NO20010203D0 - Diacylhydrazinderivater som integrininhibitorer - Google Patents
Diacylhydrazinderivater som integrininhibitorerInfo
- Publication number
- NO20010203D0 NO20010203D0 NO20010203A NO20010203A NO20010203D0 NO 20010203 D0 NO20010203 D0 NO 20010203D0 NO 20010203 A NO20010203 A NO 20010203A NO 20010203 A NO20010203 A NO 20010203A NO 20010203 D0 NO20010203 D0 NO 20010203D0
- Authority
- NO
- Norway
- Prior art keywords
- integrin inhibitors
- diacylhydrazine derivatives
- diacylhydrazine
- derivatives
- integrin
- Prior art date
Links
- 125000005077 diacylhydrazine group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19831710A DE19831710A1 (de) | 1998-07-15 | 1998-07-15 | Diacylhydrazinderivate |
PCT/EP1999/004673 WO2000003973A1 (de) | 1998-07-15 | 1999-07-06 | Diacylhydrazinderivate als integrin-inhibitoren |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20010203L NO20010203L (no) | 2001-01-12 |
NO20010203D0 true NO20010203D0 (no) | 2001-01-12 |
Family
ID=7874107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20010203A NO20010203D0 (no) | 1998-07-15 | 2001-01-12 | Diacylhydrazinderivater som integrininhibitorer |
Country Status (22)
Country | Link |
---|---|
US (1) | US6326403B1 (no) |
EP (1) | EP1097127B1 (no) |
JP (1) | JP2002520382A (no) |
KR (1) | KR20010079520A (no) |
CN (1) | CN1309633A (no) |
AR (1) | AR019777A1 (no) |
AT (1) | ATE234276T1 (no) |
AU (1) | AU753333B2 (no) |
BR (1) | BR9912072A (no) |
CA (1) | CA2337305A1 (no) |
DE (2) | DE19831710A1 (no) |
DK (1) | DK1097127T3 (no) |
ES (1) | ES2194486T3 (no) |
HU (1) | HUP0102602A3 (no) |
ID (1) | ID27168A (no) |
NO (1) | NO20010203D0 (no) |
PL (1) | PL345398A1 (no) |
PT (1) | PT1097127E (no) |
SK (1) | SK412001A3 (no) |
TW (1) | TW448145B (no) |
WO (1) | WO2000003973A1 (no) |
ZA (1) | ZA200101267B (no) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ515686A (en) | 1999-06-01 | 2005-01-28 | Biogen Inc | A blocking monoclonal antibody to integrin VLA-1 and its use for the treatment of inflammatory disorders such as arthritis |
US20020002152A1 (en) | 2000-04-14 | 2002-01-03 | Craig Richard A. | Hydrazide and alkoxyamide angiogenesis inhibitors |
PE20011222A1 (es) * | 2000-04-14 | 2001-12-07 | Abbott Lab | Hidrazidas y alcoxiamidas inhibidoras de la angiogenesis |
DE10040103A1 (de) | 2000-08-17 | 2002-02-28 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften II |
DE10040105A1 (de) | 2000-08-17 | 2002-02-28 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften |
DZ3415A1 (fr) * | 2000-08-31 | 2002-03-07 | Chiron Corp | Guanidinobenzamides comme mc4-r agonistes. |
DK1385823T3 (da) | 2001-04-09 | 2007-03-26 | Novartis Vaccines & Diagnostic | Guanidinoforbindelser som melanocortin-4-receptor- (MC4-R) -agonister |
JP4303475B2 (ja) * | 2001-04-13 | 2009-07-29 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Vla−1に対する抗体 |
US7034033B2 (en) | 2002-05-23 | 2006-04-25 | Chiron Corporation | Substituted quinazolinone compounds |
US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
US7304161B2 (en) * | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
US7456315B2 (en) | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
CA2523015A1 (en) | 2003-05-23 | 2004-12-29 | Chiron Corporation | Guanidino-substituted quinazolinone compounds as mc4-r agonists |
DE10325049A1 (de) * | 2003-06-02 | 2004-12-23 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften III |
CA2545601A1 (en) | 2003-11-19 | 2005-06-09 | Chiron Corporation | Quinazolinone compounds with reduced bioaccumulation |
EP1765362B1 (en) | 2004-06-04 | 2012-03-28 | The Scripps Research Institute | Compositions and methods for treatment of neovascular diseases |
JP4745175B2 (ja) * | 2005-12-28 | 2011-08-10 | 本田技研工業株式会社 | 自動二輪車 |
CN105381459A (zh) | 2006-05-25 | 2016-03-09 | 比奥根Ma公司 | 治疗中风的方法 |
ES2672513T3 (es) | 2007-05-29 | 2018-06-14 | Intrexon Corporation | Ligandos de diacilhidrazina quirales para modular la expresión genética exógena a través del complejo del receptor de ecdisona |
WO2013123114A2 (en) | 2012-02-16 | 2013-08-22 | Santarus, Inc. | Antibody formulations |
DK2970106T3 (en) | 2013-03-15 | 2018-08-13 | Intrexon Corp | CONTAINING DIACYL HYDRAZINES |
JP6649902B2 (ja) | 2014-05-30 | 2020-02-19 | ファイザー・インク | 選択的アンドロゲン受容体モジュレーターとしてのカルボニトリル誘導体 |
CN104027805B (zh) * | 2014-06-18 | 2017-02-15 | 北京大学 | 抑制整合素α5的物质在制备预防内皮细胞激活和/或动脉粥样硬化的产品中的新用途 |
WO2016044390A1 (en) | 2014-09-17 | 2016-03-24 | Intrexon Corporation | Boron-containing diacylhydrazine compounds |
TN2020000059A1 (en) | 2017-11-01 | 2022-01-06 | Arrowhead Pharmaceuticals Inc | Integrin ligands and uses thereof |
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5051405A (en) * | 1989-10-10 | 1991-09-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptides and pseudopeptides |
JPH06505978A (ja) * | 1991-02-05 | 1994-07-07 | スミスクライン・ビーチャム・コーポレイション | 芳香族エステルまたはアミドを含有する抗凝集性ペプチド |
US5530028A (en) * | 1992-11-23 | 1996-06-25 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
JPH08505846A (ja) * | 1992-12-29 | 1996-06-25 | スミスクライン・ビーチャム・コーポレイション | 血小板凝集阻害用化合物 |
ATE227567T1 (de) | 1994-05-27 | 2002-11-15 | Merck & Co Inc | Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption |
US5482962A (en) * | 1994-07-22 | 1996-01-09 | Rohm And Haas Company | Insecticidal N,N'-disubstituted-N-N'-diacylhydrazines |
JP2000516197A (ja) * | 1996-01-16 | 2000-12-05 | メルク エンド カンパニー インコーポレーテッド | インテグリンレセプターアンタゴニスト |
-
1998
- 1998-07-15 DE DE19831710A patent/DE19831710A1/de not_active Withdrawn
-
1999
- 1999-07-06 WO PCT/EP1999/004673 patent/WO2000003973A1/de not_active Application Discontinuation
- 1999-07-06 ID IDW20010206A patent/ID27168A/id unknown
- 1999-07-06 US US09/743,605 patent/US6326403B1/en not_active Expired - Fee Related
- 1999-07-06 HU HU0102602A patent/HUP0102602A3/hu unknown
- 1999-07-06 JP JP2000560082A patent/JP2002520382A/ja active Pending
- 1999-07-06 DK DK99934576T patent/DK1097127T3/da active
- 1999-07-06 ES ES99934576T patent/ES2194486T3/es not_active Expired - Lifetime
- 1999-07-06 KR KR1020017000359A patent/KR20010079520A/ko not_active Withdrawn
- 1999-07-06 AU AU50313/99A patent/AU753333B2/en not_active Ceased
- 1999-07-06 AT AT99934576T patent/ATE234276T1/de not_active IP Right Cessation
- 1999-07-06 CN CN99808610A patent/CN1309633A/zh active Pending
- 1999-07-06 EP EP99934576A patent/EP1097127B1/de not_active Expired - Lifetime
- 1999-07-06 PL PL99345398A patent/PL345398A1/xx unknown
- 1999-07-06 BR BR9912072-0A patent/BR9912072A/pt not_active IP Right Cessation
- 1999-07-06 DE DE59904547T patent/DE59904547D1/de not_active Expired - Fee Related
- 1999-07-06 CA CA002337305A patent/CA2337305A1/en not_active Abandoned
- 1999-07-06 SK SK41-2001A patent/SK412001A3/sk unknown
- 1999-07-06 PT PT99934576T patent/PT1097127E/pt unknown
- 1999-07-13 TW TW088111860A patent/TW448145B/zh active
- 1999-07-14 AR ARP990103436A patent/AR019777A1/es not_active Application Discontinuation
-
2001
- 2001-01-12 NO NO20010203A patent/NO20010203D0/no not_active Application Discontinuation
- 2001-02-14 ZA ZA200101267A patent/ZA200101267B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200101267B (en) | 2002-10-04 |
SK412001A3 (en) | 2001-08-06 |
NO20010203L (no) | 2001-01-12 |
HUP0102602A2 (hu) | 2002-01-28 |
PT1097127E (pt) | 2003-07-31 |
DK1097127T3 (da) | 2003-06-10 |
WO2000003973A1 (de) | 2000-01-27 |
EP1097127B1 (de) | 2003-03-12 |
ES2194486T3 (es) | 2003-11-16 |
EP1097127A1 (de) | 2001-05-09 |
AU5031399A (en) | 2000-02-07 |
JP2002520382A (ja) | 2002-07-09 |
US6326403B1 (en) | 2001-12-04 |
TW448145B (en) | 2001-08-01 |
ID27168A (id) | 2001-03-08 |
PL345398A1 (en) | 2001-12-17 |
CA2337305A1 (en) | 2000-01-27 |
HUP0102602A3 (en) | 2002-02-28 |
CN1309633A (zh) | 2001-08-22 |
BR9912072A (pt) | 2001-09-25 |
DE19831710A1 (de) | 2000-01-20 |
AR019777A1 (es) | 2002-03-13 |
KR20010079520A (ko) | 2001-08-22 |
DE59904547D1 (de) | 2003-04-17 |
AU753333B2 (en) | 2002-10-17 |
ATE234276T1 (de) | 2003-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |