NO20091976L - Nye forbindelser - Google Patents
Nye forbindelserInfo
- Publication number
- NO20091976L NO20091976L NO20091976A NO20091976A NO20091976L NO 20091976 L NO20091976 L NO 20091976L NO 20091976 A NO20091976 A NO 20091976A NO 20091976 A NO20091976 A NO 20091976A NO 20091976 L NO20091976 L NO 20091976L
- Authority
- NO
- Norway
- Prior art keywords
- new connections
- connections
- new
- applications
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Den foreliggende oppfinnelsen vedrører nye forbindelser, fremgangsmåterog anvendelser.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0202873.6A GB0202873D0 (en) | 2002-02-07 | 2002-02-07 | Organic compounds |
PCT/EP2003/001188 WO2003066613A1 (en) | 2002-02-07 | 2003-02-06 | N-phenyl-2-pyrimidine-amine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20091976L true NO20091976L (no) | 2004-11-05 |
Family
ID=9930607
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20043685A NO327366B1 (no) | 2002-02-07 | 2004-09-03 | Amider og fremgangsmåter for fremstilling derav |
NO20091976A NO20091976L (no) | 2002-02-07 | 2009-05-20 | Nye forbindelser |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20043685A NO327366B1 (no) | 2002-02-07 | 2004-09-03 | Amider og fremgangsmåter for fremstilling derav |
Country Status (26)
Country | Link |
---|---|
US (8) | US7456283B2 (no) |
EP (2) | EP1474408B1 (no) |
JP (2) | JP4653954B2 (no) |
KR (1) | KR101027044B1 (no) |
CN (2) | CN101016262A (no) |
AU (1) | AU2003244444B2 (no) |
BR (2) | BRPI0307529B1 (no) |
CA (2) | CA2474738C (no) |
CO (1) | CO5601018A2 (no) |
CY (2) | CY1112938T1 (no) |
DK (2) | DK1474408T3 (no) |
EC (2) | ECSP045220A (no) |
ES (2) | ES2384872T3 (no) |
GB (1) | GB0202873D0 (no) |
HK (2) | HK1070893A1 (no) |
IL (3) | IL163158A (no) |
MX (1) | MXPA04007642A (no) |
NO (2) | NO327366B1 (no) |
NZ (3) | NZ569731A (no) |
PL (1) | PL209475B1 (no) |
PT (2) | PT2248807E (no) |
RU (2) | RU2370493C2 (no) |
SG (1) | SG160195A1 (no) |
SI (2) | SI1474408T1 (no) |
WO (1) | WO2003066613A1 (no) |
ZA (1) | ZA200405970B (no) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
GB0202873D0 (en) | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
WO2004108699A1 (en) * | 2003-06-06 | 2004-12-16 | Natco Pharma Limited | Process for the preparation of the anti-cancer drug imatinib and its analogues |
AU2004246800B2 (en) * | 2003-06-13 | 2008-12-04 | Novartis Ag | 2-aminopyrimidine derivatives as Raf kinase inhibitors |
PE20051096A1 (es) | 2004-02-04 | 2006-01-23 | Novartis Ag | Formas de sal de 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il)pirimidin-2-ilamino)fenil]-benzamida |
US7507821B2 (en) | 2004-12-30 | 2009-03-24 | Chemagis Ltd. | Process for preparing Imatinib |
KR20110084339A (ko) | 2005-07-09 | 2011-07-21 | 아스트라제네카 아베 | 당뇨병 치료에 있어 glk 활성화제로서 사용하기 위한 헤테로아릴 벤즈아미드 유도체 |
US7977348B2 (en) | 2006-04-27 | 2011-07-12 | Sicor Inc. | Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α |
US8067421B2 (en) | 2006-04-27 | 2011-11-29 | Sicor Inc. | Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α |
US20060223816A1 (en) * | 2006-05-08 | 2006-10-05 | Chemagis Ltd. | Imatinib mesylate alpha form and production process therefor |
MX2009002336A (es) * | 2006-09-01 | 2009-03-20 | Teva Pharma | Composiciones de imatinib. |
CA2662977A1 (en) | 2006-09-22 | 2008-03-27 | Novartis Ag | Method of optimizing the treatment of philadelphia-positive leukemia with abl tyrosine kinase inhibitors |
EP2009008A1 (en) | 2006-10-26 | 2008-12-31 | Sicor, Inc. | Imatinib base, and imatinib mesylate and processes for preparation thereof |
KR20090061068A (ko) * | 2006-10-26 | 2009-06-15 | 시코르, 인크. | 이매티닙의 제조 방법 |
JP5265562B2 (ja) * | 2006-11-16 | 2013-08-14 | エッフェ.イー.エッセ. ファブリカ イタリアーナ シンテーティチ エッセ.ペー.アー. | イマチニブおよびその中間体の調製方法 |
CN100451015C (zh) * | 2007-02-14 | 2009-01-14 | 杭州盛美医药科技开发有限公司 | 一种伊马替尼的制备方法 |
US7550591B2 (en) | 2007-05-02 | 2009-06-23 | Chemagis Ltd. | Imatinib production process |
CA2689989A1 (en) | 2007-06-04 | 2008-12-11 | Avila Therapeutics, Inc. | Heterocyclic compounds and uses thereof |
WO2009042809A1 (en) * | 2007-09-25 | 2009-04-02 | Teva Pharmaceutical Industries Ltd. | Stable imatinib compositions |
WO2009080366A1 (en) * | 2007-12-22 | 2009-07-02 | Synthon B.V. | A process of making imatinib |
CN101497601B (zh) * | 2008-01-29 | 2012-11-07 | 福建南方制药股份有限公司 | 伊马替尼的合成方法 |
PL215042B1 (pl) * | 2008-08-01 | 2013-10-31 | Temapharm Spolka Z Ograniczona Odpowiedzialnoscia | Sposób wytwarzania imatinibu |
KR20100021321A (ko) * | 2008-08-14 | 2010-02-24 | 일양약품주식회사 | Ν-페닐-2-피리미딘-아민 유도체의 제조방법 |
JP2012510470A (ja) | 2008-12-01 | 2012-05-10 | ノバルティス アーゲー | メシル酸イマチニブを用いたフィラデルフィア陽性白血病の処置を最適化する方法 |
US20100330130A1 (en) | 2009-05-22 | 2010-12-30 | Actavis Group Ptc Ehf | Substantially pure imatinib or a pharmaceutically acceptable salt thereof |
CN101654416B (zh) * | 2009-09-16 | 2013-06-05 | 成都神黄医药科技开发有限公司 | N-[3-硝基-4-甲基-苯基]-4-醛基-苯甲酰胺及其制备方法以及其衍生物的制备方法 |
WO2011070588A1 (en) | 2009-12-10 | 2011-06-16 | Arch Pharmalabs Limited | Process for the preparation of imatinib and salts thereof |
WO2011095835A1 (en) | 2010-02-02 | 2011-08-11 | Actavis Group Ptc Ehf | Highly pure imatinib or a pharmaceutically acceptable salt thereof |
US8609842B2 (en) | 2010-04-23 | 2013-12-17 | Fujian South Pharmaceutical Co., Ltd. | Method for synthesizing Imatinib |
WO2011157450A1 (en) | 2010-06-18 | 2011-12-22 | Krka, D. D., Novo Mesto | New polymorphic form of imatinib base and preparation of salts thereof |
TR201007005A2 (tr) | 2010-08-23 | 2011-09-21 | Mustafa Nevzat İlaç Sanayi̇i̇ A.Ş. | İmatinib baz üretim yöntemi |
WO2013035102A1 (en) | 2011-09-05 | 2013-03-14 | Natco Pharma Limited | Processes for the preparation of imatinib base and intermediates thereof |
AU2012328979B2 (en) | 2011-10-28 | 2016-04-21 | Novartis Ag | Method of treating gastrointestinal stromal tumors |
WO2013063003A1 (en) | 2011-10-28 | 2013-05-02 | Novartis Ag | Method of treating gastrointestinal stromal tumors |
WO2013120852A1 (en) | 2012-02-13 | 2013-08-22 | Grindeks, A Joint Stock Company | Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors |
JP2015522070A (ja) | 2012-07-11 | 2015-08-03 | ノバルティス アーゲー | 消化管間質腫瘍を治療する方法 |
CN102827144A (zh) * | 2012-09-05 | 2012-12-19 | 湖南欧亚生物有限公司 | 一种伊马替尼的制备方法 |
RU2537398C1 (ru) * | 2013-08-20 | 2015-01-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный технологический университет" (СибГТУ) | Гексазамещенные пара-аминофенолы с ариламидными группами в 2,6-положениях по отношению к гидроксилу |
CN103588754B (zh) * | 2013-11-04 | 2015-05-27 | 遵义医学院 | 伊马替尼的制备方法 |
EP3527211B1 (en) | 2016-10-17 | 2023-08-23 | Delta-Fly Pharma, Inc. | Pharmaceutical composition for treatment or remission of chronic myelogenous leukemia |
WO2018089404A1 (en) | 2016-11-11 | 2018-05-17 | Mallinckrodt Nuclear Medicine Llc | Processes for generating germanium-68 with reduced volatiles |
EP3333162A1 (en) | 2016-12-12 | 2018-06-13 | Silesian Catalysts sp. z o.o. | Metod for preparing n-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine |
FI3684767T3 (fi) | 2017-09-22 | 2024-07-22 | Jubilant Epipad LLC | Heterosyklisiä yhdisteitä pad:n estäjinä |
RS64104B1 (sr) | 2017-10-18 | 2023-04-28 | Jubilant Epipad LLC | Jedinjenja imidazo-piridina kao inhibitori pad |
BR112020008851A2 (pt) | 2017-11-06 | 2020-10-20 | Jubilant Prodel LLC | composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas |
JP7368369B2 (ja) | 2017-11-24 | 2023-10-24 | ジュビラント・エピスクライブ・エルエルシー | Prmt5阻害剤としてのヘテロ環式化合物 |
CN108164505B (zh) * | 2018-01-16 | 2020-11-03 | 扬州大学 | 一种伊马替尼的合成方法 |
US11666888B2 (en) | 2018-02-05 | 2023-06-06 | Bio-Rad Laboratories, Inc. | Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand |
CA3093527A1 (en) | 2018-03-13 | 2019-09-19 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
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DE531480C (de) | 1929-07-03 | 1931-08-10 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von Aryliden einer unsymmetrischen o-Xylenolcarbonsaeure |
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US3505389A (en) * | 1966-08-18 | 1970-04-07 | Hooker Chemical Corp | 4-amino-2,3,5,6-tetrachlorobenzoic acid and derivatives thereof |
US3505398A (en) | 1966-09-22 | 1970-04-07 | Standard Oil Co | Terephthalic acid crystallization |
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JPS4987761U (no) | 1972-11-17 | 1974-07-30 | ||
JPS563375B2 (no) * | 1972-12-25 | 1981-01-24 | ||
JPS5720923B2 (no) * | 1974-04-02 | 1982-05-04 | ||
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JPS5665804A (en) * | 1979-11-01 | 1981-06-03 | Ishihara Sangyo Kaisha Ltd | Control agent against injurious organism |
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NZ219974A (en) * | 1986-04-22 | 1989-08-29 | Goedecke Ag | N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases |
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JPH03130252U (no) | 1990-04-11 | 1991-12-27 | ||
FR2664895B1 (fr) * | 1990-07-20 | 1992-10-30 | Theramex Laboratoire | Nouveaux derives de la 6-methyl 19-nor progesterone, substitues en 3 et leur procede d'obtention. |
DE4110483A1 (de) * | 1991-03-30 | 1992-10-01 | Bayer Ag | Substituierte salicylamide, mittel gegen pflanzenkrankheiten |
US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
TW225528B (no) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
FR2689925B1 (fr) | 1992-04-08 | 1994-05-27 | Valeo Securite Habitacle | Dispositif de verrouillage d'une serrure dans son support. |
US5543520A (en) * | 1993-10-01 | 1996-08-06 | Ciba-Geigy Corporation | Pyrimidine derivatives |
DE4428380A1 (de) * | 1994-08-11 | 1996-02-15 | Bayer Ag | 4-Trifluormethylbenzamide |
JPH0987761A (ja) | 1995-09-22 | 1997-03-31 | Nikko Kinzoku Kk | 銅転炉スラグからの銅の回収方法 |
JP3130252B2 (ja) | 1996-07-12 | 2001-01-31 | 小糸工業株式会社 | 座席のヘッドレスト装置 |
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DE69921986T2 (de) * | 1998-05-15 | 2005-12-22 | Astrazeneca Ab | Benzamid-derivate zur behandlung cytokin-vermittelter krankheiten |
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GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
GB0202873D0 (en) * | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
GB2398565A (en) * | 2003-02-18 | 2004-08-25 | Cipla Ltd | Imatinib preparation and salts |
US7338957B2 (en) * | 2003-08-28 | 2008-03-04 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
-
2002
- 2002-02-07 GB GBGB0202873.6A patent/GB0202873D0/en not_active Ceased
-
2003
- 2003-02-06 CN CNA2007100860099A patent/CN101016262A/zh active Pending
- 2003-02-06 EP EP03737319A patent/EP1474408B1/en not_active Expired - Lifetime
- 2003-02-06 JP JP2003565987A patent/JP4653954B2/ja not_active Expired - Fee Related
- 2003-02-06 PL PL371197A patent/PL209475B1/pl unknown
- 2003-02-06 CA CA2474738A patent/CA2474738C/en not_active Expired - Fee Related
- 2003-02-06 AU AU2003244444A patent/AU2003244444B2/en not_active Ceased
- 2003-02-06 MX MXPA04007642A patent/MXPA04007642A/es active IP Right Grant
- 2003-02-06 NZ NZ569731A patent/NZ569731A/en not_active IP Right Cessation
- 2003-02-06 BR BRPI0307529-0A patent/BRPI0307529B1/pt unknown
- 2003-02-06 ES ES03737319T patent/ES2384872T3/es not_active Expired - Lifetime
- 2003-02-06 SI SI200332155T patent/SI1474408T1/sl unknown
- 2003-02-06 WO PCT/EP2003/001188 patent/WO2003066613A1/en active Application Filing
- 2003-02-06 BR BR0307529-0A patent/BR0307529A/pt not_active IP Right Cessation
- 2003-02-06 KR KR1020047011670A patent/KR101027044B1/ko not_active Expired - Fee Related
- 2003-02-06 PT PT101713881T patent/PT2248807E/pt unknown
- 2003-02-06 DK DK03737319.8T patent/DK1474408T3/da active
- 2003-02-06 CN CNB038035561A patent/CN100347162C/zh not_active Expired - Fee Related
- 2003-02-06 CA CA2737565A patent/CA2737565C/en not_active Expired - Fee Related
- 2003-02-06 ES ES10171388T patent/ES2425980T3/es not_active Expired - Lifetime
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