ATE418555T1 - A2a-adenosinrezeptorantagonisten - Google Patents
A2a-adenosinrezeptorantagonistenInfo
- Publication number
- ATE418555T1 ATE418555T1 AT04759359T AT04759359T ATE418555T1 AT E418555 T1 ATE418555 T1 AT E418555T1 AT 04759359 T AT04759359 T AT 04759359T AT 04759359 T AT04759359 T AT 04759359T AT E418555 T1 ATE418555 T1 AT E418555T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- formula
- adenosin
- adenosin receptor
- antagonists
- Prior art date
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 2
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101150051188 Adora2a gene Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46148403P | 2003-04-09 | 2003-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE418555T1 true ATE418555T1 (de) | 2009-01-15 |
Family
ID=33299825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04759359T ATE418555T1 (de) | 2003-04-09 | 2004-04-09 | A2a-adenosinrezeptorantagonisten |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7834014B2 (de) |
| EP (1) | EP1633756B1 (de) |
| AT (1) | ATE418555T1 (de) |
| DE (1) | DE602004018637D1 (de) |
| WO (1) | WO2004092173A2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060106040A1 (en) | 2002-12-19 | 2006-05-18 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| ATE556712T1 (de) * | 2005-06-07 | 2012-05-15 | Kyowa Hakko Kirin Co Ltd | A2a antagonisten zur behandlung von motorischen störungen |
| US7728031B2 (en) | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
| EP1939197A1 (de) | 2006-12-22 | 2008-07-02 | Schwarz Pharma Ag | 8-Ethinylxanthinderivate als selektive Antagonisten des A2A-Rezeptors |
| EP2188288A1 (de) | 2007-09-11 | 2010-05-26 | Abbott Laboratories | Octahydropyrrolo[3,4-b]pyrrol-n-oxide |
| EA023267B1 (ru) * | 2008-07-23 | 2016-05-31 | Киова Хакко Кирин Ко., Лтд. | Способ для лечения и/или предотвращения мигрени |
| WO2011106688A1 (en) | 2010-02-26 | 2011-09-01 | Catabasis Pharmaceuticals, Inc. | Bis-fatty acid conjugates and their uses |
| WO2011109681A1 (en) | 2010-03-05 | 2011-09-09 | Catabasis Pharmaceuticals, Inc. | Fatty acid cox inhibitor derivatives and their uses |
| US20130045939A1 (en) | 2010-03-19 | 2013-02-21 | Catabasis Pharmaceuticals, Inc. | Fatty acid macrolide derivatives and their uses |
| AU2013344716B2 (en) | 2012-11-16 | 2018-03-01 | University Health Network | Pyrazolopyrimidine compounds |
| WO2014101120A1 (en) * | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties |
| CA3034705C (en) | 2016-08-31 | 2021-08-03 | Agios Pharmaceuticals, Inc. | Inhibitors of cellular metabolic processes |
| CA3056909A1 (en) * | 2017-03-24 | 2018-09-27 | Nanosyn, Inc. | Fused triazolo-pyrimidine compounds having useful pharmaceutical application |
| PT3611174T (pt) * | 2017-04-07 | 2022-07-07 | Medshine Discovery Inc | Derivado de [1,2,4]triazolo[1,5-c]pirimidina como inibidor do recetor a2a |
| CN109535161B (zh) * | 2017-09-22 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 三唑并嘧啶类衍生物、其制备方法及其在医药上的应用 |
| KR20200139153A (ko) | 2018-02-27 | 2020-12-11 | 인사이트 코포레이션 | A2a / a2b 억제제로서의 이미다조피리미딘 및 트리아졸로피리미딘 |
| GB201804922D0 (en) * | 2018-03-27 | 2018-05-09 | Ucl Business Plc | Traatment |
| JP7391046B2 (ja) | 2018-05-18 | 2023-12-04 | インサイト・コーポレイション | Ａ２ａ／ａ２ｂ阻害剤としての縮合ピリミジン誘導体 |
| KR102633145B1 (ko) * | 2018-06-26 | 2024-02-05 | 쩌지앙 빔그린 파머슈티컬스, 엘티디 | A2a 수용체 길항제로서의 트리아졸로 트리아진 유도체 |
| CN117304191A (zh) | 2018-07-05 | 2023-12-29 | 因赛特公司 | 作为a2a/a2b抑制剂的稠合吡嗪衍生物 |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| JP2023508182A (ja) * | 2019-12-26 | 2023-03-01 | チェジン ヴィムグリーン ファーマシューティカルズ リミテッド | トリアゾロトリアジン誘導体の疾患治療への応用 |
| EP4326724A4 (de) * | 2021-04-23 | 2025-03-26 | Chong Kun Dang Pharmaceutical Corp. | Verbindung als adenosin-a2a-rezeptorantagonist und pharmazeutische zusammensetzung damit |
| WO2023191400A1 (ko) * | 2022-04-01 | 2023-10-05 | 에이치케이이노엔 주식회사 | 에틸 피페리딘 트리아졸로 트리아진 유도체, 이의 제조방법 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7406641A (de) | 1973-05-22 | 1974-11-26 | ||
| JPS56131586A (en) | 1980-03-18 | 1981-10-15 | Ss Pharmaceut Co Ltd | Triazolopyrimidine derivative and its preparation |
| JPS56131587A (en) | 1980-03-18 | 1981-10-15 | Ss Pharmaceut Co Ltd | 7-substituted triazolopyrimidine derivative and its preparation |
| JPS5962595A (ja) | 1982-09-30 | 1984-04-10 | Ss Pharmaceut Co Ltd | ３，５，７―トリ置換―トリアゾロピリミジン誘導体 |
| DE3304330A1 (de) * | 1983-02-09 | 1984-08-09 | Basf Ag, 6700 Ludwigshafen | Neue 2h-v-triazolyl(4,5-d)-pyrimidine und deren verwendung |
| JPS60140335A (ja) | 1983-12-28 | 1985-07-25 | Konishiroku Photo Ind Co Ltd | 熱現像カラ−感光材料 |
| US5204353A (en) * | 1987-04-07 | 1993-04-20 | Ciba-Geigy Corporation | 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith |
| WO1990008148A1 (en) | 1989-01-23 | 1990-07-26 | Pfizer Inc. | Bis-aza-bicyclic anxiolytic agents |
| ZA902280B (en) | 1989-03-29 | 1990-12-28 | Merrell Dow Pharma | Selective adenosine receptor agents |
| DK0393424T3 (da) | 1989-04-17 | 1996-02-05 | Bayer Ag | Fremgangsmåde til fremstilling af 2,7-diazabicyclo(3.3.0)octaner |
| GB2240102B (en) | 1990-01-22 | 1993-10-20 | Biochemie Gmbh | Improvements in or relating to beta lactam production |
| GB2244487B (en) | 1990-05-29 | 1994-02-02 | Ici Plc | Azole derivatives |
| US5356894A (en) | 1990-05-29 | 1994-10-18 | Rodney Peter W | Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist |
| JPH0436284A (ja) | 1990-05-29 | 1992-02-06 | Sumitomo Chem Co Ltd | ジフェニルフロピリミジン誘導体、その製造法およびそれを有効成分とする除草剤 |
| CA2100863A1 (en) | 1991-01-23 | 1992-07-24 | David A. Bullough | Adenosine kinase inhibitors |
| GB9111130D0 (en) | 1991-05-23 | 1991-07-17 | Ici Plc | Azole derivatives |
| CA2112674C (en) * | 1991-07-02 | 2005-10-04 | John S. Patton | Method and device for delivering aerosolized medicaments |
| PL175327B1 (pl) | 1992-04-03 | 1998-12-31 | Upjohn Co | Dwupierścieniowe heterocykliczne aminy |
| TW444018B (en) | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
| JP2862374B2 (ja) | 1992-12-17 | 1999-03-03 | フアイザー・インコーポレイテツド | Ｃｒｆアンタゴニスト活性を有するピラゾール及びピラゾロピリミジン |
| US6005109A (en) * | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| EP0674641B1 (de) | 1992-12-17 | 1999-03-03 | Pfizer Inc. | Pyrrolopyrimidine als crf antagonisten |
| IL108523A0 (en) | 1993-02-03 | 1994-05-30 | Gensia Inc | Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain |
| WO1995003806A1 (en) | 1993-07-27 | 1995-02-09 | Kyowa Hakko Kogyo Co., Ltd. | Remedy for parkinson's disease |
| ATE198890T1 (de) | 1993-09-06 | 2001-02-15 | Kyowa Hakko Kogyo Kk | Antidepressiva |
| KR960704855A (ko) * | 1993-10-12 | 1996-10-09 | 돈 엠. 커. | 1n-알킬-n-아릴피리미딘아민 및 이들의 유도체 (1n-alkyl-n-arylpyrimidinamines and derivatives thereof) |
| US5747496A (en) * | 1995-07-11 | 1998-05-05 | Astra Pharmaceuticals Limited | Inhibitors of platelet aggregation |
| US5789416B1 (en) | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| AU743910B2 (en) | 1997-03-24 | 2002-02-07 | Kyowa Hakko Kirin Co., Ltd. | {1,2,4}triazolo{1,5-c}pyrimidine derivatives |
| SK179899A3 (en) | 1997-07-03 | 2001-12-03 | Du Pont Pharm Co | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders |
| JP2002510322A (ja) | 1997-07-03 | 2002-04-02 | デュポン ファーマシューティカルズ カンパニー | 副腎皮質刺激ホルモン放出ホルモン拮抗剤としてのアリールおよびアリールアミノ置換複素環 |
| US5939432A (en) | 1997-10-29 | 1999-08-17 | Medco Research, Inc. | Thiophenes useful for modulating the adenosine receptor |
| WO1999026627A1 (en) * | 1997-11-26 | 1999-06-03 | Cerebrus Limited | (-)-mefloquine to block purinergic receptors and to treat movement or neurodegenerative disorders |
| US6579868B1 (en) | 1998-01-05 | 2003-06-17 | Eisai Co., Ltd. | Purine derivatives and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes |
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| AU2639299A (en) | 1998-02-24 | 1999-09-15 | Kyowa Hakko Kogyo Co. Ltd. | Remedies/preventives for parkinson's disease |
| JPH11279193A (ja) | 1998-03-24 | 1999-10-12 | Akira Matsuda | アデノシン誘導体 |
| NZ508314A (en) | 1998-06-02 | 2004-03-26 | Osi Pharm Inc | Pyrrolo[2,3d]pyrimidine compositions and their use |
| GB9819384D0 (en) * | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| GB9819382D0 (en) * | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds I |
| DE69923197T2 (de) | 1998-09-22 | 2005-12-29 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE |
| TW564247B (en) | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
| GB9915437D0 (en) * | 1999-07-01 | 1999-09-01 | Cerebrus Ltd | Chemical compounds III |
| NZ516260A (en) | 1999-07-02 | 2004-08-27 | Eisai Co Ltd | Fused imidazole compounds and remedies for diabetes mellitus |
| WO2001062233A2 (en) | 2000-02-25 | 2001-08-30 | F. Hoffmann La Roche Ag | Adenosine receptor modulators |
| WO2003020723A1 (en) | 2001-08-30 | 2003-03-13 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINE DERIVATIVE |
| JP4429724B2 (ja) | 2001-11-30 | 2010-03-10 | シェーリング コーポレイション | ［１，２，４］−トリアゾール二環式アデノシンＡ２ａレセプタアンタゴニスト |
| AU2003211993A1 (en) * | 2002-02-15 | 2003-09-04 | Kyowa Hakko Kogyo Co., Ltd. | (1,2,4)TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVES |
| US20060058320A1 (en) | 2002-09-24 | 2006-03-16 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4] Triazolo[1,5-c]pyrimidine derivatives |
| WO2004092170A2 (en) * | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists |
-
2004
- 2004-04-09 AT AT04759359T patent/ATE418555T1/de not_active IP Right Cessation
- 2004-04-09 EP EP04759359A patent/EP1633756B1/de not_active Expired - Lifetime
- 2004-04-09 US US10/552,304 patent/US7834014B2/en not_active Expired - Fee Related
- 2004-04-09 WO PCT/US2004/011009 patent/WO2004092173A2/en not_active Ceased
- 2004-04-09 DE DE602004018637T patent/DE602004018637D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7834014B2 (en) | 2010-11-16 |
| US20070173505A1 (en) | 2007-07-26 |
| EP1633756A2 (de) | 2006-03-15 |
| EP1633756B1 (de) | 2008-12-24 |
| HK1083838A1 (en) | 2006-07-14 |
| WO2004092173A3 (en) | 2004-12-09 |
| WO2004092173A2 (en) | 2004-10-28 |
| DE602004018637D1 (de) | 2009-02-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE418555T1 (de) | A2a-adenosinrezeptorantagonisten | |
| EA200601160A1 (ru) | 2,6-бисгетероарил-4-аминопиримидины в качестве антагонистов аденозиновых рецепторов | |
| MXPA05008524A (es) | Pirazoles y metodos de elaboracion y uso de los mismos. | |
| NL300933I2 (nl) | Letermovir | |
| ATE461196T1 (de) | Benzodiazepin-cgrp-rezeptor-antagonisten | |
| MXPA05002442A (es) | Imidazolopiridinas y metodos para la elaboracion y uso de las mismas. | |
| DE60041710D1 (de) | Polycycloalkylpurine als adenosinrezeptorantagonisten | |
| WO2006015357A3 (en) | 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity | |
| CY1109764T1 (el) | Υποκατεστημενα βενζαζολια και χρηση αυτων ως αναστολεις κινασης raf | |
| UA81624C2 (ru) | Тризамещённые гетероарилы и способ их получения и применение | |
| NZ522326A (en) | Adenosine A2A receptor antagonists | |
| DOP2002000429A (es) | Imidazotriazinas | |
| NO20053115D0 (no) | Fremgangsmate for fremstilling av 2'-forgrenede nukleosider. | |
| EA200500520A1 (ru) | Пуриновые соединения и их применение в качестве лигандов каннабиноидных рецепторов | |
| EA200501333A1 (ru) | 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ | |
| ATE466860T1 (de) | Cgrp-rezeptorantagonisten | |
| DK1450811T3 (da) | Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf | |
| BR0314053A (pt) | Pirazolopiridinas e métodos de obtenção e uso das mesmas | |
| CY1105879T1 (el) | Αζαδικυκλο παραγωγα ως ανταγωνιστες μουσκαρινικου υποδοχεα | |
| MXPA03009185A (es) | Antagonistas de receptor a2a de adenosina combinados con compuestos de actividad neurotrofica en el tratamiento de la enfermedad de parkinson. | |
| CY1109808T1 (el) | Αρυλινδενο-πυριδινες και αρυλινδενο-πυριμιδινες και η χρηση τους ως ανταγωνιστων των υποδοχεων αδενοσινης α2α | |
| TW200621753A (en) | Pyrimidinylimidazoles and methods of making and using the same | |
| WO2004092171A3 (en) | Triazolo[1,5-a]pyrimidines and pyrazolo[1,5-a]pyrimidines useful as a2a adenosin e receptor antagonists | |
| ATE403656T1 (de) | Xanthinderivate als a2b- adenosinrezeptorantagonisten | |
| TW200621752A (en) | Pyrimidinylpyrazoles and methods of making and using the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |