NO20020758D0 - N<o>6</o> heterocykliske substituerte adenosinderivater - Google Patents

N<o>6</o> heterocykliske substituerte adenosinderivater

Info

Publication number: NO20020758D0
Authority: NO; Norway
Prior art keywords: heterocyclic substituted; adenosine derivatives; substituted adenosine; sub; substituted
Prior art date: 1996-08-27

Application number

NO20020758A

Other languages

English (en)

Other versions

NO322459B1 (no

NO20020758L (no

Inventor

Robert T Lum

Jurg R Pfister

Steven R Schow

Michael M Wick

Marek G Nelson

George F Schreiner

Original Assignee

Cv Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-27

Filing date

2002-02-15

Publication date

2002-02-15

1999-02-19 Publication of NO20020758L publication Critical patent/NO20020758L/no

2002-02-15 Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc

2002-02-15 Priority to NO20020758A priority Critical patent/NO322459B1/no

2002-02-15 Publication of NO20020758D0 publication Critical patent/NO20020758D0/no

2006-10-09 Publication of NO322459B1 publication Critical patent/NO322459B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20020758A 1996-08-27 2002-02-15 N6 heterocykliske substituerte adenosinderivater, farmasoytiske sammensetninger omfattende samme, og anvendelse av samme for fremstilling av medikament. NO322459B1 (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO20020758A NO322459B1 (no)	1996-08-27	2002-02-15	N6 heterocykliske substituerte adenosinderivater, farmasoytiske sammensetninger omfattende samme, og anvendelse av samme for fremstilling av medikament.

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US08702234 US5789416B1 (en)	1996-08-27	1996-08-27	N6 mono heterocyclic substituted adenosine derivatives
PCT/US1997/014724 WO1998008855A2 (en)	1996-08-27	1997-08-20	N6 heterocyclic substituted adenosine derivatives
NO19990787A NO312679B1 (no)	1996-08-27	1999-02-19	N6 heterocykliske substituerte adenosinderivater, farmasöytisk sammensetning inneholdende samme, og anvendelse avsamme for fremstilling av preparat
NO20020758A NO322459B1 (no)	1996-08-27	2002-02-15	N6 heterocykliske substituerte adenosinderivater, farmasoytiske sammensetninger omfattende samme, og anvendelse av samme for fremstilling av medikament.

Publications (3)

Publication Number	Publication Date
NO20020758L NO20020758L (no)	1999-02-19
NO20020758D0 true NO20020758D0 (no)	2002-02-15
NO322459B1 NO322459B1 (no)	2006-10-09

Family

ID=24820367

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO19990787A NO312679B1 (no)	1996-08-27	1999-02-19	N6 heterocykliske substituerte adenosinderivater, farmasöytisk sammensetning inneholdende samme, og anvendelse avsamme for fremstilling av preparat
NO20020758A NO322459B1 (no)	1996-08-27	2002-02-15	N6 heterocykliske substituerte adenosinderivater, farmasoytiske sammensetninger omfattende samme, og anvendelse av samme for fremstilling av medikament.
NO20020759A NO20020759D0 (no)	1996-08-27	2002-02-15	N<o>6</o> heterocykliske substituerte adenosinderivater

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO19990787A NO312679B1 (no)	1996-08-27	1999-02-19	N6 heterocykliske substituerte adenosinderivater, farmasöytisk sammensetning inneholdende samme, og anvendelse avsamme for fremstilling av preparat

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20020759A NO20020759D0 (no)	1996-08-27	2002-02-15	N<o>6</o> heterocykliske substituerte adenosinderivater

Country Status (25)

Country	Link
US (1)	US5789416B1 (no)
EP (3)	EP1081155A3 (no)
JP (1)	JP3157842B2 (no)
KR (1)	KR100331775B1 (no)
CN (1)	CN100363377C (no)
AT (2)	ATE202361T1 (no)
AU (1)	AU726597B2 (no)
BR (1)	BR9711444A (no)
CA (1)	CA2264155C (no)
CZ (1)	CZ296855B6 (no)
DE (2)	DE69719816T2 (no)
DK (2)	DK0992510T3 (no)
ES (2)	ES2157593T3 (no)
GE (1)	GEP20012419B (no)
GR (1)	GR3036332T3 (no)
HK (1)	HK1020967A1 (no)
HU (1)	HU226057B1 (no)
IL (2)	IL128652A0 (no)
NO (3)	NO312679B1 (no)
NZ (3)	NZ334095A (no)
PL (1)	PL187635B1 (no)
PT (1)	PT920438E (no)
TR (2)	TR199900377T2 (no)
UA (1)	UA62936C2 (no)
WO (1)	WO1998008855A2 (no)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6790839B2 (en)	1999-01-07	2004-09-14	Can-Fite Biopharma Ltd.	Pharmaceutical administration of adenosine agonists
IL127947A0 (en)	1999-01-07	1999-11-30	Can Fite Technologies Ltd	Pharmaceutical use of adenosine agonists
US6576619B2 (en) *	1999-05-24	2003-06-10	Cv Therapeutics, Inc.	Orally active A1 adenosine receptor agonists
EP1420021A1 (en) *	1999-05-25	2004-05-19	The Penn State Research Foundation	DNA Methyltransferase inhibitors
WO2000075142A2 (en) *	1999-05-25	2000-12-14	The Penn State Research Foundation	Dna methyltransferase inhibitors
US6180615B1 (en) *	1999-06-22	2001-01-30	Cv Therapeutics, Inc.	Propargyl phenyl ether A2A receptor agonists
US6784165B1 (en) *	1999-11-23	2004-08-31	Aderis Pharmaceuticals, Inc.	Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines
US6294522B1 (en) *	1999-12-03	2001-09-25	Cv Therapeutics, Inc.	N6 heterocyclic 8-modified adenosine derivatives
US6258793B1 (en)	1999-12-03	2001-07-10	Cv Therapeutics, Inc.	N6 heterocyclic 5′ modified adenosine derivatives
US6605597B1 (en) *	1999-12-03	2003-08-12	Cv Therapeutics, Inc.	Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
US6576620B2 (en) *	1999-12-03	2003-06-10	Cv Therapeutics, Inc.	Method of identifying partial adenosine A1 receptor agonists
HUP0302685A3 (en) *	2000-09-08	2005-02-28	Cv Therapeutics Inc Palo Alto	Purine ribosides as antiarrhythmics
GB0100623D0 (en)	2001-01-10	2001-02-21	Vernalis Res Ltd	Chemical compounds IV
EP1241176A1 (en) *	2001-03-16	2002-09-18	Pfizer Products Inc.	Purine derivatives for the treatment of ischemia
US20050227933A1 (en) *	2001-11-29	2005-10-13	Benkovic Stephen J	Treatment of bacterial induced diseases using DNA methyl transferase inhibitors
US7405304B2 (en) *	2002-01-10	2008-07-29	The Penn State Research Foundation	Methods for the preparation of alkyl diaryl borinates and complexed diarylboronic acids
KR101032005B1 (ko)	2002-02-19	2011-05-02	씨브이 쎄러퓨틱스, 인코포레이티드	부분적이거나 완전한 ａ1 아데노신 수용체의 작용제
CN1646142A (zh) *	2002-04-18	2005-07-27	Cv医药有限公司	包括给予A1腺苷激动剂以及β受体阻滞剂、钙通道阻滞剂、或强心苷的治疗心律失常的方法
EP1506194B1 (en)	2002-05-17	2006-07-19	Neurogen Corporation	SUBSTITUTED RING-FUSED IMIDAZOLE DERIVATES: GABA sb A /sb RECEPTOR LIGANDS
AU2004209986C1 (en) *	2003-02-03	2009-08-13	Gilead Palo Alto, Inc.	Partial and full agonists of A1 adenosine receptors
US7285550B2 (en)	2003-04-09	2007-10-23	Biogen Idec Ma Inc.	Triazolotriazines and pyrazolotriazines and methods of making and using the same
ATE418555T1 (de)	2003-04-09	2009-01-15	Biogen Idec Inc	A2a-adenosinrezeptorantagonisten
WO2004092177A1 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolopyrazines and methods of making and using the same
EP1633371A1 (en) *	2003-04-24	2006-03-15	Aderis Pharmaceuticals, Inc.	Method of treating atrial fibrillation or atrial flutter
US20050118262A1 (en) *	2003-09-17	2005-06-02	Jack Aurora	Controlled release formulation
US7572799B2 (en)	2003-11-24	2009-08-11	Pfizer Inc	Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
US6881851B1 (en) *	2004-04-21	2005-04-19	Eastman Chemical Company	Preparation of tetrahydro-3-furoic acid
NZ551951A (en) *	2004-05-26	2010-08-27	Inotek Pharmaceuticals Corp	Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
CA2581132A1 (en) *	2004-09-20	2006-03-30	Inotek Pharmaceuticals Corporation	Purine 5'-carboxamide derivatives and their use as adenosine receptor agonists
CN100451010C (zh) *	2004-12-21	2009-01-14	厦门大学	一种合成(r)-3-氨基四氢呋喃的方法
WO2006125190A1 (en) *	2005-05-19	2006-11-23	Cv Therapeutics, Inc.	A1 adenosine receptor agonists
US8067433B2 (en)	2005-11-09	2011-11-29	Zalicus Inc.	Methods, compositions, and kits for the treatment of ophthalmic disorders
CN100344768C (zh) *	2005-11-24	2007-10-24	东华大学	一种3－(s)－氨基四氢呋喃的酶法合成方法
EP1962597A4 (en) *	2005-11-30	2008-12-17	Inotek Pharmaceuticals Corp	PURINE DERIVATIVES AND METHOD OF USE
EP2247729B1 (en)	2008-02-11	2019-05-01	Phio Pharmaceuticals Corp.	Modified rnai polynucleotides and uses thereof
US8815818B2 (en)	2008-07-18	2014-08-26	Rxi Pharmaceuticals Corporation	Phagocytic cell delivery of RNAI
CA3027780A1 (en)	2008-09-22	2010-03-25	Phio Pharmaceuticals Corp.	Reduced size self-delivering rnai compounds
WO2010059226A2 (en)	2008-11-19	2010-05-27	Rxi Pharmaceuticals Corporation	Inhibition of map4k4 through rnai
WO2010078536A1 (en)	2009-01-05	2010-07-08	Rxi Pharmaceuticals Corporation	Inhibition of pcsk9 through rnai
US9745574B2 (en)	2009-02-04	2017-08-29	Rxi Pharmaceuticals Corporation	RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
LT2523669T (lt)	2010-01-11	2017-04-25	Inotek Pharmaceuticals Corporation	Akispūdžio mažinimo būdas, derinys ir rinkinys
CA2794189C (en)	2010-03-24	2022-01-11	Rxi Pharmaceuticals Corporation	Rna interference in dermal and fibrotic indications
WO2011119871A1 (en)	2010-03-24	2011-09-29	Rxi Phrmaceuticals Corporation	Rna interference in ocular indications
EP2550000A4 (en)	2010-03-24	2014-03-26	Advirna Inc	RNAI COMPOUNDS OF REDUCED SIZE ADMINISTERING
EA201290958A1 (ru)	2010-03-26	2013-04-30	Инотек Фармасьютикалз Корпорейшн	Способ снижения внутриглазного давления у людей с применением n6-циклопентиладенозина (cpa), производных cpa или их пролекарств
DE102011005232A1 (de)	2011-03-08	2012-09-13	AristoCon GmbH & Co. KG	Adenosin und seine Derivate zur Verwendung in der Schmerztherapie
SG10201701343QA (en)	2012-01-26	2017-04-27	Inotek Pharmaceuticals Corp	Anhydrous Polymorphs of (2r,3s,4r,5r)-5-(6-(Cyclopentylamino)-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl) } Methyl Nitrate and Processes of Preparation Thereof
NZ630759A (en)	2013-03-15	2017-07-28	Inotek Pharmaceuticals Corp	Ophthalmic formulations comprising an a1 agonist
WO2015084897A2 (en)	2013-12-02	2015-06-11	Mirimmune, Llc	Immunotherapy of cancer
CA2932753A1 (en)	2013-12-04	2015-06-11	Rxi Pharmaceuticals Corporation	Methods for treatment of wound healing utilizing chemically modified oligonucleotides
WO2015168108A2 (en)	2014-04-28	2015-11-05	Rxi Pharmaceuticals Corporation	Methods for treating cancer using nucleic targeting mdm2 or mycn
CA2947619A1 (en)	2014-05-01	2015-11-05	Rxi Pharmaceuticals Corporation	Methods for treatment of disorders in the front of the eye utilizing nucleic acid molecules
JP6836987B2 (ja)	2014-09-05	2021-03-03	フィオファーマシューティカルズコーポレーションＰｈｉｏＰｈａｒｍａｃｅｕｔｉｃａｌｓＣｏｒｐ．	Ｔｙｒまたはｍｍｐ１を標的とする核酸を用いて老化および皮膚障害を処置するための方法
WO2017007825A1 (en)	2015-07-06	2017-01-12	Rxi Pharmaceuticals Corporation	Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
JP6983752B2 (ja)	2015-07-06	2021-12-17	フィオファーマシューティカルズコーポレーションPhio Pharmaceuticals Corp.	スーパーオキシドディスムターゼ１（ｓｏｄ１）を標的とする核酸分子
CN109563509B (zh)	2015-10-19	2022-08-09	菲奥医药公司	靶向长非编码rna的减小尺寸的自递送核酸化合物
CN105218490B (zh) *	2015-11-10	2017-05-03	山东川成医药股份有限公司	一种（r）‑3‑氨基四氢呋喃的制备方法
CN115135765A (zh)	2019-11-08	2022-09-30	菲奥医药公司	用于免疫治疗的靶向含布罗莫结构域之蛋白4(brd4)的经化学修饰的寡核苷酸
WO2021138537A1 (en)	2019-12-31	2021-07-08	Phio Pharmaceuticals Corp.	Chemically modified oligonucleotides with improved systemic delivery
US20240301430A1 (en)	2021-08-04	2024-09-12	Phio Pharmaceuticals Corp.	Chemically modified oligonucleotides
WO2023015264A1 (en)	2021-08-04	2023-02-09	Phio Pharmaceuticals Corp.	Immunotherapy of cancer utilizing natural killer cells treated with chemically modified oligonucleotides

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2460929A1 (de) *	1974-12-21	1976-06-24	Boehringer Sohn Ingelheim	Neue xanthinderivate, verfahren zu ihrer herstellung und ihre anwendung
US4364922A (en) *	1980-10-14	1982-12-21	University Of Virginia Alumni Patents Foundation	Adenosine antagonists in the treatment and diagnosis of A-V node conduction disturbances
JPS57171998A (en) *	1981-04-15	1982-10-22	Fujisawa Pharmaceut Co Ltd	Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same
DE3138397A1 (de) *	1981-09-26	1983-04-07	Hoechst Ag, 6230 Frankfurt	"arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen"
AU577743B2 (en) *	1984-10-26	1988-09-29	Warner-Lambert Company	N6-benzopyrano and benzothiopyrano adenosines
WO1988003148A2 (en) *	1986-10-31	1988-05-05	Warner-Lambert Company	Heteroaromatic derivatives of adenoside
US4954504A (en) *	1986-11-14	1990-09-04	Ciba-Geigy Corporation	N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
US5565566A (en) *	1987-04-24	1996-10-15	Discovery Therapeutics, Inc.	N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US4980379A (en) *	1988-06-30	1990-12-25	The University Of Virginia	Use of adenosine antagonists in the treatment of bradyarrhythmias and hemodynamic depression associated with cardiopulmonary resucitation and/or cardiovascular collapse
IE882585L (en) *	1988-08-25	1990-02-25	Prendergast Patrick T	Viral treatment system
DE3843117A1 (de) *	1988-12-22	1990-06-28	Boehringer Ingelheim Kg	Neue xanthinderivate mit adenosin-antagonistischer wirkung
WO1990009178A1 (en) *	1989-01-31	1990-08-23	Whitby Research, Inc.	N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5017578A (en) *	1989-06-09	1991-05-21	Hoechst-Roussel Pharmaceuticals Inc.	N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents
US5155098A (en) *	1989-06-09	1992-10-13	Hoechst-Roussel Pharmaceuticals Inc.	N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them
JPH06102662B2 (ja) *	1989-09-01	1994-12-14	協和醗酵工業株式会社	キサンチン誘導体
DE4019892A1 (de) *	1990-06-22	1992-01-02	Boehringer Ingelheim Kg	Neue xanthinderivate
US5432164A (en) *	1991-10-24	1995-07-11	Novo Nordisk A/S	C2,N6 -disubstituted adenosine derivatives
DE4205306B4 (de) *	1992-02-21	2005-11-24	Glüsenkamp, Karl-Heinz, Dr.	Säureamide, Arzneimittel mit denselben und Verfahren zur Herstellung von Säureamiden
US5288721A (en) *	1992-09-22	1994-02-22	Cell Therapeutics, Inc.	Substituted epoxyalkyl xanthines
WO1994016702A1 (en) *	1993-01-26	1994-08-04	Kyowa Hakko Kogyo Co., Ltd.	Remedy for irregular bowel movement
US5736528A (en) *	1993-10-28	1998-04-07	University Of Florida Research Foundation, Inc.	N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists
US5446046A (en) *	1993-10-28	1995-08-29	University Of Florida Research Foundation	A1 adenosine receptor agonists and antagonists as diuretics
EP0704215A3 (en) *	1994-06-02	1998-04-01	Takeda Chemical Industries, Ltd.	Inhibitor of vascular permeability enhancer

1996
- 1996-08-27 US US08702234 patent/US5789416B1/en not_active Expired - Lifetime
1997
- 1997-08-20 TR TR1999/00377T patent/TR199900377T2/xx unknown
- 1997-08-20 JP JP51173698A patent/JP3157842B2/ja not_active Expired - Fee Related
- 1997-08-20 AT AT97938502T patent/ATE202361T1/de active
- 1997-08-20 EP EP00123879A patent/EP1081155A3/en not_active Withdrawn
- 1997-08-20 DE DE69719816T patent/DE69719816T2/de not_active Expired - Lifetime
- 1997-08-20 CA CA002264155A patent/CA2264155C/en not_active Expired - Fee Related
- 1997-08-20 KR KR1019997001563A patent/KR100331775B1/ko not_active IP Right Cessation
- 1997-08-20 NZ NZ334095A patent/NZ334095A/xx not_active IP Right Cessation
- 1997-08-20 ES ES97938502T patent/ES2157593T3/es not_active Expired - Lifetime
- 1997-08-20 HU HU0001640A patent/HU226057B1/hu not_active IP Right Cessation
- 1997-08-20 AU AU40809/97A patent/AU726597B2/en not_active Ceased
- 1997-08-20 NZ NZ505428A patent/NZ505428A/en unknown
- 1997-08-20 DK DK99119389T patent/DK0992510T3/da active
- 1997-08-20 UA UA99021148A patent/UA62936C2/uk unknown
- 1997-08-20 EP EP97938502A patent/EP0920438B1/en not_active Expired - Lifetime
- 1997-08-20 ES ES99119389T patent/ES2189330T3/es not_active Expired - Lifetime
- 1997-08-20 BR BR9711444-8A patent/BR9711444A/pt active Search and Examination
- 1997-08-20 AT AT99119389T patent/ATE234323T1/de active
- 1997-08-20 WO PCT/US1997/014724 patent/WO1998008855A2/en active IP Right Grant
- 1997-08-20 DE DE69705312T patent/DE69705312T2/de not_active Expired - Lifetime
- 1997-08-20 TR TR2002/02287T patent/TR200202287T2/xx unknown
- 1997-08-20 PT PT97938502T patent/PT920438E/pt unknown
- 1997-08-20 DK DK97938502T patent/DK0920438T3/da active
- 1997-08-20 CZ CZ0061499A patent/CZ296855B6/cs not_active IP Right Cessation
- 1997-08-20 EP EP99119389A patent/EP0992510B1/en not_active Expired - Lifetime
- 1997-08-20 IL IL12865297A patent/IL128652A0/xx active IP Right Grant
- 1997-08-20 GE GEAP19974728A patent/GEP20012419B/en unknown
- 1997-08-20 CN CNB971991790A patent/CN100363377C/zh not_active Expired - Fee Related
- 1997-08-20 PL PL97331853A patent/PL187635B1/pl not_active IP Right Cessation
1999
- 1999-02-19 NO NO19990787A patent/NO312679B1/no not_active IP Right Cessation
- 1999-02-22 IL IL128652A patent/IL128652A/en not_active IP Right Cessation
- 1999-12-30 HK HK99106191A patent/HK1020967A1/xx not_active IP Right Cessation
2001
- 2001-06-08 NZ NZ512242A patent/NZ512242A/xx not_active IP Right Cessation
- 2001-08-06 GR GR20010401184T patent/GR3036332T3/el unknown
2002
- 2002-02-15 NO NO20020758A patent/NO322459B1/no not_active IP Right Cessation
- 2002-02-15 NO NO20020759A patent/NO20020759D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ505428A (en)	2005-03-24
EP0920438B1 (en)	2001-06-20
HU226057B1 (en)	2008-04-28
GEP20012419B (en)	2001-04-25
US5789416A (en)	1998-08-04
DE69719816T2 (de)	2003-12-18
PL187635B1 (pl)	2004-08-31
TR199900377T2 (xx)	1999-05-21
KR20000035867A (ko)	2000-06-26
NO990787D0 (no)	1999-02-19
DE69705312T2 (de)	2001-10-11
JP2000501426A (ja)	2000-02-08
ATE234323T1 (de)	2003-03-15
NO322459B1 (no)	2006-10-09
EP0992510A1 (en)	2000-04-12
DK0992510T3 (da)	2003-07-07
DK0920438T3 (da)	2001-09-10
NO20020759D0 (no)	2002-02-15
WO1998008855A2 (en)	1998-03-05
GR3036332T3 (en)	2001-11-30
CA2264155C (en)	2003-11-18
HUP0001640A3 (en)	2002-04-29
EP0992510B1 (en)	2003-03-12
EP1081155A3 (en)	2003-05-02
WO1998008855A3 (en)	1998-09-03
UA62936C2 (en)	2004-01-15
KR100331775B1 (ko)	2002-04-09
BR9711444A (pt)	2000-01-18
ATE202361T1 (de)	2001-07-15
DE69719816D1 (de)	2003-04-17
AU4080997A (en)	1998-03-19
JP3157842B2 (ja)	2001-04-16
CZ296855B6 (cs)	2006-07-12
DE69705312D1 (de)	2001-07-26
CA2264155A1 (en)	1998-03-05
HK1020967A1 (en)	2000-05-26
NZ512242A (en)	2004-01-30
PT920438E (pt)	2001-10-30
NO312679B1 (no)	2002-06-17
NZ334095A (en)	2000-10-27
CZ61499A3 (cs)	1999-10-13
CN1234803A (zh)	1999-11-10
NO990787L (no)	1999-02-19
TR200202287T2 (tr)	2003-01-21
HUP0001640A2 (hu)	2001-05-28
CN100363377C (zh)	2008-01-23
AU726597B2 (en)	2000-11-16
IL128652A (en)	2008-06-05
EP1081155A2 (en)	2001-03-07
IL128652A0 (en)	2000-01-31
NO20020759L (no)	1999-02-19
ES2189330T3 (es)	2003-07-01
US5789416B1 (en)	1999-10-05
PL331853A1 (en)	1999-08-16
EP0920438A2 (en)	1999-06-09
ES2157593T3 (es)	2001-08-16
NO20020758L (no)	1999-02-19

Publication	Publication Date	Title
NO20020759D0 (no)	2002-02-15	N<o>6</o> heterocykliske substituerte adenosinderivater
BR9711262A (pt)	1999-08-17	Derivados 6,6 substituido hetero biciclicos
ATE340176T1 (de)	2006-10-15	Substituierte 6,5-heterobicyclische-derivate
DK0831829T3 (da)	2003-12-15	Heterocykliske, ringkondenserede pyrimidinderivater
LU91758I2 (fr)	2011-01-24	Denosumab et ses dérivés pharmaceutiquement acceptables (PROLIA®)
DK0920429T3 (da)	2003-05-12	Substituerede pyrido- eller pyrimidoholdige, 6,6- eller 6,7-bicykliske derivater
DE59501802D1 (de)	1998-05-14	Substituierte 1H-3-Aryl-pyrrolidin-2,4-dion-Derivate
FI914163L (fi)	1992-03-26	Heterocykliska derivat.
NL300203I2 (nl)	2005-11-01	Antiviraal werkzame heterocyclische azahexaan-derivaten.
DK1000048T3 (da)	2003-03-03	Substituerede 1,2,3,4-tetrahydronapthalenderivater
ATE231847T1 (de)	2003-02-15	Substituierte 1,2,3,4- tetrahydronaphthalinderivate
ATE246199T1 (de)	2003-08-15	3-descladinose-2,3-anhydroerythromycin-derivate
FR11C0047I2 (fr)	2013-01-11	Acides 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-(4.3.0)-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinocarboxyliques eventuellement substitues et leurs derives
ATE214063T1 (de)	2002-03-15	Heterocyclische substituierte pyrrolidinamid- derivate
BR9609310A (pt)	1999-07-06	Derivados de 1,3-OXA(TIA)ZINA
TR199700219A3 (tr)	1997-10-21	1,25-Dihidroksi-16, 22, 23-Trisdihidro-kolkalsiferol türevleri.

Legal Events

Date	Code	Title	Description
2012-03-26	MM1K	Lapsed by not paying the annual fees