DK1450811T3 - Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf - Google Patents
Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser herafInfo
- Publication number
- DK1450811T3 DK1450811T3 DK02795691.1T DK02795691T DK1450811T3 DK 1450811 T3 DK1450811 T3 DK 1450811T3 DK 02795691 T DK02795691 T DK 02795691T DK 1450811 T3 DK1450811 T3 DK 1450811T3
- Authority
- DK
- Denmark
- Prior art keywords
- adenosine
- receptors
- compounds
- compounds specific
- subject
- Prior art date
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000002126 C01EB10 - Adenosine Substances 0.000 title abstract 2
- 229960005305 adenosine Drugs 0.000 title abstract 2
- 101150046889 ADORA3 gene Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33527301P | 2001-11-30 | 2001-11-30 | |
| US33727401P | 2001-11-30 | 2001-11-30 | |
| PCT/US2002/038055 WO2003048120A2 (en) | 2001-11-30 | 2002-11-27 | 2-aryl pyrrologpyrimidines for a1 and a3 receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1450811T3 true DK1450811T3 (da) | 2010-02-15 |
Family
ID=26989631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02795691.1T DK1450811T3 (da) | 2001-11-30 | 2002-11-27 | Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7504407B2 (da) |
| EP (2) | EP1450811B1 (da) |
| JP (1) | JP2005529062A (da) |
| AT (1) | ATE446298T1 (da) |
| AU (1) | AU2002360436A1 (da) |
| CA (1) | CA2468673C (da) |
| DE (1) | DE60234118D1 (da) |
| DK (1) | DK1450811T3 (da) |
| WO (1) | WO2003048120A2 (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ508314A (en) * | 1998-06-02 | 2004-03-26 | Osi Pharm Inc | Pyrrolo[2,3d]pyrimidine compositions and their use |
| UA74228C2 (uk) * | 2000-12-01 | 2005-11-15 | Осі Фармасьютікалз, Інк. | ПОХІДНІ ПІРОЛО[2,3-d]ПІРИМІДИНУ, СПЕЦИФІЧНІ ДО АДЕНОЗИНОВОГО A<sub>1</sub>, A<sub>2А</sub> І A<sub>3</sub> РЕЦЕПТОРА, СПОСІБ ЇХ ОДЕРЖАННЯ ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ |
| US6680324B2 (en) * | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| NZ525885A (en) * | 2000-12-01 | 2005-01-28 | Osi Pharm Inc | Compounds specific to adenosine A1, A2A, and A3 receptor and uses as ubiquitous modulators of physiological activities |
| DK1450811T3 (da) * | 2001-11-30 | 2010-02-15 | Osi Pharm Inc | Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf |
| KR20040068317A (ko) | 2001-12-20 | 2004-07-30 | 오에스아이 파마슈티컬스, 인코포레이티드 | 피리미딘 ａ₂ｂ 선택성 길항 화합물, 그의 합성 방법 및용도 |
| US20030229067A1 (en) * | 2001-12-20 | 2003-12-11 | Arlindo Castelhano | Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use |
| US20040266776A1 (en) | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
| US20080051393A1 (en) * | 2006-05-01 | 2008-02-28 | Eastern Virginia Medical School | Novel cannabinoids and methods of use |
| CN101484004A (zh) * | 2006-05-01 | 2009-07-15 | 东弗吉尼亚医学院 | 新型大麻素及使用方法 |
| AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
| TWI443337B (zh) * | 2008-10-10 | 2014-07-01 | Ct Hospitalier Universitaire Sainte Justine | 用於脊柱側彎之分類及診斷的方法 |
| DE102008052891A1 (de) * | 2008-10-23 | 2010-05-20 | Ewald Dörken Ag | Befestigungselement für genoppte Kunststoffbahnen |
| WO2011010306A1 (en) | 2009-07-21 | 2011-01-27 | Ramot At Tel-Aviv University Ltd. | A3 adenosine receptor ligands for modulation of pigmentation |
| DE102011005232A1 (de) | 2011-03-08 | 2012-09-13 | AristoCon GmbH & Co. KG | Adenosin und seine Derivate zur Verwendung in der Schmerztherapie |
| CA2900779C (en) | 2013-02-11 | 2021-10-26 | The Regents Of The University Of California | Compositions and methods for treating neurodegenerative diseases and cardiomyopathy |
| ME02904B (me) | 2013-02-22 | 2018-04-20 | Pfizer | DERIVATI PIROLO[2,3 -d]PIRIMIDINA KAO INHIBITORI JANUS KINAZA (JAK) |
| WO2016024185A1 (en) | 2014-08-12 | 2016-02-18 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase |
| US9375478B1 (en) | 2015-01-30 | 2016-06-28 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9937223B2 (en) | 2015-01-30 | 2018-04-10 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9750785B2 (en) | 2015-01-30 | 2017-09-05 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9925233B2 (en) | 2015-01-30 | 2018-03-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9687526B2 (en) | 2015-01-30 | 2017-06-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9744209B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| CA3067695A1 (en) | 2017-06-21 | 2018-12-27 | Mitokinin, Inc. | Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease |
| CN114085178A (zh) * | 2021-12-29 | 2022-02-25 | 苏州楚凯药业有限公司 | 一种4-甲基-1-丙基-2-氨基-1h-吡咯-3-腈的制备方法 |
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| US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| US6673802B2 (en) * | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| NZ525885A (en) | 2000-12-01 | 2005-01-28 | Osi Pharm Inc | Compounds specific to adenosine A1, A2A, and A3 receptor and uses as ubiquitous modulators of physiological activities |
| DK1450811T3 (da) * | 2001-11-30 | 2010-02-15 | Osi Pharm Inc | Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf |
| US20030229067A1 (en) * | 2001-12-20 | 2003-12-11 | Arlindo Castelhano | Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use |
| BR0215279A (pt) | 2001-12-20 | 2005-05-10 | Osi Pharmaceutical Inc | Compostos antagonistas a2b seletivos da pirrolopirimidina, sua sìntese e uso |
| KR20040068317A (ko) | 2001-12-20 | 2004-07-30 | 오에스아이 파마슈티컬스, 인코포레이티드 | 피리미딘 ａ₂ｂ 선택성 길항 화합물, 그의 합성 방법 및용도 |
| US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| JP4074160B2 (ja) * | 2002-08-28 | 2008-04-09 | 富士通株式会社 | 半導体装置の製造方法及びレジストパターンの形成方法 |
| JP2006518390A (ja) | 2003-02-19 | 2006-08-10 | エンダシア，インコーポレイテッド | Ａ１アデノシンレセプターアンタゴニスト |
| CN103309150B (zh) | 2013-06-26 | 2015-06-17 | 上海华力微电子有限公司 | 版图数据的处理方法 |
| US9816053B2 (en) | 2015-03-26 | 2017-11-14 | Melynda S DelCotto | Candle having a wooden wick with figured grain |
| US9804595B1 (en) | 2015-06-19 | 2017-10-31 | Samuel E. Denard | Control system for communicating with and controlling operations of a vehicle |
-
2002
- 2002-11-27 DK DK02795691.1T patent/DK1450811T3/da active
- 2002-11-27 EP EP02795691A patent/EP1450811B1/en not_active Expired - Lifetime
- 2002-11-27 AT AT02795691T patent/ATE446298T1/de not_active IP Right Cessation
- 2002-11-27 AU AU2002360436A patent/AU2002360436A1/en not_active Abandoned
- 2002-11-27 US US10/497,451 patent/US7504407B2/en not_active Expired - Fee Related
- 2002-11-27 DE DE60234118T patent/DE60234118D1/de not_active Expired - Lifetime
- 2002-11-27 WO PCT/US2002/038055 patent/WO2003048120A2/en active Application Filing
- 2002-11-27 JP JP2003549312A patent/JP2005529062A/ja active Pending
- 2002-11-27 CA CA2468673A patent/CA2468673C/en not_active Expired - Fee Related
- 2002-11-27 EP EP09002106A patent/EP2050751A1/en not_active Withdrawn
-
2008
- 2008-08-27 US US12/231,029 patent/US20090192177A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2468673A1 (en) | 2003-06-12 |
| US20090192177A1 (en) | 2009-07-30 |
| AU2002360436A8 (en) | 2003-06-17 |
| WO2003048120A3 (en) | 2003-09-04 |
| DE60234118D1 (de) | 2009-12-03 |
| EP1450811B1 (en) | 2009-10-21 |
| JP2005529062A (ja) | 2005-09-29 |
| AU2002360436A1 (en) | 2003-06-17 |
| EP2050751A1 (en) | 2009-04-22 |
| CA2468673C (en) | 2011-01-25 |
| US7504407B2 (en) | 2009-03-17 |
| EP1450811A2 (en) | 2004-09-01 |
| ATE446298T1 (de) | 2009-11-15 |
| EP1450811A4 (en) | 2005-11-16 |
| US20050090513A1 (en) | 2005-04-28 |
| WO2003048120A2 (en) | 2003-06-12 |
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