NO303801B1 - Reagens til bestemmelse av faktor VIII aktivitet - Google Patents

Reagens til bestemmelse av faktor VIII aktivitet Download PDF

Info

Publication number: NO303801B1
Authority: NO; Norway
Prior art keywords: factor; reagent; factor viii; factors; thrombin
Prior art date: 1991-01-25

Application number

NO920330A

Other languages

English (en)

Norwegian (no)

Other versions

NO920330L (no

NO920330D0 (no

Inventor

Hartmut Lang

Berta Moritz

Manfred Oberreither

Olga Lukas

Original Assignee

Immuno Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-25

Filing date

1992-01-24

Publication date

1998-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3483265&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO303801(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-01-24 Application filed by Immuno Ag filed Critical Immuno Ag

1992-01-24 Publication of NO920330D0 publication Critical patent/NO920330D0/no

1992-07-27 Publication of NO920330L publication Critical patent/NO920330L/no

1998-08-31 Publication of NO303801B1 publication Critical patent/NO303801B1/no

Links

239000003153 chemical reaction reagent Substances 0.000 title claims description 55
108010054218 Factor VIII Proteins 0.000 title claims description 32
102000001690 Factor VIII Human genes 0.000 title claims description 32
229960000301 factor viii Drugs 0.000 title claims description 32
230000000694 effects Effects 0.000 title claims description 11
108010014173 Factor X Proteins 0.000 claims description 17
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 14
229910001424 calcium ion Inorganic materials 0.000 claims description 14
108090000190 Thrombin Proteins 0.000 claims description 12
150000003904 phospholipids Chemical class 0.000 claims description 12
229960004072 thrombin Drugs 0.000 claims description 12
108010074860 Factor Xa Proteins 0.000 claims description 10
108010048049 Factor IXa Proteins 0.000 claims description 8
238000002360 preparation method Methods 0.000 claims description 6
102000004169 proteins and genes Human genes 0.000 claims description 5
108090000623 proteins and genes Proteins 0.000 claims description 5
101800004937 Protein C Proteins 0.000 claims description 4
102000017975 Protein C Human genes 0.000 claims description 4
101800001700 Saposin-D Proteins 0.000 claims description 4
208000015181 infectious disease Diseases 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
229960000856 protein c Drugs 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 3
102000029301 Protein S Human genes 0.000 claims description 2
108010066124 Protein S Proteins 0.000 claims description 2
230000002779 inactivation Effects 0.000 claims description 2
230000002401 inhibitory effect Effects 0.000 claims description 2
239000000523 sample Substances 0.000 description 15
239000000203 mixture Substances 0.000 description 13
239000000243 solution Substances 0.000 description 13
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
238000000034 method Methods 0.000 description 12
241000283690 Bos taurus Species 0.000 description 7
239000000872 buffer Substances 0.000 description 7
238000011534 incubation Methods 0.000 description 7
239000011780 sodium chloride Substances 0.000 description 6
238000012360 testing method Methods 0.000 description 5
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
239000003593 chromogenic compound Substances 0.000 description 4
210000002966 serum Anatomy 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000000758 substrate Substances 0.000 description 4
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
230000004913 activation Effects 0.000 description 3
230000008033 biological extinction Effects 0.000 description 3
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
239000012488 sample solution Substances 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
102000015081 Blood Coagulation Factors Human genes 0.000 description 2
108010039209 Blood Coagulation Factors Proteins 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
229940124135 Factor VIII inhibitor Drugs 0.000 description 2
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
102000007625 Hirudins Human genes 0.000 description 2
108010007267 Hirudins Proteins 0.000 description 2
229920001213 Polysorbate 20 Polymers 0.000 description 2
239000007983 Tris buffer Substances 0.000 description 2
239000003114 blood coagulation factor Substances 0.000 description 2
239000011575 calcium Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000001110 calcium chloride Substances 0.000 description 2
229910001628 calcium chloride Inorganic materials 0.000 description 2
235000011148 calcium chloride Nutrition 0.000 description 2
230000009918 complex formation Effects 0.000 description 2
239000012141 concentrate Substances 0.000 description 2
238000000502 dialysis Methods 0.000 description 2
229960002897 heparin Drugs 0.000 description 2
229920000669 heparin Polymers 0.000 description 2
229940006607 hirudin Drugs 0.000 description 2
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 description 2
238000005259 measurement Methods 0.000 description 2
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
TYMLOMAKGOJONV-UHFFFAOYSA-N 4-nitroaniline Chemical compound NC1=CC=C([N+]([O-])=O)C=C1 TYMLOMAKGOJONV-UHFFFAOYSA-N 0.000 description 1
241001146702 Candidatus Entotheonella factor Species 0.000 description 1
102100023804 Coagulation factor VII Human genes 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
108010023321 Factor VII Proteins 0.000 description 1
108010061932 Factor VIIIa Proteins 0.000 description 1
229920000209 Hexadimethrine bromide Polymers 0.000 description 1
229940096437 Protein S Drugs 0.000 description 1
108010094028 Prothrombin Proteins 0.000 description 1
102100027378 Prothrombin Human genes 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
239000012507 Sephadex™ Substances 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
108010023197 Streptokinase Proteins 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
238000012742 biochemical analysis Methods 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
230000015271 coagulation Effects 0.000 description 1
238000005345 coagulation Methods 0.000 description 1
230000000536 complexating effect Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
229960000633 dextran sulfate Drugs 0.000 description 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
229940012413 factor vii Drugs 0.000 description 1
230000023597 hemostasis Effects 0.000 description 1
238000011835 investigation Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
238000005375 photometry Methods 0.000 description 1
229940039716 prothrombin Drugs 0.000 description 1
238000003908 quality control method Methods 0.000 description 1
239000011535 reaction buffer Substances 0.000 description 1
239000013049 sediment Substances 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96444—Factor X (3.4.21.6)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/9645—Factor IX (3.4.21.22)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
- G01N2405/04—Phospholipids, i.e. phosphoglycerides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Urology & Nephrology (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Cell Biology (AREA)
Biophysics (AREA)
Food Science & Technology (AREA)
General Engineering & Computer Science (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO920330A 1991-01-25 1992-01-24 Reagens til bestemmelse av faktor VIII aktivitet NO303801B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT0016491A AT395597B (de)	1991-01-25	1991-01-25	Reagens zur bestimmung von faktor viii-aktivitaet

Publications (3)

Publication Number	Publication Date
NO920330D0 NO920330D0 (no)	1992-01-24
NO920330L NO920330L (no)	1992-07-27
NO303801B1 true NO303801B1 (no)	1998-08-31

Family

ID=3483265

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO920330A NO303801B1 (no)	1991-01-25	1992-01-24	Reagens til bestemmelse av faktor VIII aktivitet

Country Status (10)

Country	Link
US (1)	US5506112A (ja)
EP (1)	EP0496723B1 (ja)
JP (1)	JPH0879B2 (ja)
AT (2)	AT395597B (ja)
CA (1)	CA2059605A1 (ja)
DE (1)	DE59203705D1 (ja)
DK (1)	DK0496723T3 (ja)
ES (1)	ES2080477T3 (ja)
FI (1)	FI920343A (ja)
NO (1)	NO303801B1 (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6100050A (en) *	1989-08-17	2000-08-08	Dade Behring Ag	Factor VIII:Ca chromogenic assay
AU690535B2 (en) *	1993-01-29	1998-04-30	Bjorn Dahlback	Novel anticoagulant cofactor activity
CA2137041C (en) *	1993-12-03	2003-06-10	Katalin Varadi	Assay for determining sensitivity to activated protein c
DE19616540A1 (de) *	1995-11-10	1997-05-15	Immuno Ag	Verwendung von von Willebrand-Faktor und pharmazeutische Zubereitung
US6379975B1 (en)	1996-11-27	2002-04-30	T.A.C. Thrombosis And Coagulation Aktiebolag	Methods and reagents for determining protein S
DE60011274T2 (de)	1999-09-03	2005-07-07	Roche Diagnostics Corp., Indianapolis	Verfahren, reagenz und messkartusche zur bestimmung der gerinnungszeit
US6448024B1 (en)	2000-10-03	2002-09-10	Roche Diagnostics Corporation	Method, reagent, cartridge, and device for determining fibrinogen
US6855509B2 (en)	2000-12-19	2005-02-15	Instrumentation Laboratory Company	Protein S functional assay and kit therefor
CA2465004A1 (en) *	2003-05-19	2004-11-19	National Institute For Biological Standards And Control	Composition
US9244073B2 (en)	2011-02-25	2016-01-26	Wellstat Diagnostics, Llc	Assays for detecting enzymatic activity
WO2014018777A2 (en)	2012-07-25	2014-01-30	Biogen Idec Ma Inc.	Blood factor monitoring assay and uses thereof
US10114017B2 (en)	2013-11-15	2018-10-30	President And Fellows Of Harvard College	Methods and assays for factor VIII activity

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE448945B (sv) *	1979-12-20	1987-03-30	Blombaeck E G B	Forfarande for rening och /eller koncentrering av faktor viii-komplexet
AT368883B (de) *	1980-07-22	1982-11-25	Immuno Ag	Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen
DE3173208D1 (en) *	1980-10-06	1986-01-23	Edward Shanbrom	Method of reducing undesirable activities of biological and pharmaceutical products
US4657894A (en) *	1983-03-31	1987-04-14	Scripps Clinic & Research Foundation	New factor VIII coagulant polypeptides
US4540573A (en) *	1983-07-14	1985-09-10	New York Blood Center, Inc.	Undenatured virus-free biologically active protein derivatives
DE3407280A1 (de) *	1984-02-28	1985-09-19	Gödecke AG, 1000 Berlin	Testsatz zur bestimmung der aktivierten partiellen thromboplastinzeit (ptt) mit erhoehter heparinempfindlichkeit
AT389815B (de) *	1984-03-09	1990-02-12	Immuno Ag	Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
US4965199A (en) *	1984-04-20	1990-10-23	Genentech, Inc.	Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
DE3516579A1 (de) *	1984-11-19	1986-05-22	Boehringer Mannheim Gmbh, 6800 Mannheim	Gerinnungstest auf teststreifen
US4786726A (en) *	1986-01-06	1988-11-22	Blood Systems, Inc.	Factor IX therapeutic blood product, means and methods of preparing same
DE3625090A1 (de) *	1986-07-24	1988-01-28	Behringwerke Ag	Mittel zur therapie faktor viii-resistenter haemophilie a und verfahren zu seiner herstellung
DE3914869C1 (ja) *	1989-05-05	1990-08-09	Biotest Pharma Gmbh, 6072 Dreieich, De

1991
- 1991-01-25 AT AT0016491A patent/AT395597B/de not_active IP Right Cessation
1992
- 1992-01-10 US US07/819,456 patent/US5506112A/en not_active Expired - Lifetime
- 1992-01-17 DE DE59203705T patent/DE59203705D1/de not_active Expired - Lifetime
- 1992-01-17 ES ES92890015T patent/ES2080477T3/es not_active Expired - Lifetime
- 1992-01-17 AT AT92890015T patent/ATE128240T1/de not_active IP Right Cessation
- 1992-01-17 EP EP92890015A patent/EP0496723B1/de not_active Expired - Lifetime
- 1992-01-17 DK DK92890015.8T patent/DK0496723T3/da not_active Application Discontinuation
- 1992-01-17 CA CA002059605A patent/CA2059605A1/en not_active Abandoned
- 1992-01-24 FI FI920343A patent/FI920343A/fi unknown
- 1992-01-24 NO NO920330A patent/NO303801B1/no not_active IP Right Cessation
- 1992-01-24 JP JP4010794A patent/JPH0879B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0496723A2 (de)	1992-07-29
JPH0879B2 (ja)	1996-01-10
ATE128240T1 (de)	1995-10-15
FI920343A0 (fi)	1992-01-24
US5506112A (en)	1996-04-09
DK0496723T3 (da)	1996-01-02
ATA16491A (de)	1992-06-15
FI920343A (fi)	1992-07-26
NO920330L (no)	1992-07-27
CA2059605A1 (en)	1992-07-26
AT395597B (de)	1993-01-25
ES2080477T3 (es)	1996-02-01
JPH04293500A (ja)	1992-10-19
DE59203705D1 (de)	1995-10-26
EP0496723B1 (de)	1995-09-20
EP0496723A3 (en)	1992-11-25
NO920330D0 (no)	1992-01-24

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2012-02-20	MK1K	Patent expired