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NO20080150L - Inhibitorer av AKT-aktivitet - Google Patents

Inhibitorer av AKT-aktivitet

Info

Publication number
NO20080150L
NO20080150L NO20080150A NO20080150A NO20080150L NO 20080150 L NO20080150 L NO 20080150L NO 20080150 A NO20080150 A NO 20080150A NO 20080150 A NO20080150 A NO 20080150A NO 20080150 L NO20080150 L NO 20080150L
Authority
NO
Norway
Prior art keywords
akt activity
inhibitors
akt
compounds
inhibit
Prior art date
Application number
NO20080150A
Other languages
English (en)
Norwegian (no)
Inventor
Jiabing Wang
Donna J Armstrong
Essa H Hu
Michael J Kelly Iii
Mark E Layton
Yiwei Li
Jun Liang
Kevin J Rodzinak
Michael A Rossi
Philip E Sanderson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20080150L publication Critical patent/NO20080150L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20080150A 2005-06-10 2008-01-09 Inhibitorer av AKT-aktivitet NO20080150L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68972605P 2005-06-10 2005-06-10
US73418805P 2005-11-07 2005-11-07
PCT/US2006/022079 WO2006135627A2 (fr) 2005-06-10 2006-06-07 Inhibiteurs de l'activite akt

Publications (1)

Publication Number Publication Date
NO20080150L true NO20080150L (no) 2008-03-10

Family

ID=37532789

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080150A NO20080150L (no) 2005-06-10 2008-01-09 Inhibitorer av AKT-aktivitet

Country Status (22)

Country Link
US (1) US8008317B2 (fr)
EP (1) EP1898903B8 (fr)
JP (1) JP5055494B2 (fr)
KR (1) KR100959771B1 (fr)
AU (1) AU2006258124B8 (fr)
BR (1) BRPI0611717A2 (fr)
CA (1) CA2610888C (fr)
CR (1) CR9580A (fr)
DK (1) DK1898903T3 (fr)
EC (1) ECSP077980A (fr)
ES (1) ES2409168T3 (fr)
HR (1) HRP20130429T1 (fr)
IL (1) IL187690A (fr)
MX (1) MX2007015578A (fr)
NI (1) NI200700320A (fr)
NO (1) NO20080150L (fr)
NZ (1) NZ563423A (fr)
PL (1) PL1898903T3 (fr)
PT (1) PT1898903E (fr)
RU (1) RU2421454C2 (fr)
TW (1) TW200800166A (fr)
WO (1) WO2006135627A2 (fr)

Families Citing this family (40)

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AU2005290081B2 (en) 2004-08-23 2010-12-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US20100047338A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
PT1898903E (pt) 2005-06-10 2013-06-28 Merck Sharp & Dohme Inibidores da atividade de akt
TW200806670A (en) * 2006-04-25 2008-02-01 Merck & Co Inc Inhibitors of checkpoint kinases
AR064010A1 (es) 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt
AU2007327992A1 (en) * 2006-12-06 2008-06-12 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US20100029697A1 (en) * 2007-03-28 2010-02-04 Debenham John S Substituted pyrido[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives as cannabinoid-1 receptor modulators
JP5628028B2 (ja) 2007-07-05 2014-11-19 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
NZ583267A (en) 2007-08-14 2012-03-30 Bayer Schering Pharma Ag Fused bicyclic pyrimidines
AU2009255358A1 (en) * 2008-06-03 2009-12-10 Msd K.K. Inhibitors of Akt activity
CA2726358A1 (fr) 2008-06-03 2009-12-10 Merck Sharp & Dohme Corp. Inhibiteurs de l'activite akt
EP2309857B1 (fr) 2008-07-17 2013-07-03 Bayer CropScience AG Composés hétérocycliques utilisés comme pesticides
EP2391623A4 (fr) * 2009-02-02 2012-09-05 Merck Sharp & Dohme Inhibiteurs de l'activité d'akt
WO2010091306A1 (fr) 2009-02-05 2010-08-12 Tokai Pharmaceuticals Nouveaux promédicaments à base d'inhibiteurs cyp17 stéroïdiens/anti-androgènes
CA2752114C (fr) 2009-02-13 2017-06-20 Bayer Pharma Aktiengesellschaft Pyrimidines condensees en tant qu'inhibiteurs d'akt
PE20120534A1 (es) 2009-02-13 2012-05-10 Bayer Pharma AG PIRIMIDINAS FUSIONADAS COMO INHIBIDORES DE Akt
US8481503B2 (en) * 2009-03-06 2013-07-09 Merck Sharp & Dohme Corp. Combination cancer therapy with an AKT inhibitor and other anticancer agents
WO2010104933A1 (fr) * 2009-03-11 2010-09-16 Merck Sharp & Dohme Corp. Inhibiteurs de l'activité akt
WO2010104705A1 (fr) 2009-03-12 2010-09-16 Merck Sharp & Dohme Corp. Inhibiteurs de l'activité akt
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
EP2266985A1 (fr) * 2009-06-26 2010-12-29 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Dérivés de pyrimidine tricycliques en tant qu'antagonistes Wnt
US8546376B2 (en) 2009-09-18 2013-10-01 Almac Discovery Limited Pharmaceutical compounds
WO2011075383A1 (fr) * 2009-12-17 2011-06-23 Merck Sharp & Dohme Corp. Inhibiteurs de l'activité akt
GB0922589D0 (en) * 2009-12-23 2010-02-10 Almac Discovery Ltd Pharmaceutical compounds
CA2804845A1 (fr) * 2010-07-12 2012-01-19 Stuart Ince Imidazo[1,2-a]pyrimidines et -pyridines substitues
EP2593447B1 (fr) * 2010-07-15 2016-08-17 Bayer Intellectual Property GmbH Composés de 3-pyridyl-heteroarylcarboxamide comme d'agents de lutte contre les nuisibles
PT2694510E (pt) 2011-04-07 2016-02-08 Bayer Pharma AG Imidazopiridazinas como inibidores da akt quinase
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
CA2873661C (fr) * 2012-05-17 2020-07-21 Genentech, Inc. Procede de fabrication de composes de cyclopentapyrimidine hydroxylee et sels de ceux-ci
MX363243B (es) 2012-11-28 2019-03-14 Merck Sharp & Dohme Composiciones para tratar cáncer y usos de dichas composiciones.
AU2014208964B2 (en) 2013-01-23 2016-09-01 Astrazeneca Ab Chemical compounds
EP4066841A1 (fr) 2013-03-14 2022-10-05 University of Maryland, Baltimore Agents de diminution du récepteur des androgènes et leurs utilisations
SG11201600525XA (en) 2013-08-12 2016-02-26 Tokai Pharmaceuticals Inc Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
EP3091016A1 (fr) * 2015-05-05 2016-11-09 Technische Universität Dortmund Inhibiteurs de kinase et leur utilisation dans la thérapie du cancer
KR102214225B1 (ko) * 2015-12-07 2021-02-10 쑤저우 시노벤트 파마슈티칼즈 씨오., 엘티디. 5원 헤테로시클릭 아미드계 wnt 경로 억제제
TW201822637A (zh) 2016-11-07 2018-07-01 德商拜耳廠股份有限公司 用於控制動物害蟲的經取代磺醯胺類
IL272909B2 (en) 2017-09-07 2024-01-01 Univ Res Inst Inc Augusta A specific AKT3 activator and its uses
CN114981298B (zh) 2019-12-12 2024-08-20 听治疗有限责任公司 用于预防和治疗听力损失的组合物和方法
WO2023081812A2 (fr) * 2021-11-05 2023-05-11 Georgiamune Llc Modulateurs d'akt3

Family Cites Families (26)

* Cited by examiner, † Cited by third party
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US4831013A (en) * 1986-03-20 1989-05-16 Ciba-Geigy Corporation 2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines, pharmaceutical compositions, and uses thereof
ES2137113B1 (es) * 1997-07-29 2000-09-16 Almirall Prodesfarma Sa Nuevos derivados de triazolo-piridazinas heterociclicos.
GB9824897D0 (en) * 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
AU2002252614B2 (en) 2001-04-10 2006-09-14 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US20030187026A1 (en) * 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
EP1494676B1 (fr) 2002-04-08 2013-05-08 Merck Sharp & Dohme Corp. Derives de quinolaxine fusionnee comme inhibiteurs de l'activite d'akt
AU2003223467B2 (en) 2002-04-08 2007-10-04 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
CA2481229C (fr) 2002-04-08 2010-09-21 Merck & Co., Inc. Pyrazines substituees inhibitrices de l'akt
CA2480880C (fr) 2002-04-08 2011-03-22 Merck & Co., Inc. Inhibiteurs de l'activite de akt
KR20050037585A (ko) * 2002-08-23 2005-04-22 카이론 코포레이션 벤지미다졸 퀴놀리논 및 그들의 사용
CA2501365C (fr) 2002-10-30 2011-05-31 Merck & Co., Inc. Inhibiteurs de l'activite de l'akt
ATE512957T1 (de) 2003-04-24 2011-07-15 Merck Sharp & Dohme Hemmer der akt aktivität
AU2004233827B2 (en) * 2003-04-24 2009-05-28 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
JP4673300B2 (ja) 2003-04-24 2011-04-20 メルク・シャープ・エンド・ドーム・コーポレイション Ａｋｔ活性の阻害剤
EP1631548B1 (fr) * 2003-04-24 2009-10-28 Merck & Co., Inc. Inhibiteurs de l'activite de l'akt
WO2005007099A2 (fr) 2003-07-10 2005-01-27 Imclone Systems Incorporated Inhibiteurs de la pkb utilises comme agents antitumoraux
EP2468729B1 (fr) 2003-10-15 2013-12-25 Ube Industries, Ltd. Nouveau dérivé d'indazole
AU2005233569B2 (en) 2004-04-09 2010-08-19 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
AU2005290081B2 (en) 2004-08-23 2010-12-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
CA2588474A1 (fr) 2004-12-02 2006-06-29 Merck & Co., Inc. Inhibiteurs de l'activite de akt
AU2005316826A1 (en) 2004-12-15 2006-06-22 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
JP2008530111A (ja) 2005-02-14 2008-08-07 メルク エンド カムパニー インコーポレーテッド Ａｋｔ活性の阻害剤
CA2602197A1 (fr) 2005-04-12 2006-10-19 Merck & Co., Inc. Inhibiteur de l'activite akt
PT1898903E (pt) 2005-06-10 2013-06-28 Merck Sharp & Dohme Inibidores da atividade de akt
AR064010A1 (es) 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt

Also Published As

Publication number Publication date
AU2006258124B8 (en) 2010-01-07
KR20080016627A (ko) 2008-02-21
EP1898903A2 (fr) 2008-03-19
BRPI0611717A2 (pt) 2009-01-13
JP5055494B2 (ja) 2012-10-24
JP2009501698A (ja) 2009-01-22
KR100959771B1 (ko) 2010-05-28
PT1898903E (pt) 2013-06-28
WO2006135627A3 (fr) 2008-07-31
IL187690A (en) 2012-06-28
NI200700320A (es) 2008-06-17
EP1898903A4 (fr) 2010-07-21
EP1898903B1 (fr) 2013-03-27
PL1898903T3 (pl) 2013-08-30
US20100222321A1 (en) 2010-09-02
ES2409168T3 (es) 2013-06-25
MX2007015578A (es) 2008-03-06
DK1898903T3 (da) 2013-07-01
AU2006258124B2 (en) 2009-09-03
CA2610888A1 (fr) 2006-12-21
CA2610888C (fr) 2011-02-08
RU2421454C2 (ru) 2011-06-20
WO2006135627A2 (fr) 2006-12-21
IL187690A0 (en) 2008-11-03
AU2006258124A1 (en) 2006-12-21
EP1898903B8 (fr) 2013-05-15
TW200800166A (en) 2008-01-01
CR9580A (es) 2008-09-23
US8008317B2 (en) 2011-08-30
NZ563423A (en) 2010-05-28
ECSP077980A (es) 2008-01-23
RU2008100045A (ru) 2009-07-20
HRP20130429T1 (en) 2013-06-30

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