[go: up one dir, main page]

NO20061840L - Legemiddelbelegg som tilveiebringer hoy legemiddeltilsetning og fremgangsmater for a tilveiebringe samme - Google Patents

Legemiddelbelegg som tilveiebringer hoy legemiddeltilsetning og fremgangsmater for a tilveiebringe samme

Info

Publication number
NO20061840L
NO20061840L NO20061840A NO20061840A NO20061840L NO 20061840 L NO20061840 L NO 20061840L NO 20061840 A NO20061840 A NO 20061840A NO 20061840 A NO20061840 A NO 20061840A NO 20061840 L NO20061840 L NO 20061840L
Authority
NO
Norway
Prior art keywords
drug
coatings
providing
present
methods
Prior art date
Application number
NO20061840A
Other languages
English (en)
Inventor
Evangeline G Cruz
Tracy Ann Fink
Gregory C Ruhlmann
Brenda Pollock
Sherry Li
Carmelita Garcia
Alfredo M Wong
Ryan Bronz
David Edgren
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of NO20061840L publication Critical patent/NO20061840L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Det beskrives vandige medikamentbelegg som inkluderer minst et uoppløselig medikament, der medikamentet står for rundt 85 til rundt 97 vekt-% av medikamentbelegget. Et medikamentbelegg ifølge oppfinnelsen kan inkludere kun et uoppløselig medikament, to eller flere slike, eller et eller flere uoppløselige medikamenter i kombinasjon med et eller flere oppløselige medikamenter. Oppfinnelsen inkluderer også medikamentbeleggsformuleringer som er egnet for å tilveiebringe medikamentbelegg ifølge oppfinnelsen og doseringsformer som inkluderer et medikamentbelegg i henhold til oppfinnelsen.
NO20061840A 2003-09-26 2006-04-26 Legemiddelbelegg som tilveiebringer hoy legemiddeltilsetning og fremgangsmater for a tilveiebringe samme NO20061840L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50619503P 2003-09-26 2003-09-26
PCT/US2004/031592 WO2005072079A2 (en) 2003-09-26 2004-09-23 Drug coating providing high drug loading and methods for providing the same

Publications (1)

Publication Number Publication Date
NO20061840L true NO20061840L (no) 2006-06-26

Family

ID=34825863

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061840A NO20061840L (no) 2003-09-26 2006-04-26 Legemiddelbelegg som tilveiebringer hoy legemiddeltilsetning og fremgangsmater for a tilveiebringe samme

Country Status (15)

Country Link
US (3) US8246986B2 (no)
EP (2) EP1708684A2 (no)
JP (1) JP4919801B2 (no)
KR (1) KR20060092255A (no)
CN (4) CN1897924B (no)
AT (1) ATE544447T1 (no)
AU (1) AU2004314693B2 (no)
CA (1) CA2540308C (no)
ES (1) ES2366721T3 (no)
IL (1) IL174561A (no)
MX (1) MXPA06003450A (no)
NO (1) NO20061840L (no)
NZ (1) NZ546148A (no)
WO (1) WO2005072079A2 (no)
ZA (4) ZA200603309B (no)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5670609B2 (ja) * 2003-09-26 2015-02-18 アルザ・コーポレーシヨン 有効成分の制御送達のためのｏｒｏｓプッシュ−スティック
JP2007506775A (ja) * 2003-09-26 2007-03-22 アルザ・コーポレーシヨン 漸増する放出速度を表す制御放出製剤
US20050158382A1 (en) * 2003-09-26 2005-07-21 Evangeline Cruz Controlled release formulations of opioid and nonopioid analgesics
AU2004314693B2 (en) 2003-09-26 2011-04-07 Alza Corporation Drug coating providing high drug loading and methods for providing the same
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
WO2006117803A2 (en) * 2005-03-14 2006-11-09 Devarajan, Padma, Venkitachalam Transmucosal drug delivery systems
MX2007012220A (es) * 2005-04-06 2007-12-06 Mallinckrodt Inc Formulacion farmaceutica de liberacion por pulsos a base de matriz.
US20100172989A1 (en) * 2006-01-21 2010-07-08 Abbott Laboratories Abuse resistant melt extruded formulation having reduced alcohol interaction
US20090317355A1 (en) * 2006-01-21 2009-12-24 Abbott Gmbh & Co. Kg, Abuse resistant melt extruded formulation having reduced alcohol interaction
US20090022798A1 (en) * 2007-07-20 2009-01-22 Abbott Gmbh & Co. Kg Formulations of nonopioid and confined opioid analgesics
US8765178B2 (en) * 2006-07-19 2014-07-01 Watson Laboratories, Inc. Controlled release formulations and associated methods
US8932345B2 (en) * 2007-02-07 2015-01-13 Cook Medical Technologies Llc Medical device coatings for releasing a therapeutic agent at multiple rates
EP2155167A2 (en) 2007-06-04 2010-02-24 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
EP2182928A1 (en) * 2007-07-20 2010-05-12 Abbott GmbH & Co. KG Formulations of nonopioid and confined opioid analgesics
MX336494B (es) * 2007-10-16 2016-01-21 Paladin Labs Inc Composicion de bicapas para la liberacion controlada de acetaminofeno y tramadol.
WO2009076764A1 (en) 2007-12-17 2009-06-25 Labopharm Inc. Misuse preventative, controlled release formulation
JP2011511782A (ja) 2008-02-12 2011-04-14 アボット・ラボラトリーズ 長期放出性ヒドロコドンアセトアミノフェンならびにその関連方法および用途
US8372432B2 (en) 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
AU2009223061B2 (en) 2008-03-11 2014-10-09 Depomed Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
US20100068233A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Modifiable dosage form
US20100069821A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable medicament release-sites final dosage form
US20100068256A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable medicament release-substance
US20100068275A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Personalizable dosage form
US20100068254A1 (en) * 2008-09-16 2010-03-18 Mahalaxmi Gita Bangera Modifying a medicament availability state of a final dosage form
US20100069887A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Multiple chamber ex vivo adjustable-release final dosage form
WO2010036777A1 (en) 2008-09-25 2010-04-01 Isp Investments Inc. Smooth, high solids tablet coating composition
ES2509497T3 (es) 2008-12-16 2014-10-17 Paladin Labs Inc. Formulación de liberación controlada para evitar un uso indebido
CA2751667C (en) 2009-02-06 2016-12-13 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
CN101856339A (zh) * 2009-04-09 2010-10-13 广州柏赛罗药业有限公司 一种控释制剂及其制备方法
CN101879146A (zh) * 2009-05-08 2010-11-10 广州柏赛罗药业有限公司 一种控释制剂及其制备方法
AU2010265213B2 (en) 2009-06-24 2012-08-23 Egalet Ltd. Controlled release formulations
RU2012112552A (ru) * 2009-08-31 2013-10-10 Дипомед, Инк. Удерживаемые в желудке фармацевтические композиции для немедленного и продленного высвобождения ацетаминофена
EP2478019B1 (de) 2009-09-17 2015-04-01 Basf Se Mit wirkstoffhaltigen überzügen beschichtete pellets
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
CN102160855B (zh) * 2011-03-30 2013-01-23 吴家安 右旋布洛芬缓释片及制备方法
US9050335B1 (en) 2011-05-17 2015-06-09 Mallinckrodt Llc Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
JP6199321B2 (ja) * 2012-03-02 2017-09-20 ローズ ファーマシューティカルズ エル．ピー． 不正使用抵抗性の即時放出製剤
US9730885B2 (en) 2012-07-12 2017-08-15 Mallinckrodt Llc Extended release, abuse deterrent pharmaceutical compositions
LT3069733T (lt) * 2013-11-13 2022-11-25 National Defense Education And Research Foundation Nauja acetaminofeno junginio sudėtis be šalutinio poveikio kepenims
CN104523644B (zh) * 2015-01-27 2017-06-20 江苏联环药业股份有限公司 一种快速溶出的氯雷他定片剂及其制备工艺
AU2016243691A1 (en) 2015-04-02 2017-10-12 Theravance Biopharma Randd Ip, LLC Combination dosage form of a mu opioid receptor antagonist and an opioid agent
JP6858729B2 (ja) * 2018-05-25 2021-04-14 ▲財▼▲団▼法人国防教育研究基金会Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成
JP7564805B2 (ja) * 2018-10-05 2024-10-09 アイエスピー インヴェストメンツ エルエルシー 水溶性セルロースエーテルを含有する平滑な高固形分フィルムコーティング組成物、その調製方法およびその使用方法
WO2020180691A1 (en) * 2019-03-01 2020-09-10 Avadel Legacy Pharmaceuticals, Llc Liquid guaifenesin compositions with stable extended release profiles

Family Cites Families (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2799241A (en) 1949-01-21 1957-07-16 Wisconsin Alumni Res Found Means for applying coatings to tablets or the like
US3173877A (en) 1957-09-09 1965-03-16 Wyandotte Chemicals Corp Detergent compositions comprising inorganic esters of epoxyhydrocarbon polymers
US3173876A (en) 1960-05-27 1965-03-16 John C Zobrist Cleaning methods and compositions
NL271831A (no) 1960-11-29
US3276586A (en) 1963-08-30 1966-10-04 Rosaen Filter Co Indicating means for fluid filters
NL145278B (nl) 1966-04-06 1975-03-17 Nebraska State Werkwijze ter uitvoering van een heresteringsreactie tussen een vloeibare polyhydrische alcohol en een hydrofobe ester van een vetzuur met lange keten.
US3546142A (en) 1967-01-19 1970-12-08 Amicon Corp Polyelectrolyte structures
US3541006A (en) 1968-07-03 1970-11-17 Amicon Corp Ultrafiltration process
US3541005A (en) 1969-02-05 1970-11-17 Amicon Corp Continuous ultrafiltration of macromolecular solutions
US3995631A (en) 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US4034756A (en) 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US3865108A (en) 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
GB1478759A (en) 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4063064A (en) 1976-02-23 1977-12-13 Coherent Radiation Apparatus for tracking moving workpiece by a laser beam
US4111201A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for delivering selected beneficial agents having varying degrees of solubility
US4111202A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for the controlled and delivery of agent over time
US4207893A (en) 1977-08-29 1980-06-17 Alza Corporation Device using hydrophilic polymer for delivering drug to biological environment
US4285987A (en) 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4235236A (en) 1979-02-12 1980-11-25 Alza Corporation Device for dispensing drug by combined diffusional and osmotic operations
US4320759A (en) 1980-04-28 1982-03-23 Alza Corporation Dispenser with diffuser
US4278087A (en) 1980-04-28 1981-07-14 Alza Corporation Device with integrated operations for controlling release of agent
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4464378A (en) 1981-04-28 1984-08-07 University Of Kentucky Research Foundation Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
US4449983A (en) 1982-03-22 1984-05-22 Alza Corporation Simultaneous delivery of two drugs from unit delivery device
GR79215B (no) 1982-06-07 1984-10-22 Glaxo Group Ltd
US4519801A (en) 1982-07-12 1985-05-28 Alza Corporation Osmotic device with wall comprising cellulose ether and permeability enhancer
US4681583A (en) 1982-12-20 1987-07-21 Alza Corporation System for dispersing drug in biological environment
US4578075A (en) 1982-12-20 1986-03-25 Alza Corporation Delivery system housing a plurality of delivery devices
US4576604A (en) 1983-03-04 1986-03-18 Alza Corporation Osmotic system with instant drug availability
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
US4777049A (en) 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
US4663149A (en) 1984-03-21 1987-05-05 Alza Corporation Dispenser comprising inner and outer walls functioning as cooperative unit
GB8414221D0 (en) 1984-06-04 1984-07-11 Sterwin Ag Unit dosage form
US4847077A (en) 1984-07-18 1989-07-11 Pennwalt Corporation Controlled release pharmaceutical preparations
AU4640985A (en) 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
GB8521350D0 (en) 1985-08-28 1985-10-02 Euro Celtique Sa Analgesic composition
US4763405A (en) 1986-08-21 1988-08-16 Matsushita Electric Industrial Co., Ltd. Chip-placement machine with test function
US4801461A (en) 1987-01-28 1989-01-31 Alza Corporation Pseudoephedrine dosage form
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US4786503A (en) 1987-04-06 1988-11-22 Alza Corporation Dosage form comprising parallel lamine
US4806359A (en) 1987-04-22 1989-02-21 Mcneilab, Inc. Iburprofen sustained release matrix and process
US5200193A (en) 1987-04-22 1993-04-06 Mcneilab, Inc. Pharmaceutical sustained release matrix and process
US4946675A (en) 1987-05-27 1990-08-07 Xoma Corporation Hepatic blocking agents
US4892778A (en) 1987-05-27 1990-01-09 Alza Corporation Juxtaposed laminated arrangement
US4940465A (en) 1987-05-27 1990-07-10 Felix Theeuwes Dispenser comprising displaceable matrix with solid state properties
US5340590A (en) 1987-06-25 1994-08-23 Alza Corporation Delivery system with bilayer osmotic engine
US5023088A (en) 1987-06-25 1991-06-11 Alza Corporation Multi-unit delivery system
US4915949A (en) 1987-07-13 1990-04-10 Alza Corporation Dispenser with movable matrix comprising a plurality of tiny pills
US5004613A (en) 1987-07-27 1991-04-02 Mcneil-Ppc, Inc. Oral sustained release pharmaceutical formulation and process
US4968509A (en) 1987-07-27 1990-11-06 Mcneilab, Inc. Oral sustained release acetaminophen formulation and process
US4820522A (en) 1987-07-27 1989-04-11 Mcneilab, Inc. Oral sustained release acetaminophen formulation and process
US4915954A (en) 1987-09-03 1990-04-10 Alza Corporation Dosage form for delivering a drug at two different rates
US4961932A (en) 1987-10-26 1990-10-09 Alza Corporation Plurality of tiny pills in liquid dosage form
US5019397A (en) 1988-04-21 1991-05-28 Alza Corporation Aqueous emulsion for pharmaceutical dosage form
US5160743A (en) 1988-04-28 1992-11-03 Alza Corporation Annealed composition for pharmaceutically acceptable drug
US5024842A (en) 1988-04-28 1991-06-18 Alza Corporation Annealed coats
US4931285A (en) 1988-04-28 1990-06-05 Alza Corporation Aqueous based pharmaceutical coating composition for dosage forms
US5006346A (en) 1988-04-28 1991-04-09 Alza Corporation Delivery system
SE461549B (sv) * 1988-06-13 1990-02-26 Sefors Ab Anordning vid ett straalningsdetekteringssystem med ett gasurladdningsroer
US5245357A (en) 1988-09-07 1993-09-14 Seiko Epson Corporation Page printer
US4854470A (en) 1988-09-16 1989-08-08 Ireland Russ L Paint brush holder
US4996047A (en) 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
US5030456A (en) 1988-11-07 1991-07-09 Alza Corporation Dosage form for treating cardiovascular diseases
SE8804629D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
CA2007181C (en) 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
US4990535A (en) 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
US5021053A (en) 1989-07-14 1991-06-04 Alza Corporation Oral osmotic device with hydrogel driving member
US5126142A (en) 1989-07-18 1992-06-30 Alza Corporation Dispenser comprising ionophore
US5221536A (en) 1990-05-07 1993-06-22 Alza Corporation Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
SE9002206D0 (sv) 1990-06-20 1990-06-20 Haessle Ab New compounds
PL166209B1 (pl) 1990-06-20 1995-04-28 Astra Ab Sposób wytwarzania nowych pochodnych benzimidazolu PL
US5156850A (en) 1990-08-31 1992-10-20 Alza Corporation Dosage form for time-varying patterns of drug delivery
US5166145A (en) 1990-09-10 1992-11-24 Alza Corporation Antiemetic therapy
US5417682A (en) 1991-01-30 1995-05-23 Alza Corporation Device for administering active agent to biological environment
US5252338A (en) 1991-06-27 1993-10-12 Alza Corporation Therapy delayed
US5190765A (en) 1991-06-27 1993-03-02 Alza Corporation Therapy delayed
GB9121204D0 (en) 1991-10-04 1991-11-20 Euro Celtique Sa Medicament
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5286493A (en) 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5273760A (en) 1991-12-24 1993-12-28 Euroceltigue, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5478577A (en) 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5858407A (en) 1992-02-27 1999-01-12 Alza Corporation Method for administering tandospirone
US5512299A (en) 1992-03-30 1996-04-30 Alza Corporation Method of treating oral inflammatory disease
US5314697A (en) * 1992-10-23 1994-05-24 Schering Corporation Stable extended release oral dosage composition comprising loratadine and pseudoephedrine
DE4313726A1 (de) 1993-04-27 1994-11-03 Byk Nederland Bv Feste Darreichungsform
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
IL110014A (en) 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
SE9302396D0 (sv) 1993-07-09 1993-07-09 Ab Astra A novel compound form
AU7966694A (en) 1993-07-21 1996-05-02 University Of Kentucky Research Foundation, The A multicompartment hard capsule with control release properties
JPH07112932A (ja) * 1993-08-27 1995-05-02 Mitsui Toatsu Chem Inc 徐放性医薬製剤
EP0640341A1 (en) 1993-08-27 1995-03-01 Mitsui Toatsu Chemicals, Incorporated Sustained release pharmaceutical composition and process for producing same
US6210714B1 (en) 1993-11-23 2001-04-03 Euro-Celtique S.A. Immediate release tablet cores of acetaminophen having sustained-release coating
GB9407386D0 (en) 1994-04-14 1994-06-08 Smithkline Beecham Plc Pharmaceutical formulation
ZA953078B (en) 1994-04-28 1996-01-05 Alza Corp Effective therapy for epilepsies
ES2183841T3 (es) 1994-06-13 2003-04-01 Alza Corp Formas de dosificacion para administrar un farmasco en una formulacion lquidid.
US5460826A (en) 1994-06-27 1995-10-24 Alza Corporation Morphine therapy
US5914131A (en) 1994-07-07 1999-06-22 Alza Corporation Hydromorphone therapy
US5529787A (en) 1994-07-07 1996-06-25 Alza Corporation Hydromorphone therapy
US5633011A (en) 1994-08-04 1997-05-27 Alza Corporation Progesterone replacement therapy
US6491945B1 (en) 1994-09-16 2002-12-10 Alza Corporation Hydrocodone therapy
US5614578A (en) 1994-10-28 1997-03-25 Alza Corporation Injection-molded dosage form
US20020006438A1 (en) 1998-09-25 2002-01-17 Benjamin Oshlack Sustained release hydromorphone formulations exhibiting bimodal characteristics
DE19500644B4 (de) 1995-01-12 2010-09-09 Henkel Ag & Co. Kgaa Sprühgetrocknetes Waschmittel oder Komponente hierfür
US5534263A (en) 1995-02-24 1996-07-09 Alza Corporation Active agent dosage form comprising a matrix and at least two insoluble bands
TW493991B (en) 1995-05-08 2002-07-11 Novartis Ag Pharmaceutical composition for oral administration of active agent having low water solubility and process for preparation of the same
US5912268A (en) 1995-05-22 1999-06-15 Alza Corporation Dosage form and method for treating incontinence
US5780058A (en) 1995-07-21 1998-07-14 Alza Corporation Oral delivery of discrete units
US6132420A (en) 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
EP0914097B1 (en) 1996-03-12 2002-01-16 Alza Corporation Composition and dosage form comprising opioid antagonist
US5993858A (en) 1996-06-14 1999-11-30 Port Systems L.L.C. Method and formulation for increasing the bioavailability of poorly water-soluble drugs
WO1998006380A2 (en) 1996-08-16 1998-02-19 Alza Corporation Dosage form for providing ascending dose of drug
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
JPH10139659A (ja) * 1996-09-10 1998-05-26 Freunt Ind Co Ltd 球形粒子群、その製造方法及びそれを用いた球形粒子製剤
US6919373B1 (en) 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
US5859060A (en) 1997-01-15 1999-01-12 Platt; Chris Timed release tablet comprising naproxen and pseudoepherine
US5998478A (en) 1997-01-15 1999-12-07 Platt; Chris E. Timed release tablet comprising naproxen and pseudoephedrine
US5948787A (en) 1997-02-28 1999-09-07 Alza Corporation Compositions containing opiate analgesics
CA2261787C (en) 1997-05-30 2006-11-14 Laboratorios Phoenix U.S.A., Inc. Multi-layered osmotic device
MY125849A (en) 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
WO1999018159A1 (en) 1997-10-06 1999-04-15 Alza Corporation Injection-moldable composition and article of manufacture comprising same
ATE216238T1 (de) 1997-11-03 2002-05-15 Janssen Pharmaceutica Nv Arzneimittel enthaltend lipidsenkende verbindungen
CN1204890C (zh) * 1997-12-22 2005-06-08 欧罗赛铁克股份有限公司 防止阿片样物质滥用的方法
SE9704870D0 (sv) 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
CA2315890C (en) 1997-12-22 2009-08-11 Alza Corporation Rate controlling membranes for controlled drug delivery devices
FR2772615B1 (fr) 1997-12-23 2002-06-14 Lipha Comprime multicouche pour la liberation instantanee puis prolongee de substances actives
AU1828599A (en) 1997-12-29 1999-07-19 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
AU1937099A (en) 1997-12-31 1999-07-19 Alza Corporation Osmotic drug delivery monitoring system and method
US6245357B1 (en) 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
KR20010041460A (ko) 1998-04-27 2001-05-25 디르크 반테 지질 저하제 및 중합체로 피복된 핵을 갖는 펠릿
US6365183B1 (en) 1998-05-07 2002-04-02 Alza Corporation Method of fabricating a banded prolonged release active agent dosage form
JP2002516848A (ja) 1998-06-03 2002-06-11 アルザ・コーポレーション 長時間の薬物療法を与える方法および装置
US6183466B1 (en) 1998-08-21 2001-02-06 Alza Corporation Dosage form comprising a capsule
JP2002523358A (ja) * 1998-08-25 2002-07-30 プラット，クリス ナプロキセンおよびプソイドエフェドリンを含む徐法性錠剤
US6254891B1 (en) 1998-09-03 2001-07-03 Ascent Pediatrics, Inc. Extended release acetaminophen
US6174547B1 (en) 1999-07-14 2001-01-16 Alza Corporation Dosage form comprising liquid formulation
US20010031279A1 (en) 1998-11-02 2001-10-18 Evangeline Cruz Controlled delivery of antidepressants
NZ511465A (en) 1998-11-02 2003-10-31 Alza Corp Controlled delivery of active agents
DK1126853T3 (da) 1998-11-02 2006-08-14 Alza Corp Kontrolleret levering af antidepressine midler
EP1005863A1 (en) 1998-12-04 2000-06-07 Synthelabo Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof
US6419960B1 (en) 1998-12-17 2002-07-16 Euro-Celtique S.A. Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
EP1027888B1 (en) 1999-02-10 2009-06-10 Pfizer Products Inc. Osmotic system for delivery of solid amorphous dispersions of drugs
DE19915420A1 (de) * 1999-04-06 2000-10-12 Basf Ag Stabilisierte Polyvinylpyrrolidon-Zubereitungen
US6458383B2 (en) * 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6491683B1 (en) 1999-09-07 2002-12-10 Alza Corporation Osmotic dosage form composed of an extruded polymer tube form
US6387403B1 (en) 1999-09-15 2002-05-14 Alza Corporation Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing
ATE292453T1 (de) 1999-12-09 2005-04-15 Alza Corp Antivirale arznei
US6613357B2 (en) 2000-01-13 2003-09-02 Osmotica Corp. Osmotic device containing pseudoephedrine and an H1 antagonist
US6491949B2 (en) 2000-01-14 2002-12-10 Osmotica Corp. Osmotic device within an osmotic device
US6245657B1 (en) 2000-04-03 2001-06-12 Taiwan Semiconductor Manufacturing Company Self-aligned, low contact resistance, via fabrication process
EP1272035A1 (en) 2000-07-13 2003-01-08 Euro-Celtique, S.A. Salts and bases of 17-(cyclopropylmethyl)-4,5 alpha-epoxy-6-methylenemorphinan-3,14 diol for optimizing dopamine homeostasis during administration of opioid analgesics
WO2002034240A2 (en) 2000-10-26 2002-05-02 Mehta Atul M Delayed and sustained release formulations and method of use thereof
JP3895570B2 (ja) 2000-12-28 2007-03-22 株式会社ルネサステクノロジ 半導体装置
UA81224C2 (uk) 2001-05-02 2007-12-25 Euro Celtic S A Дозована форма оксикодону та її застосування
MXPA04000209A (es) 2001-07-10 2005-03-07 Teva Pharma Sistema de administracion para la administracion de droga de orden cero, bifasica de orden cero, ascendente o descendente.
US6605302B2 (en) 2001-07-17 2003-08-12 Osmotica Corp. Drug delivery device containing oseltamivir and an H1 antagonist
GB0117618D0 (en) 2001-07-19 2001-09-12 Phoqus Ltd Pharmaceutical dosage form
US6669955B2 (en) 2001-08-28 2003-12-30 Longwood Pharmaceutical Research, Inc. Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
US20030092724A1 (en) * 2001-09-18 2003-05-15 Huaihung Kao Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic
EP1465592A2 (en) 2001-12-19 2004-10-13 Alza Corporation Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
IL162294A0 (en) 2001-12-19 2005-11-20 Alza Corp Formulation & dosage form for the controlled delivery of therapeutic agents
JP4510467B2 (ja) 2002-02-19 2010-07-21 スリーエム イノベイティブ プロパティズ カンパニー 高エネルギー電気化学電池のための温度制御装置および方法
WO2003092633A2 (en) * 2002-05-06 2003-11-13 Massachusetts Institute Of Technology Diffusion-controlled dosage form and method of fabrication including three dimensional printing
NZ536693A (en) 2002-05-31 2007-01-26 Alza Corp Controlled release dosage forms and compositions for osmotic delivery of variable dosages of oxycodone
AU2003245738A1 (en) 2002-06-28 2004-01-19 Alza Corporation C/O Johnson & Johnson Oral dosage from comprising a liquid active agent formulation andcontrolling release thereof by an expandable osmotic composition
EP1534238A1 (en) 2002-07-29 2005-06-01 ALZA Corporation Formulations and dosage forms for controlled delivery of topiramate
EP1538207B1 (en) 2002-09-12 2010-06-02 Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute Human anti-human mcp-1 antibody and antibody fragment thereof
US6893660B2 (en) 2002-11-21 2005-05-17 Andrx Pharmaceuticals, Inc. Stable pharmaceutical compositions without a stabilizer
CA2510465A1 (en) 2002-12-18 2004-07-08 Pain Therapeutics Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats
FR2855756B1 (fr) * 2003-06-06 2005-08-26 Ethypharm Sa Comprime orodispersible multicouche
CN1859897A (zh) 2003-07-31 2006-11-08 阿尔扎公司 用于液态活性剂制剂控制释放的抗渗透的渗透装置和剂型
US20080031901A1 (en) 2004-09-24 2008-02-07 Abbott Laboratories Sustained release monoeximic formulations of opioid and nonopioid analgesics
US20050158382A1 (en) 2003-09-26 2005-07-21 Evangeline Cruz Controlled release formulations of opioid and nonopioid analgesics
AU2004314693B2 (en) 2003-09-26 2011-04-07 Alza Corporation Drug coating providing high drug loading and methods for providing the same
JP2007506775A (ja) 2003-09-26 2007-03-22 アルザ・コーポレーシヨン 漸増する放出速度を表す制御放出製剤
JP5670609B2 (ja) 2003-09-26 2015-02-18 アルザ・コーポレーシヨン 有効成分の制御送達のためのｏｒｏｓプッシュ−スティック
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7457343B2 (en) 2004-11-01 2008-11-25 Avago Technologies Fiber Ip (Singapore) Pte. Ltd. Lens structure, optical transmitter, and method for producing same
MX2008009267A (es) 2006-01-21 2008-10-09 Abbott Gmbh & Co Kg Forma farmaceutica y metodo para la administracion de farmacos de abuso.
US8765178B2 (en) 2006-07-19 2014-07-01 Watson Laboratories, Inc. Controlled release formulations and associated methods

Also Published As

Publication number Publication date
US20120165361A1 (en) 2012-06-28
ZA200603309B (en) 2007-09-26
CA2540308A1 (en) 2005-08-11
AU2004314693A1 (en) 2005-08-11
ZA200603301B (en) 2008-11-26
MXPA06003450A (es) 2006-08-31
ZA200603304B (en) 2007-11-28
JP2007506786A (ja) 2007-03-22
NZ546148A (en) 2009-05-31
EP1708684A2 (en) 2006-10-11
WO2005072079A3 (en) 2006-04-06
CN101208076B (zh) 2011-07-06
CN1897924A (zh) 2007-01-17
JP4919801B2 (ja) 2012-04-18
ATE544447T1 (de) 2012-02-15
US8246986B2 (en) 2012-08-21
CN101208076A (zh) 2008-06-25
CA2540308C (en) 2013-08-06
EP2184058B1 (en) 2012-02-08
EP2184058A1 (en) 2010-05-12
ZA200603303B (en) 2007-09-26
US20110318392A1 (en) 2011-12-29
IL174561A (en) 2012-02-29
CN1972666A (zh) 2007-05-30
WO2005072079A2 (en) 2005-08-11
IL174561A0 (en) 2006-08-20
CN1917863A (zh) 2007-02-21
KR20060092255A (ko) 2006-08-22
CN1897924B (zh) 2011-09-21
ES2366721T3 (es) 2011-10-25
US20050112195A1 (en) 2005-05-26
US8226979B2 (en) 2012-07-24
AU2004314693B2 (en) 2011-04-07

Similar Documents

Publication Publication Date Title
NO20061840L (no) Legemiddelbelegg som tilveiebringer hoy legemiddeltilsetning og fremgangsmater for a tilveiebringe samme
ATE415166T1 (de) Antivirale pharmazeutische zusammensetzungen
NO20011721D0 (no) N-aralkylaminotetraliner som ligander for neuropeptid Y Y5 reseptor
HRP20060240T3 (en) Intranasal formulation of rotigotine
CY1110664T1 (el) Ενδορινικες συνθεσετς
HK1079207A1 (en) Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor
DK1389137T3 (da) Sammensætninger til lungelægemiddellevering af protein
WO2007056142A3 (en) Methods of preventing the serotonin syndrome and compositions for use therefor
ATE345775T1 (de) Zusammensetzungen zur verabreichung von arzneimittelkombinationen
WO2004105737A3 (en) Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions using various agents
PT1121127E (pt) Composicoes farmaceuticas orais contendo buprenorfina
BR0213379A (pt) Formulação resistente a derramamento de mascaramento de gosto
GEP20084490B (en) Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses thereof
EP1940432A4 (en) ANTI-INFLAMMATORY COMPOSITIONS AND METHODS OF USE
EP1354602A4 (en) MEDICAL COMPOSITIONS WITH DIURETIC AGENT AND IMPROVING INSULIN RESISTANCE
BRPI0414305A (pt) sistema de liberação de drogas por via oral
AR030140A1 (es) Composiciones derivadas de la 2-piridinamina y metodos relacionados
PT1355906E (pt) Derivados de 2h-1-benzopirano processos para a sua preparacao e as suas composicoes farmaceuticas
EE200300129A (et) Distamütsiini alfa-halogenoakrüloüülderivaadi kasutamine
TR200302134T4 (tr) 2-metil-tiazolidin-2,4-dikarboksilik asit ve/veya bunun fizyolojik olarak uygun tuzlarının anti-kanser ajanları olarak kullanımı.
ITRM20030394A1 (it) Uso dell'indometacina e derivati come farmaci antivirali e relative composizioni farmaceutiche.
HRP20040165B1 (en) Citalopram for the treatment of elevated blood pressure
ITMI20031015A1 (it) Poli-(amminopirrolcarbossammidi) per uso nella profilassi e nel trattamento delle endoparassitosi animali e loro composizioni con ciclodestrine.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application