909647A BR9909647A BR 9909647 A BR9909647 A BR 9909647A BR 9909647 A BR9909647 A BR 9909647A BR 9909647 A BR9909647 A BR 9909647A
Authority
BR
Brazil
Prior art keywords
treatment
benign prostatic
prostatic hyperplasia
compounds
substituted
Prior art date
Application number
BR9909647-1A
Other languages
English (en)
Inventor
Gee-Hong Kuo
William V Murray
Catherine P Prouty
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR9909647A publication Critical patent/BR9909647A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS DE PIRIDINO ARILPIPERAZINAS SUBSTITUìDOS, DE UTILIDADE NO TRATAMENTO DE HIPERPLASIA PROSTáTICA BENIGNA"<D>. A presente invenção se refere a uma série de piperazinas heterocíclicas substituídas de Fórmula I A métodos de tratamento, a composições farmacêuticas que contenham os ditos compostos e aos intermediários usados na sua fabricação. Os compostos da invenção seletivamente inibem a ligação ao receptor adrenérgico <244>-1~ a~, um receptor que foi comprometido na hiperplasia prostática benigna. Sendo assim, os compostos da presente invenção são potencialmente úteis no tratamento dessa doença.
BR9909647-1A 1998-02-20 1999-02-19 Compostos de piridino arilpiperazinas substituìdos, de utilidade no tratamento de hiperplasia prostática benigna BR9909647A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7532198P 1998-02-20 1998-02-20
PCT/US1999/003608 WO1999042448A1 (en) 1998-02-20 1999-02-19 Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia

Publications (1)

Publication Number Publication Date
BR9909647A true BR9909647A (pt) 2000-11-21

Family

ID=22124955

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909647-1A BR9909647A (pt) 1998-02-20 1999-02-19 Compostos de piridino arilpiperazinas substituìdos, de utilidade no tratamento de hiperplasia prostática benigna

Country Status (24)

Country Link
US (1) US6218396B1 (pt)
EP (1) EP1054868B1 (pt)
JP (1) JP2002503724A (pt)
KR (1) KR100591028B1 (pt)
CN (1) CN1121390C (pt)
AR (1) AR014626A1 (pt)
AT (1) ATE250580T1 (pt)
AU (1) AU766398B2 (pt)
BR (1) BR9909647A (pt)
CZ (1) CZ294136B6 (pt)
DE (1) DE69911582T2 (pt)
DK (1) DK1054868T3 (pt)
ES (1) ES2209468T3 (pt)
HK (1) HK1030776A1 (pt)
HU (1) HUP0100781A3 (pt)
IL (2) IL137954A0 (pt)
NO (1) NO317103B1 (pt)
NZ (1) NZ506462A (pt)
PL (1) PL342339A1 (pt)
PT (1) PT1054868E (pt)
TR (1) TR200003220T2 (pt)
TW (1) TW565555B (pt)
WO (1) WO1999042448A1 (pt)
ZA (1) ZA991315B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2206928T3 (es) * 1997-05-12 2004-05-16 Ortho-Mcneil Pharmaceutical, Inc. Piperacinas sustituidas con arilo utiles en el tratamiento de la hiperplasia benigna de prostata.
HUP0302893A3 (en) 2000-08-08 2006-04-28 Ortho Mcneil Pharm Inc Non-imidazole aryloxypiperidines and pharmaceutical compositions containing them and their use
AU2002367425B2 (en) 2001-12-28 2006-03-09 Takeda Pharmaceutical Company Limited Preventives/remedies for urinary disturbance
US8470859B2 (en) 2006-10-23 2013-06-25 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
UY31781A (es) * 2008-04-23 2009-12-14 Takeda Pharmaceutical Derivados de iminopiridina y su uso
US8481569B2 (en) 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
US20110039892A1 (en) * 2008-04-23 2011-02-17 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
CN103980195A (zh) * 2014-04-28 2014-08-13 广州医科大学 酰胺类苯基哌嗪衍生物及其盐与在制备治疗良性前列腺增生症药物中的应用
CN108530391B (zh) * 2018-05-17 2022-05-17 袁牧 一种酰胺类芳基哌嗪衍生物及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2027898A6 (es) * 1991-01-24 1992-06-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina.
US5403847A (en) 1992-11-13 1995-04-04 Synaptic Pharmaceutical Corporation Use of α1C specific compounds to treat benign prostatic hyperlasia
IT1266582B1 (it) * 1993-07-30 1997-01-09 Recordati Chem Pharm Derivati (di)azacicloesanici e diazacicloeptanici
DE4425146A1 (de) * 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
US5688795A (en) * 1994-11-08 1997-11-18 Syntex (U.S.A.) Inc. 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
WO1999003833A1 (en) * 1997-07-15 1999-01-28 Sankyo Company, Limited Piperazine derivatives

Also Published As

Publication number Publication date
ATE250580T1 (de) 2003-10-15
ES2209468T3 (es) 2004-06-16
HK1030776A1 (en) 2001-05-18
AU3302599A (en) 1999-09-06
NO317103B1 (no) 2004-08-09
NZ506462A (en) 2003-07-25
US6218396B1 (en) 2001-04-17
EP1054868A1 (en) 2000-11-29
IL137954A (en) 2007-06-03
AR014626A1 (es) 2001-03-28
PT1054868E (pt) 2004-01-30
CN1291188A (zh) 2001-04-11
PL342339A1 (en) 2001-06-04
WO1999042448A1 (en) 1999-08-26
TW565555B (en) 2003-12-11
CN1121390C (zh) 2003-09-17
HUP0100781A2 (hu) 2001-08-28
KR100591028B1 (ko) 2006-06-22
TR200003220T2 (tr) 2001-04-20
EP1054868B1 (en) 2003-09-24
DE69911582T2 (de) 2005-09-15
DK1054868T3 (da) 2003-12-22
DE69911582D1 (de) 2003-10-30
AU766398B2 (en) 2003-10-16
NO20004141D0 (no) 2000-08-18
NO20004141L (no) 2000-10-19
KR20010041115A (ko) 2001-05-15
CZ20003044A3 (cs) 2001-04-11
ZA991315B (en) 2000-11-20
CZ294136B6 (cs) 2004-10-13
HUP0100781A3 (en) 2002-12-28
IL137954A0 (en) 2001-10-31
JP2002503724A (ja) 2002-02-05

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AOS REQUISITOS DOS ARTIGOS 8 E 13 DA LPI.