NL300103I2 - Toepassing van tetrahydrocarbazoolderivaten als 5HT1-receptoragonisten. - Google Patents

Toepassing van tetrahydrocarbazoolderivaten als 5HT1-receptoragonisten.

Info

Publication number: NL300103I2
Authority: NL; Netherlands
Prior art keywords: receptor agonists; tetrahydrocarbazole derivatives; tetrahydrocarbazole; derivatives; agonists
Prior art date: 1991-06-26

Application number

NL300103C

Other languages

English (en)

Other versions

NL300103I1 (nl

Original Assignee

Vernalis Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-26

Filing date

2002-10-14

Publication date

2003-02-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300103(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-10-14 Application filed by Vernalis Ltd filed Critical Vernalis Ltd

2002-12-02 Publication of NL300103I1 publication Critical patent/NL300103I1/nl

2003-02-03 Publication of NL300103I2 publication Critical patent/NL300103I2/nl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NL300103C 1991-06-26 2002-10-14 Toepassing van tetrahydrocarbazoolderivaten als 5HT1-receptoragonisten. NL300103I2 (nl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB919113802A GB9113802D0 (en)	1991-06-26	1991-06-26	Medicaments
US08/167,846 US5464864A (en)	1991-06-26	1992-06-17	Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists
PCT/GB1992/001082 WO1993000086A1 (en)	1991-06-26	1992-06-17	Use of tetrahydrocarbazone derivatives as 5ht1 receptor agonists

Publications (2)

Publication Number	Publication Date
NL300103I1 NL300103I1 (nl)	2002-12-02
NL300103I2 true NL300103I2 (nl)	2003-02-03

Family

ID=10697363

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL300103C NL300103I2 (nl)	1991-06-26	2002-10-14	Toepassing van tetrahydrocarbazoolderivaten als 5HT1-receptoragonisten.

Country Status (35)

Country	Link
US (2)	US5464864A (nl)
EP (1)	EP0591280B1 (nl)
JP (1)	JP3261502B2 (nl)
KR (1)	KR100251571B1 (nl)
CN (1)	CN1034072C (nl)
AP (1)	AP344A (nl)
AT (1)	ATE170746T1 (nl)
BR (2)	BR9206237A (nl)
CA (1)	CA2113726C (nl)
CZ (3)	CZ282083B6 (nl)
DE (2)	DE69226953T2 (nl)
DK (1)	DK0591280T3 (nl)
FI (1)	FI103967B1 (nl)
GB (1)	GB9113802D0 (nl)
HK (1)	HK1014669A1 (nl)
HU (1)	HU218907B (nl)
IE (1)	IE922062A1 (nl)
IL (4)	IL102322A (nl)
LU (1)	LU90939I2 (nl)
MA (1)	MA22563A1 (nl)
MX (1)	MX9203444A (nl)
NL (1)	NL300103I2 (nl)
NO (2)	NO304774B1 (nl)
NZ (1)	NZ243288A (nl)
PL (3)	PL171034B1 (nl)
PT (1)	PT100620B (nl)
RU (1)	RU2137474C1 (nl)
SA (1)	SA92130141B1 (nl)
SG (1)	SG47877A1 (nl)
SI (1)	SI9200125B (nl)
SK (3)	SK280906B6 (nl)
TW (1)	TW214544B (nl)
UA (1)	UA41254C2 (nl)
WO (1)	WO1993000086A1 (nl)
ZA (1)	ZA924658B (nl)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9211277D0 (en)	1992-05-28	1992-07-15	Glaxo Group Inc	Pharmaceutical compositions
GB9226566D0 (en) *	1992-12-21	1993-02-17	Smithkline Beecham Plc	Compounds
GB9226530D0 (en) *	1992-12-21	1993-02-17	Smithkline Beecham Plc	Compounds
US5616603A (en) *	1995-05-26	1997-04-01	Smithkline Beecham Plc	Enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5618948A (en) *	1995-05-26	1997-04-08	Smithkline Beecham P.L.C.	Process for preparing an enantiomer of a carbazole derivative
ES2151993T3 (es) *	1995-06-23	2001-01-16	Lilly Co Eli	1,2,3,4-tetrahidro-9h-carbazoles 6-sustituidos y 10h-ciclohepta(7,6-b)indoles 7-sustituidos.
US5917054A (en) *	1995-07-18	1999-06-29	Smithkline Beecham P.L.C.	Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) *	1996-06-27	1998-01-13	Eli Lilly And Company	6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) *	1996-10-09	1999-04-06	Algos Pharmaceutical Corporation	Method for treating migraine
GB9723061D0 (en) *	1997-10-31	1998-01-07	Vanguard Medica Ltd	Medicaments
US6066092A (en) *	1997-11-06	2000-05-23	Cady; Roger K.	Preemptive prophylaxis of migraine device and method
US7189753B1 (en)	1997-11-06	2007-03-13	Cady Roger K	Preemptive prophylaxis of migraine
GB9808069D0 (en)	1998-04-16	1998-06-17	Vanguard Medica Ltd	Novel processes
GB9817911D0 (en) *	1998-08-17	1998-10-14	Vanguard Medica Ltd	New use
US6685951B2 (en)	2001-07-05	2004-02-03	R. T. Alamo Ventures I, Inc.	Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) *	2001-07-05	2003-01-23	R.T. Alamo Ventures I, Inc.	Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) *	2001-07-05	2003-10-23	R.T. Alamo Ventures I, Llc	Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
ATE444965T1 (de)	2002-06-21	2009-10-15	Suven Life Sciences Ltd	Sich als therapeutische mittel eignende arylalkylindole mit affinität für den serotoninrezeptor, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
AU2003249582B2 (en)	2002-06-21	2006-08-03	Suven Life Sciences Limited	Tetracyclic arylsulfonyl indoles having serotonin receptor affinity
KR100818508B1 (ko)	2002-11-28	2008-03-31	수벤 라이프 사이언시스 리미티드	세로토닌 수용체 친화력을 가지는 엔-아릴술포닐-3-치환인돌, 그 제조방법 및 그를 포함하는 약제학적 조성물
EP1567492B1 (en)	2002-11-28	2013-05-22	Suven Life Sciences Limited	N-arylsulfonyl-3-aminoalkoxyindoles
DE60312226T2 (de)	2002-12-18	2007-11-15	Suven Life Sciences Ltd.	Tetrazyklische 3-substituierte indole mit serotoninrezeptoraffinität
SI2051962T1 (sl) *	2006-08-07	2012-02-29	Actelion Pharmaceuticals Ltd	Derivati (3-amino-1,2,3,4-tetrahidro-9h-karbazol-9-il)-ocetne kisline
EP2813144A1 (en)	2006-10-09	2014-12-17	Charleston Laboratories, Inc.	Analgesic compositions comprising an antihistamine
DK2120875T3 (en)	2007-02-11	2018-10-22	Map Pharmaceuticals Inc	METHOD OF THERAPEUTIC ADMINISTRATION OF DHE TO POSSIBLE QUICK PREVENTION OF MIGRANE AT THE MINIMUM OF THE SIDE EFFECT PROFILE
US20090069399A1 (en) *	2007-09-12	2009-03-12	Protia, Llc	Deuterium-enriched frovatriptan
JP5714910B2 (ja)	2008-01-09	2015-05-07	チャールストンラボラトリーズ，インコーポレイテッド	薬学的組成物
WO2010073253A1 (en) *	2008-12-22	2010-07-01	Natco Pharma Limited	Method for preparing an optically active frovatriptan
EP3311667A1 (en)	2009-07-08	2018-04-25	Charleston Laboratories, Inc.	Pharmaceutical compositions
US10098674B2 (en)	2009-10-22	2018-10-16	Nuvasive, Inc.	System and method for posterior cervical fusion
WO2011050140A1 (en)	2009-10-22	2011-04-28	Blue Fury Consulting, L.L.C.	Posterior cervical fusion system and techniques
US9399053B2 (en)	2011-07-22	2016-07-26	The University Of Chicago	Treatments for migraine and related disorders
EP2935280A4 (en)	2012-12-21	2016-05-25	Map Pharmaceuticals Inc	8'-HYDROXY-DIHYDROERGOTAMINE COMPOUNDS AND COMPOSITIONS
EP2816030A1 (en)	2013-06-20	2014-12-24	Duke Chem, S. A.	Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) *	2013-07-17	2013-08-28	Ge Healthcare Ltd	Work-up procedure
CA3055170A1 (en)	2016-03-04	2017-09-08	Charleston Laboratories, Inc.	Pharmaceutical compositions
EP3766483A1 (en)	2019-07-19	2021-01-20	BioPharma Synergies, S. L.	Orodispersible powder composition comprising a triptan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3642816A (en) *	1967-08-10	1972-02-15	Sterling Drug Inc	3-acetamido-1 2 3 4-tetrahydrocarbazole
US4062864A (en) *	1968-01-24	1977-12-13	Sterling Drug Inc.	3-Hydroxy carbazole derivatives
US3959309A (en) *	1968-01-24	1976-05-25	Sterling Drug Inc.	3-Amido-1,2,3,4-tetrahydrocarbazoles
US3592824A (en) *	1970-03-12	1971-07-13	Miles Lab	3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) *	1971-08-16	1979-10-30	Sterling Drug Inc.	3-Amino-tetrahydrocarbazoles
BE787537A (fr) *	1971-08-16	1973-02-14	Sterling Drug Inc	Tetrahydrocarbazoles
US4257952A (en) *	1977-06-06	1981-03-24	Sterling Drug Inc.	3-Amino-tetrahydrocarbazoles
US4254134A (en) *	1978-03-17	1981-03-03	Endo Laboratories, Inc.	Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) *	1983-01-04	1984-08-15	MERCK PATENT GmbH	Tetrahydrocarbazolderivate

1991
- 1991-06-26 GB GB919113802A patent/GB9113802D0/en active Pending
1992
- 1992-06-17 UA UA93002251A patent/UA41254C2/uk unknown
- 1992-06-17 BR BR9206237A patent/BR9206237A/pt not_active Application Discontinuation
- 1992-06-17 SK SK1054-98A patent/SK280906B6/sk not_active IP Right Cessation
- 1992-06-17 SG SG1996004938A patent/SG47877A1/en unknown
- 1992-06-17 JP JP51108692A patent/JP3261502B2/ja not_active Expired - Lifetime
- 1992-06-17 SK SK1685-98A patent/SK280907B6/sk not_active IP Right Cessation
- 1992-06-17 DE DE69226953T patent/DE69226953T2/de not_active Expired - Lifetime
- 1992-06-17 CZ CS932861A patent/CZ282083B6/cs not_active IP Right Cessation
- 1992-06-17 AT AT92912379T patent/ATE170746T1/de active
- 1992-06-17 CA CA002113726A patent/CA2113726C/en not_active Expired - Lifetime
- 1992-06-17 KR KR1019930704055A patent/KR100251571B1/ko not_active IP Right Cessation
- 1992-06-17 DE DE2002199042 patent/DE10299042I2/de active Active
- 1992-06-17 WO PCT/GB1992/001082 patent/WO1993000086A1/en active IP Right Grant
- 1992-06-17 EP EP92912379A patent/EP0591280B1/en not_active Expired - Lifetime
- 1992-06-17 CZ CZ961505A patent/CZ150596A3/cs not_active IP Right Cessation
- 1992-06-17 HU HU9303731A patent/HU218907B/hu active IP Right Revival
- 1992-06-17 US US08/167,846 patent/US5464864A/en not_active Expired - Lifetime
- 1992-06-17 RU RU93058534A patent/RU2137474C1/ru active Protection Beyond IP Right Term
- 1992-06-17 PL PL92311304A patent/PL171034B1/pl unknown
- 1992-06-17 PL PL92307118A patent/PL169410B1/pl unknown
- 1992-06-17 DK DK92912379T patent/DK0591280T3/da active
- 1992-06-17 PL PL92301883A patent/PL169392B1/pl unknown
- 1992-06-17 CZ CZ961506A patent/CZ150696A3/cs not_active IP Right Cessation
- 1992-06-17 SK SK1319-93A patent/SK280905B6/sk not_active IP Right Cessation
- 1992-06-24 ZA ZA924658A patent/ZA924658B/xx unknown
- 1992-06-24 PT PT100620A patent/PT100620B/pt not_active IP Right Cessation
- 1992-06-24 NZ NZ243288A patent/NZ243288A/en not_active IP Right Cessation
- 1992-06-24 MA MA22853A patent/MA22563A1/fr unknown
- 1992-06-25 IL IL102322A patent/IL102322A/xx not_active IP Right Cessation
- 1992-06-25 AP APAP/P/1992/000403A patent/AP344A/en active
- 1992-06-25 CN CN92108831A patent/CN1034072C/zh not_active Expired - Lifetime
- 1992-06-25 IL IL11710596A patent/IL117105A0/xx unknown
- 1992-06-25 IL IL117105A patent/IL117105A/en not_active IP Right Cessation
- 1992-06-25 IL IL117104A patent/IL117104A/xx not_active IP Right Cessation
- 1992-06-25 TW TW081104991A patent/TW214544B/zh not_active IP Right Cessation
- 1992-06-26 MX MX9203444A patent/MX9203444A/es unknown
- 1992-06-26 SI SI9200125A patent/SI9200125B/sl unknown
- 1992-07-01 IE IE206292A patent/IE922062A1/en not_active IP Right Cessation
- 1992-10-04 SA SA92130141A patent/SA92130141B1/ar unknown
1993
- 1993-12-23 FI FI935842A patent/FI103967B1/fi not_active IP Right Cessation
- 1993-12-23 NO NO934759A patent/NO304774B1/no not_active IP Right Cessation
1995
- 1995-05-15 US US08/442,719 patent/US5637611A/en not_active Expired - Lifetime
1997
- 1997-05-06 BR BR1100460-6A patent/BR1100460A/pt active IP Right Grant
1998
- 1998-12-28 HK HK98116054A patent/HK1014669A1/xx not_active IP Right Cessation
2002
- 2002-07-24 LU LU90939C patent/LU90939I2/fr unknown
- 2002-10-14 NL NL300103C patent/NL300103I2/nl unknown
2005
- 2005-05-03 NO NO2005011C patent/NO2005011I2/no unknown

Also Published As

Publication number	Publication date
HU218907B (hu)	2000-12-28
IL102322A (en)	1997-09-30
FI103967B (fi)	1999-10-29
CN1069726A (zh)	1993-03-10
NZ243288A (en)	1994-09-27
NO934800D0 (no)	1993-12-23
EP0591280A1 (en)	1994-04-13
CZ282327B6 (cs)	1997-06-11
KR100251571B1 (ko)	2000-07-01
BR1100460A (pt)	2000-07-18
AP344A (en)	1994-07-05
GB9113802D0 (en)	1991-08-14
PT100620B (pt)	1999-01-29
US5464864A (en)	1995-11-07
NO2005011I2 (no)	2008-02-11
FI103967B1 (fi)	1999-10-29
ZA924658B (en)	1993-12-24
LU90939I2 (fr)	2002-09-24
CA2113726A1 (en)	1993-01-07
AU1977592A (en)	1993-01-25
CZ282061B6 (cs)	1997-05-14
NO304774B1 (no)	1999-02-15
HK1014669A1 (en)	1999-09-30
CZ150596A3 (en)	1997-05-14
HUT68961A (en)	1995-08-28
IL117104A (en)	1997-09-30
BR9206237A (pt)	1995-04-11
IL117105A (en)	1998-01-04
DE69226953D1 (de)	1998-10-15
PL171034B1 (en)	1997-02-28
PL169410B1 (pl)	1996-07-31
AU652842B2 (en)	1994-09-08
SA92130141B1 (ar)	2005-12-18
IL117104A0 (en)	1996-06-18
SK280907B6 (sk)	2000-09-12
NL300103I1 (nl)	2002-12-02
TW214544B (nl)	1993-10-11
DE10299042I2 (de)	2005-02-03
SK280906B6 (sk)	2000-09-12
SI9200125B (en)	2001-12-31
SK131993A3 (en)	1994-06-08
RU2137474C1 (ru)	1999-09-20
DE10299042I1 (de)	2003-02-20
FI935842A (fi)	1993-12-23
IL102322A0 (en)	1993-01-14
ATE170746T1 (de)	1998-09-15
PL169392B1 (pl)	1996-07-31
AP9200403A0 (en)	1992-07-31
MX9203444A (es)	1993-12-01
CZ150696A3 (en)	1997-06-11
IL117105A0 (en)	1996-06-18
WO1993000086A1 (en)	1993-01-07
NO2005011I1 (no)	2005-05-18
CZ282083B6 (cs)	1997-05-14
SK280905B6 (sk)	2000-09-12
CZ286193A3 (en)	1994-07-13
UA41254C2 (uk)	2001-09-17
CN1034072C (zh)	1997-02-19
CA2113726C (en)	2008-02-19
EP0591280B1 (en)	1998-09-09
JPH06508827A (ja)	1994-10-06
DK0591280T3 (da)	1999-02-15
MA22563A1 (fr)	1992-12-31
SG47877A1 (en)	1998-04-17
PT100620A (pt)	1993-09-30
IE922062A1 (en)	1992-12-30
FI935842A0 (fi)	1993-12-23
SI9200125A (en)	1992-12-31
JP3261502B2 (ja)	2002-03-04
US5637611A (en)	1997-06-10
DE69226953T2 (de)	1999-05-12
NO934800L (no)	1993-12-23

Publication	Publication Date	Title
NL300103I2 (nl)	2003-02-03	Toepassing van tetrahydrocarbazoolderivaten als 5HT1-receptoragonisten.
KR950700906A (ko)	1995-02-20	5-ht1 작동약으로서의 인돌 유도체(indole derivatives as 5-ht1 agonists)
FI944805A (fi)	1994-10-12	Indolijohdannaisia 5-HT1-kaltaisina agonisteina
DK0516349T3 (da)	1995-11-06	2-hydroxy-2-phenylethylamin-derivater som beta-3-adrenoceptoragonister
DE69127791D1 (de)	1997-11-06	Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten
DE10199002I2 (de)	2001-12-13	Substituierte thiazolidindion derivate
DE69401823D1 (de)	1997-04-03	Indolin derivate als 5ht2c antagonisten
FI961628A0 (fi)	1996-04-12	Indolijohdannaisia NMDA-antagonisteina
DE69233356D1 (de)	2004-07-01	Carbostyrilderivate als Phosphodiesterase-Hemmstoffe
FI962969A (fi)	1996-07-25	Indolijohdannaisia 5-HT1:n agonisteina
ATE222492T1 (de)	2002-09-15	Verwendung von indolderivaten als 5ht1-agonisten
DE59006366D1 (de)	1994-08-11	Substituierte Pyrazolinderivate.
DE69003213D1 (de)	1993-10-14	Imidazol-Derivate als Histamin-H3-Agonisten.
DE69703242D1 (de)	2000-11-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
DE69320653D1 (de)	1998-10-01	Tetrahydrocarbazolderivate als 5-ht1-ähnliche agonisten
DE69717449D1 (de)	2003-01-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
ATE217619T1 (de)	2002-06-15	Endothelin-rezeptor-antagonisten
MX9201931A (es)	1992-11-01	Nuevos derivados de tiazol.
KR930000944U (ko)	1993-01-21	플로어 힌지용 피스톤 지지편
DE69222983D1 (de)	1997-12-11	Heterocyclische Derivate
DE69004827D1 (de)	1994-01-13	Alpha-adrenergene Rezeptor-Antagonisten.
MX9202442A (es)	1992-11-01	Derivados de azol.
FI911109A (fi)	1992-09-07	Mekanism foer i aendan utdragbar roekspjaell