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NO314090B1 - HIV-proteingenekspresjonsenhet, DNA-vektor som omfatter den, Drosophila-celle transfektert med vektoren, HIV gp 120 og HIV gp 160-proteinprodusert i en kultur av nevnte celler, vaksine og diagnostisk agens som omfatterproteinet, samtfremgangs - Google Patents

HIV-proteingenekspresjonsenhet, DNA-vektor som omfatter den, Drosophila-celle transfektert med vektoren, HIV gp 120 og HIV gp 160-proteinprodusert i en kultur av nevnte celler, vaksine og diagnostisk agens som omfatterproteinet, samtfremgangs Download PDF

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Publication number
NO314090B1
NO314090B1 NO19912099A NO912099A NO314090B1 NO 314090 B1 NO314090 B1 NO 314090B1 NO 19912099 A NO19912099 A NO 19912099A NO 912099 A NO912099 A NO 912099A NO 314090 B1 NO314090 B1 NO 314090B1
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NO
Norway
Prior art keywords
protein
hiv
cells
vector
gene expression
Prior art date
Application number
NO19912099A
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English (en)
Norwegian (no)
Other versions
NO912099D0 (no
NO912099L (no
Inventor
Hanne Ranch Johansen
Martin Rosenberg
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO912099D0 publication Critical patent/NO912099D0/no
Publication of NO912099L publication Critical patent/NO912099L/no
Publication of NO314090B1 publication Critical patent/NO314090B1/no

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036Retroviridae, e.g. leukemia viruses
    • C07K16/1045Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • C12N9/6459Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21069Protein C activated (3.4.21.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/001Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/75Vector systems having a special element relevant for transcription from invertebrates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO19912099A 1988-12-01 1991-05-31 HIV-proteingenekspresjonsenhet, DNA-vektor som omfatter den, Drosophila-celle transfektert med vektoren, HIV gp 120 og HIV gp 160-proteinprodusert i en kultur av nevnte celler, vaksine og diagnostisk agens som omfatterproteinet, samtfremgangs NO314090B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27838688A 1988-12-01 1988-12-01
PCT/US1989/005155 WO1990006358A1 (fr) 1988-12-01 1989-11-29 EXPRESSION DE PROTEINES HIV DANS DES CELLULES DE $i(DROSOPHILA)

Publications (3)

Publication Number Publication Date
NO912099D0 NO912099D0 (no) 1991-05-31
NO912099L NO912099L (no) 1991-07-31
NO314090B1 true NO314090B1 (no) 2003-01-27

Family

ID=23064787

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19912099A NO314090B1 (no) 1988-12-01 1991-05-31 HIV-proteingenekspresjonsenhet, DNA-vektor som omfatter den, Drosophila-celle transfektert med vektoren, HIV gp 120 og HIV gp 160-proteinprodusert i en kultur av nevnte celler, vaksine og diagnostisk agens som omfatterproteinet, samtfremgangs

Country Status (12)

Country Link
EP (1) EP0446272A4 (fr)
JP (1) JP3085704B2 (fr)
KR (1) KR0152525B1 (fr)
AU (1) AU630649B2 (fr)
CA (1) CA2003794C (fr)
DK (1) DK175461B1 (fr)
FI (1) FI113475B (fr)
IL (1) IL92470A (fr)
NO (1) NO314090B1 (fr)
PT (1) PT92477A (fr)
WO (1) WO1990006358A1 (fr)
ZA (1) ZA899150B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2841376C (fr) * 2011-07-05 2023-02-28 Duke University Immunogenes gp120 a extremite n-terminale deletee
WO2013052095A2 (fr) 2011-10-03 2013-04-11 Duke University Vaccin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272858A3 (fr) * 1986-12-15 1989-07-12 Repligen Corporation Protéines recombinantes d'enveloppe du HIV, produites dans des cellules d'insectes
CA1341345C (fr) * 1987-05-08 2002-03-05 Hanne Ranch Johansen Expression de genes etrangers dans des cellules de drosophile
AP129A (en) * 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
KR910700352A (ko) * 1988-12-21 1991-03-14 스미스클라인 바이올로지칼즈(s.a.) 곤충 세포내에서 플라스모듐 서컴스포로 조이트 단백질의 발현

Also Published As

Publication number Publication date
EP0446272A1 (fr) 1991-09-18
AU4755290A (en) 1990-06-26
CA2003794A1 (fr) 1990-06-01
WO1990006358A1 (fr) 1990-06-14
PT92477A (pt) 1990-06-29
NO912099D0 (no) 1991-05-31
AU630649B2 (en) 1992-11-05
EP0446272A4 (en) 1993-01-07
CA2003794C (fr) 2000-02-08
KR910700344A (ko) 1991-03-14
DK175461B1 (da) 2004-11-01
FI113475B (fi) 2004-04-30
IL92470A0 (en) 1990-08-31
IL92470A (en) 1997-01-10
KR0152525B1 (ko) 1998-10-01
NO912099L (no) 1991-07-31
JPH04501954A (ja) 1992-04-09
DK104991A (da) 1991-05-31
DK104991D0 (da) 1991-05-31
JP3085704B2 (ja) 2000-09-11
FI912635A0 (fi) 1991-05-31
ZA899150B (en) 1991-04-24

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