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NO20055535L - Makrodkonjugater med anti-inflammatorisk aktivitet - Google Patents

Makrodkonjugater med anti-inflammatorisk aktivitet

Info

Publication number
NO20055535L
NO20055535L NO20055535A NO20055535A NO20055535L NO 20055535 L NO20055535 L NO 20055535L NO 20055535 A NO20055535 A NO 20055535A NO 20055535 A NO20055535 A NO 20055535A NO 20055535 L NO20055535 L NO 20055535L
Authority
NO
Norway
Prior art keywords
macro
formula
conjugates
inflammatory activity
substructure
Prior art date
Application number
NO20055535A
Other languages
English (en)
Other versions
NO20055535D0 (no
NO333909B1 (no
Inventor
Mladen Mercep
Milan Mesic
Visnja Poljak
Boska Hrvacic
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO20055535D0 publication Critical patent/NO20055535D0/no
Publication of NO20055535L publication Critical patent/NO20055535L/no
Publication of NO333909B1 publication Critical patent/NO333909B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Forehggende oppfirmelse angår nye forbindelser representert ved formel (I); hvori M representerer en makrohdundererihet med understrukturen II, formel (II); L representerer kjeden til understrukturen m, formel (III), D representerer steroid- eller ikke-steroidimderenhet avledet fra steroid eller ikke-steroid (NSAID) legemidler med anti-inflammasjonsaktivitet. Foreliggende oppfinnelse angår også farmasøytisk akseptable salter og solvater av slike fremstilte forbindelser, fremgangsmåter og intermediater for deres fremstilling, så vel som den forbedrede terapeutiske virkningen og anvendelsen ved behandling av inflanmiasjonssykdommer og tilstander hos mermesker og dyr.
NO20055535A 2003-04-24 2005-11-23 Makrolidkonjugater med anti-inflammatorisk aktivitet, farmasøytisk sammensetning og anvendelse NO333909B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR20030324A HRP20030324A2 (en) 2003-04-24 2003-04-24 Compounds of antiinflammatory effect
PCT/IB2004/001235 WO2004094449A1 (en) 2003-04-24 2004-04-23 Macrolide-conjugates with anti-inflammatory activity

Publications (3)

Publication Number Publication Date
NO20055535D0 NO20055535D0 (no) 2005-11-23
NO20055535L true NO20055535L (no) 2006-01-16
NO333909B1 NO333909B1 (no) 2013-10-14

Family

ID=33307078

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20055535A NO333909B1 (no) 2003-04-24 2005-11-23 Makrolidkonjugater med anti-inflammatorisk aktivitet, farmasøytisk sammensetning og anvendelse
NO20130898A NO335552B1 (no) 2003-04-24 2013-06-28 Makrolidkonjugater med anti-inflammatorisk aktivitet, anvendelse derav og farmasøytisk sammensetning inneholdende en slik forbindelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20130898A NO335552B1 (no) 2003-04-24 2013-06-28 Makrolidkonjugater med anti-inflammatorisk aktivitet, anvendelse derav og farmasøytisk sammensetning inneholdende en slik forbindelse

Country Status (28)

Country Link
US (1) US7579334B2 (no)
EP (2) EP2070940B1 (no)
JP (1) JP4613366B2 (no)
KR (1) KR101107336B1 (no)
CN (1) CN100393741C (no)
AR (1) AR044083A1 (no)
AT (1) ATE518876T1 (no)
AU (1) AU2004232546B2 (no)
BR (1) BRPI0410490A (no)
CA (1) CA2523081C (no)
CL (1) CL2004000872A1 (no)
CY (2) CY1109491T1 (no)
DE (1) DE602004022047D1 (no)
DK (2) DK1633771T3 (no)
ES (2) ES2330109T3 (no)
HK (2) HK1086842A1 (no)
HR (3) HRP20030324A2 (no)
IS (2) IS2736B (no)
ME (1) MEP34708A (no)
MX (1) MXPA05011359A (no)
NO (2) NO333909B1 (no)
PL (2) PL1633771T3 (no)
PT (2) PT1633771E (no)
RS (1) RS52621B (no)
RU (1) RU2355699C2 (no)
SI (2) SI2070940T1 (no)
WO (1) WO2004094449A1 (no)
ZA (1) ZA200508388B (no)

Families Citing this family (16)

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US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
WO2006018698A2 (en) * 2004-08-12 2006-02-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract
US20060183696A1 (en) * 2004-08-12 2006-08-17 Pliva-Istrazivacki Institut D.O.O. Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
KR20070083811A (ko) * 2004-10-27 2007-08-24 글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오. 항-염증 활성을 가진 접합체
CA2634152A1 (en) * 2005-12-22 2007-06-28 Hydra Biosciences, Inc. Trpa1 inhibitors for treating pain
WO2007093840A2 (en) * 2006-02-15 2007-08-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract
AU2009220779A1 (en) * 2008-03-05 2009-09-11 Panacea Biotec Limited Modified release pharmaceutical compositions comprising mycophenolate and processes thereof
CN102838660B (zh) * 2011-06-23 2016-11-02 上海市第一人民医院 一种抑制炎症免疫反应的小肽及其应用
CN112552364A (zh) * 2013-01-23 2021-03-26 司菲埃拉制药私人有限公司 用于线粒体生物发生和与线粒体功能障碍或耗竭相关的疾病的新颖11β-羟基类固醇化合物
JP2016510750A (ja) 2013-03-08 2016-04-11 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ステロイド薬と直接結合した抗生物質共役体
WO2014138343A1 (en) * 2013-03-08 2014-09-12 Allergan, Inc. Antibiotic conjugates with nonsteroidal anti-inflammatory drugs
SG11201507250YA (en) * 2013-03-08 2015-10-29 Allergan Inc Antibiotic conjugates linked with steroid drugs
WO2014138359A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Steroid antibiotic conjugates
CN106714770B (zh) 2014-07-23 2024-04-19 斯法尔制药私人有限公司 羟基类固醇化合物、其中间体、制备方法、组合物及其用途

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HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect

Also Published As

Publication number Publication date
CL2004000872A1 (es) 2005-03-18
NO20055535D0 (no) 2005-11-23
PT1633771E (pt) 2009-10-20
EP2070940A3 (en) 2009-11-25
PL2070940T3 (pl) 2011-12-30
CN100393741C (zh) 2008-06-11
ES2330109T3 (es) 2009-12-04
IS2736B (is) 2011-06-15
ATE518876T1 (de) 2011-08-15
WO2004094449A1 (en) 2004-11-04
EP2070940B1 (en) 2011-08-03
SI2070940T1 (sl) 2011-12-30
RS20050873A (en) 2007-08-03
HRP20090551T1 (hr) 2010-01-31
NO333909B1 (no) 2013-10-14
HK1129681A1 (en) 2009-12-04
PT2070940E (pt) 2011-11-14
IS8141A (is) 2005-11-22
HRP20030324A2 (en) 2005-02-28
EP1633771B1 (en) 2009-07-15
CY1109491T1 (el) 2014-08-13
ES2370371T3 (es) 2011-12-14
EP2070940A1 (en) 2009-06-17
RS52621B (en) 2013-06-28
SI1633771T1 (sl) 2009-12-31
DK2070940T3 (da) 2011-10-31
JP4613366B2 (ja) 2011-01-19
CY1111978T1 (el) 2015-11-04
AR044083A1 (es) 2005-08-24
JP2006524221A (ja) 2006-10-26
RU2005131937A (ru) 2006-06-27
NO335552B1 (no) 2014-12-29
RU2355699C2 (ru) 2009-05-20
HK1086842A1 (en) 2006-09-29
NO20130898L (no) 2006-01-16
EP1633771A1 (en) 2006-03-15
DK1633771T3 (da) 2009-11-16
CA2523081A1 (en) 2004-11-04
ZA200508388B (en) 2006-07-26
KR101107336B1 (ko) 2012-01-19
KR20060024770A (ko) 2006-03-17
DE602004022047D1 (de) 2009-08-27
PL1633771T3 (pl) 2009-12-31
IS8941A (is) 2010-12-29
HRP20110763T1 (hr) 2011-11-30
CN1777619A (zh) 2006-05-24
BRPI0410490A (pt) 2006-06-13
MXPA05011359A (es) 2006-05-12
US20050080003A1 (en) 2005-04-14
MEP34708A (en) 2011-05-10
AU2004232546A1 (en) 2004-11-04
US7579334B2 (en) 2009-08-25
AU2004232546B2 (en) 2011-06-09
CA2523081C (en) 2010-08-03
WO2004094449A8 (en) 2005-03-31

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