NO117128B - - Google Patents
Download PDFInfo
- Publication number
- NO117128B NO117128B NO158254A NO15825465A NO117128B NO 117128 B NO117128 B NO 117128B NO 158254 A NO158254 A NO 158254A NO 15825465 A NO15825465 A NO 15825465A NO 117128 B NO117128 B NO 117128B
- Authority
- NO
- Norway
- Prior art keywords
- deoxyuridine
- nitro
- solution
- thymidine
- enzyme
- Prior art date
Links
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims description 18
- USBZWPXQQCSGAV-RRKCRQDMSA-N 1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-nitropyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C([N+]([O-])=O)=C1 USBZWPXQQCSGAV-RRKCRQDMSA-N 0.000 claims description 9
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 claims description 9
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims description 9
- 229940104230 thymidine Drugs 0.000 claims description 9
- TUARVSWVPPVUGS-UHFFFAOYSA-N 5-nitrouracil Chemical compound [O-][N+](=O)C1=CNC(=O)NC1=O TUARVSWVPPVUGS-UHFFFAOYSA-N 0.000 claims description 7
- 238000000855 fermentation Methods 0.000 claims description 6
- 230000004151 fermentation Effects 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 241001134654 Lactobacillus leichmannii Species 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 230000002255 enzymatic effect Effects 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 11
- 102000004190 Enzymes Human genes 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 238000005119 centrifugation Methods 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 239000008363 phosphate buffer Substances 0.000 description 5
- 238000011534 incubation Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000006911 enzymatic reaction Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 229940113082 thymine Drugs 0.000 description 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 description 1
- VVLAIYIMMFWRFW-UHFFFAOYSA-N 2-hydroxyethylazanium;acetate Chemical compound CC(O)=O.NCCO VVLAIYIMMFWRFW-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- 101001091385 Homo sapiens Kallikrein-6 Proteins 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 102100034866 Kallikrein-6 Human genes 0.000 description 1
- 241000700665 Sheeppox virus Species 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000002021 butanolic extract Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000012230 colorless oil Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000013048 microbiological method Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000004816 paper chromatography Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/385—Pyrimidine nucleosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB21935/64A GB1107014A (en) | 1964-05-27 | 1964-05-27 | 5-nitro-2'-deoxyuridine and the preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO117128B true NO117128B (es) | 1969-07-07 |
Family
ID=10171278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO158254A NO117128B (es) | 1964-05-27 | 1965-05-26 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3366626A (es) |
| AT (1) | AT259142B (es) |
| BE (1) | BE664538A (es) |
| BR (1) | BR6569937D0 (es) |
| CH (1) | CH425803A (es) |
| DE (1) | DE1278438B (es) |
| DK (1) | DK108311C (es) |
| ES (1) | ES313097A1 (es) |
| FI (1) | FI44403B (es) |
| FR (2) | FR1443435A (es) |
| GB (1) | GB1107014A (es) |
| IL (1) | IL23540A (es) |
| NL (1) | NL131549C (es) |
| NO (1) | NO117128B (es) |
| SE (1) | SE306744B (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1072249B (de) * | 1959-12-31 | F. Hoffmann-La Roche &. Co. Aktiengesellschaft Basel (Schweiz) | Verfahren zur Herstellung eines N-Desoxyribosides von 5-Fluor-uracil | |
| US3235363A (en) * | 1964-05-01 | 1966-02-15 | Du Pont | Method for the control of undesirable vegetation |
| US3282921A (en) * | 1964-06-04 | 1966-11-01 | Syntex Corp | Halo-deoxynucleosides and processes for the preparation thereof |
-
1964
- 1964-05-27 GB GB21935/64A patent/GB1107014A/en not_active Expired
-
1965
- 1965-05-14 IL IL23540A patent/IL23540A/xx unknown
- 1965-05-14 NL NL6506228A patent/NL131549C/xx active
- 1965-05-18 US US456813A patent/US3366626A/en not_active Expired - Lifetime
- 1965-05-19 ES ES0313097A patent/ES313097A1/es not_active Expired
- 1965-05-19 AT AT454065A patent/AT259142B/de active
- 1965-05-20 DE DEL50768A patent/DE1278438B/de active Pending
- 1965-05-20 DK DK254665AA patent/DK108311C/da active
- 1965-05-25 FI FI1248/64A patent/FI44403B/fi active
- 1965-05-25 SE SE6888/65A patent/SE306744B/xx unknown
- 1965-05-25 CH CH731765A patent/CH425803A/fr unknown
- 1965-05-26 FR FR18471A patent/FR1443435A/fr not_active Expired
- 1965-05-26 NO NO158254A patent/NO117128B/no unknown
- 1965-05-26 BE BE664538D patent/BE664538A/xx unknown
- 1965-05-26 BR BR169937/65A patent/BR6569937D0/pt unknown
- 1965-08-25 FR FR29447A patent/FR4591M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BR6569937D0 (pt) | 1973-12-26 |
| DE1278438B (de) | 1968-09-26 |
| IL23540A (en) | 1968-12-26 |
| GB1107014A (en) | 1968-03-20 |
| FR1443435A (fr) | 1966-06-24 |
| NL6506228A (es) | 1965-11-29 |
| FR4591M (es) | 1966-12-19 |
| CH425803A (fr) | 1966-12-15 |
| FI44403B (es) | 1971-08-02 |
| ES313097A1 (es) | 1965-12-16 |
| SE306744B (es) | 1968-12-09 |
| US3366626A (en) | 1968-01-30 |
| BE664538A (es) | 1965-09-16 |
| AT259142B (de) | 1967-12-27 |
| NL131549C (es) | 1971-06-15 |
| DK108311C (da) | 1967-11-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2020119828A1 (zh) | 一株克劳氏芽孢杆菌及使用其生产四氢嘧啶的方法 | |
| JPS60114197A (ja) | 微生物によるジカルボン酸の製造法 | |
| CN103146786A (zh) | 一种采用梯度pH顺序控制发酵生产腺苷的方法 | |
| US4321376A (en) | Neplanocin-B and -F | |
| Laland et al. | Synthesis of pyrimidin-2-one deoxyribosides and their ability to support the growth of the deoxyriboside-requiring organism Lactobacillus acidophilus R26 | |
| NO158254B (no) | Analogifremgangsmaate for fremstilling av bicyklo(3,2,1)oktan-karboksylsyrederivater. | |
| US4713372A (en) | 2-chloropentostatin compound having adenosine diaminase inhibitory activity | |
| NO117128B (es) | ||
| US4423218A (en) | Antibiotic neplanocin A | |
| KR930006994B1 (ko) | 우리딘의 제조방법 | |
| Benesch et al. | a Model for the Configuration of Sulf-Hydryl Groups in Proteins | |
| JPS6111598B2 (es) | ||
| Huang | Preparation of 5-Amino-1-β-ribosyl-4-imidazolecarboxamide-5'-phosphate and N-(5-Amino-1-β-D-ribosyl-4-imidazolecarbonyl)-L-aspartic Acid 5'-Phosphate | |
| CN110372606A (zh) | 一种从微生物发酵液中分离纯化胞嘧啶的方法 | |
| Wright et al. | Influence of Certain Purines, Pyrimidines, and Pterins on Synthesis of “Folic Acid” by Aerobacter aerogenes. | |
| JPH02291293A (ja) | エチル―α―グルコシドの製造方法 | |
| JPH02138996A (ja) | カンタキサンチンの製造法 | |
| JPS5829078B2 (ja) | 補酵素ｑ↓１↓０の製造法 | |
| van Horn et al. | Growth of Bacterium coli and Staphylococcus albus in Heavy Water | |
| Sato et al. | Extracellular accumulation of organic acids by isopropanol-utilizing microorganisms | |
| JPS63219368A (ja) | 選択醗酵法 | |
| JPS59179094A (ja) | トリアゾ−ルデオキシリボヌクレオシドの製造法 | |
| JPS61289898A (ja) | 植物病原菌胞子発芽抑制因子の製造方法 | |
| JPS59179092A (ja) | ３−（２−置換−オキサゾ−ル−５−イル）インド−ル、その塩およびそれらの製造法 | |
| CN116042748A (zh) | 一种酶法合成烟酰胺核糖的方法 |