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NI200700320A - Inhibidores de la actividad akt - Google Patents

Inhibidores de la actividad akt

Info

Publication number
NI200700320A
NI200700320A NI200700320A NI200700320A NI200700320A NI 200700320 A NI200700320 A NI 200700320A NI 200700320 A NI200700320 A NI 200700320A NI 200700320 A NI200700320 A NI 200700320A NI 200700320 A NI200700320 A NI 200700320A
Authority
NI
Nicaragua
Prior art keywords
akt activity
activity inhibitors
akt
stipulates
compounds
Prior art date
Application number
NI200700320A
Other languages
English (en)
Inventor
Mdonna J Armstrong
Essa H Hu
Iii Michael J Kelly
Yiwei Li
Jun Liang
Kevin John Krodzinak
Michael A Rossi
Philip E Sanderson
Jiabing Wang
Mark E Layton
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NI200700320A publication Critical patent/NI200700320A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención actual estipula compuestos de naftiridina sustituidos que inhiben actividad Akt. En particular, los compuestos descritos inhiben selectivamente una o dos de las isoformas de Akt. La invención también estipula composiciones que comprenden tales compuestos inhibidores y procedimientos para inhibir actividad Akt administrando el compuesto a un paciente en necesidad de tratamiento de cáncer.
NI200700320A 2005-06-10 2007-12-06 Inhibidores de la actividad akt NI200700320A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68972605P 2005-06-10 2005-06-10
US73418805P 2005-11-07 2005-11-07

Publications (1)

Publication Number Publication Date
NI200700320A true NI200700320A (es) 2008-06-17

Family

ID=37532789

Family Applications (1)

Application Number Title Priority Date Filing Date
NI200700320A NI200700320A (es) 2005-06-10 2007-12-06 Inhibidores de la actividad akt

Country Status (22)

Country Link
US (1) US8008317B2 (es)
EP (1) EP1898903B8 (es)
JP (1) JP5055494B2 (es)
KR (1) KR100959771B1 (es)
AU (1) AU2006258124B8 (es)
BR (1) BRPI0611717A2 (es)
CA (1) CA2610888C (es)
CR (1) CR9580A (es)
DK (1) DK1898903T3 (es)
EC (1) ECSP077980A (es)
ES (1) ES2409168T3 (es)
HR (1) HRP20130429T1 (es)
IL (1) IL187690A (es)
MX (1) MX2007015578A (es)
NI (1) NI200700320A (es)
NO (1) NO20080150L (es)
NZ (1) NZ563423A (es)
PL (1) PL1898903T3 (es)
PT (1) PT1898903E (es)
RU (1) RU2421454C2 (es)
TW (1) TW200800166A (es)
WO (1) WO2006135627A2 (es)

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BRPI0611717A2 (pt) 2005-06-10 2009-01-13 Merck & Co Inc composto, composiÇço farmacÊutica e uso do composto
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AR064010A1 (es) 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt
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US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
KR101650956B1 (ko) 2007-07-05 2016-08-24 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
PA8793201A1 (es) 2007-08-14 2009-04-23 Bayer Schering Pharma Ag Pirimidinas bicíclicas fusinadas
US20100048912A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
AU2009255358A1 (en) * 2008-06-03 2009-12-10 Msd K.K. Inhibitors of Akt activity
US8536193B2 (en) * 2008-06-03 2013-09-17 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
KR20110030700A (ko) 2008-07-17 2011-03-23 바이엘 크롭사이언스 아게 살해충제로 사용되는 헤테로사이클릭 화합물
EP2391623A4 (en) * 2009-02-02 2012-09-05 Merck Sharp & Dohme INHIBITORS OF AKT ACTIVITY
AU2010210422A1 (en) 2009-02-05 2011-08-18 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens
EA201101186A1 (ru) 2009-02-13 2012-04-30 Байер Фарма Акциенгезельшафт Конденсированные пиримидины
ES2435804T3 (es) 2009-02-13 2013-12-23 Bayer Intellectual Property Gmbh Pirimidinas condensadas como inhibidores de Akt
US8481503B2 (en) * 2009-03-06 2013-07-09 Merck Sharp & Dohme Corp. Combination cancer therapy with an AKT inhibitor and other anticancer agents
EP2406250B1 (en) * 2009-03-11 2015-08-12 Merck Sharp & Dohme Corp. Inhibitors of akt activity
US8168652B2 (en) 2009-03-12 2012-05-01 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
EP2266985A1 (en) * 2009-06-26 2010-12-29 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Tricyclic Pyrimidine Derivatives as Wnt antagonists
WO2011033265A1 (en) * 2009-09-18 2011-03-24 Almac Discovery Limited Pharmaceutical compounds
US20120252806A1 (en) * 2009-12-17 2012-10-04 Kelly Iii Michael J Inhibitors of akt activity
GB0922589D0 (en) * 2009-12-23 2010-02-10 Almac Discovery Ltd Pharmaceutical compounds
WO2012007345A2 (en) * 2010-07-12 2012-01-19 Bayer Pharma Aktiengesellschaft Substituted imidazo[1,2-a]pyrimidines and -pyridines
CN104086528A (zh) * 2010-07-15 2014-10-08 拜耳知识产权有限责任公司 作为杀虫剂的新杂环化合物
BR112013025777A2 (pt) 2011-04-07 2016-12-20 Bayer Ip Gmbh imidazopiridazinas como inibidores da quinase akt
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
MA37647A1 (fr) * 2012-05-17 2016-03-31 Genentech Inc Procédé de fabrication de composés de cyclopentapyrimidine hydroxylée et sels de ceux-ci
CA2892361A1 (en) 2012-11-28 2014-06-05 Merck Sharp & Dohme Corp. Use of a wee1 inhibitor for treating a cancer characterized by low pkmyt1 expression levels
MA38287B1 (fr) 2013-01-23 2018-08-31 Astrazeneca Ab Nouveaux dérivés aminopyrazine pour le traitement ou la prévention du cancer
EP4066841A1 (en) 2013-03-14 2022-10-05 University of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
KR20160058774A (ko) 2013-08-12 2016-05-25 토카이 파마슈티컬, 아이엔씨. 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커
EP3091016A1 (en) * 2015-05-05 2016-11-09 Technische Universität Dortmund Kinase inhibitors and their use in cancer therapy
KR102214225B1 (ko) * 2015-12-07 2021-02-10 쑤저우 시노벤트 파마슈티칼즈 씨오., 엘티디. 5원 헤테로시클릭 아미드계 wnt 경로 억제제
TW201822637A (zh) 2016-11-07 2018-07-01 德商拜耳廠股份有限公司 用於控制動物害蟲的經取代磺醯胺類
CA3074641A1 (en) 2017-09-07 2019-03-14 Augusta University Research Institute, Inc. Specific akt3 activator and uses thereof
WO2021118924A2 (en) 2019-12-12 2021-06-17 Ting Therapeutics Llc Compositions and methods for the prevention and treatment of hearing loss
US20250074905A1 (en) * 2021-11-05 2025-03-06 Georgiamune Inc. Akt3 modulators

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BRPI0611717A2 (pt) 2005-06-10 2009-01-13 Merck & Co Inc composto, composiÇço farmacÊutica e uso do composto
AR064010A1 (es) * 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt

Also Published As

Publication number Publication date
RU2421454C2 (ru) 2011-06-20
BRPI0611717A2 (pt) 2009-01-13
US20100222321A1 (en) 2010-09-02
CA2610888A1 (en) 2006-12-21
KR100959771B1 (ko) 2010-05-28
MX2007015578A (es) 2008-03-06
DK1898903T3 (da) 2013-07-01
US8008317B2 (en) 2011-08-30
ECSP077980A (es) 2008-01-23
PT1898903E (pt) 2013-06-28
RU2008100045A (ru) 2009-07-20
CR9580A (es) 2008-09-23
ES2409168T3 (es) 2013-06-25
NZ563423A (en) 2010-05-28
TW200800166A (en) 2008-01-01
IL187690A0 (en) 2008-11-03
IL187690A (en) 2012-06-28
NO20080150L (no) 2008-03-10
WO2006135627A2 (en) 2006-12-21
EP1898903B1 (en) 2013-03-27
WO2006135627A3 (en) 2008-07-31
EP1898903A4 (en) 2010-07-21
KR20080016627A (ko) 2008-02-21
JP5055494B2 (ja) 2012-10-24
HRP20130429T1 (en) 2013-06-30
JP2009501698A (ja) 2009-01-22
CA2610888C (en) 2011-02-08
AU2006258124B2 (en) 2009-09-03
AU2006258124A1 (en) 2006-12-21
EP1898903B8 (en) 2013-05-15
EP1898903A2 (en) 2008-03-19
AU2006258124B8 (en) 2010-01-07
PL1898903T3 (pl) 2013-08-30

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