NO20002038D0 - Uløselig insulinsammensetning - Google Patents

Uløselig insulinsammensetning

Info

Publication number: NO20002038D0
Authority: NO; Norway
Prior art keywords: insulin composition; insoluble insulin; insoluble; composition; insulin
Prior art date: 1997-10-24

Application number

NO20002038A

Other languages

English (en)

Other versions

NO20002038L (no

Inventor

Mark Laurence Brader

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-24

Filing date

2000-04-18

Publication date

2000-04-18

2000-04-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2000-04-18 Publication of NO20002038D0 publication Critical patent/NO20002038D0/no

2000-06-26 Publication of NO20002038L publication Critical patent/NO20002038L/no

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
229940125396 insulin Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

NO20002038A 1997-10-24 2000-04-18 Uløselige insulinsammensetninger NO20002038L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6310497P	1997-10-24	1997-10-24
US8893098P	1998-06-11	1998-06-11
PCT/US1998/022434 WO1999021578A1 (en)	1997-10-24	1998-10-22	Insoluble insulin compositions

Publications (2)

Publication Number	Publication Date
NO20002038D0 true NO20002038D0 (no)	2000-04-18
NO20002038L NO20002038L (no)	2000-06-26

Family

ID=26743043

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20002038A NO20002038L (no)	1997-10-24	2000-04-18	Uløselige insulinsammensetninger

Country Status (21)

Country	Link
US (3)	US6268335B1 (no)
EP (1)	EP1039920A4 (no)
JP (2)	JP2001521006A (no)
KR (1)	KR20010024556A (no)
CN (1)	CN1276731A (no)
AR (1)	AR020047A1 (no)
AU (2)	AU747926B2 (no)
BR (1)	BR9813111A (no)
CA (2)	CA2306877A1 (no)
CO (1)	CO4970769A1 (no)
EA (1)	EA200000453A1 (no)
HR (1)	HRP20000236A2 (no)
HU (1)	HUP0004169A3 (no)
ID (1)	ID24890A (no)
IL (1)	IL134901A0 (no)
NO (1)	NO20002038L (no)
PE (1)	PE123799A1 (no)
PL (1)	PL340255A1 (no)
SV (1)	SV1998000125A (no)
TR (1)	TR200001050T2 (no)
WO (2)	WO1999021578A1 (no)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6444641B1 (en)	1997-10-24	2002-09-03	Eli Lilly Company	Fatty acid-acylated insulin analogs
US6531448B1 (en)	1997-12-23	2003-03-11	Eli Lilly And Company	Insoluble compositions for controlling blood glucose
US7169889B1 (en) *	1999-06-19	2007-01-30	Biocon Limited	Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
WO2002051428A1 (fr) *	2000-12-25	2002-07-04	Shiseido Company, Ltd.	Composition de parfum stimulant le systeme sympathique
US7060675B2 (en) *	2001-02-15	2006-06-13	Nobex Corporation	Methods of treating diabetes mellitus
US6867183B2 (en)	2001-02-15	2005-03-15	Nobex Corporation	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US20020155614A1 (en) *	2001-02-21	2002-10-24	Tomlinson Andrew J.	Peptide esterification
US6828305B2 (en) *	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en)	2001-06-04	2004-03-30	Nobex Corporation	Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en)	2001-06-04	2005-02-22	Nobex Corporation	Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en)	2001-06-04	2004-12-28	Nobex Corporation	Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7713932B2 (en)	2001-06-04	2010-05-11	Biocon Limited	Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en)	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7238663B2 (en) *	2001-08-28	2007-07-03	Eli Lilly And Company	Pre-mixes of GLP-1 and basal insulin
US6770625B2 (en)	2001-09-07	2004-08-03	Nobex Corporation	Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7030082B2 (en) *	2001-09-07	2006-04-18	Nobex Corporation	Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7312192B2 (en) *	2001-09-07	2007-12-25	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) *	2001-09-07	2005-07-05	Nobex Corporation	Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) *	2001-09-07	2007-01-23	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en)	2001-09-07	2007-03-27	Biocon Limited	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
DK1429731T3 (da) *	2001-09-19	2007-05-14	Elan Pharma Int Ltd	Nanopartikelformuleringer indeholdende insulin
AU2002346491A1 (en) *	2001-12-19	2003-07-09	Eli Lilly And Company	Crystalline compositions for controlling blood glucose
CA2468100A1 (en) *	2001-12-20	2003-07-03	Eli Lilly And Company	Insulin molecule having protracted time action
WO2003105768A2 (en)	2002-06-13	2003-12-24	Nobex Corporation	Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US20040038864A1 (en) *	2002-06-27	2004-02-26	Per Balschmidt	Use of dimethyl sulfone as isotonicity agent
JP2006519791A (ja) *	2003-03-13	2006-08-31	ノボ　ノルディスク　アクティーゼルスカブ	新規なｎｐｈインスリン製剤
US20060258561A1 (en) *	2003-03-13	2006-11-16	Novo Nordisk A/S	Novel NPH insulin preparations
US20050054818A1 (en) *	2003-07-02	2005-03-10	Brader Mark Laurence	Crystalline compositions for controlling blood glucose
EP1648933B1 (en) *	2003-07-25	2009-06-17	ConjuChem Biotechnologies Inc.	Long lasting insulin derivatives and methods thereof
BRPI0413276B8 (pt)	2003-08-05	2021-05-25	Novo Nordisk As	derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
CN102816228A (zh)	2003-12-03	2012-12-12	诺和诺德公司	单链胰岛素
CN101027318B (zh) *	2004-07-19	2016-05-25	比奥孔有限公司	胰岛素-低聚物共轭物，制剂及其用途
ES2391776T3 (es)	2004-11-22	2012-11-29	Novo Nordisk A/S	Formulaciones solubles, estables conteniendo insulina con una sal de protamina
EP1679065A1 (en) *	2005-01-07	2006-07-12	OctoPlus Sciences B.V.	Controlled release compositions for interferon based on PEGT/PBT block copolymers
JP2008533100A (ja) *	2005-03-18	2008-08-21	ノボノルディスクアクティーゼルスカブ	Ｐｅｇ化された単鎖インスリン
CN101389650B (zh)	2005-12-28	2012-10-10	诺沃-诺迪斯克有限公司	包含酰化胰岛素和锌的组合物以及制备所述组合物的方法
WO2007081824A2 (en) *	2006-01-06	2007-07-19	Case Western Reserve University	Fibrillation resistant proteins
US8927015B2 (en) *	2006-04-12	2015-01-06	Emisphere Technologies, Inc.	Formulations for delivering insulin
US20100160209A1 (en) *	2006-05-10	2010-06-24	Smithkline Beecham Corporation	Composition and Method for Increasing Cell Permeability of a Compound
WO2007135118A1 (en) *	2006-05-24	2007-11-29	Novo Nordisk A/S	Soluble, stable insulin-containing formulations
ES2542146T3 (es)	2006-07-31	2015-07-31	Novo Nordisk A/S	Insulinas extendidas PEGiladas.
DK2074141T3 (en)	2006-09-22	2016-11-28	Novo Nordisk As	The protease resistant insulin analogues.
ES2554773T3 (es) *	2006-10-04	2015-12-23	Case Western Reserve University	Insulina y análogos de la insulina resistentes a la fibrilación
WO2008132224A2 (en)	2007-04-30	2008-11-06	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
WO2008152106A1 (en)	2007-06-13	2008-12-18	Novo Nordisk A/S	Pharmaceutical formulation comprising an insulin derivative
ES2548304T3 (es) *	2007-08-15	2015-10-15	Novo Nordisk A/S	Análogos de la insulina que contienen una fracción acilo y alquilenglicol
CN101939023B (zh)	2007-10-16	2016-08-03	百康有限公司	可经口给药的固体药物组合物及其方法
NZ586589A (en)	2008-01-09	2012-04-27	Sanofi Aventis Deutschland	Novel insulin analogues having an extremely delayed time-action profile
DE102008003566A1 (de) *	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
CN102007143B (zh)	2008-01-09	2015-08-26	塞诺菲-安万特德国有限公司	具有超延迟时效特征的新型胰岛素衍生物
WO2009112583A2 (en)	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
HUE032287T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
WO2009129250A2 (en) *	2008-04-14	2009-10-22	Case Western Reserve University	Meal-time insulin analogues of enhanced stability
US20110195896A1 (en) *	2008-04-22	2011-08-11	Case Western Reserve University	Isoform-specific insulin analogues
KR20120129875A (ko)	2008-07-31	2012-11-28	케이스 웨스턴 리저브 유니버시티	염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en)	2008-07-31	2015-12-01	Case Western Reserve University	Insulin analogues containing penta-fluoro-Phenylalanine at position B24
WO2011072288A2 (en) *	2009-12-11	2011-06-16	Case Western Reserve University	Insulin analogues with chlorinated amino acids
US9526764B2 (en)	2008-10-17	2016-12-27	Sanofi-Aventis Deutschland Gmbh	Combination of an insulin and a GLP-1-agonist
MX2011004357A (es)	2008-10-30	2011-05-23	Novo Nordisk As	Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyeccion menor que a diario.
SG193837A1 (en)	2009-01-28	2013-10-30	Smartcells Inc	Conjugate based systems for controlled drug delivery
EP2391217A4 (en)	2009-01-28	2015-05-20	Smartcells Inc	SYNTHETIC CONJUGATES AND USES THEREOF
US20100198188A1 (en) *	2009-02-05	2010-08-05	Abbott Diabetes Care Inc.	Devices and Methods for Metering Insoluble Active Agent Particles
WO2010107519A1 (en)	2009-03-20	2010-09-23	Smartcells, Inc.	Terminally-functionalized conjugates and uses thereof
EP2451471A1 (de) *	2009-07-06	2012-05-16	Sanofi-Aventis Deutschland GmbH	Langsamwirkende insulinzubereitungen
EP2451472A1 (de) *	2009-07-06	2012-05-16	Sanofi-Aventis Deutschland GmbH	Hitze- und schüttelstabile insulinzubereitungen
US8399407B2 (en) *	2009-09-17	2013-03-19	Case Western Reserve University	Non-standard insulin analogues
HUE038147T2 (hu)	2009-11-13	2018-09-28	Sanofi Aventis Deutschland	GLP-1 agonistát, inzulint és metionint tartalmazó gyógyászati készítmény
WO2011058082A1 (de)	2009-11-13	2011-05-19	Sanofi-Aventis Deutschland Gmbh	Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten und methionin
JP5892940B2 (ja)	2009-11-25	2016-03-23	アリスジェンソシエテアノニム	クラウン化合物及び／又は対イオンと複合体化されたペプチドを含む粘膜送達組成物
AU2011202239C1 (en)	2010-05-19	2017-03-16	Sanofi	Long-acting formulations of insulins
MX337549B (es)	2010-06-23	2016-03-10	Novo Nordisk As	Derivados de insulina que contienen enlaces disulfuro adicionales.
WO2012028172A1 (en)	2010-08-30	2012-03-08	Sanofi-Aventis Deutschland Gmbh	Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
JP6049625B2 (ja)	2010-10-27	2016-12-21	ノヴォノルディスクアー／エス	様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
EP2720711A1 (en)	2011-06-15	2014-04-23	Novo Nordisk A/S	Multi substituted insulins
AR087693A1 (es)	2011-08-29	2014-04-09	Sanofi Aventis Deutschland	Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
CN104364260B (zh)	2012-04-11	2017-02-22	诺和诺德股份有限公司	胰岛素制剂
EP2925345B1 (en)	2012-12-03	2018-09-05	Merck Sharp & Dohme Corp.	Method for making o-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
TWI780236B (zh)	2013-02-04	2022-10-11	法商賽諾菲公司	胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
HUE042381T2 (hu)	2013-04-03	2019-06-28	Sanofi Sa	Cukorbetegség kezelése hosszan ható inzulinkészítményekkel
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
JP6499184B2 (ja)	2013-10-07	2019-04-10	ノヴォノルディスクアー／エス	インスリン類似体の新規な誘導体
WO2015104310A1 (en)	2014-01-09	2015-07-16	Sanofi	Stabilized pharmaceutical formulations of insulin aspart
CA2932875A1 (en)	2014-01-09	2015-07-16	Sanofi	Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
JP6641280B2 (ja)	2014-01-09	2020-02-05	サノフイＳａｎｏｆｉ	インスリンアナログおよび／またはインスリン誘導体の安定化された医薬製剤
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
CA2957714A1 (en) *	2014-08-11	2016-02-18	Albany Medical College	Myristoylated leptin-related peptides and uses thereof
EP3204410B1 (en)	2014-10-06	2021-01-20	Case Western Reserve University	Biphasic single-chain insulin analogues
HRP20230470T1 (hr)	2014-12-12	2023-07-21	Sanofi-Aventis Deutschland Gmbh	Formulacija fiksnog omjera inzulin glargin/liksisenatid
CN105884879A (zh) *	2015-01-26	2016-08-24	漳州博欣生物技术有限公司	一种胰岛素类似物的化学合成方法
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
JP2018531900A (ja) *	2015-08-25	2018-11-01	ノヴォノルディスクアー／エス	新規インスリン誘導体及びその医学的使用
CN105597087B (zh) *	2016-01-06	2019-04-26	山东新时代药业有限公司	一种甘精胰岛素注射液及其制备方法
BR112019004314A2 (pt) *	2016-09-06	2019-05-28	Chemical & Biopharmaceutical Laboratories Of Patras S A	derivados pró-insulina
EP3329930A1 (en)	2016-12-05	2018-06-06	Nuritas Limited	Pharmaceuctical compositions
CN110381976A (zh)	2016-12-05	2019-10-25	努里塔斯有限公司	包括肽wkdeagkplvk的组合物
WO2018109162A1 (en)	2016-12-16	2018-06-21	Novo Nordisk A/S	Insulin containing pharmaceutical compositions
WO2018200462A1 (en) *	2017-04-24	2018-11-01	Friedman Simon H	Drug conjugates with photocleavable solubility modulators
JOP20190273A1 (ar) *	2017-05-26	2019-11-24	Lilly Co Eli	مركب إنسولين معالج بأسيل
EP3727424A4 (en)	2017-12-18	2021-10-27	Merck Sharp & Dohme Corp.	CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY
US11413352B2 (en)	2017-12-18	2022-08-16	Merck, Sharp & Dohme LLC	Conjugate based systems for controlled insulin delivery
EP3793568A4 (en) *	2018-05-14	2022-01-19	Aerami Therapeutics, Inc.	INSULIN FORMULATIONS FOR RECONSTITUTION INTO HIGH CONCENTRATION LIQUID SOLUTIONS
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
AU2019398579A1 (en)	2018-12-11	2021-07-29	Sanofi	Peptide binder
CN110063932A (zh) *	2019-04-12	2019-07-30	浙江大学	一种多肽蛋白类药物的缓释组合物制剂及其制备方法
WO2021116292A1 (en)	2019-12-11	2021-06-17	Novo Nordisk A/S	Novel insulin analogues and uses thereof
CA3173417A1 (en)	2020-03-31	2021-10-07	Alborz Mahdavi	Conjugates for selective responsiveness to vicinal diols
JP7456007B2 (ja) *	2020-05-15	2024-03-26	イーライリリーアンドカンパニー	長時間作用アシル化インスリン化合物
US20240374735A1 (en)	2020-11-19	2024-11-14	Protomer Technologies Inc.	Aromatic boron-containing compounds and insulin analogs
US20240043493A1 (en) *	2020-12-07	2024-02-08	Case Western Reserve University	Acylated single-chain insulin analogues
KR20250005573A (ko)	2022-05-18	2025-01-09	프로토머 테크놀로지스 인크.	방향족 붕소-함유 화합물 및 관련 인슐린 유사체

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2538018A (en)	1944-04-04	1951-01-16	Nordisk Insulinlab	Crystalline product of insulin and alkaline protein and process of making it
US2801953A (en)	1952-02-28	1957-08-06	Hoechst Ag	Process of preparing crystallized insulin preparations
US2849370A (en)	1953-06-04	1958-08-26	Novo Terapeutisk Labortorium A	Injectable insulin preparations with protracted effect and process of producing same
US3102077A (en)	1953-08-19	1963-08-27	Christensen Henry Marinus	Preparation of insulin containing 2.75 to 8 percent zinc content
US3060093A (en)	1957-07-18	1962-10-23	Nordisk Insulinlab	Slowly acting insulin preparation in crystalline form and method of preparation
DE1793517C3 (de)	1968-09-28	1974-12-05	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	N(Al),N(B29>Bis-(tert.-butyloxycarbonyl)-insulin und Verfahren zu seiner Herstellung
US3869437A (en)	1970-05-08	1975-03-04	Nat Res Dev	Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
US3950517A (en)	1970-05-08	1976-04-13	National Research Development Corporation	Insulin derivatives
GB1381274A (en)	1971-01-28	1975-01-22	Nat Res Dev	Insulin derivatives
US3868358A (en)	1971-04-30	1975-02-25	Lilly Co Eli	Protamine-insulin product
US3865325A (en)	1971-07-02	1975-02-11	Dylaker Computer Systems Inc	Flexible tape reel
US3907763A (en)	1972-03-01	1975-09-23	Bayer Ag	Insulin derivatives crosslinked by a dicarboxylic acid moiety
US4183849A (en)	1975-01-15	1980-01-15	Nordisk Insulinlaboratorium	Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect
JPS55138391A (en)	1979-04-13	1980-10-29	Shionogi & Co Ltd	New synthetic method of peptide derivative
JPS55138393A (en)	1979-04-13	1980-10-29	Shionogi & Co Ltd	Semisynthesis of insulin
US4343898A (en)	1980-02-11	1982-08-10	Novo Industri A/S	Process for preparing esters of human insulin
DE3101382A1 (de)	1981-01-17	1982-09-02	Hoechst Ag, 6000 Frankfurt	"verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
DK353781A (da)	1981-08-10	1983-02-11	Novo Industri As	Fremgangsmaade til fremstilling af insulinderivater
IT1189353B (it)	1982-06-07	1988-02-04	Nordisk Insulinlab	Procedimento per la preparazione di insulina umana e suoi esteri
DE3326473A1 (de)	1983-07-22	1985-01-31	Hoechst Ag, 6230 Frankfurt	Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3327709A1 (de)	1983-07-29	1985-02-07	Hoechst Ag, 6230 Frankfurt	Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
US4946828A (en) *	1985-03-12	1990-08-07	Novo Nordisk A/S	Novel insulin peptides
PH25772A (en)	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
JPH01254699A (ja)	1988-04-05	1989-10-11	Kodama Kk	インスリン誘導体及びその用途
WO1990001038A1 (en)	1988-07-20	1990-02-08	Nordisk Gentofte A/S	Human insulin analogs and preparations containing them
DE3837825A1 (de) *	1988-11-08	1990-05-10	Hoechst Ag	Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
HUT56857A (en)	1988-12-23	1991-10-28	Novo Nordisk As	Human insulin analogues
US5514646A (en)	1989-02-09	1996-05-07	Chance; Ronald E.	Insulin analogs modified at position 29 of the B chain
PT93057B (pt)	1989-02-09	1995-12-29	Lilly Co Eli	Processo para a preparacao de analogos da insulina
DK134189D0 (da)	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
EP0705275B1 (en)	1993-06-21	1999-02-03	Novo Nordisk A/S	Asp-b28 insulin crystals
DK72793D0 (da)	1993-06-21	1993-06-21	Novo Nordisk As	Nyt produkt
CN1056618C (zh) *	1993-09-17	2000-09-20	诺沃挪第克公司	酰化的胰岛素和含有这种胰岛素的药物组合物
US5461031A (en) *	1994-06-16	1995-10-24	Eli Lilly And Company	Monomeric insulin analog formulations
US5474978A (en)	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
US5597893A (en)	1994-10-31	1997-01-28	Eli Lilly And Company	Preparation of stable insulin analog crystals
US5646242A (en) *	1994-11-17	1997-07-08	Eli Lilly And Company	Selective acylation of epsilon-amino groups
US5693609A (en) *	1994-11-17	1997-12-02	Eli Lilly And Company	Acylated insulin analogs
WO1996029344A1 (en)	1995-03-17	1996-09-26	Novo Nordisk A/S	Insulin derivatives
US5700904A (en) *	1995-06-07	1997-12-23	Eli Lilly And Company	Preparation of an acylated protein powder
US5877153A (en)	1996-06-11	1999-03-02	Commonwealth Biotechnologies Inc.	Heparin-binding peptides
ES2292189T3 (es)	1996-06-20	2008-03-01	Novo Nordisk A/S	Preparaciones a base de insulina conteniendo manitol.
US5948751A (en)	1996-06-20	1999-09-07	Novo Nordisk A/S	X14-mannitol
JP3343129B2 (ja)	1997-02-07	2002-11-11	ノボノルディスクアクティーゼルスカブ	タンパク質の結晶化
ZA989744B (en)	1997-10-31	2000-04-26	Lilly Co Eli	Method for administering acylated insulin.

1998
- 1998-10-22 AU AU11166/99A patent/AU747926B2/en not_active Ceased
- 1998-10-22 EP EP98953852A patent/EP1039920A4/en not_active Withdrawn
- 1998-10-22 TR TR2000/01050T patent/TR200001050T2/xx unknown
- 1998-10-22 JP JP2000517736A patent/JP2001521006A/ja not_active Withdrawn
- 1998-10-22 CA CA002306877A patent/CA2306877A1/en not_active Abandoned
- 1998-10-22 KR KR1020007004395A patent/KR20010024556A/ko not_active Application Discontinuation
- 1998-10-22 WO PCT/US1998/022434 patent/WO1999021578A1/en not_active Application Discontinuation
- 1998-10-22 PL PL98340255A patent/PL340255A1/xx not_active Application Discontinuation
- 1998-10-22 IL IL13490198A patent/IL134901A0/xx unknown
- 1998-10-22 CN CN98810334A patent/CN1276731A/zh active Pending
- 1998-10-22 US US09/177,685 patent/US6268335B1/en not_active Expired - Lifetime
- 1998-10-22 WO PCT/US1998/022313 patent/WO1999021573A1/en not_active Application Discontinuation
- 1998-10-22 BR BR9813111-7A patent/BR9813111A/pt not_active IP Right Cessation
- 1998-10-22 PE PE1998000996A patent/PE123799A1/es not_active Application Discontinuation
- 1998-10-22 ID IDW20000748A patent/ID24890A/id unknown
- 1998-10-22 EA EA200000453A patent/EA200000453A1/ru unknown
- 1998-10-22 CA CA002306905A patent/CA2306905A1/en not_active Abandoned
- 1998-10-22 CO CO98061475A patent/CO4970769A1/es unknown
- 1998-10-22 SV SV1998000125A patent/SV1998000125A/es unknown
- 1998-10-22 JP JP2000517731A patent/JP2001521004A/ja not_active Withdrawn
- 1998-10-22 AU AU11117/99A patent/AU1111799A/en not_active Abandoned
- 1998-10-22 AR ARP980105267A patent/AR020047A1/es unknown
- 1998-10-22 HU HU0004169A patent/HUP0004169A3/hu unknown
2000
- 2000-04-18 NO NO20002038A patent/NO20002038L/no not_active Application Discontinuation
- 2000-04-21 HR HR20000236A patent/HRP20000236A2/hr not_active Application Discontinuation
2001
- 2001-01-17 US US09/761,903 patent/US6465426B2/en not_active Expired - Fee Related
- 2001-12-06 US US10/010,038 patent/US20020082199A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL340255A1 (en)	2001-01-29
US20010036916A1 (en)	2001-11-01
AR020047A1 (es)	2002-04-10
IL134901A0 (en)	2001-05-20
SV1998000125A (es)	1999-05-24
EP1039920A1 (en)	2000-10-04
PE123799A1 (es)	1999-12-13
AU1116699A (en)	1999-05-17
US20020082199A1 (en)	2002-06-27
JP2001521004A (ja)	2001-11-06
CO4970769A1 (es)	2000-11-07
BR9813111A (pt)	2000-08-15
US6465426B2 (en)	2002-10-15
JP2001521006A (ja)	2001-11-06
WO1999021578A1 (en)	1999-05-06
CA2306877A1 (en)	1999-05-06
TR200001050T2 (tr)	2000-08-21
ID24890A (id)	2000-08-31
HRP20000236A2 (en)	2001-02-28
AU1111799A (en)	1999-05-17
NO20002038L (no)	2000-06-26
WO1999021573A1 (en)	1999-05-06
CN1276731A (zh)	2000-12-13
EA200000453A1 (ru)	2000-10-30
HUP0004169A3 (en)	2001-06-28
KR20010024556A (ko)	2001-03-26
HUP0004169A2 (hu)	2001-05-28
AU747926B2 (en)	2002-05-30
US6268335B1 (en)	2001-07-31
EP1039920A4 (en)	2003-05-28
CA2306905A1 (en)	1999-05-06

Publication	Publication Date	Title
NO20002038D0 (no)	2000-04-18	Uløselig insulinsammensetning
NO2006014I1 (no)	2006-11-13	Insulin glulisin
PT1283051E (pt)	2006-08-31	Formulacoes de insulina estaveis
DE69825982D1 (de)	2004-10-07	Spritze
IS5425A (is)	2000-03-31	Læknislyf
DE69812370D1 (de)	2003-04-24	Landwirtschaftliche zusammensetzung
ATE376568T1 (de)	2007-11-15	Epoxy-polysiloxan polymerzusammensetzung
ID25533A (id)	2000-10-12	Formulasi 2-metil-tieno-benzodiazepin
FI972292L (fi)	1998-12-01	Diabeteksen hallinta
IS4974A (is)	1999-02-11	Lyfjasamsetning á þrýstingsúðaformi
IS5430A (is)	2000-04-06	Ný samsetning
DE69824961D1 (de)	2004-08-12	Härtbare zusammensetzung
ID25508A (id)	2000-10-05	Komposisi dematologis
DK0897667T3 (da)	2005-03-14	Brödforbedrende sammensætning
ID23250A (id)	2000-03-30	Komposisi paroksetin
ID21906A (id)	1999-08-12	Komposisi adesif
DE69821948D1 (de)	2004-04-01	Härtbare zusammensetzung
ID29294A (id)	2001-08-16	Komposisi farmasi
DE69824331D1 (de)	2004-07-15	Fungizide Zusammensetzung
ID25857A (id)	2000-11-09	Komposisi farmasi
FI19992526A (fi)	2000-01-25	Sahakokoonpano
DE69811682D1 (de)	2003-04-03	Dosiervorrichtung
FI961364L (fi)	1997-09-26	Lääkeainekoostumus
EP0949331A4 (en)	2001-05-02	Established microglial cells
ID23531A (id)	2000-04-27	Komposisi farmasi

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2003-06-23	FC2A	Withdrawal, rejection or dismissal of laid open patent application