NO20082559L - Humane monoklonale antistoffer mot protein tyrosin kinase 7 (PTK7) og fremgangsmater for anvendelse av anti-PTK7 antistoffer - Google Patents
Humane monoklonale antistoffer mot protein tyrosin kinase 7 (PTK7) og fremgangsmater for anvendelse av anti-PTK7 antistofferInfo
- Publication number
- NO20082559L NO20082559L NO20082559A NO20082559A NO20082559L NO 20082559 L NO20082559 L NO 20082559L NO 20082559 A NO20082559 A NO 20082559A NO 20082559 A NO20082559 A NO 20082559A NO 20082559 L NO20082559 L NO 20082559L
- Authority
- NO
- Norway
- Prior art keywords
- ptk7
- antibodies
- methods
- monoclonal antibodies
- human monoclonal
- Prior art date
Links
- 102100039813 Inactive tyrosine-protein kinase 7 Human genes 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 101710099452 Inactive tyrosine-protein kinase 7 Proteins 0.000 title 2
- 101000606465 Homo sapiens Inactive tyrosine-protein kinase 7 Proteins 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74837305P | 2005-12-08 | 2005-12-08 | |
PCT/US2006/046837 WO2007067730A2 (en) | 2005-12-08 | 2006-12-08 | Human monoclonal antibodies to protein tyrosine kinase 7 ( ptk7 ) and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20082559L true NO20082559L (no) | 2008-07-07 |
Family
ID=38123515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20082559A NO20082559L (no) | 2005-12-08 | 2008-06-02 | Humane monoklonale antistoffer mot protein tyrosin kinase 7 (PTK7) og fremgangsmater for anvendelse av anti-PTK7 antistoffer |
Country Status (21)
Country | Link |
---|---|
US (3) | US8222375B2 (me) |
EP (1) | EP1957539B1 (me) |
JP (1) | JP5401639B2 (me) |
KR (1) | KR101373464B1 (me) |
CN (1) | CN101360761B (me) |
AU (1) | AU2006321841C1 (me) |
BR (1) | BRPI0619582A2 (me) |
CA (1) | CA2632552C (me) |
DK (1) | DK1957539T3 (me) |
EA (1) | EA017812B1 (me) |
ES (1) | ES2406063T3 (me) |
IL (1) | IL191788A (me) |
ME (1) | ME02002B (me) |
NO (1) | NO20082559L (me) |
NZ (2) | NZ569236A (me) |
PL (1) | PL1957539T3 (me) |
PT (1) | PT1957539E (me) |
RS (1) | RS52804B (me) |
SG (1) | SG177194A1 (me) |
SI (1) | SI1957539T1 (me) |
WO (1) | WO2007067730A2 (me) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101360761B (zh) | 2005-12-08 | 2012-09-12 | 米德列斯公司 | 抗蛋白质酪氨酸激酶7(ptk7)的人单克隆抗体及其用途 |
NZ568015A (en) * | 2005-12-08 | 2012-03-30 | Medarex Inc | Human monoclonal antibodies to O8E |
EP2185188B1 (en) | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
US7960125B2 (en) * | 2007-09-25 | 2011-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of thymically derived CD4 T cells by protein tyrosine kinase 7 expression |
SG187482A1 (en) * | 2007-11-07 | 2013-02-28 | Celldex Therapeutics Inc | Antibodies that bind human dendritic and epithelial cell 205 (dec-205) |
EP2229187A2 (en) * | 2007-11-30 | 2010-09-22 | Bristol-Myers Squibb Company | Monoclonal antibody partner molecule conjugates directed to protein tyrosine kinase 7 (ptk7) |
WO2009116764A2 (ko) * | 2008-03-17 | 2009-09-24 | 연세대학교 산학협력단 | Ptk7 단백질의 기능 저해를 통한 세포의 이동, 침윤 또는 혈관신생 억제제 |
KR101123130B1 (ko) * | 2008-03-17 | 2012-03-30 | 연세대학교 산학협력단 | Ptk7 단백질의 기능 저해를 통한 세포의 이동, 침윤 또는 혈관신생 억제제 |
WO2011004028A2 (en) | 2009-07-10 | 2011-01-13 | Innate Pharma | Tlr3 binding agents |
US8394922B2 (en) * | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
EP2380909A1 (en) * | 2010-04-26 | 2011-10-26 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | PTK-7 protein involved in breast cancer |
US9290499B2 (en) | 2010-05-19 | 2016-03-22 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
SA112330278B1 (ar) * | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
CN103958510B (zh) | 2011-10-03 | 2016-10-19 | 北卡罗来纳大学教堂山分校 | 用于治疗癌症的吡咯并嘧啶化合物 |
MX350539B (es) | 2012-02-13 | 2017-09-08 | Bristol Myers Squibb Co | Compuestos de enediino, conjugados de los mismos y sus usos y metodos. |
RU2014145121A (ru) | 2012-05-22 | 2016-07-10 | Зэ Юниверсити Оф Норд Каролина Эт Чапел Хилл | Пиримидиновые соединения для лечения злокачественной опухоли |
MX361773B (es) | 2012-05-31 | 2018-12-17 | Innate Pharma | Agentes de ligación a tlr3. |
WO2014062774A1 (en) | 2012-10-17 | 2014-04-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
EP2925752A4 (en) | 2012-11-27 | 2016-06-01 | Univ North Carolina | PYRIMIDINE COMPOUNDS FOR CANCER TREATMENT |
MX356698B (es) | 2013-02-14 | 2018-06-11 | Bristol Myers Squibb Co | Compuestos de tubulisina, metodos para obtenerlos y uso. |
ES2769876T3 (es) | 2013-08-14 | 2020-06-29 | Univ Rice William M | Derivados de uncialamicina, métodos de síntesis y su uso como agentes antitumorales |
AU2015244179A1 (en) * | 2014-04-11 | 2016-11-03 | The University Of North Carolina At Chapel Hill | Mertk-specific pyrrolopyrimidine compounds |
US9777070B2 (en) * | 2014-04-30 | 2017-10-03 | Pfizer Inc | Anti-PTK7 antibody-drug conjugates |
US10077287B2 (en) | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
BR112017010094A2 (pt) | 2014-11-21 | 2018-02-06 | Bristol-Myers Squibb Company | anticorpos compreendendo regiões constantes de cadeias pesadas modificadas |
ES2747386T3 (es) | 2015-01-14 | 2020-03-10 | Bristol Myers Squibb Co | Dímeros de benzodiacepina unidos por heteroarileno, conjugados de los mismos y métodos de preparación y uso |
EA035412B1 (ru) * | 2015-05-29 | 2020-06-10 | Бристол-Майерс Сквибб Компани | Антитела к ox40 и их применение |
BR112018012524A2 (pt) | 2015-12-21 | 2018-12-11 | Bristol Myers Squibb Co | anticorpos variantes para conjugação sítio-específica |
MX378572B (es) | 2016-01-22 | 2025-03-11 | Merck Sharp & Dohme Llc | Anticuerpos anti-factor de la coagulacion xi. |
US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
WO2017196598A1 (en) | 2016-05-10 | 2017-11-16 | Bristol-Myers Squibb Company | Antibody-drug conjugates of tubulysin analogs with enhanced stability |
KR102379580B1 (ko) | 2016-06-14 | 2022-03-29 | 머크 샤프 앤드 돔 코포레이션 | 항응고 인자 xi 항체 |
US10287291B2 (en) | 2016-08-19 | 2019-05-14 | Bristol-Myers Squibb Company | Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use |
US10398783B2 (en) | 2016-10-20 | 2019-09-03 | Bristol-Myers Squibb Company | Antiproliferative compounds and conjugates made therefrom |
CN110352068A (zh) | 2016-12-02 | 2019-10-18 | 南加利福尼亚大学 | 合成的免疫受体及其使用方法 |
EP4098662A1 (en) | 2017-05-25 | 2022-12-07 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
US10487084B2 (en) | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
IL312163B2 (en) | 2018-05-29 | 2025-04-01 | Bristol Myers Squibb Co | Modified atomic groups that lend themselves to use in prodrugs and conjugates and methods for use and preparation |
US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
CA3118830A1 (en) * | 2018-11-07 | 2020-05-14 | Crispr Therapeutics Ag | Anti-ptk7 immune cell cancer therapy |
EP3887397A1 (en) | 2018-11-28 | 2021-10-06 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
KR20210098488A (ko) | 2018-11-30 | 2021-08-10 | 브리스톨-마이어스 스큅 컴퍼니 | 글루타민-함유 경쇄 c-말단 연장부를 포함하는 항체, 그의 접합체, 및 방법 및 용도 |
EP3894443A2 (en) | 2018-12-12 | 2021-10-20 | Bristol-Myers Squibb Company | Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses |
KR102236127B1 (ko) | 2019-08-08 | 2021-04-07 | 주식회사 하울바이오 | 티로시나아제를 억제하는 항-티로시나아제 항체 및 이의 용도 |
US20240377413A1 (en) | 2019-09-16 | 2024-11-14 | Bristol-Myers Squibb Company | Dual capture method for analysis of antibody-drug conjugates |
AR122014A1 (es) * | 2020-05-06 | 2022-08-03 | Crispr Therapeutics Ag | Receptor de antígenos quimérico enmascarado específico para la proteína tirosina cinasa de tipo 7 (ptk7) y células inmunitarias que expresan el mismo |
WO2022015113A1 (ko) * | 2020-07-16 | 2022-01-20 | 연세대학교 산학협력단 | Ptk7에 특이적으로 결합하는 항체 및 이의 용도 |
CN115894696A (zh) * | 2021-08-18 | 2023-04-04 | 和迈生物科技有限公司 | 抗ptk7单域抗体及其应用 |
CN114213541B (zh) * | 2021-12-20 | 2022-12-30 | 南京诺唯赞生物科技股份有限公司 | 一种全能核酸酶的单克隆抗体及其制备方法 |
EP4496592A1 (en) | 2022-03-23 | 2025-01-29 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing ptk7 |
KR20250012620A (ko) | 2022-05-19 | 2025-01-24 | 마이틱 테라퓨틱스, 인크. | Ph 의존적으로 결합하는 ptk7-결합 단백질 및 이의 용도 |
GB202209196D0 (en) * | 2022-06-22 | 2022-08-10 | Almac Discovery Ltd | Bi-specific antigen binding molecules |
CN119604535A (zh) * | 2022-08-19 | 2025-03-11 | 四川科伦博泰生物医药股份有限公司 | Ptk7结合蛋白及其用途 |
WO2024054030A1 (ko) * | 2022-09-06 | 2024-03-14 | 연세대학교 산학협력단 | 항-ptk7 항체 및 이의 용도 |
WO2024080325A1 (ja) * | 2022-10-14 | 2024-04-18 | Jsr株式会社 | 抗体及びその使用 |
WO2024193679A1 (en) * | 2023-03-23 | 2024-09-26 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Antibodies and uses thereof |
CN118852442A (zh) * | 2023-04-26 | 2024-10-29 | 上海麦科思生物医药有限公司 | 抗ptk7抗体及其用途 |
WO2025117639A1 (en) * | 2023-11-27 | 2025-06-05 | Profoundbio Us Co. | Antibodies and methods for ptk7 detection |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4708930A (en) * | 1984-11-09 | 1987-11-24 | Coulter Corporation | Monoclonal antibody to a human carcinoma tumor associated antigen |
WO1996037610A2 (en) * | 1995-05-25 | 1996-11-28 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Cck-4, a receptor tyrosine kinase, and methods for diagnosis and treatment of cck-4 signal transduction disorders |
WO1997012862A1 (en) | 1995-10-03 | 1997-04-10 | The Scripps Research Institute | Cbi analogs of cc-1065 and the duocarmycins |
AU6887698A (en) | 1997-04-08 | 1998-10-30 | Sugen, Inc. | Study and treatment of diseases related to specific cellular functions of receptor protein tyrosine kinases |
EP0983248B1 (en) | 1997-05-22 | 2004-07-14 | The Scripps Research Institute | Analogs of duocarmycin and cc-1065 |
ATE384744T1 (de) | 1999-07-29 | 2008-02-15 | Medarex Inc | Menschliche antikörper gegen her2/neu |
JP2005503760A (ja) | 2001-01-24 | 2005-02-10 | プロテイン デザイン ラブス, インコーポレイテッド | 乳癌の診断方法、組成物および乳癌のモジュレーターのスクリーニング方法 |
WO2002086443A2 (en) | 2001-04-18 | 2002-10-31 | Protein Design Labs, Inc | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
AU2002303929B9 (en) | 2001-05-31 | 2007-01-25 | E. R. Squibb & Sons, L.L.C. | Cytotoxins, prodrugs, linkers and stabilizers useful therefor |
GB0114033D0 (en) | 2001-06-09 | 2001-08-01 | Innovata Biomed Ltd | Process |
CA2450316A1 (en) | 2001-06-11 | 2002-12-19 | Medarex, Inc. | Cd10-activated prodrug compounds |
IL159225A0 (en) | 2001-06-13 | 2004-06-01 | Genmab As | Human monoclonal antibodies to epidermal growth factor receptor (egfr) |
US20040076955A1 (en) | 2001-07-03 | 2004-04-22 | Eos Biotechnology, Inc. | Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer |
CA2459308A1 (en) | 2001-09-07 | 2003-03-20 | Dale L. Boger | Cbi analogues of cc-1065 and the duocarmycins |
JP2003088388A (ja) | 2001-09-14 | 2003-03-25 | Herikkusu Kenkyusho:Kk | 新規な全長cDNA |
CA2459219A1 (en) | 2001-09-17 | 2003-03-27 | Protein Design Labs, Inc. | Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer |
WO2003031930A2 (en) | 2001-10-09 | 2003-04-17 | The Johns Hopkins University | A phosphatase associated with metastasis |
WO2003042661A2 (en) | 2001-11-13 | 2003-05-22 | Protein Design Labs, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
CA2471645A1 (en) | 2002-01-03 | 2003-07-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Immunoconjugates useful for treatment of tumours |
EP1461359B1 (fr) * | 2002-01-18 | 2007-03-21 | Pierre Fabre Medicament | Anticorps anti-igf-ir et leurs applications |
US20040197792A1 (en) | 2002-07-15 | 2004-10-07 | Sugen, Inc. | Novel Kinases |
GB0219776D0 (en) * | 2002-08-24 | 2002-10-02 | Oxford Glycosciences Uk Ltd | A protein involved in carcinoma |
EP1605044A4 (en) | 2003-03-10 | 2006-12-06 | Japan Science & Tech Agency | MARKERS FOR DETECTING MESENCHYMAL STEM CELLS AND METHOD FOR IDENTIFYING MESENCHYMAL STEM CELLS USING THE MARKER |
EP2003196A3 (en) | 2003-06-09 | 2009-01-07 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing cancer |
WO2005063987A1 (en) | 2003-12-19 | 2005-07-14 | Aveo Pharmaceuticals, Inc. | Gp153: methods and compositions for treating cancer |
WO2005117941A2 (en) | 2004-04-29 | 2005-12-15 | Genzyme Corporation | Methods and compositions for the treatment of polycystic diseases |
MXPA06013413A (es) | 2004-05-19 | 2007-01-23 | Medarex Inc | Enlazadores quimicos y conjugados de los mismos. |
US7691962B2 (en) | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
JP2008504270A (ja) | 2004-06-23 | 2008-02-14 | ジェンザイム・コーポレイション | 嚢胞性疾患を処置するための方法および組成物 |
WO2006110593A2 (en) | 2005-04-07 | 2006-10-19 | Macrogenics, Inc. | Biological targets for the diagnosis, treatment and prevention of cancer |
ES2416136T3 (es) | 2005-09-26 | 2013-07-30 | Medarex, Inc. | Conjugados de anticuerpo-fármaco y su uso |
CN101360761B (zh) | 2005-12-08 | 2012-09-12 | 米德列斯公司 | 抗蛋白质酪氨酸激酶7(ptk7)的人单克隆抗体及其用途 |
EP2229187A2 (en) | 2007-11-30 | 2010-09-22 | Bristol-Myers Squibb Company | Monoclonal antibody partner molecule conjugates directed to protein tyrosine kinase 7 (ptk7) |
AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
-
2006
- 2006-12-08 CN CN2006800510578A patent/CN101360761B/zh not_active Expired - Fee Related
- 2006-12-08 ME MEP-2013-230A patent/ME02002B/me unknown
- 2006-12-08 SI SI200631569T patent/SI1957539T1/sl unknown
- 2006-12-08 NZ NZ569236A patent/NZ569236A/en not_active IP Right Cessation
- 2006-12-08 CA CA2632552A patent/CA2632552C/en not_active Expired - Fee Related
- 2006-12-08 DK DK06848508.5T patent/DK1957539T3/da active
- 2006-12-08 PT PT68485085T patent/PT1957539E/pt unknown
- 2006-12-08 EP EP06848508.5A patent/EP1957539B1/en not_active Revoked
- 2006-12-08 EA EA200801509A patent/EA017812B1/ru not_active IP Right Cessation
- 2006-12-08 PL PL06848508T patent/PL1957539T3/pl unknown
- 2006-12-08 NZ NZ594466A patent/NZ594466A/xx not_active IP Right Cessation
- 2006-12-08 AU AU2006321841A patent/AU2006321841C1/en not_active Ceased
- 2006-12-08 JP JP2008544528A patent/JP5401639B2/ja not_active Expired - Fee Related
- 2006-12-08 KR KR1020087015763A patent/KR101373464B1/ko not_active Expired - Fee Related
- 2006-12-08 US US12/095,986 patent/US8222375B2/en active Active
- 2006-12-08 ES ES06848508T patent/ES2406063T3/es active Active
- 2006-12-08 SG SG2011090792A patent/SG177194A1/en unknown
- 2006-12-08 BR BRPI0619582-2A patent/BRPI0619582A2/pt not_active Application Discontinuation
- 2006-12-08 RS RS20130230A patent/RS52804B/en unknown
- 2006-12-08 WO PCT/US2006/046837 patent/WO2007067730A2/en active Application Filing
-
2008
- 2008-05-28 IL IL191788A patent/IL191788A/en not_active IP Right Cessation
- 2008-06-02 NO NO20082559A patent/NO20082559L/no not_active Application Discontinuation
-
2012
- 2012-04-09 US US13/442,499 patent/US9505845B2/en active Active
- 2012-05-10 US US13/468,624 patent/US9102738B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20082559L (no) | Humane monoklonale antistoffer mot protein tyrosin kinase 7 (PTK7) og fremgangsmater for anvendelse av anti-PTK7 antistoffer | |
NO20092285L (no) | Humane, monoklonale antistoffer til BTLA og fremgangsmater for anvendelse | |
NO20080590L (no) | Humane, monoklonale antistoffer mot programmert dodsligand (PD-L1) | |
NO20081987L (no) | Humane, monoklonale antistoffer mot CD70 | |
NO20083062L (no) | Humane monoklonale antistoffer mot fukosyl-GM1 og fremgangsmater for anvendelse av anti-fukosyl-GM1 | |
NO20083053L (no) | Humane monoklonale antistoffer mot O8E | |
NO20064866L (no) | IRTA-5 antistoffer og deres anvendelse | |
NO20091283L (no) | Humane antistoffer som binder CXCR4 og anvendelser derav | |
NO20073797L (no) | Humane monoklonale antistoffer mot prostata spesifikt membran antigen (PSMA) | |
CY1121648T1 (el) | ΑΝΘΡΩΠΙΝΑ ΜΟΝΟΚΛΩΝΙΚΑ ΑΝΤΙΣΩΜΑΤΑ ΠΡΟΣ ΠΡΟΓΡΑΜΜΑΤΙΣΜΕΝΟ ΘΑΝΑΤΟ l(PD-l) ΚΑΙ ΜΕΘΟΔΟΙ ΓΙΑ ΤΗΝ ΑΝΤΙΜΕΤΩΠΙΣΗ ΚΑΡΚΙΝΟΥ ΧΡΗΣΙΜΟΠΟΙΩΝΤΑΣ ANTI-PD-1 ΑΝΤΙΣΩΜΑΤΑ ΜΟΝΑ Ή ΣΕ ΣΥΝΔΥΑΣΜΟ ΜΕ ΑΛΛΕΣ ΑΝΟΣΟΘΕΡΑΠΕΥΤΙΚΕΣ | |
NO20080362L (no) | CD19-antistoffer og deres anvendelser | |
EA200901436A1 (ru) | Антигенсвязывающие белки, связывающие par-2 | |
DE602005027258D1 (de) | Humane monoklonale antikörper gegen hendra- und nipah-viren | |
MEP53308A (en) | Novel peptides that bind to the erythropoietin receptor | |
EA201101516A1 (ru) | Антитела, специфические для кадгерина-17 | |
EA200801174A1 (ru) | Антитела-миметики glp-2, полипептиды, композиции, способы и применения | |
FI20011664A7 (fi) | Syöpäpesifiset oligoskkaridisekvenssit ja niiden käyttö | |
DE602005027399D1 (de) | Für humane matriptase spezifische bindungsproteine | |
WO2008109533A3 (en) | Human antibodies that bind multiple irta family proteins, and uses thereof | |
WO2006116192A3 (en) | Irta-1 antibodies and their uses | |
EA200700990A1 (ru) | Новые пептиды, которые связывают рецептор эритропоэтина | |
CY1116843T1 (el) | Ανθρωπινα μονοκλωνικα αντισωματα προς συνδετη 1 προγραμματισμενου θανατου (pd-l1) | |
CY1114151T1 (el) | Ανθρωπινα μονοκλωνικα αντισωματα ως προς την κιναση τυροσινης πρωτεϊνης 7 (ρτκ7) και η χρηση αυτων | |
CY1113958T1 (el) | Ανθρωπινα μονοκλωνικα αντισωματα σε φουκοζυλ-gμ1 και μεθοδοι για τη χρηση αντι-φουκοζυλ-gμ1 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: MEDAREX LLC, US |
|
CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: E.R. SQUIBB & SONS, US |
|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |