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MXPA05007561A - Derivados de acido hidroxamida como inhibidores de histona desacetilasa (hdac). - Google Patents

Derivados de acido hidroxamida como inhibidores de histona desacetilasa (hdac).

Info

Publication number
MXPA05007561A
MXPA05007561A MXPA05007561A MXPA05007561A MXPA05007561A MX PA05007561 A MXPA05007561 A MX PA05007561A MX PA05007561 A MXPA05007561 A MX PA05007561A MX PA05007561 A MXPA05007561 A MX PA05007561A MX PA05007561 A MXPA05007561 A MX PA05007561A
Authority
MX
Mexico
Prior art keywords
histone deacetylase
hdac
inhibitors
acid derivatives
hydroxamid
Prior art date
Application number
MXPA05007561A
Other languages
English (en)
Inventor
Kazunori Kamijo
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2003900116A external-priority patent/AU2003900116A0/en
Priority claimed from AU2003905406A external-priority patent/AU2003905406A0/en
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MXPA05007561A publication Critical patent/MXPA05007561A/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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Abstract

Un compuesto que tiene la siguiente formula (I) (ver formula (I)): Donde R1 es un anillo heterociclico que contiene N opcionalmente sustituido con uno o mas sustituyentes apropiados, R2 es hidroxiamino, R3 es hidrogeno o un sustituyente apropiado, L1 es -(CH2)n- (donde n es un numero de 0 a 6) opcionalmente sustituido con uno o mas sustituyentes apropiados, donde uno o varios metilenos pueden estar reemplazados con heteroatomos apropiados, y L2 es alquenileno inferior, O una sal del mismo. El compuesto es util como inhibidor de histona desacetilasa.
MXPA05007561A 2003-01-13 2004-01-13 Derivados de acido hidroxamida como inhibidores de histona desacetilasa (hdac). MXPA05007561A (es)

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AU2003900116A AU2003900116A0 (en) 2003-01-13 2003-01-13 Hdac inhibitor
AU2003905406A AU2003905406A0 (en) 2003-10-06 HDAC Inhibitor
PCT/JP2004/000157 WO2004063169A1 (en) 2003-01-13 2004-01-13 Hydroxamid acid derivatives as histone deacetylase (hdac) inhibitors

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US7495022B2 (en) 2002-04-11 2009-02-24 Sk Chemicals Co., Ltd. α,β-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors

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AR042851A1 (es) 2005-07-06
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EP1585735A1 (en) 2005-10-19
US20040229889A1 (en) 2004-11-18
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