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MXPA04001935A - Pirrolo pirimidinas como agentes para la inhibicion de proteasas de cisteina. - Google Patents

Pirrolo pirimidinas como agentes para la inhibicion de proteasas de cisteina.

Info

Publication number
MXPA04001935A
MXPA04001935A MXPA04001935A MXPA04001935A MXPA04001935A MX PA04001935 A MXPA04001935 A MX PA04001935A MX PA04001935 A MXPA04001935 A MX PA04001935A MX PA04001935 A MXPA04001935 A MX PA04001935A MX PA04001935 A MXPA04001935 A MX PA04001935A
Authority
MX
Mexico
Prior art keywords
inhibition
agents
cystein proteases
cathepsin
pyrimidines
Prior art date
Application number
MXPA04001935A
Other languages
English (en)
Inventor
Missbach Martin
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MXPA04001935A publication Critical patent/MXPA04001935A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invencion proporciona compuestos de la formula I o una sal o ester farmaceuticamente aceptable del mismo, en donde los simbolos tienen los significados definidos, que son inhibidores de la catepsina K y encuentran uso farmaceuticamente para el tratamiento de enfermedades y condiciones medicas en las cuales esta involucrada la catepsina K, por ejemplo varios trastornos que incluyen inflamacion, artritis reumatoide, osteoartritis, osteoporosis y tumores.
MXPA04001935A 2001-08-30 2002-08-29 Pirrolo pirimidinas como agentes para la inhibicion de proteasas de cisteina. MXPA04001935A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0121033.5A GB0121033D0 (en) 2001-08-30 2001-08-30 Organic compounds
PCT/EP2002/009663 WO2003020721A1 (en) 2001-08-30 2002-08-29 Pyrrolo pyrimidines as agents for the inhibition of cystein proteases

Publications (1)

Publication Number Publication Date
MXPA04001935A true MXPA04001935A (es) 2004-06-15

Family

ID=9921234

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04001935A MXPA04001935A (es) 2001-08-30 2002-08-29 Pirrolo pirimidinas como agentes para la inhibicion de proteasas de cisteina.

Country Status (30)

Country Link
US (2) US7452886B2 (es)
EP (1) EP1423391B8 (es)
JP (1) JP4629334B2 (es)
KR (1) KR100695845B1 (es)
CN (1) CN100372849C (es)
AR (1) AR036374A1 (es)
AT (1) ATE326469T1 (es)
AU (1) AU2002333760B2 (es)
BR (1) BR0212226A (es)
CA (1) CA2458684C (es)
CY (1) CY1105573T1 (es)
DE (1) DE60211530T2 (es)
DK (1) DK1423391T3 (es)
EC (1) ECSP044998A (es)
ES (1) ES2262888T3 (es)
GB (1) GB0121033D0 (es)
HK (1) HK1072254A1 (es)
HU (1) HUP0401301A3 (es)
IL (3) IL160367A0 (es)
MX (1) MXPA04001935A (es)
MY (1) MY157368A (es)
NO (1) NO328890B1 (es)
NZ (1) NZ531343A (es)
PE (1) PE20030418A1 (es)
PL (1) PL368280A1 (es)
PT (1) PT1423391E (es)
RU (1) RU2331644C2 (es)
TW (1) TWI297690B (es)
WO (1) WO2003020721A1 (es)
ZA (1) ZA200401042B (es)

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Also Published As

Publication number Publication date
HK1072254A1 (en) 2005-08-19
PE20030418A1 (es) 2003-06-12
ECSP044998A (es) 2004-04-28
GB0121033D0 (en) 2001-10-24
DK1423391T3 (da) 2006-09-25
CA2458684A1 (en) 2003-03-13
KR20040029123A (ko) 2004-04-03
US20090054467A1 (en) 2009-02-26
HUP0401301A3 (en) 2008-03-28
IL160367A0 (en) 2004-07-25
CN1549817A (zh) 2004-11-24
EP1423391B8 (en) 2007-12-12
KR100695845B1 (ko) 2007-03-20
NZ531343A (en) 2006-01-27
EP1423391B1 (en) 2006-05-17
CN100372849C (zh) 2008-03-05
IL160367A (en) 2009-12-24
NO20041180L (no) 2004-03-19
EP1423391A1 (en) 2004-06-02
NO328890B1 (no) 2010-06-07
PT1423391E (pt) 2006-09-29
BR0212226A (pt) 2004-08-17
ZA200401042B (en) 2004-10-25
US7452886B2 (en) 2008-11-18
RU2331644C2 (ru) 2008-08-20
JP2005502683A (ja) 2005-01-27
AR036374A1 (es) 2004-09-01
CY1105573T1 (el) 2010-07-28
ATE326469T1 (de) 2006-06-15
PL368280A1 (en) 2005-03-21
DE60211530D1 (de) 2006-06-22
HUP0401301A2 (hu) 2004-10-28
CA2458684C (en) 2009-04-07
US20050054851A1 (en) 2005-03-10
AU2002333760B2 (en) 2007-01-04
JP4629334B2 (ja) 2011-02-09
DE60211530T2 (de) 2006-12-21
MY157368A (en) 2016-06-15
RU2004109815A (ru) 2005-10-20
IL198643A (en) 2010-12-30
WO2003020721A1 (en) 2003-03-13
TWI297690B (en) 2008-06-11
ES2262888T3 (es) 2006-12-01

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